Stimpod as an Adjunct for Intraoperative Functional Mapping During Brachial Plexus Repair- A Case Series

Review Article | DOI: https://doi.org/DOI:10.31579/2578-8868/400

Stimpod as an Adjunct for Intraoperative Functional Mapping During Brachial Plexus Repair- A Case Series

  • Kunal Kumar Sharma 1*
  • Digvijay Singh Thakur 2
  • Bhavya Thakur 3

1Assistant Professor, Neuroanesthesia, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

2Assistant Professor, Neurosurgery, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

3Assistant Professor, Plastic surgery, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

*Corresponding Author: Kunal Kumar Sharma, Assistant Professor, Neuroanesthesia, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Citation: Kunal K. Sharma, Digvijay S. Thakur, Bhavya Thakur, (2026), Stimpod as an Adjunct for Intraoperative Functional Mapping During Brachial Plexus Repair- A Case Series, J. Neuroscience and Neurological Surgery, 19(2); DOI:10.31579/2578-8868/400

Copyright: Copyrights: © 2026, Kunal Kumar Sharma. This is an open-access article distributed under the terms of The Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Received: 31 January 2026 | Accepted: 05 February 2026 | Published: 19 February 2026

Keywords: Keywords: brachial plexus; nerve repair; TIVA; entropy

Abstract

Intraoperative decision-making during brachial plexus exploration hinges on rapid assessment of nerve identity, continuity, and distal motor unit recruitment. Conventional techniques rely on EMG and visual inspection. We describe the use of the Stimpod device (Xavant technologies) as a non-invasive functional screening adjunct during brachial plexus exploration and repair.After pre-operative nerve conduction studies and neuroimaging, 21 patients scheduled for brachial plexus repair underwent Stimpod guided intra-operative functional mapping. The responses were correlated with surgical decisions of grafting/transfer and postoperative motor outcomes. Stimpod provided real-time functional information regarding axonal continuity and distal motor unit recruitment, guiding surgical strategy. Postoperative muscle strength in the target muscles, improved in 19 out of 21 patients, with no device-related complications.Stimpod assisted functional screening is a rapid, low-footprint adjunct that complements surgical judgment and conventional monitoring, particularly valuable in resource-limited settings. Limitations include inability to distinguish sensory from motor fibers and to quantify conduction velocity.

Introduction

Brachial plexus injuries (BPI) present a complex surgical challenge where real-time intraoperative decisions critically influence outcomes. During exploration and repair, surgeons must rapidly answer three practical questions: (i) is the identified structure viable nerve or fibrotic scar, (ii) does conduction persist across the lesion, and (iii) is distal motor unit recruitment sufficient to justify neurolysis rather than nerve grafting or transfer [1].

Traditional assessment tools include intraoperative electromyography (EMG) or nerve conduction studies (NCS), and visual inspection. However, there are limitations - EMG and NCS necessitate trained neurophysiology support and bulky setups, whereas visual inspection is subjective and can be misleading [2]. These constraints are amplified in time-sensitive operations and resource-limited environments of tertiary care centers located in Himalayan region.

The Stimpod device (Xavant technologies) is a portable transcutaneous electrical nerve stimulator designed for clinical neuromodulation and assessment. Its application as a functional mapping tool during brachial plexus surgery can bridge the gap between invasive neuromonitoring and purely anatomical judgment. In our literature review we only came across a retrospective study comparing VARI STIM III nerve stimulator (Medtronic Inc, Jacksonville, Florida) and Stimuplex HNS11 (Braun Medical Inc, Bethlehem, Pennsylvania) [3].  This case series describes its principle of use, technique, and clinical utility.

This device delivers controlled electrical stimulation over targeted anatomical structures like proximal plexus elements, suspected nerve trunks, and distal muscle motor points. A visible or palpable muscle contraction following stimulation suggests preserved axonal continuity and functional motor units distal to the stimulation site. Absence or attenuation of response provides complementary information regarding the severity and level of injury. This physiologic principle allows rapid functional assessment without invasive exposure, serving as an adjunct for definitive intraoperative neuromonitoring [4].

Aim

The aim of our case series was to assess the efficacy of Stimpod with Locoplex needle for intraoperative functional mapping of brachial plexus during surgical repair. Secondary objective was to assess the postoperative outcomes after the use of this technique in the study participants.

Case Presentation

The present case series encompasses the use of this device in 21 patients undergoing brachial plexus exploration and repair for traumatic injuries. Procedures included neurolysis, nerve grafting, and nerve transfers based on intraoperative findings. The patients underwent anesthetic induction and endotracheal intubation under total intravenous anesthesia (TIVA) without the aid of muscle relaxant [5]. Entropy monitoring was used to assess anesthetic depth throughout the anesthetic protocol. Thereafter, surface electrodes of Stimpod were placed over the supraclavicular fossa, infraclavicular region, and motor points of the selected muscles of the upper limb. 

After surgical exposure but prior to definitive repair, stimulation was applied using the Locoplex needle (Vygon, France) along the exposed nerve trajectory using a sterile barrier or proximally while observing distal muscle groups for contraction. These responses were interpreted in following manner : (i) robust distal contraction- favored neurolysis and preservation of native nerve; (ii) equivocal or absent response- supported decision for grafting or nerve transfer; (iii) segmental response loss- helped localize the functional level of injury [6]. The technique provided a rapid intraoperative checkpoint, complementing anatomical inspection and surgeon experience.

The series enrolled 21 patients, in which 6 patients underwent Somsak's procedure, 1 patient underwent modified Saha's procedure, 6 patients underwent double Oberlin procedure, 4 patients underwent thoracodorsal to axillary nerve transfer and 4 patients of pan-brachial plexus injury underwent spinal accessory nerve to suprascapular nerve transfer alongwith intercostobrachial nerve to musculocutaneous nerve transfer (Figure 1-5).

Figure 1: Intraoperative use of a Locoplex needle connected to the Stimpod device for targeted electrical stimulation during brachial plexus exploration. The setup demonstrates real-time functional assessment of neural structures prior to nerve transfer, facilitating identification of viable donor fascicles and recipient targets

Figure 2: Intraoperative depiction of Somsak’s nerve transfer technique, illustrating selective fascicular transfer to restore elbow flexion. The image highlights donor fascicle isolation and coaptation under magnification following functional confirmation

Figure 3: Surgical view demonstrating the double Oberlin nerve transfer technique, wherein fascicles from the ulnar and median nerves are selectively transferred to the motor branches of the biceps and brachialis muscles. Functional intraoperative stimulation was used to confirm donor integrity prior to coaptation.

Figure 4: Intraoperative photograph of the modified Saha’s procedure showing nerve identification, preparation of recipient branches, and tension-free microsurgical coaptation. Functional stimulation guidance was utilized to optimize donor–recipient matching.

Figure 5.jpg

Figure 5: Surgical exposure illustrating thoracodorsal nerve transfer to the axillary nerve for restoration of shoulder abduction. The image demonstrates donor nerve mobilization, preparation of the axillary nerve, and microsurgical coaptation following intraoperative stimulation-based assessment.

The responses elicited by Stimpod through Locoplex needle, influenced the intraoperative decisions in a substantial proportion of cases, where visual assessment alone was inconclusive. Postoperative functional outcomes were assessed using the Medical Research Council (MRC) grading system for muscle strength in target muscle groups corresponding to the repaired or transferred nerves. At follow-up, the majority of patients demonstrated meaningful motor recovery (≥ MRC grade 3) in at least one primary target muscle [7]. Patients in whom intraoperative Stimpod stimulation elicited robust distal motor responses prior to repair showed earlier and more consistent recovery compared with those demonstrating absent or equivocal responses. 

A qualitative association was observed between Stimpod responses and surgical strategy. Nerves selected for neurolysis based on preserved distal motor recruitment generally exhibited superior functional outcomes compared with segments requiring grafting or nerve transfer, reflecting underlying axonal continuity. In borderline lesions, Stimpod assisted functional assessment helped avoid unnecessary grafting, without compromising postoperative recovery.

No device-related adverse events were observed. Nerve stimulation did not interfere with anesthetic management. Standard surgical complications related to brachial plexus reconstruction such as donor site morbidity and delayed reinnervation, were comparable to institutional experience and existing literature.

Patients were followed clinically with structured physiotherapy and rehabilitation protocols. Early identification of viable motor units facilitated timely initiation of targeted rehabilitation strategies, potentially contributing to improved functional outcomes. Tables 1 and 2 summarize the key results of the present case series.

Quality of endotracheal intubation
AttemptFirst attempt in all patients
Laryngoscopy duration (in seconds) (mean + SD)17.33 + 4.1096
Desaturation during laryngoscopyNo
Capnography confirmationYes
RSI requiredNo
Adverse Event at IntubationNo
Heart rate during Intubation (beats/min) (mean + SD)94.16  + 9.227
Mean arterial pressure during Intubation (mmHg) (mean + SD)87.66  + 6.446
Surgical procedure
Somsak's procedure6
Double Oberlin procedure6
Modified Saha's procedure1
Thoracodorsal to axillary nerve transfer4
Spinal accessory nerve to suprascapular nerve transfer alongwith intercostobrachial nerve to musculocutaneous nerve transfer4
Intraoperative device metrics
Stimulus at which contraction observed (Excluding 2 cases) (mean + SD)2.94 + 0.3006 mA
Device malfunctionNo
Quality of extubation
Time to extubation7.6 + 0.16 min
Time to respond to verbal commands from cessation of anaesthesia8.7 + 2.6 minutes
Any incidence of coughingNo
Heart rate during Extubation (beats/min) (mean + SD)86.3 + 4.8
Mean arterial pressure during Extubation (mmHg) (mean + SD)103.6 + 5.7
MOASS at 15 min in the PACU (mean + SD)4.333 + 0.471
MOASS at 60 min in the PACU (mean + SD)4.8333 + 0.372
CAM-S form score at 15 min in PACU (mean + SD)0.8333 + 0.3726
CAM -S form at 60 min in PACU (mean + SD)0.3333 + 0.471

Table 1: The table summarizes airway management quality (intubation conditions, hemodynamic stability, and adverse events), types of surgical procedures performed, intraoperative stimulation thresholds required to elicit muscle contraction using the device, and extubation/recovery characteristics including hemodynamic variables, sedation scores (MOASS), and delirium assessment (CAM-S) in the post-anesthesia care unit (PACU). Values are presented as mean ± standard deviation where applicable.

Number of patientsPre- operative MRC scorePost-operative MRC score
102/54+/5
51/53  /5
30/54  /5
20/50  /5

Table 2: Preoperative and postoperative Medical Research Council (MRC) muscle strength grades are shown according to the number of patients in each functional category, demonstrating improvement in motor power following surgical intervention.

Discussion

Brachial plexus injuries (BPI), particularly traumatic and avulsion-type lesions, pose a formidable reconstructive challenge due to the extensive loss of motor and sensory function and the limited window for reinnervation. Over the past two decades, nerve transfer techniques have emerged as a cornerstone of functional restoration, especially when proximal nerve roots are irreparable or unavailable. The guiding principle of nerve transfer surgery i.e. redirecting expendable donor nerves with preserved function to denervated target muscles, has allowed surgeons to bypass long regeneration distances and achieve more reliable outcomes [8].

Early reports demonstrated the feasibility of targeted nerve transfers for shoulder and elbow function [9-13]. Leechavengvongs et al. described transfer of the nerve to the long head of the triceps to the axillary nerve for deltoid reinnervation, reporting meaningful shoulder abduction recovery in the majority of patients [14]. This work was seminal in establishing intraplexal nerve transfers as a reliable option for restoring shoulder stability and function, particularly in upper trunk injuries.

Restoration of shoulder abduction and external rotation remains a primary objective in BPI reconstruction, as it underpins upper limb positioning and functional reach. Transfer of the spinal accessory nerve to the suprascapular nerve has been widely adopted to restore supraspinatus and infraspinatus function [15]. Bertelli and Ghizoni demonstrated consistent recovery of shoulder abduction and external rotation following this transfer, highlighting its reliability and favorable donor morbidity profile [16].

Alternative donor nerves have been explored to optimize outcomes in complex or delayed presentations. Janes et al. reported the use of thoracodorsal and medial triceps nerves to the anterior division of the axillary nerve, demonstrating satisfactory shoulder reanimation when conventional donor nerves were unavailable [17]. Similarly, Samardzic et al. described thoracodorsal nerve transfer in irreparable C5–C6 lesions, achieving functional shoulder recovery in a subset of patients [18]. These studies emphasize the importance of donor nerve selection based on availability, injury pattern, and residual function.

In chronic and salvage scenarios, reconstructive strategies may extend beyond nerve transfers alone. Bordelon et al. reported a modified Saha procedure for paralytic shoulder following reverse shoulder arthroplasty complicated by BPI, illustrating how tendon transfers and muscle balancing procedures can complement nerve reconstruction when denervation is longstanding [19].

Restoration of elbow flexion is widely regarded as the most critical functional goal in BPI reconstruction. Fascicular transfers to the musculocutaneous nerve have shown consistently favorable outcomes. Texakalidis et al. described double fascicular nerve transfers targeting musculocutaneous branches, achieving meaningful recovery of elbow flexion strength with minimal donor morbidity [20].

In more extensive injuries, including infraclavicular and global plexus lesions, extraplexal donors have been utilized. Soldado et al. demonstrated the utility of thoracodorsal nerve transfer for elbow flexion reconstruction, reporting functional recovery even in challenging infraclavicular injuries [21]. Intercostal-to-musculocutaneous nerve transfer remains another established technique, particularly in complete plexus avulsions. de Mendonça Cardoso et al. reported functional elbow flexion in a majority of patients following intercostal nerve transfers, although outcomes were variable and dependent on rehabilitation intensity and timing of surgery [22].

Precise titration of anesthetic depth is critical during nerve exploration and repair, particularly when intraoperative nerve stimulation, electromyography, or emerging neuromodulation tools are employed. Photoacoustic detection of propofol in breath gas highlights the evolving paradigm of real-time propofol quantification as a surrogate for anesthetic depth, especially relevant in neuroanesthesia contexts where conventional indices may lag behind physiological changes [23]. The ability to finely tune hypnotic depth with propofol-based TIVA supports stable cortical and peripheral neural responsiveness, minimizing both burst suppression and unintended awareness during prolonged microsurgical dissections. This precision is particularly advantageous in brachial plexus surgery, where subtle changes in anesthetic depth can alter nerve excitability and surgeon interpretation of functional responses [24].

Maintenance of stable perfusion pressure is a cornerstone of nerve protection during prolonged reconstructive procedures. Exploratory modeling of intraoperative co-oximetry data by demonstrated that intravenous anesthetic techniques allow predictable coupling between oxygen delivery indices and hemodynamic trends, even in physiologically complex patients [25]. While conducted in a thalassemic neuroanesthesia setting, the implications extend to peripheral nerve surgery, where ischemia–reperfusion injury and microvascular compromise can adversely affect nerve regeneration [26].

TIVA, through reduced sympathetic fluctuation and absence of volatile-induced vasodilation, offers tighter control over mean arterial pressure and tissue oxygenation—factors crucial in brachial plexus repair performed under magnification and extended operative times. Observational data comparing TIVA with volatile anesthetic maintenance in anterior cervical discectomy and fusion (ACDF) surgeries further strengthen the argument for intravenous techniques in nerve-adjacent surgeries [27]. Sharma et al. demonstrated that TIVA was associated with more stable intraoperative hemodynamics and smoother emergence profiles, attributes that directly translate to improved neurological assessment in the immediate postoperative period [28]. Given the anatomical and functional proximity of ACDF to brachial plexus elements, these findings provide relevant comparative insight.

Additionally, simulation-based and literature-driven analyses of anesthesia–neurological disorder interactions in brain–computer interface (BCI) procedures emphasize that volatile agents can interfere with neural signal integrity, whereas propofol-based regimens preserve signal-to-noise ratios critical for functional mapping [29]. Although BCI procedures differ technically, the underlying principle of neural signal preservation aligns closely with the goals of brachial plexus repair.

The perioperative psychological milieu is increasingly recognized as a modifier of anesthetic requirements and recovery trajectories. A natural experiment during the 2025 India–Pakistan conflict demonstrated heightened perioperative anxiety influencing anesthetic depth and sympathetic tone [30]. In this context, TIVA—especially when combined with agents such as dexmedetomidine—may offer superior anxiolysis, opioid-sparing effects, and smoother perioperative transitions.

Supporting this concept, an integrated dexmedetomidine–sevoflurane algorithm for neurosurgical induction has come into light [31]. This underscores the growing emphasis on alpha-2 agonist–based modulation of stress responses. While the algorithm includes volatile agents, the central role of dexmedetomidine aligns well with TIVA strategies in brachial plexus repair, where attenuation of sympathetic surges and preservation of neural physiology are paramount [32].

Patients with global brachial plexus avulsion represent the most severe end of the injury spectrum. Liu et al. evaluated functional outcomes of nerve transfers in such patients and demonstrated that, while full restoration is rarely achievable, meaningful improvements in elbow flexion and shoulder stability are possible, significantly enhancing independence and quality of life [33]. These findings underscore the role of nerve transfers as part of a staged reconstructive strategy rather than a curative intervention.

Free functional muscle transfer (FFMT) is often employed when nerve transfers are not feasible or have failed. However, these procedures carry substantial complexity and morbidity. Atthakomol et al. reported reoperation rates following FFMT in traumatic BPI, highlighting complications such as inadequate reinnervation, muscle necrosis, and need for revision surgery [34]. These data reinforce the importance of careful patient selection and realistic expectation setting.

Beyond objective motor recovery, patient-reported outcomes and satisfaction are increasingly recognized as critical measures of success. Kretschmer et al. demonstrated that even partial functional recovery after brachial plexus surgery can lead to significant improvements in perceived disability and patient satisfaction, particularly when elbow flexion and shoulder stability are restored [35].

Despite advances in surgical techniques, outcome reporting in BPI literature remains heterogeneous. Dy et al. conducted a systematic review highlighting substantial variability in outcome measures, follow-up duration, and reporting standards, limiting cross-study comparisons [36]. Similarly, Armas-Salazar et al. emphasized inconsistencies in clinical outcome reporting across different surgical strategies, calling for standardized functional scales and patient-reported outcome measures to improve comparability and evidence synthesis [37].

The present case series highlights the utility of stimulation with the Stimpod as a pragmatic adjunct during brachial plexus surgery. The device offers immediate functional feedback without the logistical burden of conventional neuromonitoring. Its value is most evident in differentiating salvageable nerves suitable for neurolysis from those requiring reconstruction.

Nevertheless this device has certain limitations- (i) it cannot distinguish sensory from motor fibers; (ii) quantify conduction velocity; (iii) replace formal EMG/NCS when precise neurophysiologic characterization is required. The responses may also be influenced by edema, scarring, and anesthetic depth. Despite these constraints, its simplicity and portability make it particularly attractive in resource-limited setting.

While outcomes are influenced by injury severity, timing, and rehabilitation, even partial restoration of key functions yields meaningful improvements in patient independence and quality of life. Ongoing challenges include managing chronic injuries, optimizing donor nerve selection, and standardizing outcome reporting to strengthen the evidence base and guide future innovation.

The present case series focuses on real-time functional screening and correlation with muscle strength outcomes that can be juxtaposed with this evidence. Motor strength improvement  was consistent with current evidence in literature. Stimpod responses could potentially refine surgical decision pathways  supported by published outcomes. There is an opportunity to add quality of life, functional scores, and patient satisfaction to future analyses to match broader trends in the field.

Clinical Implications

From a clinical standpoint, the findings of this case series suggest that handheld functional stimulators such as the Stimpod may serve as a pragmatic intraoperative adjunct in brachial plexus exploration, particularly in environments where formal neuromonitoring infrastructure is unavailable or limited. The device may assist surgeons in real-time differentiation between intact but compressed nerves amenable to neurolysis and non-conducting segments requiring grafting or transfer. In practical terms, its use should be considered as a screening tool rather than a replacement for conventional electrophysiological assessment. Standardized stimulation protocols, careful titration of anesthetic depth to preserve neuromuscular responsiveness, and correlation with intraoperative anatomical findings are recommended to minimize false interpretation. Integration of stimulation responses with preoperative imaging, injury chronicity, and postoperative rehabilitation planning may enhance surgical decision-making. In resource-constrained settings, the Stimpod may offer a cost-effective bridge between clinical examination and advanced neuromonitoring, thereby potentially improving intraoperative confidence and optimizing reconstructive strategies.

Limitations

This case series has several limitations that warrant acknowledgment. First, the small sample size limits generalizability and precludes statistical inference. Second, the absence of a control group using conventional intraoperative neuromonitoring prevents direct comparative evaluation of diagnostic accuracy or prognostic value. Third, quantitative neurophysiologic parameters such as conduction velocity, amplitude mapping, or electromyographic characterization were not systematically recorded, limiting objective correlation between stimulation response and long-term functional recovery. Fourth, responses to stimulation may have been influenced by anesthetic depth, peri-neural scarring, edema, and variability in surgical exposure. Additionally, follow-up duration and standardized functional outcome measures were not uniformly applied, restricting comprehensive outcome comparison with published literature. Finally, the observational nature of the series introduces inherent selection and interpretation bias. Future prospective, controlled studies incorporating standardized functional scales and patient-reported outcomes are necessary to validate the clinical utility and reproducibility of this technique.

Conclusion

Stimpod represents a novel, non-invasive adjunct for functional screening during brachial plexus exploration and repair. By providing rapid insight into nerve continuity and distal motor unit recruitment, it supports informed surgical decision-making, especially where conventional neuromonitoring is unavailable. Further prospective studies are warranted to validate its impact on long-term functional outcomes.

References

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George Varvatsoulias

Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.

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Rui Tao

Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.

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Khurram Arshad

Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.

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Gomez Barriga Maria Dolores

The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.

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Lin Shaw Chin

Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.

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Maria Dolores Gomez Barriga

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.

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Dr Maria Dolores Gomez Barriga

Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.

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Dr Maria Regina Penchyna Nieto

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.

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Dr Marcelo Flavio Gomes Jardim Filho

Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”

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Zsuzsanna Bene

Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner

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Dr Susan Weiner

My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.

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Lin-Show Chin

My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.

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Sonila Qirko

My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.

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Luiz Sellmann

I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.

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Zhao Jia

Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."

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Thomas Urban

I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.

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Cristina Berriozabal

To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.

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Dr Tewodros Kassahun Tarekegn

"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".

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Dr Shweta Tiwari

I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.

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Dr Farooq Wandroo

Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.

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Dr Anyuta Ivanova

We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.

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Dr David Vinyes

My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.

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Gertraud Teuchert-Noodt

To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina

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Dr Elvira Farina

Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.

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Dr Oleg Golyanovski

Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.

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Dr Farahnaz Fallahian

Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.

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Dr Victor Olagundoye

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD

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Dr Eric S Nussbaum

Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.

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Hala Al Shaikh

Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.

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Dr Rakhi Mishra

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.

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Dr Walter F Riesen

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.

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Dr Jelle Lettinga

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora

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Dariusz Ziora

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.

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Dr Ravi Shrivastava

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.

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Dr Aline Tollet

Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.

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Dr Chiara Giuseppina Beccaluva

Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti

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Dr Claudio Ligresti

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.

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Dr Matteo Bonori

I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.

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Edouard Kujawski

Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell

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Dr Andriy Sinelnyk

Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.

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Dr Meng-JouLe

Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed

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Mahmoud Kamal Moustafa Ahmed

Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.

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Dr Elena Salvatore

Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal

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Christoph Maurer

Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.

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Baciulescu Laura

Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.

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Dr Mamoun Magzoub

International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.

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Joel Yat Seng Wong

Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.

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Dr Perlat Kapisyzi

Dear Grace Pierce, International Journal of Clinical Case Reports and Reviews I appreciate the opportunity to review for Auctore Journal, as the overall editorial process was smooth, transparent and professionally managed. This journal maintains high scientific standards and ensures timely communications with authors, which is truly commendable. I would like to express my special thanks to editor Grace Pierce for his constant guidance, promt responses, and supportive coordination throughout the review process. I am also greatful to Eleanor Bailey from the finance department for her clear communication and efficient handling of all administrative matters. Overall, my experience with Auctore Journal has been highly positive and rewarding. Best regards, Sabita sinha

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Sabita sinha

Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.

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Dr Ted Christopher