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Research Article | DOI: https://doi.org/10.31579/2641-0419/027
1 Cardiology Department, Alshifa Hospital, Gaza, and Palestine
*Corresponding Author: Mohammed Habib, Cardiology Department, Alshifa Hospital, Gaza, and Palestine
Citation: Hasirah M., Habib M. (2019) ST-Segment– Elevation Myocardial Infarction for Pharmacoinvasive Strategy or Primary Percutaneous Coronary Intervention in Gaza (STEPP- PCI). J Clinical Cardiology and Cardiovascular Interventions, 2(3); DOI:10.31579/2641-0419/027
Copyright: © 2019 Mohammed Habib. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 04 November 2019 | Accepted: 08 November 2019 | Published: 12 November 2019
Keywords: primary percutaneous coronary intervention; ST-segment– elevation myocardial infarction;pharmacoinvasive strategy
Background
A primary percutaneous coronary intervention (PCI) Primary PCI continues to be the optimal reperfusion therapy in patients with ST elevation myocardial infarction however, in areas where PCI centers are not readily available, a pharmacoinvasive strategy has been proposed. This study investigated the safety and efficacy of a pharmacoinvasive strategy compared with primary (PCI) strategy for ST-segment elevation myocardial infarction (STEMI) in Gaza.
Methods:
We randomized 145 patients presenting within 2 hours of symptom onset of acute ST elevation myocardial infarction to primary CPI (PCI) or for pharmaco-invasive PCI 2-24 hours after streptokinase, except in the event of failed reperfusion, in which case, emergency angiography was recommended. The primary endpoint a composite of death, shock and congestive heart failure at 30 days.
Results:
Total 145 patients with mean age 56.5+10.48 years. (The mean age of patients is) The primary endpoint in primary PCI (17%) and in pharmaco-invasive PCI (16.1%) p = 0.24.???? There was no difference in 30-day mortality (4.7 % in primary PCI and 4.9% in pharmacoinvasive strategy (P=0.94). Secondary endpoints:Emergency angiography was required in 39.5% of the patients in the pharmaco-invasive strategy and the median time for underwent angiography was 6 hours after randomization. TIMI major bleeding occurred among 4 patients ( 4.9 % ) in the pharmacoinvasive group and in 2 patients (3.1%) of the primary PCI group (P = 0.59).The pharmacoinvasive group had 1.9 times the odds of having TIMI major bleed compared with the primary PCI group
Conclusions
In this randomized trial, early-presenting STEMI patients unable to undergo primary PCI within 1 hour (median, 75±20 minutes) were randomized to primary PCI or a pharmaco-invasive strategy with streptokinase followed by PCI. At 1 month follow-up, there was no statistical difference in all-cause mortality, heart failure or shock. This study suggests that, if primary PCI cannot be performed within 1 hour of presentation, a pharmaco-invasive strategy may be as good as primary PCI.
American College of Cardiology/American Heart Association guidelines recommend primary percutaneous coronary intervention (PCI) for patients with ST-segment–elevation myocardial infarction presenting ≤12 hours of symptom onset with a first medical contact-to-device time goal of ≤120 minutes. Pharmacoinvasive strategy where fibrinolysis is followed by immediate transfer to a PCI-capable hospital for either rescue PCI in case of failed fibrinolysis or routine coronary angiography and PCI in case of successful fibrinolysis may be a valid alternative to primary PCI and part of the primary reperfusion in patients with ST-segment–elevation myocardial infarction in whom long PCI-related delay is anticipated. [1]
The aim of the our study is to evaluate safety and efficacy of Primary PCI compared to pharmaco-invasive strategy using streptokinase in patients with ST elevation acute myocardial infarction in Gaza.
This prospective, randomize, case-control study was conducted on 145 patients with first attack of acute STEMI who had symptoms onset of myocardial Ischemia within 12 h in association with persistent electrocardiographic (ECG) ST elevation and subsequent release of biomarkers of myocardial necrosis.
The subjects were randomly divided (using fixed block randomization) into 2 groups: (figure 1)
The study population was single Center trial derived from alshifa hospital between January 2019 and October 2012. We identified 145 patients (≥18 years) with STEMI (<12 hours) eligible for either pharmaco-invasive strategy or Primary PCI.
All subjects received acetylsalicylic acid, clopidogrel, unfractionated heparin and high dose statin (Atorvastatin 80 mg) according to the our guidelines.
Patients were excluded from the study if their age was < 18 years or if they have contraindications of fibrinolytic therapy, or multi-vessel coronary artery diseases not (because of inappropriate) suitable for revascularization.
3. Clinical definitions
STEMI was defined as chest pain suggestive of myocardial ischemia for ≈30 minutes, ST-segment elevation >0.1 mV in ≥2 contiguous leads, or new or presumably new left bundle-branch block on the 12-lead ECG and elevated cardiac markers (creatine kinase-MB or troponin I/T).
PPCI was defined as PCI within 12 hours of symptom onset in a patient not receiving streptokinase .Time to start of reperfusion therapy was defined as time to intravenous injection of fibrinolytics and time to balloon inflation in patients treated with fibrinolysis and PPCI, respectively.
Rescue PCI was defined as PCI mandated by persisting symptoms or persisting ST-segment elevation (failure to achieve ≈50% ST resolution) within 90 minutes after the administration of streptokinase.
Pharmacoinvasive strategy was defined as fibrinolysis followed by rescue or or by routine elective PCI (beyond 2 hours of fibrinolytic administration).
TIMI bleeding classification includes major and minor bleeding. TIMI major bleeding is defined as patients with intracranial hemorrhage or a > 5 g/dl decrease in hemoglobin concentration or a>15 % absolute decrease inhematocrit. If observed with blood loss >3 g/dl, decreasein hemoglobin concentration or >10 % decrease inhematocrit, or no observed blood loss with > 4 g/dldecrease in hemoglobin concentration or >12 % decreasein hematocrit, it is defined as TIMI minor bleeding [2]
Efficacy (primary) endpoint: total death, shock or heart failure at 30 days after myocardial infarction. Secondary (safety) endpoint: Major Bleeding, minor bleeding or failed streptokinase required emergent PCI.
5. Statistical analysis
Data was analyzed by SPSS version 19. Continuous variables were presented as mean± standard deviation (SD) and categorical variables as absolute numbers and percentages. Comparison of demographic and clinical data among the groups was performed using independent t-test for continuous variables and chi-square (χ2) for categorical variables. Pearson's correlation coefficients were calculated to illustrate certain relationships. P values < 0.05 were considered significant.
Total 145 patient with mean age 56.5±10.48 years, The mean age was 55.8±10.4 years for the pharmacoinvasive group and 57.5±10.6 for the in the primary PCI group. 123 patients (84.8%) male and 22 patient (15.2%) were female, 53.1% were hypertensive, 31.7 % diabetes mellitus,49.7 smoker,4.8% previous CABG, 17.2 % previous PCI, 7.6% COPD, Familial history of CAD 14.7 %. Table 1 baseline characterizes of the patients.
Localization of STEMI
A 75 (51.7%) of study population were presented with anterior STEMI, 58 patients ( 40 %) with inferior STEMI, 8 patients (5.5%) with lateral STEMI and only 4 patients (2.8 %) with posterior STEMI. There was no significant difference among the study groups as regards localization of STEMI.
Type of intervention
A 64 (44.1%) patients underwent standard primary PCI and 81 (55.9%) patient underwent pharmacoinvasive PCI. The Rescue intervention was performed if there was <50% ST-segment resolution in the single lead of an electrocardiogram or clinical evidence of failed reperfusion within 90 minutes after streptokinase. The rate of rescue PCI was performed in 32 patients (39.5% of pharmacoinvasive PCI strategy).
Culprit lesion
PCI was performed only to the culprit artery. The culprit artery was LAD in 75 patients (51.7% of total study population), LCX in 22 (15%) patients, and RCA in 42 (28%) patients, OM branch in 6 (4 %) patients and diagonal branch in 2 (1.3%) patient diagonal branch
Door to needle and door to balloon time
In pharmaco-invasive strategy: Average time from medical contact to streptokinase administration was 33.17±15 min. in patient with successful streptokinase all Coronary angiography was performed with 24 hrs., with average time 16 hrs., but in patient with failed streptokinase emergency angiography was required in 39.5% of the patients the median time 6 hours after randomization.
In primary PCI strategy: a 54% of the patients the Door to balloon time was < 20 min. The Door to balloon time was 75.25±20 min, and the Door to balloon was performed in 81% in the time < 90 min.
Endpoints
Primary endpoint: The primary endpoint in primary PCI (17%) and in pharmaco-invasive PCI (16.1%) p = 0.24. There was no difference in 30-day mortality (4.7 % in primary PCI and 4.9% in pharmacoinvasive strategy (P=0.94)
Secondary endpoints:Emergency angiography was required in 39.5% of the patients in the pharmaco-invasive strategy and the median time for underwent angiography was 6 hours after randomization. TIMI major bleeding occurred among 4 patients ( 4.9 % ) in the pharmacoinvasive group and in 2 patients (3.1%) of the primary PCI group (P = 0.59).The pharmacoinvasive group had 1.9 times the odds of having TIMI major bleed compared with the primary PCI group .
TIMI flow before and after PCI
There were heavier thrombus burden and lower pre-PCI TIMI flow (TIMI-0 and TIMI-I) in patients within primary PCI (79%) compared to Pharmacoinvasive PCI (23%) (P value 0.001). Post-PCI TIMI flow was improved in all study groups with no significant differences among them (P value 0.1). Thrombus aspiration was done in only 2 (1.3 %) patients while GP IIb/IIIa inhibitors were needed in 14 (9.6%) patients.
Subgroup Analysis
In the pharmacoinvasive group, 32 patients did receive coronary angiography within 6 hours and 57 patients was receive coronary angiography within 24 hours of presentation; 5 underwent angiography later during the index hospitalization and 3 were treated medically (two patients ectatic coronary arteries and slow flow another patient was nonsignificant stenosis). Three patients died within 48 h of presentation, and 1 patient died later on due to subacute stent thrombosis.
In the primary PCI group, 1 patients died just before reaching the catheterization laboratory, >>> the patient should be excluded from study because the patient could not take any theraphy you cannot include the patient in any categories) can Cardiopulmonary resuscitation and primary PCI was done but patient died in the table of cardiac catheterization, 2 patients within 24 h of presentation.
The results of the analysis including only patients who underwent coronary angiogram and PCI within 24 h.
In our trial, we report on the efficacy and safety of a pharmacoinvasive strategy compared with a primary PCI strategy in Gaza, we found that:
The our primary endpoints was similar with The STREAM (Strategic Reperfusion Early After Myocardial Infarction) trial compared fibrinolysis followed by PCI within 6 to 24 h to primary PCI. The investigators found that there was no difference in the composite endpoint of death, shock, congestive heart failure, or reinfarction at 30 days between the 2 treatments [2] However, a fibrinolysis-based therapy was associated with slightly higher rates of intracranial hemorrhage, a trend that was not observed after protocol amendment to reduce TNK by 50% for patients > 75 years of age, in our trial we use streptokinase and number of patients who had age > 75 years only 8 patients and 5 of them was randomize to primary PCI strategy. [3]
Within this regional STEMI system, > 50% of the patients managed with a pharmacoinvasive strategy underwent PCI within 260 min (4 h and 20 min) from the time of receiving fibrinolytic therapy. In randomized controlled trials looking at a pharmacoinvasive strategy, the median time from fibrinolysis to PCI was 84 min in CAPITAL-AMI (Combined angioplasty and pharmacological intervention versus
thrombolysis alone in acute myocardial infarction), 125 min in CARESS-in-AMI (Combined AbciximabREteplase Stent Study in Acute Myocardial Infarction), 163 min in NORDISTEMI (NORwegian study on DIstrict treatment of ST-elevation myocardial infarction) and 234 min in TRANSFER-AMI (Trial of Routine Angioplasty and Stenting After Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction) [4-8]
In a large meta-analysis of 7 trials and 2,961 patients, early PCI after fibrinolysis has been found to be associated with a reduced risk of the combined endpoint of death and reinfarction without a significant increase in the risk of major bleeding or stroke [9].
The result is similar to the STEPP-AMI, trial which a prospective, observational, multicentric study evaluated the efficacy and safety of a strategy of pharmaco-invasive therapy with primary PCI. In this study, tenecteplase was given as the lytic agent followed by catheterization (pharmaco-invasive strategy) within 3–24 hours with timely coronary intervention as appropriate versus standard primary PCI in 200 patients with acute myocardial infarction within 12 hours of symptom onset. The primary endpoint of 30 day incidence of death, cardiogenic shock, reinfarction, repeat revascularization, and congestive heart failure, was similar in both groups, although there was a trend toward benefit in the primary PCI group (11.1% vs. 3.9%, p = 0.07). At the end of 2-year follow-up, the initial benefit from primary PCI seemed to be narrowed as more events have occurred in the primary PCI group vspharmaco-invasive group (17.8% vs. 13.6%, p = 0.47) [10]
The limitations in this study were the small sample size, short term 30 days of follow-up
In this randomized trial, early-presenting STEMI patients unable to undergo primary PCI within 1 hour (median, 75±20 minutes) were randomized to primary PCI or a pharmaco-invasive strategy with streptokinase followed by PCI. At 1 month follow-up, there was no statistical difference in all-cause mortality, heart failure or shock. This study suggests that, if primary PCI cannot be performed within 1 hour of presentation, a pharmaco-invasive strategy may be as good as primary PCI.
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