Despite dozens of studies and the American NIH’s $1.6 billion expenditure on research, 18 million people in the US and 65 million globally still have long COVID. The symptoms range from neuropsychiatric to somatic, and the ongoing variant infections will further the toll. Like other unresolved chronic infections, the exact reasons for the chronicity and pathophysiology of long COVID remain obscure. Unlike the prevalent biochemical and molecular research on chronic infections and diseases, the presented model explores pathogens and afflicted organs on an ontologically deeper level (submolecular or electromagnetic), for their detection and treatment. The applied diagnostic and therapeutic technology in this domain resembles the physics of Smartphone medicine, by applying a scan-like diagnosis and water-imprinted therapeutic signals. The latter constitutes the nature of homeopathic and other production platforms. Based on the reported reversals of long COVID through this specific treatment, that matches the identified pathogens and afflicted organs, this pathology appears to have a multifactorial nature consisting of multisystemic malfunctions, infections, toxicological agents, and other pathogens. The approach does not requireknowledge of physics,is enrooted in prudent conventional medical knowledge, and can be implemented by physicians. Despite being ostracized as “alternative,” these interventions have substantial scientific support and are free from scientific conflicts, further emphasizing the need for proper studies to validate this approach. If verified, it may prompt the development of novel medical technologies, including physics-based vaccines and treatments.

Currently, the American CDC reports 18 million long COVID cases inthe US, and 65 millionglobally, with these numbers likely rising from the millions of developing COVID-19 cases, with thousands dying each month despite mass vaccinations [1]. The sources express concern that high long COVID-19 numbers highlight the puzzle of multisystemic pathology, the human and economic tolls, as well as the stress on healthcare systems. Despite the failure of the NIH, after spending

$1.6B, and many studies to establish the responsible causes and effective treatments with drugs or alternatives, hundreds of more studies are in the process of using the same, pharmaceutically focused model of molecular biology [2]. As benevolent lawmakers, such as US Senator Bernard Sanders (VT) who seeks to appropriate 10 billion more dollars for the challenge, the medical community shuns reexamining this model which besides long COVID-19, also fails other chronic infections. Amongthe latter are EBV, HSV-1,HSV-2, herpes zoster,HIV, H. Pylori, Lyme disease and co-infections. All of these carry essentially the same gaps as long COVID: unknown exact causes for their chronicity and failure of the antimicrobial drugs. While the pharmaceutical model emphasizes its rigor in applying the scientific method, it continues to overlook the need to reassess whether its criticalinitial stage—defining the research focus—isoptimally inclusive of background research and knowledge that would offer superior solutions to problems. Concerning infections, including COVID-19, an extensive toxicological background indicates more severe outcomes and poor recovery due to compromised local and systemic immunity by toxicants [3-4]

These may also cause an overactive autoimmune response, with dysfunction in multiple organs, which has also been detectedin long COVID-19, as the overallpathogenicity of these agents in COVID-19 and other chronic infections was emphasized [5-11].

The data of medical toxicology and the US Environmental Protection Agency list these agents, particularly heavy and other metals, as direct and indirect immunosuppressants, through invasion of the immune system and ones that support it, such as endocrine, gastrointestinal, neurological, and others [12-13]. Additionally, the disruption of the cytoskeleton by toxicants, including the mitochondria, and epigenetic and intercellular communications, further perturb global homeostasis through the interconnectedness and interdependence of body systems [14]. Also considering the fact that thousands of pollutants commonly act in unpredictable and impossible for laboratory assessments to establish combinations, the consequent multisystemic pathogenesis eludes the ability of the specialty-confined research model to match it [15]. The problem of public protection from pollutants has failed as according to the Harvard University EPA Working Group 2007 Report, traces of hundreds of environmental pollutants have been found in the bodies of 100% of testedAmericans, which can be extrapolated to all industrialized nations. The ubiquitous presence of toxicological agents in modern societies, with common internal presence from birth and increasing thereafter through nursing, in baby and regular food, air, and water, significantly raises their pathogenic potential in chronic infections and diseases [16- 21].

The most ubiquitous toxicants, mercury, lead, and the rest of the heavy and other metals, carry the highest pathogenicity that can produce any of the immunological dysfunctions that have been encountered in long COVID and other chronic infections. Mercury, which is the most toxic non-radioactive element, exerts multisystemic, including immune pathologies, from common exposures to fossil fuels, seafood, and silveramalgam fillings [22-26]. The presence of mercury since childhood is correlated with silver amalgam fillings, whose utilization is global [27].

Metallic dental restorations, particularly silver amalgams, and metals in general that are widely present in modern populations are also electromagnetic conductors that act as internalreceiving antennas for pervasive electromagnetic fields, resulting in mutually enhanced pathogenicity.

This furtherexacerbates stress on the immune,central nervous, and other systems[28-33].

Besides the ubiquitous exposure starting neonatally, the pathogenicity of metals is particularly ominous because these are not metabolizable, are only partially excreted, and cause deep, down to the DNA, cellular penetration [34].

In addition to this relevant toxicological research being essentially void in medical training, even when laboratory screening is performed for mercury, other metals, and toxicants it poorly correlates with their presence in the seed of pathologies, internal organs [24,34].

Relevant background information also listsother factors that compromise immunity, such as the perturbed gut microbiome and dysbiosis, linking them to complications and mortality in COVID-19 [35]. Subclinical opportunistic infections of the candida genus, with evasion from immune cells, their suppression and apoptosis, can be commonly present among not severely immunocompromised populations as the result of ubiquitous consumption of antibiotics and simple sugars [36-38]. Antibiotics themselves undermine host resistance by damaging immune cells and their response and have been associated with numerous chronic diseases, including cancer [39-41]. Another common subclinical infection, helminth parasitosis, is also proneto immunomodulation [42]. As a Candida species, it does not receive proper clinical vigilance, and stool diagnosis is compromised by varying laboratory sensitivity methods and irregular egg shedding. Chronically stressed and depleted by toxicants and infections, the endocrine system and limbic zone further contribute to immune deficiency and exacerbate the overall pathophysiology of long COVID, which also presents with associated cortisol deficiency [43].

Besides endocrinedysfunctions not being commonly suspectedin chronic infections, even when obtained, the hormonal profiles falling in the low normal ranges may not necessarily correlate with a patient’s individual physiologic normal range, leading to the potentially overlooked importance of hypofunctioning hypothalamic-pituitary-adrenalaxis. To addressthese limitations in managing chronic infections and long COVID, the reported cases were examined through another critical background research factor: the submolecular ontological level of both living organisms and pathogens. Physicists refer to this level as depth that addresses the limitations of the specialty-focused molecular research model, by rendering the detection of disease etiology more accessible and treatment more successful [44]. This level is fundamental and formative to molecular structures, representing their very identity,and is clinically indistinguishable from the material ones being used in practice and research. Its noninvasive diagnostic ability to access the seed of diseases, the internal organs, via the phenomenon of resonance, offers great potential.

The reason Einstein referred to our visible material molecular reality as an “optical illusion,” is based on the well-accepted matter-energy duality principle of all substances. By illusion, he implied that our eyes cannot discern the fact that matter is actually condensed energy fields, as his famous E = mc2 equation postulated. This applies also to the living, microbes, and human organs, including the DNA. These possess electric, electromagnetic, magnetic, and electronic properties that are reflected in the sciences of quantum biology, magnetic biology, bioelectronics, and biophysics, among others. Physics,materials science, and water sciencedeem water to be an ideal medium for the delivery of therapeutic signals at the level of depth. Due to its semiconducting and other physical and chemical properties, water is readily programmable with information of the molecular field, of any pathogen, organ, or cellular structure for which specific pharmaceuticals do not exist, rendering it to be “tomorrow’s wonder drugs” [45]. Also, neither programming nor therapeutic actions require the addition of chemical, biological, or genetic agents that favor safety and its related shortened testing time. Water also constitutes an important internal biophysical regulator of the body.

Nobel laureate in physics, Brian Josephson, and Nobelists in medicine, Albert Szent-Györgyi and Luc Montagnier either supported the validity of programmed water or commented on the importance of the physics of water and organisms in biology and medicine. Szent-Györgyi warned that biology was studying dead matter without engaging the physics of organisms and water.Immunologist Benveniste, who first registered the immune responseto water programmed through a homeopathic preparation platform, named this paradigm digital biology [46].

Referring to the submolecular level of the living that is innatelyreceptive to energetic signals, physicists posited that biology and medicine are only physics [47].

Figure 1:  The scientific premise of neutralizing pathogens through the physicsof organisms and substances.

The submolecular energetic domain is fundamental to all of the three vital components to address the resolution and prevention of disease: humanorgans, pathogens, and water. Fieldsof pathogens and organs can be detected diagnostically, and programmed in water. Humans, as fundamentally electromagnetic-quantum systems unconditionally respond to the delivered therapeutic fields.

This grants a wide versatility in producing energetic antidotes against any toxicant and programmedvaccines and therapeutics against infections. Likewise, submolecular fields of organs and their cytoskeleton may stimulate detoxification and restoration of their function.

The phenomenon of hormesis, as homeopathy is based on the similiaprinciple, and the theory of chaos, indicates that natural systems can robustly respond to low-volume meaningful signals as in programmed water [48-52]. Arthritis patients experienced reliefonly from those water-programmed homeopathic remedies whose electromagnetic frequencies were similarto ones of their serums [53]. Physics emphasizes the role of the resonance phenomenon in the similia principle between energetic systems. Similia is also widely utilized in vaccinology, allergology, and Botox treatment for certain neurological disorders.

Scientific literature provides abundant support for the physics of living, humans, microbes, includingcoronaviruses, as macroquantum, biocomputer systems with magnetic components and energetic communication [54-77].

Modern medicine widelyutilizes physical properties and magnetic elementsof human tissuesfor common tests, ECG, EEG, MRI, and CT scans, yet scientists were baffled by the absence of the utilization of alternative biophysical tests and therapeutics such as homeopathy [78]. Specific submolecular fields also make each substance unique through the natural resonant frequency phenomenon, that can serve as the basis for programmed vaccinology, therapeutics, and

scan-like diagnostic testing via resonance. Since viral mutations, such as SARS-CoV-2, with the corresponding change in their resonant frequency can be absorbed by water, it was proposed to create a library of submolecular microbial signatures in watersamples, parallel to their molecular genomes [79]. Common diagnostic tools, biospectroscopy, vibrational spectroscopy, and mass spectrometry, are based on the same concept, the presence and detection of electromagnetic fields of microorganisms, such as coronaviruses, and chemicals, including pollutants [80-82].

All of these factors are based on the fundamental matter-energy duality concept and natural resonant frequency phenomenon for all living and nonliving, which offer a deeper parallel dimension of molecular biology and any pathogen that is more amenable to research, diagnosis, and specific and safe treatments [83]. Diagnostic possibilities at this level aim to overcome difficulty in identifying precise causes of pathophysiological terrain of disease—pathogens and key afflictedorgans. These can be determined through field-to-field resonantinteraction directly with the internal organs, including the immune, using samples of organs and pathogens. The response to this testing can be elicited through a change in the muscle tone of a patient, and possibly other neuro-reflexory reactions. The natural resonant frequency of the brain cells was already proposed for a new diagnostic method and resonance-based testing has been reported as sensitive and specific for early cancer detection [84-85]. Alternative medicine has used one of the bioresonance tests based on the resonance phenomenon, applied kinesiology [86-88].

Water programming in medicine and its alleged controversies:

One of the platforms for programming water is represented by its oldest prototype, which has established most of the scientific confirmations, the FDA-registered therapy,homeopathy. It uses manual serial dilutions and mechanical impacts or potentization of a substance that produces a rising piezoelectric effect for programming the field of substance into water. Despite the substantial scientific support for this process and biological actions of homeopathy, the mainstream medical literature still misrepresents it, by stressing only a dilution part of the preparation. Since dilutions of many remedies may exceed the Avogadro number, the conclusion becomes “overdilution” rendering “impossible biological effects”. However, materials scientists and physicists deem this notion as “ignorance in and distortion of science,” and “unnecessary confusion”, akin to confusing physics with chemistry, since the energetic nature of these solutions is not subjected to the Avogadro number [89-90]. The elucidated structure and properties of homeopathic preparations consisted of cluster networks, crystal growth, epitaxy, dissipative structures, ferroelectricity, and coherence based on quantumelectrodynamics and quantumfield theory (QFT) of superradiance [91-94]. The key programming process of delivering mechanical impacts, potentization correlated with an exponential rise in the remedies’ electric voltage, with these registering individual electromagnetic signatures [95-96]. Nuclear magnetic resonance and other instrumentation registered different remedy patterns against the controls, and the physicochemical properties of these preparations were elucidated by other authors [97-102].

Many of the cited studies and those that registered gene expressions, EEG, and immune responses,abolition of infections, and cancer concerned remedies diluted beyond the Avogadro number

[103-110]. A simplified manual method, Korsakov, can be also used by physicians for preparing energetic vaccines-therapeutics from infected, and antidotes from intoxicated bodilyfluids [111]. Other water programming platforms conduct it electronically or magnetically, producing homeopathic-like remedies [112-113].

Experiments, including those by Nobelistand virologist Montagnier, with bacteria and viruses, demonstrated their signal absorption in water and biological effects of even electronically transmitted information of programmed water samples, including antimicrobial and anticancer drugs [114-134].

The paramagnetic and overall plasticproperties of this media make it an ideal liquidCD that can readily change its structure and information by mechanical, electromagnetic, or magnetic impacts. This renders a unique versatility for the recording and delivery of specific therapeutic information that can also be promptly provided in medical emergencies, in any setting. The notion of the water-mirror approach is based on evidence of the water molecular networks behaving as a matter and energy mirror for biological or aqueous systems [135]. To underscore the water’s plasticity, its structure, pH, and dissolved DNA have been altered even by imponderable human intention, with the brain being known to emit electric and magnetic fields [136]. Biochemical and biological impacts were registered following the magnetic and electromagnetic transfer of molecular information in water [137-159].

Besides water beingcapable of delivering external therapeutic signals to the body, itis its major biological component that acts as an internalconductor of electromagnetic communications due to its colloidal, crystalline nature extending to DNA [160-172].

Studies of energetic water vaccines and therapeutics:

Immunological studies demonstrated the efficacy of homeopathic medicines in addressing immunity and inflammation [173]. Beneficial immune responses were induced by water- programmed homeopathic flu vaccineswith influenza strains,and clinical trialsdisplayed overall 90

All of the patients were initially diagnosed with COVID-19 based on laboratory tests and treated by their primary care physicians.

Applied kinesiology testing was used to explore the putative causes of COVID chronicity. Samples of homeopathic organsand infectious and toxicological agentsthat were obtainedfrom homeopathic pharmacies were utilized for bioresonance screenings of the internal organs to elicit their malfunction and responsible causes. Homeopathic-like remedies that were prepared from saliva or nasal swab of COVID patients throughout the pandemic, were used for the identification of the original SARS-CoV-2 and its variants. Determination of the different variants was conducted empirically, based on consistent curative responses to these remedies during the corresponding dominant periods of these infections. It is a well-known fact that laboratory COVID-19 antigenand PCR tests were generallyunable to identifyspecific variants.

The test is performed with a patient in a supine position on an examining table, holding a metal rod that is connectedto a metal platform througha cable that forms a conductive circuitbetween the patient and the platform. When glass vials with energetic imprints of body organs, toxicological, infectious, or other pathogens are separately placed on the platform, a person senses their corresponding fields and responds with an involuntary muscle stress response, if a tested substanceis related to one’s pathology. Muscle response manifests by a change in muscle tone and a slight upward movement of the right leg. This reaction can be likened to acknowledgment of meaningful information, as in alie detector test throughstressful brain wave patterns. Due to the fact that multiple intertwined connections exist betweenthe skin and internal organs representing biological conductors that form a conducting circuit, it is challenging to eliminate its exact confines. Among the tissues and phenomena are electrical signaling of the brain, spinal cord, sensory and motor nerves, and visceral reflexes of the autonomic nervous system, as well as widespread connective tissue and biological water [189]. A tester detects the muscle response by holding hands on the subject’s ankles. In the event of a tested substance not being part of the pathology or stressful information, muscle response is absent. The test can also suggest the potential benefit, absence, or iatrogenicity of a therapeutic. A projected benefit is alleged when placement of a therapeutic on a testing platform alleviates a muscle stress response against a dysfunctional organ and/or its cause. A therapeutic substance that fails to produce this is deemed ineffective and if it enhances muscle stress response, iatrogenic. Remedy prescriptions were based on the findings of the bioresonance test, with the aim of neutralizing pathogens and stimulating recovery of the afflicted organs. In cases of a virtual service, prescriptions were based on the heuristic method that entailed addressing pathogens and malfunctioned organs, based on detailed medical, toxicological, and lifestyle history.

Perhaps, due to a positive preventative and curative experience of this method in this pandemic, long COVID was rarely encountered in this practice, with a total of five patients with this pathology havingbeen treated and presented here.Three of these patients were new and two were established, who were last seen before the pandemic. Four of them promptly recovered, and another after three treatments, due to the supervened clinical circumstances. Multi-organ malfunctions, environmental causes such as mercury, excessive electromagnetic screen radiation, residues of antibiotics, and multiple infections, were determined either based on the test findings or clinically through symptomatology and history. Additionally, the harm of common medicinal substances or ones that are promoted as healthy, certain “mineral-rich” salts, were deemed to contain toxicants that were also supported by scientific literature.

A seventy-year-old femalewas fully vaccinated with the mRNA vaccine a year and a half before she contracted COVID in September 2022. Her mild flu symptoms subsided at the time after Paxlovid, but brain fog, irritability with bouts of anger, dizziness, depression, decreased memory, body imbalance, and fatigue worsened. Alternative treatments brought insignificant relief.

She was initially evaluated in January 2024 and received remedies that were made of a variant, mercury (history of 16 silver amalgam fillings containing 50% mercury) hippocampus, brain- capillaries, and kidney to aid mercuryexcretion. Five weeks later she reported completerecovery and confirmed it four months later.

A seventy-three-year-old alternative medicine practitioner who, following COVID in November 2020, complained of “sensingsomething inside of my head”, a stuffy,foggy brain, impairedshort- term memory, body imbalance, neuropathy with pain in the lower legs, and the overall feeling of falling apart with being on the verge of a nervous breakdown. Old, pre-COVID symptoms included tinnitus, arthritic knee pain, sciatica, and genital herpes. Her neurological diagnosis was brain COVID, but the prescribed physical therapy and self-administered alternative treatments helped marginally.

Following her initial evaluation in January 2023, she received combination remedies of two variants, brain-mercury (history of several silver amalgam fillings) and multiple brain regions. Other remedies:the hippocampus, frontallobe, imprinted computerrays to antidote the excessive computer radiation in the brain (prolonged computer use at work), peripheral nerve tissue, lymphatic system, musculoskeletal apparatus, and kidney to detoxify mercury. Her therapeutic response: “I feel like COVID is gone from my brain, like something was inside of my head and gone, my fear of highway driving disappeared because I no longer feel out of control.” Other progress was the resolution of genital herpes,and much improved balancethat was confirmed by her physical therapist, decreased tinnitus, sciatica, and knee pain.

The second protocol contained combination remedies of frontal lobe mercury, multiple brain regions,and single remediesfor another COVID-19variant, brain, lymphatic system, and kidney. Following this she reporteda further increasein balance, cessationof tinnitus, and that “my brain works so much better.” She confirmed her lasting recovery and satisfaction, in July 2024, by “having my brain back” and stated that further treatment was unnecessary.

A fifty-six-year-old woman with decreased sense of taste and smell, excessive thirst, chronic cough, frequent colds, and low energy for three years following acute COVID in 2020, and chronic arthralgia from Lyme disease. She started her remedies in December 2023, against a variant, candida tropicalis, helminth parasites, mercury in the large intestine, salt (known to contain mercury and other toxic metals), strep pneumonia, and borrelia burgdorferi. Thyroid (history of nodules) and lymphatic system remedies were also prescribed, to aid detoxification of mercury and stimulation of function. Six weeks later she reported a near-complete recovery that became complete weeks after.

To note, homeostatic adjustments to homeopathic and like energetic signals may last up to several months.

A one-year-old male presented in April 2024 with neurological symptoms since beingdiagnosed with COVID-19 in January 2024, had involuntary head movements that were deemed partial seizures by a neurologist, OCD, and tiptoe walking with turning around. The preexisting health problems consisted of restlesslegs syndrome, regurgitating liquid food formulas, aversion to and spitting milk, intermittent diarrhea, bursts of energy at bedtime, and waking up 2-5 times, nightly.

Neurological and pediatric care failed to elicit the etiology of or mitigate these disorders. His blood tests indicated only a slight decrease in hemoglobin, and the brain MRI of March 2024 reported hyperintense signals in parietal white matter and toward the overlying cortex. He received separate remediesagainst helminth parasites and candida albicansinfections (history of repeated antibiotics), and residues of antibiotics in the gut. A combination of small intestine mucosa-mercury remedies and separate ones, brain, and kidney were dispensed. Following this treatment, his regurgitations of formulas and milk, diarrhea, multiple nocturnal awakenings, and restless legs syndrome ceased. Yet, after the report contradicted the expected clinicalprogress in head movements, further questioning elicited the history of a new respiratory infection of unknown etiology, and sources of potential repoisoning with mercury through Himalayan salt that was used in cooking, and topical Vaseline applications prescribed by a dermatologist. The mother noted the increase of head movements duringthe days of the Vaselineuse and that it is a petroleum derivative.

Toxicological literature indicates that all of the earth-derived products, such as mined salt and petroleum, commonly contain toxic metals, including mercury. Based on this information and clinical picture of the malfunctioned lymphatic system, brain, and colon, likely from mercury toxicity, he was given the corresponding remedies to stimulate their detoxification and function. Remedies of Himalayan salt antidote and COVID-19 variants to address his acute cold symptoms were also prescribed and recommendations were made to abstain from Himalayan salt and Vaseline.

The follow-up, months later, indicated that the cold was promptlyresolved, head movementsand OCD remained, but he had another setback with a new COVID variant diagnosis by a laboratory, that he clinically recovered on his own. The motherstated that, overall,he was doing great.

His last protocol contained remedies of a COVID variant, brain, hippocampus-mercury, and lymphatic system. Following this regiment, the boy’s grandfather emailed a statementthat both OCD and abnormal head movements were resolved.

A 69-year-old male presented in October 2024 with the chief complaint of chronic fatigue and intermittent cold symptoms for some five months. Other relevant medical history contained complete Pfizervaccination in 2021 with experiencing severe heart palpitations after the second injection, being diagnosed with COVID in 2022, and regularly consumingsweets. His remedies consisted of a chronologically recent variant, lymphaticsystem combined with mercury (history of amalgam fillings), Pfizer vaccine antidote, Epstein-Barr virus, thymus, combined candida strains, helminth parasites, large intestine mucosa, kidney, and hypothalamus.

After his return in January 2025, he stated that several days after his previous visit his home COVID-19 test confirmed him carrying the virus. He also stated that his fatigue started significantly liftingfollowing the firstthree remedies and, consequently, his energy level was completely restored.

Based on the presented recovered cases that were managed through specific treatment matching pathogens and afflicted organs, long COVID appears to be a multifactorial chronic disease. The methodological limitations of the presented case management lack rigor due to a small group size, and difficulty in confirming most of the findings by laboratory assessments, largely because of their aforementioned limitations. Professional pressure to provide timely relief to patients, without waiting for tests with marginal clinical weight, was also a factor. However, dozens of rigorous research studies that failed to resolve long COVID and thousands of randomized clinical trials (RCTs) of other chronic infections and diseases, raise more important scientific issues than rigor. Even as the latter is necessary for confirming a scientific theory, it is the meaning or its scholastic weight that ultimately achieves the actual goal of science—solutions to complex problems. The second law of thermodynamics of physics edifiesthat no amount of rigor with its studies can ever accomplish a construction of timeless technology that is based on its internal energy source.

In this context, the NIH’s admission, in the Road Map Initiative of 2004, that the pharmaceutical medical model failed in its “bench to bedside” strategyto solve chronicdiseases, despite a century length of research and numerous studies, raises the notorious issue of Kuhnian paradigms and their theories [190]. There, questions of the necessity of more research must also concern the revision of a dominant paradigm, whenever failures to solve similar problems are common, particularly when it is deemed to be dated by its own scientists. They state its inability to match functional interdependencies between the vast molecular components with intracellular and intercellular networks in chronic diseases [191]. It concerns identifying and properly addressing etiologic factors of both chronic infections and diseases. In a searchfor answers, medicalliterature has also started revising the long-adopted “bench to bedside” strategy for medical practice, which long- - neglected the input of bedside servants, physicians. It encourages the cultivation of their capabilities in solving pathologies over the mere volume of dictated knowledge, by academia and studies, and deems the exclusion of physicians from participation in improving quality of care counterproductive [192-193]. Ultimately, both hypotheses of physicians and ones behind rigorous studies, produce the same scientific denominator—observation. Besides the fact that the weight of RCTs’ generated observations has no priori over the one by physicians, the latter holds an advantage in displaying failure or success, faster. Considering the aforementioned complexity and multisystemic nature of chronic pathologies, interdisciplinary scientists suggested widening their epistemological match through broader sciences and their based interventions, at the interface of biology and physics that the presented cases reflect. This raises a divisive issue of conventional and alternative therapies that was addressed by an editorial that stated: “There cannot be two kinds of medicine, conventional and alternative, once a treatment has been tested rigorously and found to be reasonably safe and effective” [194]. Even as these authors displayed the aforementioned “distortion of and ignorance in science” concerning homeopathy, the latter was tested rigorously and produced reasonably safe and effective outcomes in infectious diseases.

Despite the prevailing view in medical training of alternative medical interventions as mere esoteric, the scientific evidence presented in this report concerning the ability of some of these interventions to act at a submolecular dimension of organisms and employ the programmable capacity of water, carries no discernible scientific conflicts. Additionally, the observed positive responses to long COVID through this method raise the question of its potential applicability in vaccinology, and the treatment of infectious and chronic diseases. This extrapolation may be relevant since the ubiquitous environmental pollutants, infections, and other pathogens that play a dominant role in chronic diseases in industrialized nations, can be addressed through the similia principle.

Besides the presence of immunosuppressive factors in long COVID patients, the prolonged pandemic, the evolution of variants, and the need for sufficiently specific and effective vaccines raise questions about its resolution [195-198]. Yet, recent observational studies in COVID-19 produced encouraging results of programmed water vaccines and therapeutics [184]. Physics- based programmed vaccines combine the benefits of live vaccines in specificity by delivering microbe-specific information and the safety of attenuated vaccines, by having no risk of infectivity, thereby optimizing the likelihood of maximum neutralizing immunity. Also, due to the same benefits and unlike pharmaceutical vaccines, they can also be used therapeutically, saving significant time and resources in developing new vaccines, and drugs in case of emergent pandemics and other infections.

Recent academic publications further support the vantage point of utilizing the interface of biology and physics in medicine, by presenting more positive results in addressing the variety of biological and environmental targets and calling for a “time to go quantum in medicine” [199- 200]. This interface might also offer a real opportunity for far more productive utilization of relevant medical molecular research and knowledge, which often remain disjoined from solutions, by communicating these through a parallel submolecular domain of human physiology. This may lead to both uncovering the root causes of chronic infections and diseases and their successful therapies.

As this case report suggests,long COVID presentsa multifactorial diseasethat can be resolved at a deeper ontological level of nature. Well-designed studies are necessary to probe this approach on a larger scalefor long COVID and otherchronic infections, where positive resultsmay lead to novel medical technologies in vaccinology, diagnosis, and treatment.