Review of Current Guidelines for the Treatment of Obesity

Review Article | DOI: https://doi.org/10.31579/2641-0419/406

Review of Current Guidelines for the Treatment of Obesity

  • Damian Machaj 1
  • Aleksandra Mazurek 2
  • Dominik Machaj 3*

1Medical University of Warsaw Silesian Piasts in Wrocław.

2Medical University of Warsaw Karol Marcinkowski in Poznań.

3Medical University of Lublin.

*Corresponding Author: Dominik Machaj, Uniwersytet Medyczny w Lublinie.

Citation: Damian Machaj, Aleksandra Mazurek, Dominik Machaj, (2024), Review of Current Guidelines for the Treatment of Obesity, J Clinical Cardiology and Cardiovascular Interventions, 7(10); DOI: 10.31579/2641-0419/406

Copyright: © 2024, Dominik Machaj. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: 16 August 2024 | Accepted: 30 August 2024 | Published: 11 September 2024

Keywords: obesity; diet; exercises; BMI; pharmacotherapy; laparoscopy

Abstract

Obesity is the most common metabolic disease that has become a serious health problem in both developed and developing countries. Proper treatment of obesity should primarily include the use of an appropriate diet and lifestyle modification. In addition, pharmacotherapy is also used, and in some cases surgical treatment [1]. Before deciding on the choice of obesity treatment method, the cause and severity of the disease, the patient's general health condition, including the complications of obesity, and the goals of treatment should be taken into consideration. It is also necessary to take into account the patient's level of involvement in the treatment process and ensure that the patient fully understands and accepts the proposed therapeutic method [2].

Introduction

Obesity is becoming serious health problem to an increasing extent due to its frequency and numerous complications. According to the World Health Organization, it is the most common metabolic disease which occurrence is defined as an epidemic[1]. The development of medicine has made it possible to establish a procedure for treating obesity.

Methods

We performed a literature search of publications available on Google Scholar describing the procedure for the treatment of obesity.

Description of the state of knowledge

Medical divisions of obesity

Obesity, according to the definition recognized by the World Health Organization (WHO), is the abnormal, excessive accumulation of fat tissue, which may be harmful to health. Obesity should be differentiated from overweight, which we can do using the BMI (Body Mass Index). Obesity in adults is diagnosed when BMI ≥ 30.0. There are two important divisions of obesity. Taking into account the cause of this disease, primary (simple) and secondary (symptomatic) obesity are distinguished. Primary obesity occurs as a result of the patient's incorrect eating habits and too little physical activity, which leads to a long-term positive energy imbalance and increased body weight. Secondary obesity, may result from hormonal disorders, taking certain medications, organic diseases or genetic factors. The second division takes into account the distribution of accumulated fat tissue in the body as a criterion. A distinction is made between generalized, android and gynoid obesity. In a patient suffering from generalized obesity, adipose tissue accumulates in whole body. In turn, the android form of the disease occurs more often in men and means the accumulation of fat on the belly. Gynoid obesity, which affects the buttocks and thighs, is more common in women[3].

Obesity from a social perspective

Obesity is an increasingly common social phenomenon. Statistical data prove that the percentage of obese people in the population has increased since 1975, when it was less than 1%, and in 2016 it was already 3-15%[3,4]. The World Health Organization estimated that over 650 million people were obese in 2016[3]. Between 1975 and 2016, the incidence of childhood obesity quadrupled. Forecasts are also disturbing, predicting that as many as 30% of people will be obese by 2030[3,5]. This problem constitutes a serious challenge for health care, as obese people are significantly more exposed to type II diabetes, cardiovascular diseases, rheumatism, stroke, coronary heart disease, heart failure, pancreatic, esophageal and kidney cancer, colon cancer, multiple myeloma, meningioma, gastric cardia cancer, hepatocellular carcinoma, endometrial adenocarcinoma, ovarian, breast, thyroid and gallbladder cancer[3].

First-line treatmentThe choice of treatment method and setting a specific goal depends on the cause, the degree of advancement of the disease, the presence of complications and the patient's awareness of his health condition, and thus his readiness to make the necessary lifestyle changes. The initial stage of treatment for people with obesity includes an appropriately selected diet, physical activity plan and behavioral intervention, the aim of which is to maintain control over the quantity and quality of meals consumed, as well as to consolidate healthy habits. The basis for weight loss is a diet with reduced energy value, i.e. with a deficit of 500-800 kcal/day in relation to the demand, which is full-value and does not require the elimination of any nutrients. It is important to remember about the safe rate of weight reduction, which depends on gender, age, initial body weight, as well as the patient's individual response to treatment. It is assumed that it should be 0.5–1 kg/week for the first 3–6 months of following the diet. Patients with diabetes or prediabetes should be educated on the correct assessment of carbohydrate content in the diet. When choosing products, they should take into account their glycemic index and choose those with a low value. Research shows that a low-carbohydrate diet is comparable in weight loss to a low-fat diet. The United States Preventive Services Task Force (USPSTF) also recommends limiting sodium chloride intake while increasing consumption of vegetables, whole grains and omega-3 fatty acids. Patients may be recommended diets such as DASH and the Mediterranean diet[2]. Another diet that may be used in the treatment of obesity is the Atkins diet, the assumptions of which are based on a limited supply of carbohydrates with a free intake of fats and proteins. The diet program consists of four phases. In the first (initial) phase, patients receive a maximum of 20 grams of carbohydrates per day in the form of strictly defined types of food, such as nuts, yellow cheese, cereal seeds or olives. The initial phase lasts at least 2 weeks, but if the intended weight loss is not achieved, it may be extended. Phase 2 is the "balancing phase" (also called the "ongoing weight loss phase"). Then the amount of carbohydrates consumed by patients is increased by 5 grams per day (reaching approximately 30–50 g per day) at weekly intervals until the weight loss indicator is reached will amount to0.9 kg per week. Then, a constant supply of carbohydrates is maintained until the weight is reduced by another 2.2–4.5 kg. In the third phase still gradual is used increasing supply carbohydrates such as whole grains and fruit, adding about 10g to your diet per week until sick stop lose weight. In the fourth phase, patients take this number of carbohydrates, at which they maintain body weight at a constant level. This phase starts when patient achieves target body weight and eats foods from normal healthy eating pattern, combining proteins and fats with carbohydrates[6,7]. To assess the impact of various diets, including the Atkins diet, in obese people, Samaha et al conducted a study on a group of 132 people with class III obesity, of which 64 participants were recommended to use the Atkins diet. After 6 months of observation, a significantly greater decrease in body weight and triglyceride levels was found in patients treated with a low-carbohydrate diet compared to study participants using a low-fat diet. Moreover, in non-diabetic people treated with the Atkins diet, a significantly higher increase in insulin sensitivity was also observed, which was also observed in the study conducted by Volek et al. on 28 people with excessive body weight. Importantly, this study noted that the short-term use of the Atkins diet, compared to a low-fat diet, does not reduce the concentration of LDL-cholesterol. In turn, according to Foster et al. The Atkins diet is associated with greater weight loss compared to the classic diet during both three-month and six-month follow-up. However, the differences disappeared after 12 months of observation of participants in both groups. The authors of the study also attributed the Atkins diet to a reduced risk of cardiovascular diseases. After 12 months of observation, no significant differences were noted in both groups in terms of LDL-cholesterol concentration, diastolic and systolic blood pressure, and an increase in insulin sensitivity. The presence of ketone bodies in urine was recorded in a higher percentage of patients using the Atkins diet only in the third month of the study. The results of studies conducted so far on the Atkins diet are ambiguous and do not allow drawing clear conclusions regarding the effectiveness of this diet in long-term weight loss. This issue requires large, multicenter, randomized clinical trials that would clearly allow for the assessment of its effectiveness and health safety[6].

The first stage of obesity treatment - non-pharmacological treatment, in addition to diet, also includes physical activity and lifestyle changes. Patients who avail oneself of  a diet combined with physical activity achieve better results than patients who base their treatment solely on diet. Activities that burden the musculoskeletal system, such as running, playing football or skiing should be avoided in this case. Instead, obese patients should focus on leisurely walking, cycling, practicing yoga and swimming. Initially, energy expenditure should be 100-200 kcal per day, and exercise should be performed three times a week at 50-70% VO2  max (maximum VO2 max). Subsequently, gradual increase of physical activity intensity should be carried out. An average of 30-60 minutes of activity per day is recommended. Moreover, it has been observed that the combination of aerobic training with resistance (strength) training has a better impact on the patient's health than the type of exercise alone [1,2,8,9]. Strength training is particularly important because it prevents the loss of muscle tissue and thus maintains your resting metabolic rate. It should consist of 8-10 exercises strengthening individual muscle groups. These exercises should be performed 2-3 times a week. The number of repetitions of a given exercise should be 12-15, and the exercise should involve approximately 30-50% of the maximum muscle strength. The series can be performed 1-3 times, with breaks between series ranging from 30 to 60 seconds[10]. The fastest effects in terms of weight loss are observed at the initial stage - when you start physical activity. Over time, this effect decreases in view of the fact that, in addition to reducing fat tissue, the exercises performed by the patient expand the tissue muscle. Research confirms that obese people who exercise achieve better results in weight loss than people who are on a diet but do not undertake any form of physical exercise[1,2,8,9]. Before implementing physical activity in the treatment of obesity, contraindications such as cancer, circulatory system failure, acute infections, uncontrolled diabetes, periods of exacerbation of coronary heart disease, uncontrolled hypertension, inflammation or degenerative changes in bones and joints should be excluded. It is important that in the case of concomitant cardiovascular diseases, an exercise test is performed to determine the patient's exercise tolerance. Before each phase of the actual exercise, the patient should perform a warm-up consisting of gentle and slow stretching exercises aimed at improving joint mobility and muscle flexibility. Avoiding fatigue when performing them is recommended. The warm-up should primarily cover those muscle groups that will be involved in the proper phase of the exercise. During exercise, patient should breathe slowly and deeply. It is recommended to perform exercises mainly in positions in which the spine is less exposed to overload (low, isolated positions). As part of the warm-up, you can also perform an appropriate general fitness exercise (at a slow pace). The training should be ended with a so-called cool-down phase lasting from 5 to 15 minutes, the aim of which is to calm down the breathing and reduce the heart rate to resting values. During the cooling phase, exercises from the proper phase continue to be performed, involving large muscle groups, but the intensity of the exercise is much lower. Another activity in this phase is stretching exercises. Ending physical activity in this way supports the return of venous blood from working muscles, which helps avoid fainting and heart rhythm disturbances [10, 11]. The time of day when you exercise is also important in the process of losing weight. Most effective training is performed hour before a meal (preferably before breakfast). If the feeling of increased hunger occurs after physical exercise, the patient should be advised to wait this period, which may be helped by eating a low-calorie meal or drinking still water[10,12]. 

Medicines used to treat obesity

If the introduction of a diet, physical activity and lifestyle modification have not yielded results, pharmacological treatment should be implemented, the aim of which, in addition to weight loss, is also the prevention and control of metabolic disorders associated with obesity[1]. One of the drugs used is orlistat, which is a strong and selective inhibitor of pancreatic lipase leading to moderate weight loss. It is recommended in a dose of 120 mg 3 times a day before each fatty meal. Side effects of orlistat mainly concern the gastrointestinal tract, and most often they are the so-called steatorrhea. Orlistat cannot be used in pregnant and breastfeeding women, as well as in people with chronic malabsorption syndrome and cholestasis[1,2,3]. Another drug used is liraglutide, an analogue of glucagon-like peptide 1 (GLP-1), secreted by the ileum in response to a meal. The mechanism of action includes stimulation of insulin secretion and reduction of glucagon release, depending on blood glucose levels. Liraglutide also reduces gastrointestinal motility, which results in a reduction in the amount of calories consumed by the patient. Moreover, animal studies have shown that this drug stimulates the satiety center and indirectly inhibits the hunger center. The drug is used in subcutaneous injections, and side effects include nausea and vomiting (occur mainly at the beginning of treatment). The maximum therapeutic dose is 3 mg daily[2,3,15]. Liraglutide should be used as the drug of choice in overweight and obese people who have prediabetes, type 2 diabetes, atherosclerosis, metabolic syndrome, clinical features of insulin resistance and risk factors for cardiovascular events[13]. Another GLP-1 analogue used to treat obesity is semaglutide. It can be given as a subcutaneous injection or oral tablets. The patient should be informed that oral semaglutide must be administered on an empty stomach, at least half an hour before the first meal[3]. Another option for pharmacotherapy is the combination of bupropion - a norepinephrine and dopamine reuptake inhibitor - with naltrexone - an opioid receptor antagonist. The combination of these drugs has an anorexic effect through long-term activation of anorexigenic neurons located in the hypothalamus. Bupropion stimulates neurons secreting proopiomelanocortin (POMC) and the CART (cocaine amphetamine related transcript) system, resulting in a decrease in appetite and an increase in energy expenditure. In turn, naltrexone intensifies and prolongs this effect by blocking the inhibitory feedback loop on POMC neurons, because as an antagonist of opioid receptors, it prevents β-endorphins from attaching to them. Side effects of this type of drug therapy may include headaches and dizziness, dry mouth, and digestive system symptoms such as vomiting and constipation. The combination of naltrexone and bupropion should not be offered to people with hypertension[2,3]. Recently, setmelanotide has also been used in the treatment of obesity. This drug is an agonist of the melanocortin 4 receptor (MC4R), thanks to which it binds to this receptor, restoring the appropriate activity of its pathway. As a result, the patient's feeling of satiety increases and the feeling of hunger decreases. Setmelanotide can be used in patients over 6 years of age. The reported side effects include: increased skin pigmentation, gastrointestinal disorders and spontaneous penile erection[3,14].

Surgical treatment

In the case of morbid obesity, the most effective method of treatment is surgery. European guidelines for the surgical treatment of morbid obesity recommend bariatric procedures for people aged 18–60 with class III obesity (BMI ≥ 40 kg/m2) and for people with class II obesity (35–40 kg/m2) with comorbidities, such as hypertension, heart failure, type 2 diabetes, metabolic disorders, obstructive sleep apnea, osteoarthritis, as well as psychological problems related to obesity. Surgical treatment of children and adolescents can be performed in a center with specialized pediatric facilities (including anesthesiological, nursing and psychological staff) and concerns young patients with class III obesity who show signs of skeletal and developmental maturity. In the case of people over 60 years of age, indications for bariatric surgery are considered individually[1,16]. Surgical techniques are divided into: restrictive (limiting food intake), exclusionary (limiting digestion and absorption of consumed food) and mixed - hybrid surgeries. Restrictive surgeries include: vertical-banded gastroplasty (VBG), gastric bypass (RYGB), gastric sleeve resection, adjustable gastric banding (AGB), gastric banding and long/limb RYGB. An example of a disabling operation is biliopancreatic diversion (BPD). Mixed procedures include: biliopancreatic diversion with duodenal switch (BPD-DS) and distal gastric bypass. The first choice when performing surgery should be the laparoscopic technique[16]. The most frequently performed laparoscopic surgeries in the treatment of obesity are gastric bypass and Adjustable Silicone Gastric Banding[17].

Conclusions

The basic treatment for obesity is non-pharmacological treatment, including diet (e.g. low-carbohydrate), physical activity and lifestyle changes. If non-pharmacological treatment does not bring positive results, pharmacotherapy should be introduced. Drugs used to treat obesity include liraglutide, semaglutide, orlistat, setmelanotide, and a combination of naltrexone and bupropion. In the case of morbid obesity, the most effective method of treatment is surgical treatment. When performing bariatric surgery, the laparoscopic technique is first used.

Funding

None

Conflict of interest

The authors declare no conflict of interest.

References

Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.

img

Virginia E. Koenig

Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.

img

Delcio G Silva Junior

Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.

img

Ziemlé Clément Méda

Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.

img

Mina Sherif Soliman Georgy

We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.

img

Layla Shojaie

The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.

img

Sing-yung Wu

Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.

img

Orlando Villarreal

Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.

img

Katarzyna Byczkowska

Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.

img

Anthony Kodzo-Grey Venyo

Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.

img

Pedro Marques Gomes

Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.

img

Bernard Terkimbi Utoo

This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.

img

Prof Sherif W Mansour

Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.

img

Hao Jiang

As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.

img

Dr Shiming Tang

Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.

img

Raed Mualem

International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.

img

Andreas Filippaios

Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.

img

Dr Suramya Dhamija

Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.

img

Bruno Chauffert

I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!

img

Baheci Selen

"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".

img

Jesus Simal-Gandara

I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.

img

Douglas Miyazaki

We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.

img

Dr Griffith

I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.

img

Dr Tong Ming Liu

I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.

img

Husain Taha Radhi

I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.

img

S Munshi

Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.

img

Tania Munoz

“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.

img

George Varvatsoulias

Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.

img

Rui Tao

Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.

img

Khurram Arshad

Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.

img

Gomez Barriga Maria Dolores

The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.

img

Lin Shaw Chin

Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.

img

Maria Dolores Gomez Barriga

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.

img

Dr Maria Dolores Gomez Barriga

Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.

img

Dr Maria Regina Penchyna Nieto

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.

img

Dr Marcelo Flavio Gomes Jardim Filho

Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”

img

Zsuzsanna Bene

Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner

img

Dr Susan Weiner