Review Article | DOI: https://doi.org/10.31579/2690-8794/314
1Department of Obstetrics and Gynecology, Alneelain University, Khartoum, Sudan.
2Department of Obstetrics and Gynecology, Omar Al Mukhtar General Hospital, Jabal Al Akhdar District, Libya.
3Department of Obstetrics and Gynaecology, Faculty of Medicine, Najran University, Saudi Arabia.
4Department of Obstetrics and Gynecology, Alhayat National Hospital, Khamis Mushait, Saudi Arabia.
5Department of Obstetrics &Gynecology, Najran Armed Forces Hospital, Najran, Saudi Arabia.
*Corresponding Author: Awadalla Abdelwahid, Head of Department of Obstetrics and Gynecology, Faculty of Medicine, Al Neelain University, Khartoum- Sudan. Bashair Hospital.
Citation: Awadalla Abdelwahid, Hajar Suliman, Bashir Abdeen, Fath E. Elrasheed, Ahazeej Gurashi, et al, (2026), Reproductive Outcomes in Women with Polycystic Ovary Syndrome: A Systematic Review of Interventional and Observational Evidence, Clinical Medical Reviews and Reports, 8(4); DOI:10.31579/2690-8794/314
Copyright: © 2026, Awadalla Abdelwahid. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 26 March 2026 | Accepted: 08 April 2026 | Published: 23 April 2026
Keywords: polycystic ovary syndrome; reproductive outcomes; phenotype stratification; bmi; follicular biomarkers; assisted reproduction
Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder among reproductive-aged women, one of the leading causes of anovulatory infertility. Women affected by PCOS consistently experience increased risk of adverse reproductive and pregnancy outcomes despite the advancement of assisted reproductive technologies (ART).
Aim: The aim of this systematic review was to provide an overview of the recent evidence on the impact of PCOS on fertility and maternal-neonatal outcomes.
Methods: We conducted a systematic review of our findings, using PubMed, Scopus, Web of Science as well as the Cochrane Library following the PRISMA 2020 standards. This search was conducted after incorporating randomized controlled trials, cohort studies and meta-analyses of reproductive health outcomes, primarily in women with PCOS (Rotterdam or NIH criteria). The outcomes measured were the rate of ovulation, time to conception, rate of pregnancy and live birth rate, miscarriage, gestational diabetes mellitus (GDM), preeclampsia and neonatal complications. The risk of bias was assessed by Cochrane RoB and ROBINS-I tools.
Results: A total of over 92,000 participants were included in thirty-three studies. Women with PCOS have markedly decreased ovulation and pregnancy rates, longer time to conception, greater risks of miscarriage (OR 1.70), GDM (OR 1.51), and preeclampsia (OR 2.12). Neonatal outcomes included an increase in low birth weight and NICU admissions. Subgroup analyses showed that lean PCOS phenotypes had a greater response to ART protocols than obese ones.
Conclusion: PCOS adversely affects reproductive outcomes, with increased maternal and neonatal risks. Some treatment strategies based on phenotypic and metabolic traits can, at least in part, improve fertility and pregnancy outcomes. More research is needed to achieve optimal ART protocols and reduce negative outcomes.
Polycystic ovary syndrome (PCOS) is a complex endocrine condition that affects some 6–20% of reproductive age women worldwide, determined by diagnostic criteria and population studied [1]. PCOS is most often associated with hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology, and it is a leading cause of anovulatory infertility [2]. Nonetheless, up to 70% of affected women remain undiagnosed, leading to delayed treatment and increased risks for reproductive and metabolic complications [3].
PCOS pathophysiology is highly mediated by an interaction of genetic, hormonal, and environmental factors. Insulin resistance and compensatory hyperinsulinemia worsen hyperandrogenism, impairing folliculogenesis and ovulation [4]. Obesity, commonly linked to PCOS, exacerbates these adverse effects and leads to a vicious cycle that impairs reproductive function [5]. Increases in luteinizing hormone (LH) relative to follicle stimulating hormone (FSH) are more frequent with PCOS and play a role in abnormal ovarian steroidogenesis [6].
Clinically, PCOS frequently manifests with menstrual irregularities, hirsutism, acne, and infertility [7]. The syndrome is also associated with higher risk of miscarriage, gestational diabetes mellitus (GDM), preeclampsia (PE), and adverse neonatal outcomes including low birth weight (LBW) and preterm birth [8][9]. Such complications are especially prominent in women using assisted reproductive technologies (ART), as PCOS has been found to be associated with ovarian hyperstimulation syndrome (OHSS) and poor endometrial receptivity [10][11].
Clomiphene citrate, letrozole, and metformin—pharmacological treatments to induce ovulation—are widely used. Letrozole (an aromatase inhibitor) exhibits better effect in clomiphene resistant patients [12]. Metformin enhances insulin sensitivity and ovulatory function, particularly in obese and insulin resistant models [13]; thus, lifestyle changes—particularly weight loss and diet—remain the mainstay of PCOS therapy and have demonstrated significant reproductive improvement [14].
Even with availability of multiple treatment techniques, reproductive efficacy is variable in PCOS and reproductive outcome is inconsistent. ART protocols must be individualized to minimize risk and maximize success. A growing body of evidence shows that phenotype specific treatments can increase fertility and decrease complications [15]. Furthermore, the role of follicular fluid biomarkers and endometrial receptivity in predicting ART success is developing as well [16].
Due to the wide heterogeneity of PCOS and its effect on fertility, a full body synthesis of the available evidence is necessary. Previous literature reviews have examined only narrow interventions or outcomes and have not stratified by phenotype or mode of intervention. This review systematically evaluates reproductive outcomes—including ovulation, pregnancy, live birth, miscarriage, and time to conception—in women with PCOS across interventional and observational studies. This review combines subgroup analyses with risk stratification to guide clinical decision making and future research.
To provide methodological rigor, transparency and reproducibility, this systematic review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020). The protocol detailing research objectives, inclusion criteria, search strategy, data extraction, and planned analysis was prepared before the initiation of the studies and registered under the registration number CRD420251162018 in the International Prospective Register of Systematic Reviews (PROSPERO). Registration facilitated prospective documentation of review methods and reduced the potential for selective reporting.
Eligibility Criteria
The study selection adopted structure based on the PICOS model. Women aged 18–45 years diagnosed with polycystic ovary syndrome (PCOS) according to Rotterdam, NIH, or AE PCOS criteria were included in the population of interest. Compatible modes of study included randomized controlled trials (RCTs), cohort studies, case–control studies and systematic reviews or meta-analyses with reproductive outcomes in PCOS. The intervention types consisted of ovulation induction agents (clomiphene citrate, letrozole, metformin), lifestyle modification programmes, with ART (in vitro fertilization [IVF], intracytoplasmic sperm injection [ICSI]). Comparators utilized placebo, no treatment, or alternative treatment protocols. Primary outcomes were ovulation rate, clinical and biochemical pregnancy rates, live birth rate, miscarriage rate, and time to conception.
Secondary outcomes were:
• Gestational diabetes mellitus (GDM)
• Preeclampsia
• Neonatal complications
We excluded studies where they were:
• Case reports
• Editorials
• Conference abstracts
• Animal studies
• Non-indexed literature
or where clear reproductive outcomes were not established.
Search Strategy
A systematic and extensive search of four main electronic databases – PubMed, Scopus, Web of Science and Cochrane Library has been performed. The search strategy included both Medical Subject Headings (MeSH) and free text terms (e.g., “Polycystic Ovary Syndrome,” “PCOS,” “reproductive outcomes,” “ovulation induction,” “pregnancy rate,” “live birth,” “miscarriage,” and “assisted reproduction”). To optimize the search and sensitivity, Boolean operators (AND, OR) were applied. Filters were used to limit results specifically to human studies in English published within the last ten years to ascertain the contemporary relevance at hand. To broaden our coverage as well, all reference lists of the participating studies and relevant systematic screened from the review databases and further eligible studies were searched in the reference lists to increase the coverage of all involved studies.
Study Selection
All retrieved records were imported into Rayyan QCRI, which is a web-based platform for blinded and independent screening. Reviewing titles and abstracts for relevance, two reviewers independently selected studies. Where eligibility was unclear or studies that met initial screening criteria, full text articles were obtained. Any discrepancies between reviewers were resolved in discussion or through consultation with a third reviewer. The study selection process was documented via a PRISMA flow diagram that recorded the number of records identified, screened, excluded and included.
Data Extraction
Extraction was achieved with a standardized and piloted Excel sheet. Included data was author, year, country of publication, study design, sample size, PCOS diagnosis criteria, as well as patient-specific intervention and comparator data, results reproductive outcome demographic information (age, BMI, phenotype), duration of follow-up, as well as statistical analysis methods. Other variables like sources of funding and conflicts of interest reported were also documented. Two reviewers independently extracted data; differences were resolved by consensus.
Quality Assessment
Reviews were manually
Validated tools were utilized to assess the methodological quality and risk of bias of included studies. The Cochrane Risk of Bias 2.0 (RoB 2.0) tool was used to assess domains for randomized controlled trials including randomization process, deviations from intended interventions, missing outcome data, outcome measurement and selective reporting. Observational studies were rated with the Risk of Bias in Nonrandomized Studies of Interventions (ROBINS-I) tool, in which confounding, participant selection, intervention classification, deviations from intended interventions, missing data, outcome measurement, and reporting bias were evaluated. Three risk factors (low, moderate, or high risk of bias) of the studies were included. Bias distribution in the studies was represented graphically with summary tables and visual plots.
Integration of datasets and analysis of statistics
Narrative synthesis was performed for studies with heterogeneous designs or outcomes. Wherever homogeneity was available, meta-analysis was conducted by Review Manager (RevMan) software. Analysis of dichotomous outcomes was performed using pooled odds ratios (ORs) with 95% confidence intervals while continuous outcome analyses of weighted mean differences were made. Statistical heterogeneity (I², > 50% as significant) was considered. We performed predefined subgroup analyses based on PCOS phenotype, BMI category, types of intervention, and geographic region. Sensitivity analyses were conducted to assess the robustness of pooled estimates by excluding studies with a high risk for bias and/or extreme effect sizes.
Evaluation of Publication Bias and Evidence Quality
Publication bias was screened via visual funnel plots and Egger's regression test when applicable. The overall certainty of evidence for each outcome was judged against Grading of Recommendations Assessment, Development and Evaluation (GRADE) standards, taking into account risk of bias, inconsistency, indirectness, imprecision and publication bias. The outcomes were given high, moderate, low or very low certainty.
33 studies met inclusion criteria (randomized controlled and cohort studies, systematic reviews) comprising populations in Asia, Europe, and North America (Table 1). The participants are 45 to >3,000 participants and generally the population was diagnosed by Rotterdam criteria and interventions included lifestyle change, pharmacologic ovulation induction and/or assisted reproductive technologies (ART) of IVF and ICSI.
Study Quality and Bias Evaluation
(Table 2) showed that risk of bias was low across the randomized domains, with five studies reporting overall low risk. Observational studies often mask allocation concealment and blinding. Finally, one study was deemed high risk because of incomplete reporting and suboptimal randomization procedures. The vast majority were carried out with methodological rigor, which allowed for credible synthesis.
Overall Reproductive Outcomes
as Table 3 illustrates inter-treatment effectiveness comparison. Letrozole had the highest incidence of ovulation (OR 1.82, 95% CI 1.45–2.29) and pregnancy (OR 1.67, 95% CI 1.32–2.11) rates of all non-ART treatments. Metformin and lifestyle interventions exhibited some degree of success. ART procedures were associated with significantly elevated pregnancy (OR 1.89, CI 1.53–2.33) and live birth rates (OR 1.76, CI 1.42–2.19), but at the same time increased miscarriage risk (OR 1.31, CI 1.02–1.68). Heterogeneity in different outcomes was moderate (I² = 38–55%), suggesting moderate effects.
Subgroup Analysis by PCOS Phenotype and BMI
Table 4 showed distinct trends of subgroup analysis by PCOS phenotype and BMI. Phenotype A (classic PCOS) appeared to have the greatest risk of miscarriage (OR 1.82) and gestational diabetes (OR 1.51), whereas Phenotype D had better live birth rates (Table 4). The stratification by BMI indicated that lean PCOS patients had superior ART related outcomes such as more ovulation and birth rates, and lower miscarriage rates. Obese patients showed an increased risk for gestational diabetes (OR 1.72) and preeclampsia (OR 2.15) suggesting metabolic burden significantly contributes to reproductive prognosis. These findings endorse phenotypic and BMI-based therapy approaches in terms of fertility outcomes.
Evidence Quality Assessment
The evidence quality assessment summary is shown in Table 5. Results like ovulation and pregnancy rates were supported by moderate quality evidence with low bias risk and acceptable consistency. For live birth and miscarriage outcomes, which were low due to heterogeneity and imprecision from effect estimates. Publication bias was assessed in a funnel plot (Figure 3), with mild asymmetry among smaller studies indicating selective reporting could affect pooled outcomes. Egger’s regression intercept test was only marginally significant and cautious interpretations were indicated for the respective analyses.
Biochemical Insights from Follicular Fluid Analysis
as Table 6 integrates molecular data from follicular fluid analyses, suggesting that some reproductive success biomarkers may play important roles in the female reproductive tract during PCOS. Markers of oxidative stress, including 8-Isoprostane, were elevated and associated with higher miscarriage rates. Low antioxidant capability (e.g., TAC levels) was associated with poor oocyte quality. Lipidomic changes such as higher ceramide and free fatty acids were linked to decreased embryo viability and fertilization results. The inflammatory markers (such as TNF-α, IL-6), were higher in the PCOS cohorts, which hampered blastocystogenesis. Hormonal biomarkers, including AMH and estradiol had the paradoxical trend of elevation, which suggested a follicular arrest in the presence of high follicle counts. Placental growth factor (PlGF) was found to be an early marker predicting ovarian response in ART cycles.
Visual Summaries
The flow of PRISMA studies selection (Figure 1) can be summarized visually including study selection of 33 studies, where 26 studies (Table 1) and 914 cases included and included by inclusion of meta-analysis. Forest plots in Figure 2 represent pooled effect sizes over major reproductive outcomes it summarizes pooled effect estimates derived from meta-analysis studies comparing reproductive outcomes among women with PCOS and controls. The forest plot shows substantial increases in gestational diabetes (OR 1.51), preeclampsia (OR 2.12), and low birth weight (OR 1.29), suggesting moderate heterogeneity across studies (I² = 48%). This agreement underscores increased perinatal risks of PCOS that underscore the importance of personalized antenatal protocols and metabolic risk screening.
As shown in Figure 3, the funnel plot that measures publication bias. The effect sizes scatter pattern versus standard errors reveals some subtle asymmetry with the small studies reporting good results. Most are in standardized confidence interval, but a number of outliers result from selective reporting or small-study effects. Egger’s regression intercept test presents near significant, cautioning caution as well as transparency as for future studies of PCOS. A stratified forest plot comparing reproductive outcome in women with PCOS for different phenotypes (A–D) and BMI (lean, overweight, obese) is presented in Figure 4.
The results show that phenotype A, (classic PCOS), is the type with the highest miscarriage and gestational complications, whereas phenotype D demonstrates a less severe prognosis. Lean individuals with PCOS demonstrate early ovulation and live birth after ART, and obese populations show increased likelihood of developing gestational diabetes (OR 1.72) and preeclampsia (OR 2.15). Effect sizes between subgroups are moderate to high heterogeneity, highlighting the effect of endocrine profile and body composition on fertility interventions. This number highlights the significance of phenotype- and weight-mediated-guided treatment regimens for achieving optimal reproductive attainment in women with PCOS.
Figure 1: PRISMA Flow Diagram
Legend: PRISMA diagram summarizing identification, screening, eligibility assessment, and final inclusion of studies in the review.
Figure 2: Forest Plot of Meta-analysis
Legend: Forest plot presenting pooled odds ratios for reproductive outcomes across interventions among women with PCOS.
Figure 3: Funnel Plot for Publication Bias
Legend: Funnel plot evaluating publication bias and small‑study effects across included studies in the meta‑analysis
Figure 4: Subgroup Forest Plot by Phenotype and BMI
Legend: Subgroup forest plot comparing reproductive outcomes across PCOS phenotypes and BMI categories in included studies.
This systematic review and meta-analysis synthesized data from 33 studies evaluating reproductive outcomes in women with PCOS, with emphasis on BMI/phenotype stratification, ART response, and biochemical information obtained from follicular fluid (FF). The evidence demonstrates distinct reproductive risk profiles based on endocrine subtype and metabolic status. Women with PCOS undergoing ART experienced higher risks of gestational diabetes mellitus (GDM), preeclampsia (PE), miscarriage, and low birth weight (LBW) [20][21]. These complications were especially pronounced among classic phenotype A and obese individuals, reflecting the interplay between hyperandrogenism, insulin resistance, and systemic inflammation [22].
Subgroup analysis showed that lean PCOS phenotypes (BMI <25>
Phenotypic variation also influenced pregnancy outcomes. Phenotype D (ovulatory dysfunction/polycystic ovaries) demonstrated improved outcomes when lifestyle factors were optimized, whereas phenotype A showed increased miscarriage risk and poorer ART response, likely due to combined hormonal and inflammatory disturbances [26]. Publication bias—identified through funnel plot asymmetry and Egger’s test—suggested overrepresentation of small positive studies. GRADE assessment indicated moderate quality evidence for ovulation and pregnancy rates, but low-quality evidence for live birth and miscarriage due to heterogeneity and variability [27].
Biochemical characterization of FF in PCOS revealed elevated oxidative stress markers (e.g., 8 Isoprostane) and reduced total antioxidant capacity (TAC), both associated with poor oocyte quality and increased miscarriage [28][29]. These redox disturbances impair mitochondrial function and granulosa cell dynamics, contributing to subfertility. Lipidomic analyses identified elevated ceramide (Cer 36:1;2) and free fatty acid (FFA C14:1) concentrations in PCOS FF, which correlated negatively with embryo quality and fertilization success [30]. Reduced lysophosphatidylglycerol (LPG 18:0) suggested compromised membrane fluidity and impaired oocyte maturation [31].
In obese PCOS phenotypes, inflammatory markers such as TNF α, IL 6, and CRP were persistently elevated, indicating chronic low-grade inflammation associated with impaired blastocyst formation and implantation failure [32]. These cytokines disrupt granulosa cell signaling and steroidogenesis. Hormonal FF markers including AMH and estradiol were paradoxically increased, reflecting high follicular count but follicular arrest. Placental Growth Factor (PlGF) emerged as a potential indicator of ovarian responsiveness, with elevated levels predicting hyper responsiveness to gonadotropins [33]. Proteomic analyses in PCOS FF identified abnormalities in oxidative phosphorylation, MAPK signaling, and cell cycle checkpoint pathways, suggesting potential therapeutic targets to enhance reproductive performance [34].
Lifestyle interventions—particularly low glycemic diets and structured exercise—significantly improved insulin sensitivity and restored ovulatory cycles [35]. Emerging evidence supports the role of nutritional supplements such as inositol, omega 3 fatty acids, and chromium in ameliorating hormonal and metabolic abnormalities in PCOS. A recent network meta-analysis ranked these agents favorably for lipid modulation and insulin regulation [36].
Despite strong findings, limitations persist. Generalizability is restricted by heterogeneity in diagnostic criteria, phenotype classification, and intervention design. Standardizing FF biomarker thresholds and incorporating phenotype stratified outcomes in future trials would strengthen the evidence base. This review underscores the importance of tailoring reproductive management to the metabolic and endocrine profile of PCOS. Stratified treatment approaches guided by biochemical and phenotypic markers may optimize ART outcomes and reduce pregnancy complications. FF biomarkers offer promising avenues for personalized fertility protocols, particularly for high risk PCOS subgroups.
Strength
Strengths of this review include detailed phenotype and BMI stratification, integration of mechanistic FF biomarkers, and synthesis across 33 studies with moderate to low bias. Global representation enhances external validity. GRADE based assessment provided transparency regarding evidence quality.
Limitations
Limitations include study heterogeneity, incomplete phenotype stratification, short follow up durations, publication bias, and underrepresentation of lean PCOS phenotypes, highlighting the need for standardized, longitudinal research.
This review finds that phenotypic presentation and BMI are associated with reproductive outcomes in women with PCOS. Classic phenotype A and obesity were consistently correlated with lower ART success and increased gestational complications, while lean phenotypes demonstrated better fertility outcomes. Follicular fluid biomarkers highlighted the underlying oxidative, lipidomic, and inflammatory dysregulation underlying subfertility. The integration of personalized reproductive regimes with a focus on metabolic and endocrine diversity for PCOS was supported by these findings.
Recommendations
In patients with PCOS, care based on phenotype and BMI are paramount to optimize reproductive results for optimal treatment. Follicular fluid biomarkers improve prognostication and inform ART planning. A common diagnosis framework is also needed for consistent stratification and reporting. Long term follow-up studies of maternal and neonatal follow-up is essential to measure the larger effects. And finally, predictive models driven by AI can help make fertility care better and more personalized — from accurate risk assessment to personalized reproductive intervention.
Acknowledgements
The authors would like to extend their heartfelt thanks to Dr. Rayia Abdelwahid for her profound clinical advice, well-reasoned scholarly input, and dedication during the preparation process of this writing.
Author Contributions
Awadalla Abdelwahid conceptualized the study and performed the statistical analysis. Awadalla Abdelwahid, Fathelrahman Elrasheed, and Hajar Suliman conducted screening, data extraction, quality assessment, and drafted the manuscript. Bashir Abdeen, Ahazeej Gurashi, and Nisrin Magboul Elfadel contributed to the methodology, search strategy, and manuscript review. All authors interpreted the findings, approved the final manuscript, and accepted responsibility for the integrity of the work.
Funding
Neither governmental, commercial, nor nonprofit funding bodies provided financial support for this study.
Ethical Approval
Since this systematic review was based solely on research published prior to this study and had neither direct human participants nor identifiable data, there was no requirement to obtain formal ethical approval. All studies included had ethics clearance from their institutions. To ensure methodological transparency, the review protocol was prospectively registered in PROSPERO (CRD420251162018).
Conflict of Interest
The authors declare they have no conflicts of interest in the conduct, analysis, or publication of this research. No personal, financial, professional, or other ties to a client shaped and influenced the findings in this manuscript.
Data Availability
All the data used for this review comes from existing publicly published studies indexed in databases such as PubMed, Scopus, Web of Science, and the Cochrane Library. It generated no primary new data. Such extracted datasets, summarized tables, and analytical materials can be obtained from the respective author on a reasonable request.
List of Abbreviations
PCOS Polycystic Ovary Syndrome
ART Assisted Reproductive Technologies
IVF In Vitro Fertilization
ICSI Intracytoplasmic Sperm Injection
BMI Body Mass Index
FF Follicular Fluid
GDM Gestational Diabetes Mellitus
PE Preeclampsia
AMH Anti-Müllerian Hormone
TAC Total Antioxidant Capacity
OR Odds Ratio
CI Confidence Interval
PlGF Placental Growth Factor
LPG Lysophosphatidylglycerol
FFA Free Fatty Acids
CRP C-Reactive Protein
TNF-α Tumor Necrosis Factor-alpha
IL-6 Interleukin-6
RCT Randomized Controlled Trial
PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analyses
AE-PCOS Androgen Excess Polycystic Ovary Syndrome Society criteria
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Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
