Substances are usually known as a series of inadmissible materials, which are used for the induction of some fictional mindsets, like peacefulness, leisureliness, happiness, liveliness, or holiness. Substances include opioids (like methadone or codeine), stimulants (like cocaine or amphetamine), hallucinogens (like phencyclidine), sedatives, hypnotics, anxiolytics, inhalants, cannabis, alcohol, caffeine, and tobacco

Substances are usually known as a series of inadmissible materials, which are used for the induction of some fictional mindsets, like peacefulness, leisureliness, happiness, liveliness, or holiness. Substances include opioids (like methadone or codeine), stimulants (like cocaine or amphetamine), hallucinogens (like phencyclidine), sedatives, hypnotics, anxiolytics, inhalants, cannabis, alcohol, caffeine, and tobacco. Substances have, generally, attained their importance due to the induction of a kind of egoistic relaxation, excitation, cheerfulness, or gratification in individuals who feel that they are devoid of them but are in search of them, even if such fulfillments are transitory, hollow, immoral, or unjustifiable. Today, substances are frequently judged in relation to their physical or psychological physiognomies, like tolerance, withdrawal, intoxication, and mental or medical side effects, and consequently, the legality or criminality of them, whether absolutely or partially. But substances may have medical benefits, too, like the sedation and analgesic effects of opioids in medicine. On the other hand, there have been various rumors as well regarding the usage of substances in some cults or circles for the induction of ecstasy or trance in admirers and the heightening of malleability by transcendent experiences. Even, as stated by some scholars, substance abuse may play a role in creating vulnerability and triggering pathways to extremism and lowering behavioral and mental thresholds for committing violent acts against adversaries (1-4). Theoretically, induction of ‘hypnoid state’, as stated by Joseph Breuer in ‘studies on hysteria’, or dissociative states, like trance, in contemporaneous taxonomies, whether autonomously, or by hypnosis, especially in persons with dependent or schizotypal traits, may enhance devotees’ suggestibility or misconception so intensely that they may fallaciously perceive nebulous supernatural powers in their favorite charismatic mentors, and submit eagerly to tutors’ rules or commands; a process, which, while may come about even without the said states of mind and may take place due to innate psychological weaknesses or unawareness, it may take place under the influence of euphoric ingredients and role of their suppliers, too. As is known, causing addiction in some prostitutes by their boss or pimp was sometimes a strong gismo for suppression of resistance and keeping them dependable. So, traditionally, substances were acknowledged by, at least, some individuals as a kind of instrument for control of cognizance and conduct, an intention that was always one of the most important desires of rulers as well throughout history. In some of the recent uprisings, too, there was vigorous gossip regarding the consumption of some substances, like stimulants, by activists or rebels during demonstrations; the same accusation, as well, was appealed by protesters against antagonist custodians—allegations that were never probed or proved logically or rightfully in either group. In this regard, the protestors had been accused because the guardians believed that among the demonstrators were individuals who, while they were without any radical or criminal background, were remonstrating and behaving so viciously and tactlessly that no justification or explanation could elucidate that. On the other hand, the guards had been blamed because, according to activists, they were overpowering protestors too violently, and they were not controllable even by their own commanders-in-chief. Moreover, sometimes a series of incidents happen that may make many people astonished at how such felonious acts may occur by those who have not had any earlier criminal history or have not been ever mentioned as wrongdoers by their coworkers, neighbors, or relatives. Anyhow, though neither of the criminals has had any recorded crime after birth, and there is usually a few decades' interval between birth and felonious misconduct, some felonies may be barely attributable to some persons, even when it has really happened and there is no doubt regarding the identity of the offender. Sometimes, even the sinner may grasp that as a painful dream during sleep, which demands awakening. Anyhow, with respect to every felony, a series of parameters may be accounted for as predisposing or precipitating factors, which may have pushed the occurrence of such misbehaviors. One of these possibilities, among the missed likelihoods, may be hush-hush contamination of some lawbreakers by some ingredients. In this regard, a stimulant substance, like amphetamine, which may induce paranoid ideation and hostility, even up to a full-scale psychosis, deserves more attention. During the past decades, amphetamine medications have been used broadly in child psychiatry for the management of Attention-Deficit/Hyperactivity Disorder (ADHD) or in neurology for the declining of cataplexy attacks in narcolepsy. But, for persons with, for example, paranoid, borderline, antisocial, or schizotypal traits, or irritable depressed persons with negative cognitive distortions, who may typically have worries, resentment, or fantasies of demolition or revenge (though without venturing to enact them), gradual and out-of-sight exposure to nominal quantities of ingredients like amphetamine or its derivatives, which may not cause overt clinical symptoms or intoxication, may, hypothetically, turn their usual paranoid ideas into unshakable partial or complete delusions, which may, as a final point, result in acting out of the said internal conflicts and consequent misfortunes. Parenthetically, amphetamine and related derivatives are, today, one of the most important causes of aggression and secondary psychosis in psychiatry. At this juncture, amphetamine has, allegorically, been cited as a sample of stimulant, because in addition to amphetamine, its by-products, like methamphetamine (METH) and its derivative, methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methylenedioxyethylamphetamine (MDEA, MDE), methylenedioxyamphetamine (MDA), 4-methylthioamphetamine (4-MTA), and para-methoxyamphetamine (PMA), are extensively abused drugs, and the acute effects of these drugs include increased alertness, hyperthermia, decreased appetite, euphoria, paranoid delusions, including Ekbom syndrome (delusional parasitosis), and hallucinations. Likewise, the most frequent effects after MDMA/ecstasy administration are euphoria, well-being, happiness, stimulation, increased energy, extroversion, feeling close to others, increased empathy, increased sociability, enhanced mood, mild perceptual disturbances, changed perception of colors and sounds, and derealization (5). There are other simulants, too, like cocaine, methylxanthine, phencyclidine, and other sympathomimetics, which may cause the same medical or psychological side effects. Also, while amphetamine may be ingested, snorted, or injected, methamphetamine can be smoked as well (6, 7). Forensically, while such an imagined exposure has not been systematically validated, it does not look implausible. Likewise, while ease of access to such substances is not unlikely, detection of predisposed and unaware targets, too, via social media, communications, or chitchats, is not a hard mission. The supposed pollution, as well, may be caused by contamination of food or drink, or even by breathing of polluted fumes. Therefore, for dubious folks, who are fond of ‘conspiracy theories’ and may see themselves as a target for factual or fictional circles but do not want to commit wrongdoing, it may be mannerly advised to not accept suspicious foods or drinks, especially when they may not be frozen or boiled, techniques which may degrade and naturalize ingredients, and to avoid dehydration, which may decrease their clearance. Also, leave places where weird smells may be sensed. In case of a great suspicion, as well, a negative urine or blood test for detection of substances, which may be requested by a primary care physician, may end the tension rapidly. But, if the conclusion of such a checkup proves otherwise, then it may be pursued lawfully for finding the source of contagion. Also, preferably, do not pay attention to fishy dialogues or whispers, or do not react thoughtlessly to melodramatic scenes, especially when their content is, fortuitously or incredibly, too comparable or challenging with your own concerns, feelings, or standards—processes that may directly or indirectly push or inspire you towards bad behaviors. Furthermore, since evaluation of substances is usually restricted to psychiatric wards, for differential diagnosis of mental disorders (substance-induced vs. primary), or to forensic facilities, for substantiation of proof in alleged cases, no assessment may customarily be done after many crimes, unless there are clear-cut physical symptoms, past history, or a convincing report. Additionally, the short half-life of stimulant ingredients, which may range between a few hours and a few days, may complicate their late detection after routine paperwork or initial investigations. Besides, amphetamine- or methamphetamine-induced psychosis (PIP or MIP, respectively) may persist from a few hours to a few months after cessation of the material. Likewise, when amphetamine is ingested, a dose may vary from several tens to several hundreds of milligrams depending on the purity, and there is still considerable debate as to what level of amphetamines can be toxic or even potentially lethal (8). So, while there is not constantly a definite relationship between an abused substance, its detection, and the ensued clinical symptoms, the aforesaid parameters may intensify the abovementioned bafflement. Correspondingly, there are a series of articles that examine the clinical and legal aspects of the involuntary intoxication defense, like violent acts that have been perpetrated by minor and adult patients who have been prescribed selective serotonin reuptake inhibitors (SSRIs) and related psychoactive medications in a therapeutic context (9), or when voluntary intoxication may be used to prove that the defendant could not possess the capacity to formulate the intent as a necessary element of the crime (10, 11). In conclusion, though concealed contamination of uninformed targets by some ingredients, for motivating them to commit wrongdoing, seems to be an unreasonable, eccentric, or pessimistic likelihood, it is not an unlikelihood and may deserve a more systematic approach, evaluation, and study in the field of criminology (12-25).