AUCTORES
Globalize your Research
Editorial Note | DOI: https://doi.org/10.31579/2578-8949/031
Deportment of Pharmaceutics, Jangaon Institute of Pharmaceutical sciences, Jangaon, India.
*Corresponding Author: Prasad Garrepally, Deportment of Pharmaceutics, Jangaon Institute of Pharmaceutical sciences, Jangaon, India.
Citation: Prasad Garrepally, and Swathi Goli. PRP: Alopecia Areata an Autoimmune Destruction of the Hair. J .Dermatology and Dermatitis. Doi: 10.31579/2578-8949/031
Copyright: © 2018 Prasad Garrepally. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 02 April 2018 | Accepted: 22 April 2018 | Published: 27 April 2018
Keywords: Keywords
Abstract
PRP has been used mostly for androgenetic alopecia and alopecia areata since these are the most common types of hair loss. Especially androgenetic alopecia is an extremely prevalent disorder resulting in gradual conversion of terminal hairs into vellus hairs. This is more obvious in men affecting more than 50%, with its well-known hair loss pattern, although there are studies suggesting an almost equal prevalence for women too. A self-renewal of the hair follicle by the keratinocyte stem cells of the bulge have been indicated in androgenetic alopecia, making growth factors signalling a promising future therapy.
In alopecia areata an autoimmune destruction of the hair in part or parts of the body, usually in the scalp, is taking place resulting in spot balding. Quite often balding is asymmetrical causing serious aesthetic issues. Alopecia areata can be reversible in the type where the hair shafts are gone but the hair follicles are preserved. However there is also a type where inflammation results in fibrosis and irreversible hair loss. Histopathological findings show an accumulation of T-lymphocytes around hair follicles in areas of alopecia areata suggesting an autoimmune aetiology. That there is trichoscopy shows regularly distributed "yellow dots" (hyperkeratotic plugs), small exclamationmark hairs, and "black dots" (destroyed hairs in the hair follicle opening).
Various studies trying to delineate the physiology and the various molecular mechanisms behind hair growth have implicated several growth factors such as PDGF, TGF, VEGF and IGF. For example, endothelial cells and keratinocytes and possibly other types of cells located in the area of a hair follicle produce Platelet Derived Growth Factors (PDGF) which is fundamental for cell growth and proliferation. Thus, PDGF signals are involved in both epidermis-follicle interaction and the dermal mesenchyme interaction required for hair canal formation and the growth of dermal mesenchyme [1]. In experimental animal models, PDGF expression, which is either positively or negatively modified by various cytokines, has been shown to induce and maintain anagen phase [2]. In addition, IGF-I extends the overall anagen phase whereas both IGF-I and IGF-II prevent the HF from developing catagen like status [3].
Vascular Endothelial Growth Factor (VDGF) also plays an important role in hair follicle growth and cyclin by improving follicle revascularization, since anagen-associated angiogenesis has been suggested as one of the important factors in active hair growth [4]. Conversely TGF-b1, which is induced by androgens, seems to act as an inhibitory paracrine mediator in androgenetic alopecia.
As reported previously, platelets concentrate contain an increased concentration of growth factors, such as VEGF, PDGF and IGF. Thus the utilization of PRP for the treatment of baldness is a rational consequence of the knowledge we have so far on the physiology of hair growth. Although there are several studies for the treatment of androgenic alopecia and alopecia areata, the exact mechanisms of action as well as the molecular signalling pathways remain largely unknown.
In general, PRP increases proliferation of epidermal and hair follicle bulge cells, as indicated by the Ki-67 marker of cell proliferation in both androgenic alopecia and alopecia areata [5,6]. Several molecular pathways have been implicated in this action, such as ERK signalling, WNT b-catenin pathway and Akt signalling activity.
In more details, phosphorylation of extracellular signal-regulated kinases (ERK) and Akt by PRP that has been shown recently [7] are important steps in well-established molecular cascades that result in mutagenesis, cell growth or apoptosis. Growth factors, such as PDGF, trigger complex downstream signalling cascades upon their interaction with their specific receptors, e.g. tyrosine kinase receptor, and the phosphorylation and activation of molecules such as phosphoinositide 3-kinases (PI3Ks), and PIP2. Phosphorylation of PIP2 to PIP3 causes its activation and further phosphorylation and activation of AKT that is an anti-apoptotic signalling molecule implicated also in cellular growth, metabolism and angiogenesis [8].
In addition, modulation of WNT signalling activity affects the fate of hair follicle cells significantly. In an animal study, WNT10a mRNA and protein as well as WNT5a mRNA and protein, were higher among skin samples treated with PRP. WNTs 10a and 10b act as the first epidermal signals of the canonical WNT/β-catenin signaling pathway that regulates stemness and hair regeneration [9].
Nevertheless the increased transcriptional activity of b-catenin, which plays an important role in the differentiation of stems cells to hair follicle cells and the prolongation of survival of derma papilla cells [10] may not be the indirect result of the activation of signalling pathways within the hair follicle. As it has been shown in an in vitro model the activated PRP approximately doubled transcriptional activity of b-catenin Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth [11]. Indicating that activated PRP may have additional direct actions through exogenously expressed molecules, such as b-catenin.
Other molecules that have been shown to be upregulated by PRP are the FGF-7, which is known to stimulate hair growth [10], and the FGF-9 that enhances follicular neogenesis [9]. In addition, the expression of cyclin D1and Cdk4 is also significantly affected by PRP [7] as well as the synthesis of anti-apoptotic protein Bcl-2 [11]. The study of these proteins was not random since similar results have been shown with Minoxidil. Minoxidil, which is one of the very few FDA approved medications for androgenetic alopecia along with Finasteride, promotes the survival of dermal papilla cells by increasing Bcl-2/Bax ratio and by activating ERK and Akt [12].
It seems that this mechanism succeeds through the stimulation of potassium channels and prostaglandin endoperoxide synthase-1, which has been shown to increase anagen phase [5]. Finasteride also induces the prolongation of anagen hairs and activates anagen hair growth, as shown by the gradual thickening and elongation of the hairs in clinical studies, by affecting the expression of caspases and apoptosis inhibitors [5].
Briefly, activation of wingless (Wnt)/β-catenin, extracellular signalling regulated kinase (ERK), and protein kinase B (Akt) signalling pathways leads to the necessary cellular proliferation and differentiation that encourages hair follicles to enter and extend the duration of the anagen phase of the growth cycle [13]. Another possible mechanism that is activated through growth factors and affects hair growth is the promotion of vascularization and angiogenesis. It is well known since many years that PRP improves cutaneous ischemic conditions and increases vascular structures around hair follicles. This is a very important process in hair transplantation (FUT) since in the early phases of folliculoneo genesis, that is initiated before angiogenesis, grafted cells can obtain only limited nutrition and growth factors from surrounding tissue fluid [14]. Thus loss or reduction of nutrients and signalling factors does not allow full development of hair follicles and explains at least partially the up to 30% HF loss that have been reported in FUT. VEGFs and platelet-derived growth factors contribute in increasing peri-follicular vasculature thus, improving the blood supply and nourishment to the transplanted grafts [10].
It is obvious that the exact pathophysiologic mechanisms that are being initiated by PRP are still unknown. For example the importance of slower and steadier increase of growth factors in PRF by endogenous activation or the role of increased numbers of leucocytes have not been studied yet. A steady unlock of the expression of normal gene sequences that are related to the anagen phase may be beneficial in the long term or on the contrary the release of proinflammatory cytokines of leucocytes could have negative effects on hair growth. Nevertheless, PRP and PRF action on hair restoration remains an active and interesting field of study.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
