Opinion | DOI: https://doi.org/10.31579/2690-8794/226

Platelet factor 4

  • Solomons

DR.H.D. Solomons, P.O. Box 64203, Highlands North, 2037, South Africa.

*Corresponding Author: Solomons, P.O. Box 64203, Highlands North, 2037, South Africa.

Citation: Solomons, (2024), Platelet factor 4, Clinical Medical Reviews and Reports, 6(6); DOI:10.31579/2690-8794/226

Copyright: © 2024, Solomons. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: 25 August 2024 | Accepted: 02 September 2024 | Published: 09 September 2024

Keywords: Platelet factor;neutrophils ; fibroblasts.

Abstract

Platelet factor is a cytokine It is also known as chemokine ligand 4. It is released from alpha granules and promotes coagulation.

Summary

Platelet factor is a cytokine It is also known as chemokine ligand 4. It is released from alpha granules and promotes coagulation.

Platelet factor 4 is chemotactic for neutrophils, platelets and monocytes.

It is a 70 amino acid structure and is released from the alpha granules.

It has a high affinity to heparin and neutralises heparin-like molecules.

It inhibits protein C activity.

There are also cases of antibodies being formed against platelet factor 4 .

It is usually found in a complex with proteoglycan.

It is a strong chemo-attractant for neutrophils and fibroblasts.

It has been found to be the antigen in heparin-induced thrombocytopaenia

The gene for platelet factor 4 is located on chromosome 4.

PF 4 inhibits antithrombin III and promotes coagulation !


 

 

References

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