Review Article | DOI: https://doi.org/10.31579/2692-9759/197
Morning star hospital, Marthandam, Kanyakumari District, Tamil nadu state, India.
*Corresponding Author: Ramachandran Muthiah, Morning star hospital, Marthandam, Kanyakumari District, Tamil nadu state, India.
Citation: Ramachandran Muthiah, (2026), Plasmodium vivax infection in Rheumatic Fever- A Coexistence, Cardiology Research and Reports, 8(3); DOI:10.31579/2692-9759/197
Copyright: © 2026, Ramachandran Muthiah. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 04 June 2026 | Accepted: 19 June 2026 | Published: 29 June 2026
Keywords: febrile episodes; acute rheumatic fever; aso titer; malarial infection; carditis; immune response; duffy blood group antigen
Fever pattern is helpful to diagnose the associated infection in Acute Rheumatic Fever. The gold standard for diagnosis of GAS (Group A streptococcus) pharyngitis is bacterial culture. However, throat culture takes 24 - 48 hours and requires culture facilities. Therefore, culture tests are difficult to use in primary care practice. To compensate for these shortcomings, a rapid antigen detection test (RADT) was developed to detect GAS within a few minutes without the need of laboratory facilities. The Korean upper respiratory tract infection guideline recommends that the RADT to be performed in patients with modfied Centor score of 3 or above. A rapid slide agglutination test (streptozyme, Carter Wallace test) that looks at antibodies against several (five) streptococcal extracellular antigens and it is thought to improve the detection of streptococcal infection. The coexistence of acute rheumatic fever with malarial infection is uncommon. Relapsing pattern of fever is the short febrile periods occurring between one or several days of normal temperature. Malaria, in particular that caused by infection with plasmodium vivax, produces relapsing fever at 48 hrs interval. The exact mechanism for acute rheumatic fever remains unexplained and ‘molecular mimicry’ appears to be most likely. Similarly for coexistence of acute rheumatic fever with malarial infection remains unexplained and related to ‘altered immune status’, particularly with P. vivax infection which may be related to specific duffy blood group antigen.
Acute Rheumatic Fever remains a daily challenge to doctors who work in developing countries. Febrile paroxysms synchronous with periodicity develop in partially immune patients who were previously infected with malarial parasites and are cyclic fevers and chills [1] driven by the synchronous rupture of infected red blood cells and the subsequent release of parasites and toxins into the bloodstream [2]. In partially immune patients, these episodes become highly regular and predictable due to acquired defences clearing asynchronous parasites. In nonimmune patients, who were previously not infected with malarial parasites, the febrile paroxysms are asynchronous with no periodicity. Altered immune status occurred in this patient due to previous infection with P. vivax since this patient is partially immune as evidenced by 48 hrs periodicity of fever pattern. Similarly repeated pharyngeal infection with group A β hemolytic streptococci as evidenced by raised ASO titers is necessary to prime the immune response [3] before the first episode of acute rheumatic fever to occur. In tropical countries, there is high prevalence of mixed infections. So, the possibilities of other infections must be evaluated if fever is not responding to routine therapy in acute rheumatic fever.
A 12 year old boy was admitted for sudden onset of fever with major joint pains for 10 days duration. The patient was febrile, not anemic, not jaundiced, no generalized lymphadenopathy and no edema legs. Pulse rate was 123/min, Blood pressure was 110/80 mmHg. Cardiovascular examination revealed normal Jugular Venous Pressure, slightly laterally displaced hyperdynamic apical impulse and no precordial bulge or pulsation. Auscultation revealed normal heart sounds with 2/6 apical systolic murmur, a short, soft basal early diastolic murmur and no additional sounds. Respiratory system revealed normal breath sounds with mild basal crackles. Abdominal examination showed just palpable, soft, tender splenomegaly and neurological examination revealed no abnormal findings. ECG revealed sinus tachycardia and X-ray chest showed mild cardiomegaly. Echocardiography revealed thickened mitral valve as shown in Figure 1 with mild mitral regurgitation, moderate aortic regurgitation as shown in Figure 2, suggesting Rheumatic carditis, normal LV function and no vegetation. ESR raised to 80mm/hr, ASO titer was 400 Todd units/ml and mild leukocytosis with slightly increased proportion of polymorphonuclear leukocytes. Other blood, renal and liver parameters were normal. Ultrasound abdomen revealed mild splenomegaly. The patient was diagnosed as Acute Rheumatic Fever with carditis and treated with injection Benzathine Penicillin 12 lakhs intramuscularly and acetyl salicylic acid (aspirin) 300mg three times daily until the ESR became normal and then tapered to reduced doses and continued for 6 weeks. Small doses of diuretics given to clear the crackles. Steroids were not given to the patient. Arthritis responded well to salicylates. The fever was relapsing with a periodicity of 48 hrs interval. Blood culture revealed no organisms. Peripheral smear for malarial parasites showed trophozoites of plasmodium vivax as shown in Figure 3. Then the patient was treated with tablets chloroquine for 3 days. Fever subsided and radical treatment with primaquine was given. The patient was discharged in good condition and advised RF prophylaxis and there was no further febrile episodes.
Figure 1: shows Thickened mitral valve tips suggesting Rheumatic involvement.\
Figure 2: shows mild mitral regurgitation and moderate aortic regurgitation suggesting Rheumatic carditis.
Figure 3: shows Trophozoites of P. vivax.
Malarial fever
Malaria transmission does not occur at temperature below 16◦C or above 33◦C and at altitude greater than 2000 m above sea level [4] since development in the mosquito (sporogony) cannot take place. The ecological assumptions about the thermal physiology of insects, it is found that most malaria models to date assume constant or linear responses of mosquito and parasite life-history traits to temperature, predicting optimal transmission at 31 °C. A large data set on malaria transmission risk in Africa validates both the 25 °C optimum and the decline above 28 °C [5]. The favourable conditions for transmission are high humidity and an ambient temperature between 20°C and 30°C. Although rainfall provides breeding sites for mosquitoes, excessive rainfall may wash away mosquito larvae and pupae. P. falciparum is the only human malarial parasite that causes severe microvascular disease (such as cerebral malaria and placental malaria involving the intervillous space, jeopardizing pregnancies [6]) by causing infected red blood cells to stick to blood vessel wall. and can cause recrudescence (the return of symptoms from surviving blood-stage parasites that were never fully cleared). True relapses originate from dormant liver stages called hypnozoites, which are produced by P. vivax and P. oval [7]. A small fraction of intraerythrocytic parasites switch to sexual development, producing morphologically distinct male and female gametocytes that reach the host's dermis and are ingested by a mosquito, rendering the mosquito infectious to humans After ingestion by a female Anopheles mosquito, the male microgametocytes go through exflagellation in the mosquito's midgut, fusing with female macrogametes to form a zygote. The zygote then develops into an ookinete, which migrates through a thin wall and matures into an oocyst, which produces and, upon rupture, releases numerous sporozoites that are dispersed throughout the mosquito's body, including the salivary glands, thereby completing the life cycle. Gametocytes are therefore of vital importance to the transmission cycle of malaria. However, the clinical symptoms predominantly result from the asexual stages of parasite replication in human blood [8]. Clinically, the cardiac involvement is rare in malaria. Histologically, myocardial capillaries are often filled and even distended with an accumulation of parasites, sometimes totally occluding the lumen of the vessels. Thrombosis of capillaries and ischemic myocardial changes may be seen. Definitive diagnosis of malaria generally requires direct observation of malaria parasites in Giemsa-stained thick and thin blood smears. Thick blood smears are more difficult to interpret than thin blood smears but they are much more sensitive as more blood is examined. Thin blood smears, in which parasites are seen within erythrocytes as in Figure 3, are used to determine the species of the infecting parasite [9].
Streptococcal pharyngitis
Viral sore throat has more prominent catarrhal, common cold-like symptoms (watery eyes, running nose), gradual onset with uncomfortable throat, and cervical nodes are not enlarged. Tonsils and throat are red with vesicles and ulcers. Streptococcal sore throat may be associated with headache, abdominal pain, nausea, vomiting and no diarrhea. Centor criteria, which are highly effective for estimating the probability of a Group A streptococcal (GAS) infection in adults, but ineffective in children from 2 to 15 years of age [10] and modified centor [11] by Dr. Jack McIsaac, a Canadian physician (Canadian criteria) to include the patient's age as under 15 (3 to 14 years) adds 1 point; Age 15 to 44 years: 0 points, Age 45 years and older: Subtract 1 point for the diagnosis of streptococcal sore throat using the four same features of centor criteria as tonsillar exudates (white patches/pus on the tonsils) or swelling, Tendor or swollen anterior cervical nodes, a history of fever of more than 38◦C and lack of cough. It is also known as the McIsaac criteria, a screening tool for the suspicious of group A Streptococcal (GAS) pharyngitis [12]. Score -1 to 1: Very low probability of strep (under 10%), no antibiotics or testing are typically required. Score 2 to 3: Intermediate probability, consider a Rapid Streptozyme Antigen Test (RADT), antibiotics should only be prescribed if the test is positive. Score 4 to 5: high probability of streptococcus infection (up to 50% or more). Empiric treatment or testing can be considered depending on the clinical context.Following well documented group A streptococcal pharyngitis, vague signs and symptoms and non specific laboratory abnormalities may occur. Discomfort in the extremities, borderline temperature elevation, increased intensity of functional murmurs, tachycardia, elevated ESR and prolonged PR interval can occur in the absence of major manifestations. These patients do not develop RHD (Rheumatic heart disease) on follow up and so the diagnosis of acute rheumatic fever should not be made in the absence of at least one major manifestations [13]. Rheumatogenic pharyngeal strains are M types 1,3,5,6,14,18,19,27,29 and nephritogenic pharyngeal strains are M types 1,4,6,12,25. Nephritogenic strains associated with pyoderma include M types 49,53,55,56 and 57. Rheumatogenic streptococcal strains fail to elaborate α-lipoproteinase (serum opacify factor-SOF negative) and they are frequently heavily encapsulated which is manifested by the formation of mucoid colonies on blood agar plates. It is probable that not all strains of rheumatogenic serotypes are equally dangerous. Pharyngeal strains having both nephritogenic and rheumatogenic potential are M types 1,6, but nephritogenic pharyngeal strains are SOF (serum opacify factor) positive and rheumatogenic pharyngeal strains are SOF negative [14].
Acute Rheumatic Fever (ARF)
Acute Rheumatic fever (ARF) occurs in people previously infected with Streptococcal sore throat or due to recurrent infection with GAS. Evidence of preceding streptococcal infection is a prerequisite for the diagnosis of Rheumatic fever and raised ASO antibodies are helpful to diagnose recent infection rather than acute infection. In healthy adults, the titers are usually less than 85 Todd units/ml, whereas school age children can have ASO titers up to 170 U. ASO antibodies are present in approximately 85% of patients 2 to 4 weeks after streptococcal pharyngitis. Generally, ASO level of more than 240 U in adults or more than 330 U in children is used for the diagnosis of Acute Rheumatic Fever. A single value of 500 units indicate recent streptococcal infection and a value of 333 units is of borderline significance. If ASO titer is 333units or less, additional antistreptococcal antibody assays such as anti DNase B, antihyaluronidase should be obtained [15]. With pharyngitis associated poststreptococcal acute glomerulonephritis, 90 to 95% of patients have an elevated ASO or anti DNase B titer. With pyoderma associated poststreptococcal acute glomerulonephritis, ASO titer is not consistently elevated since streptolysin O is irreversibly inactivated by lipids (probably cholesterol) present in the skin which in turn unable to induce increased magnitude of the immune response to cause rheumatic fever and this property may be responsible for the lack of association between streptococcal skin infection and Rheumatic fever [16].
Acute Rheumatic Carditis
About 50 to 80% of people with ARF develops carditis (pancarditis), can also present with valvulitis, affecting mitral ( 50% to 60% and mitral regurgitation is usually the earliest manifestation [17]) and aortic valves (20%) predominantly as shown in Figure 2 and tricuspid valve (10%). The inflammatory process takes weeks to months to resolve and the average duration of an attack of rheumatic fever, unaltered by anti-inflammatory therapy, is approximately 3 months. Less than 5% of cases persists for longer than 6 months, justifying the designation as ”chronic rheumatic fever”. Stollerman [18],[19] lists the criteria for continuing clinical activity in rheumatic fever as follows: joint symptoms, new organic murmurs, a changing heart size, congestive heart failure in the absence of long standing valvular disease, subcutaneous nodules, a sleeping pulse rate greater than 100 beats/min, erythema marginatum, chorea, a positive test for C- reactive protein and a rectal temperature of 100.4◦C or higher for 3 or more consecutive days. The most recent modification of Jones Criteria (updated Jones Criteria) was published in 1992. The Jones Criteria was designed to establish the diagnosis of rheumatic fever during the acute stage of illness and not to measure rheumatic activity, diagnose inactive or chronic RHD, or predict the course or severity of the disease. Jones Criteria aid in the diagnosis of initial attack of acute rheumatic fever based on combination of clinical and laboratory findings. In practice, the characteristic murmurs of acute rheumatic fever are almost always present in cases of rheumatic carditis. The diagnosis of carditis require the presence of one of these four manifestations- organic cardiac murmurs not previously present, cardiomegaly, pericarditis, congestive heart failure. For a major criterion of carditis, pathological mitral and/or aortic regurgitation must be present. First degree or even greater degrees of heart block is a toxic phenomenon associated with acute rheumatic fever and rarely complete heart block [20] occurs and may responds to anti-inflammatory therapy (steroids)[21],[22].
Echocardiographic screening
The 2023 World Heart Federation (WHF) [23] guidelines for the echocardiographic diagnosis of rheumatic heart disease present a staging process for RHD diagnosis on the basis of the risk of disease progression in the population category varies between low and moderate to high risk (high-risk populations, as defined by a prevalence of more than 2 cases per 1,000 persons for RHD (all ages) or an incidence of more than 30 cases per 100,000 persons aged 5–14 years annually for ARF). Stage A is the baseline or minimum criteria for individuals ≤ 20 years old who are at clinical risk of RHD with mild mitral regurgitation (MR) or aortic regurgitation (AR) without structural/morphological features of the valve (echocardiographic features from normal variant to mild RHD). The presence of morphological features alone, without valvular regurgitation, does not qualify individuals for stage A disease. Stage B indicates mild RHD with the presence of both pathological regurgitation (MR jet length measures ≥ 1.5 cm (in individuals weighing < 30 kg) or ≥ 2.0 cm (in individuals weighing ≥ 30 kg), AR jet length ≥ 1.0 cm, body of the pan-systolic envelope should be ≥3.0 m/s) and morphological features (the mitral valve: the thickening of the valvular apparatus (defined by the presence of either or both valvular and chordal thickening) and valve mobility (defined by the presence of either or both restricted and excessive leaflet motion). Anterior mitral valve leaflet (AMVL) thickness is age-specific and defined as follows: ≥3.0 mm for individuals aged ≤20 years, ≥4.0 mm for individuals aged 21–40 years and ≥5.0 mm for individuals aged > 40 years and should be measured during diastole at the full excursion, taken at the thickest portion of the leaflet, including focal thickening, beading and nodularity on a frame with maximal separation of chordae from the leaflet tissue. Restricted leaflet motion of either the AMVL or the posterior mitral valve leaflet is usually the result of chordal shortening or fusion, commissural fusion or leaflet thickening. Excessive leaflet tip motion results from elongation of the primary chords and is defined as displacement of the tip or edge of an involved leaflet towards the left atrium, resulting in abnormal coaptation and regurgitation. Pathological regurgitation, but without morphological features, is also classified as stage B. Stage C indicates established valvular disease detected by echocardiography, and are at risk of developing complications and might require medical treatment or surgical intervention. Mitral stenosis (Restricted leaflet motion with reduced valve opening, mean peak gradient ≥ 4.0 mmHg) of any severity is included in this category. Stage D indicates established valvular disease detected by echocardiography (the same as stage C), but with overt clinical complications (such as heart failure, arrhythmia, stroke or the need for cardiac surgery). The stage-based criteria outlined in these guidelines acknowledge the spectrum of early echocardiographic rheumatic changes by incorporating the assessment of the risk of progression and replacing the previously described borderline and definite categories [24]. Valvular regurgitation in ARF is attributable to various mechanisms, including valvulitis, mitral annular dilatation, leaflet prolapse and chordal elongation or rupture, all of which can be detected on echocardiography. [25] The morphological changes associated with RHD often develop at a later stage of disease or might never transpire and thus are not required for the diagnosis of acute carditis in the setting of ARF. Some patients with acute rheumatic fever have echocardiographic evidence of thickened mitral leaflet tips as in Figure 1 with mitral and aortic regurgitations as in Figure 2 are suggesting the rheumatic carditis in this patient was stage B category.
Molecular mimicry
ARF is characterized by an aberrant immune response to GAS infection triggered by molecular mimicry between GAS antigens and self-antigens There are several lines of evidence suggesting that the molecular mimicry always plays a very important role in the development of carditis by stimulating the cross reactive responses of the cellular and humoral immunity. The alpha-helical structures of protein are found in the N-acetyl-beta-D-glucosamine (S. pyogenes carbohydrate antigen). M protein shares the epitopes of cross-reaction antibodies with myosin. Vascular cell adhesion molecule 1(VCAM 1) may be the connection between humoral and cellular immunity at the surface of the valve. VCAM 1 gets upregulated at the surface of the endothelium because of the cross reactive antibodies binding which results in the adherence of CD4+ T cells to the endothelium thereby subsequently infiltrating those cells to the valve [26].
Genetic correlations
HLA genotypes
There is some controversy exists by some authors regarding the definite correlation of HLA (human leukocyte antigen) genotypes and genetic markers with rheumatic fever. HLA antigen may account for individual susceptibility to rheumatic fever. HLA types are genetically determined and are not the same in all individuals of a family cohort, although they are same in monozygotic twins. This may explain why within a family in whom all individuals have been infected with streptococcus, only a few develop rheumatic fever, and why the incidence is three times higher in monozygotic than in dizygotic twins [27]. Studies have shown a statistically significant association between specific HLA class II antigens (HLA DR2 in blacks, HLA DR4 in whites) and rheumatic fever [28]. The risk has been associated with increased prevalence of HLA DR4 in the United States and Saudi Arabia and HLA DR3 and DQw2 in India. There was a significant increase in the frequency of HLA-DR15 and DRB5 alleles in cases group with Mitral valve disease (10%). In contrast, Ozkan et al study revealed HLA-DR5 as a protective factor against RHD [29]. Some other markers such as B cell alloantigen D8/17 have shown a strong association with susceptibility to rheumatic fever. The distribution of class I HLA antigens in rheumatic fever patients is inconclusive.
Duffy Antigen Receptor
HLA BW53 protects against malaria. A polymorphism in TNFα promoter region is responsible for this protection. In the case of infections caused by Plasmodium vivax, the most studied evolutionary change that determines resistance is the genetic polymorphism of parasite receptor known as Duffy Antigen Receptor for Chemokines (DARC) [30], [31], in which form of absent alleles (Duffy-negative allele with lack of expression of chemokines receptor and Chemokines sink to amplify the immune response) does not allow the receipt and entry of the parasite to the red cell [32]. Concerning the susceptibility to Plasmodium vivax infection, there are two kinds of alleles related to the receptors DARC: Fya and Fyb, which identifies four possible phenotypic presentations: homozygous Fy (ab−) (absence of the receiver or null), homozygous Fy (a+ b+) and heterozygous Fy (a− b+) and Fy (a+ b−). These receptors belong to the family of seven transmembrane molecules, initially recognized as a receptor for the Plasmodium vivax in human red blood cells and the simian Plasmodium Knowlesi and then recognized as a “promiscuous” receptor which is able to bind both CC (β-chemokines, primarily attract monocytes, macrophages, and T lymphocytes to the sites of chronic inflammation) and CXC chemokines (α-chemokines, predominantly recruit neutrophils to sites of acute inflammation) and to have a cleaner role of these molecules [33].
Mannose-binding lectin (MBL)
In RHD patients, there is significantly increased levels of mannose-binding lectin (MBL- an innate mediator) occurs. MBL acts as a primary pathogen-recognition molecule that drives the lectin complement pathway. This cascade exacerbates inflammation and tissue damage, targets the body’s own heart valves, causing severe valvular damage. There is a beneficial role for MBL deficiency in these patients [34].
Superantigens
Two streptococcal antigens the pepsin generated fraction of M protein and a streptococcal pyrogenic exotoxin (Spe’s) are believed to behave as “Superantigens”. These antigens do not bind to antigen binding clefts in T or B cells and can amplify an immune response by clonal expansion of T and B cells, release several cytokines (TNFα, IL I β, IL-6), inducible nitric oxide synthase and adhesion molecules, which could help to localize immune responses to certain tissues. Super antigenic stimulation may help T cells respond to antigens like M proteins suggest a potential mechanism mediating the unrestrained immunologic assault postulated to cause acute rheumatic fever [35].
Secondary antibiotic prophylaxis (SAP)
RHD results from cumulative valvular damage that is largely preventable by secondary antibiotic prophylaxis (SAP) [36] to reduce the global burden of RHD. The echocardiographic features of RHD might regress, remain unchanged or progress over time. The GOAL study [37] showed that treating early-stage RHD with SAP reduced disease progression at 2 years of follow-up. However, the study also highlighted the heterogeneous nature of early disease, with 50% of borderline and 30% of mild cases regressing spontaneously (without the need for SAP). In high-risk populations, some individuals with mild valvular changes do indeed have RHD (and are at risk of disease progression), whereas the mild changes in other individuals might be classified as being normal. Of note, individuals might oscillate between these two classifications. All children with stage A disease must have to monitor the disease progression and SAP to be continued until a follow-up echocardiogram has been obtained and also recommended for all individuals aged ≤20 years with stage B disease, who have a moderate-to-high risk of disease progression and stage C or stage D disease [38]. This patient belongs to Stage B with carditis (Rheumatic Heart Disease): Prophylaxis must continue for at least 10 years after the most recent episode, or until the patient is 21 to 40 years old (whichever is longer). First-Line: Intramuscular (IM) Benzathine Penicillin G (Dose: 1.2 million units for patients ≥ 30 kg; 600,000 units for patients < 30>
Epidemiological surveys
In tropical countries, mixed infections of streptococci both in the throat and skin due to various strains are more common and there is high prevalence of rheumatic fever in patients with skin lesions even though streptococcal pyoderma does not cause Rheumatic Fever definitely [42]. Group C or G streptococcus are more commonly isolated from the throat than Group A streptococcus in Rheumatic Fever patients in specific high-incidence populations—such as Aboriginal communities in Australia [43] and they can occur virulence factors by horizontal transmission from Group A streptococci. Epidemiological surveys are necessary to find out whether any higher incidence of acute rheumatic fever in endemic areas of malaria and any association with specific blood group antigen especially with duffy factor. More recent progress in the area of point-of-care tests for GAS pharyngitis include Nucleic Acid Amplification Tests (NAATs), which have much better sensitivity and specificity than RADTs [44].
Therapeutics
In 1965, American chemist Robert Burns Woodward was awarded the Nobel Prize in Chemistry for the first total synthesis of quinine, one of the earliest and most effective antimalarial drugs. Mefloquine is not recommended for patients with cardiac conduction defects or who are taking β blockers. Arrhythmogenic effects of chloroquine are not seen at normal doses, but do occur with rapid intravenous infusion or massive overdoses. In areas co-endemic for P vivax and Plasmodium falciparum, there is an increased risk of P. vivax parasitaemia with sexual stages [45] and it is a rationale for opportunistically eradicating P. vivax hypnozoites from the liver, an approach termed universal radical cure. Most endemic countries currently recommend a low-dose regimen of primaquine (total dose 3·5 mg/kg) for the radical cure of P vivax malaria, administered over 14 days [46],[47]. This prolonged treatment limits the daily dose of primaquine to 0·25 mg/kg per day to improve tolerability and reduce the risk of drug-induced haemolysis [48]. In 2022, WHO endorsed a 7-day regimen (0·5 mg/kg per day, total dose 3·5 mg/kg primaquine), which has been widely used for more than a decade in South America [49]. A single-dose tafenoquine combined with chloroquine for the radical cure of P vivax infection has also become available [50], but poor efficacy against latency has been observed [51]. This effectively prohibits the use of tafenoquine where P vivax is resistant to chloroquine and no longer usable, as occurs in Indonesia and the Western Pacific [52]. Primaquine requiring activation by CYP2D6 to kill latent hypnozoites [53], whereas tafenoquine does not appear to be CYP2D6-dependent. Whether tafenoquine or primaquine is applied, the treatment is potentially dangerous without screening for glucose-6-phosphate dehydrogenase (G6PD) deficiency, a highly prevalent (on average, 8%) genetic abnormality among people residing in malaria-endemic zones [54]. ASA (Aspirin (Acetylsalicylic Acid) (60 to 100 mg/kg/day in divided doses until symptom resolution) is the most commonly used NSAID in the treatment of ARF with a dramatic response and resolution of fever and arthritis in 1 to 3 days. However, there is no documented evidence showing superior efficacy of any drug (steroids or NSAIDs) in reducing the risk of rheumatic valve disease (RVD) in patients with ARF [55]. The successful use of NSAIDs other than ASA has been reported in the treatment of other childhood rheumatic disease. However, such studies are lacking for the treatment of ARF. There are a few reports showing good results with naproxen (NXN-5 to 10 mg/kg every 12 hours) [56] and tolmetin [57] and the outcomes have not been tested in a randomised and controlled manner. A recent study suggests that ibuprofen may be equally effective [58]. ‘Rebound’ occurs while tapering or within weeks after stopping initial therapy. ‘Relapse’ is a worsening of symptoms while still actively on treatment and ‘Recurrence’ is a new episode of ARF caused by a new Group A Streptococcal infection, usually appearing > 8 weeks after treatment has ceased. “Rebound” manifested by reappearance of mild symptoms or of acute phase reactants, may occur in some patients after discontinuation of anti-inflammatory therapy [59] usually within 2 weeks. Many centers use salicylates in full doses at the same time and continue this beyond the course of steroid therapy in the hope of avoiding a rebound until the active inflammation subsides. Acetyl Salicylic Acid (Aspirin) do not decrease the incidence of residual RHD and corticosteroids produce prompt control of the subcutaneous nodules, erythema marginatum, fever and arthritis in Acute Rheumatic Fever. Recently it is found that Immunoglobulins are of no value in the management of acute rheumatic fever [60]. IE prophylaxis is necessary in rheumatic fever patients with residual heart disease. Antibiotic regimens used to prevent recurrence of acute rheumatic fever are inadequate for prevention of bacterial endocarditis. Because α hemolytic streptococci in the oropharynx may have developed resistance to oral penicillin being used for secondary prevention of rheumatic fever, the agent selected to prevent endocarditis should not be a penicillin. The standard general prophylaxis is Amoxicillin, clindamycin, clarithromycin, cefadroxil are also used in IE prophylaxis of RHD patients. Amoxicillin is the globally preferred, administered as 2 g for adults and 50 mg/kg for children, administered orally 30 to 60 minutes before the procedure [61].
Acute rheumatic fever (ARF) is an autoimmune response to untreated Group A streptococcal throat infections, whereas malaria is a parasitic infection. These two distinct conditions are often medically intertwined due to overlapping symptoms—such as high fevers and joint pain—which frequently leads to delayed or complicated diagnoses, which can make it difficult to differentiate them in tropical regions of India. Studies have shown diagnostic overlaps where patients (especially children) test positive for malaria but also meet the criteria for ARF. Failing to treat ARF can lead to permanent Rheumatic Heart Disease. Clinicians rely on rapid diagnostic tests for malaria, throat cultures, antistreptolysin O (ASO) titers and echocardiography to distinguish and treat both diseases appropriately. ARF Treatment requires immediate antibiotic therapy to eradicate the streptococcus bacteria, anti-inflammatory medications (like aspirin) to control joint and heart inflammation, and long-term antibiotic prophylaxis to prevent recurrences. Malaria Treatment via standard antimalarial medications (e.g., Artemisinin-based Combination Therapy or chloroquine), depending on the specific parasite strain (P. falciparum or P. vivax) and local resistance patterns. India bears a significant burden of both diseases. Because a missed ARF diagnosis can cause irreversible heart valve damage and treating ARF aggressively alongside malaria is crucial for preventing RHD. Local healthcare infrastructure continues to focus on improving both public awareness and early echocardiographic screening.
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Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.
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Dear Maria Emerson, Editorial Coordinator of - Journal of Clinical Research and Reports. ''I am pleased to provide this testimonial following the publication of our recent case report in this journal. The peer review process was rigorous, constructive, thorough, and conducted in a timely manner. The reviewers’ comments were thoughtful, detailed, and highly constructive, contributing substantially to the refinement, clarity, and scientific robustness of our manuscript. The process was conducted with professionalism and academic integrity throughout. The support provided by the editorial office was exemplary. Communication was consistently prompt, clear, and courteous at all stages of the submission and publication process. The editorial team demonstrated a high level of organization and responsiveness, ensuring that all queries were addressed efficiently and that the process remained transparent and well-coordinated. The overall quality of the journal is reflected in its strong editorial standards, commitment to scientific excellence, and dedication to publishing clinically meaningful research. It has been a privilege to publish our work in this journal, and we would welcome the opportunity to contribute further in the future.'' Best wishes from, Dr. Efstratios Trogkanis, Cardiologist.
Dear Grace Pierce, Editorial Coordinator of the journal IJCCR, I had a very positive experience with Auctores - Journal throughout the publication process. The Editorial Team was highly responsive, professional, and supportive at every stage. I would like to extend my sincere thanks to the Editor: Grace Pierce, for her guidance and assistance. The peer-review process was smooth and constructive, helping improve the quality of my work. I would gladly recommend Auctores Journal to fellow researchers and authors. Dr. SABITA SINHA, Medical Oncologist, MD (Electro Homeopathy).
Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.
International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
