AUCTORES
Globalize your Research
Research Article | DOI: https://doi.org/10.31579/2692-9406/140
Department of Chemistry, Colloege of Natural and Computational Chemistry, Mekdela Amba University, P.O. Box 32, Tulu Awuliya, Ethiopia.
*Corresponding Author: Adamu Tizazu Yadeta, International Higher School of Medicine, Bishkek, Kyrgyzstan
Citation: Adamu Tizazu Yadeta, (2023). Phytochemical screening of Aloe elegans leaf skin. J. Biomedical Research and Clinical Reviews. 8(1); DOI:10.31579/2692-9406/140
Copyright: © 2023 Adamu Tizazu Yadeta, this is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 12 December 2022 | Accepted: 23 December 2022 | Published: 06 January 2023
Keywords: aloe elegans; leaf skin; medicinal; and phytochemicals
Aloe species can store water and chemical compositions in their swollen and succulent leaves. This makes the genus Aloe a unique source of phytochemicals. The various compounds of the Aloe species can be used in preparing medicinal and pharmaceutical, beauty and cosmetics, personal care and toiletry products, and bittering agents in alcoholic drinks. Aloe elegans is one of the indigenous plants in Ethiopia. Concerning the phytochemical content of Aloe species, the existent literature data is mostly focused on leaf gel, leaf latex, whole leaf, and fewer on flower extracts, and root. However, as far as I know, no work has been done on leaf skin, in this context; my study came to announce the phytochemical content of Aloe elegans leaf skin. Methanol extracts of leaf skin revealed the presence of flavonoids, tannins, anthraquinones, alkaloids, and terpenoids while saponin was absent. Generally, the presence of these phytochemicals has various applications mainly medicinal and industrial applications in the species. Therefore, further analysis is needed to isolate these constituents and test their biological activities.
Aloe species can store water and chemical compositions in their swollen and succulent leaves because of their ability to survive in conditions such as dry and hot. This makes the genus Aloe a unique source of phytochemicals [1]. The various compounds of the Aloe species can be used in preparing medicinal and pharmaceutical, beauty and cosmetics, personal care and toiletry products, and bittering agents in alcoholic drinks, and they are also grown as ornamental plants [2]. The phytochemicals and bioactivity of Aloe spp. have attracted research interest since the trade-in ‘drug Aloes’, prepared from the leaf exudate, expanded rapidly in the 19th century [3]. Aloes have various parts like leaf, stem, root, and flowers. Aloe plant leaves, Figure 1, [4], which are the most commonly used are heterogeneous and can be divided into three major parts, namely: (i) the outer green epidermis, which majorly consists of structural components of the leaf; (ii) the outer pulp region below the epidermis, consists of vascular bundles are placed where the bitter latex or sap is obtained part; and (iii) the inner leaf pulp, which consists of Aloe gel and containing parenchyma cells Figure 2, [5]. The chemical constituents that have been identified in Aloe plants include vitamins, minerals, enzymes, simple and complex polysaccharides, fatty acids, indoles, hydrocarbons, dicarboxylic acids, aldehydes, ketones, phenolic compounds, phytosterols, pyrimidines, etc. with potential biological and toxicological activities [6-8].
A. elegans is found in Eritrea and Ethiopia [9]. This species is one of the indigenous plants in Ethiopia and is found in most regions of the country like the Tigray, Welo, Gojam, Shewa, and Harerge regions [10], and they are used for different to cure various ailments and prevent the cause of diseases [11]. The phytochemical analyses of this species have been checked for the presence/absence of phytochemicals. The preliminary phytochemical analysis of leaf gel [2, 12-13] and root [14] revealed the presence of various phytochemicals which are used as a guide to isolate the compound that is used for many purposes. The difference in presence/absence of medicinally active constituents from the same Aloe might vary due to water stress, climate change, seasonality, growth period, light intensity as well as processing techniques, such as drying procedures [15]. In addition to this the solvent system used for extraction also affects the presence/absence of Aloe phytochemicals. Concerning the phytochemical content of Aloe species, the existent literature data is mostly focused on leaf gel [2], leaf latex [16], whole-leaf [17], fewer flower extracts [18], and root [14]. However, as far as I know, no work has been done on leaf skin extracts. In this context, my study came to announce the phytochemical content of Aloe elegans leaf skin. Therefore, the present study reports the detail of the phytochemical analysis of A. elegans leaf skin for further analysis.
Figure 1: Aloe elegans
Figure 2: A cross-section illustration of Aloe leaf; A: epidermis or the outer rind, B: the outer leaf pulp, sap/exudate (latex) C: mesophyll or the inner leaf pulp (gel).
2.1 Collection and specimen of plant materials
The leaves of A. elegans Todaro were collected from Mekelle city around Messebo Mountain Tigray Region, Northern Ethiopia (located at an altitude of 2140 m). The fully expanded and matured leaves of A. elegans Todaro (7-9) parts were selected by counting top to bottom. Then, they were cut by knife and brought to the Organic Research Laboratory of Mekelle University. The plant identification was done at the Department of Biology, Addis Ababa University.
2.2. Separating the skin part
The plant material was washed with water to remove dirt particles. The leaf latex of A. elegans Todaro was collected by cutting the leaves transversally near the base and arranging them concentrically around a plate. The collection of leaf latex was to make the skin part of leaf froe from latex. The gel of the leaf was separated by cutting the leaves’ edge and skin with a sharp knife. The skin part was collected and dried under the shadow. The dried skin was ground by an electric machine. The powder of the sample was kept for further analysis. Generally, the procedure of sample preparing, starting from the plant selection to making it powder has been shown in the Figure 3.
Figure 3: Separating and preparing powder of the Aloe leaf skin.
To get the crude extract, solvent extraction was taken place as described in the literature [19] with modification. A 200.0 g powder of skin was extracted with 400 mL of methanol (3 times for 24 hr each). The samples were then filtered and concentrated using a rotary evaporator. The obtained sample was kept for further analysis.
Crude extracts of leaf skin were preliminarily evaluated to determine the presence and/ or absence of flavonoids, tannins, anthraquinones, alkaloids, saponins, and terpenoids according to standard methods. Any change of colors or the precipitate formation was used as indicative of a positive response to these tests.
2.4.1. Flavonoid test
The flavonoids test was taken place by the method known as the alkaline reagent test. About 3 drops of sodium hydroxide were added to the extracts to give an intense yellow color. Then diluted hydrochloric acid was added. The disappearance of the yellow color indicates the presence of flavonoids [20].
2.4.2. Tannin test
The tannin test was taken place by the method known as the ferric chloride test. A 0.15 g of methanol extract was mixed with water and heated in the water bath. The mixture was filtered and 0.15 g solid FeCl3 was added to the filtrate. The formation of dark-green color indicates the presence of tannin [21].
2.4.3. Anthraquinone test
The anthraquinone test was taken place by the method known as Borntrager’s test. A 3 mL of aqueous extract was mixed with 3 mL of benzene; filtered and 5 mL of 10% ammonia was added to the filtrate. The mixture was shaken. The formation of pink, red, or violet color indicates the presence of anthraquinones [22].
2.4.4. Alkaloid test
The alkaloids test was taken place by the method known as Wagner’s test. A 0.15 g of extract was stirred with 2.0 mL of dil. HCl and filtered. Then, 6 drops of Wagner’s reagent were added. The presence of alkaloids is confirmed by the formation of reddish-brown precipitate [23].
2.4.5. Saponin test
The saponin test was taken place by the method known as the froth test. A 0.2 g extract was shaken with 10.0 mL of distilled water in a test tube and heated in the water bath for 15 min. The formation of the froth shows the presence of saponin [24].
2.4.6. Terpenoid test
The terpenoids test was taken place by the method known as Salkowski’s test. A 0.1 g of extract was shaken with 2.0 mL of CHCl3 followed by the addition of concentrated 2.0 mL H2SO4 along the side of the test tube; a reddish-brown coloration of at interface indicates the presence of terpenoid [25].
Since the leaves of Aloe species have three parts and these parts can be analyzed separately. Therefore, the study has been focused on the skin of the leaf. The preliminary phytochemical screening of A. elegans leaf skin was tested for flavonoids, tannins, anthraquinones, alkaloids, saponin, and terpenoids showed the tested constituents are medicinally active. The crude extracts of methanol were used. Based on the organic solvent methanol and the methods used for each phytochemical, the leaf skin of A.elegans revealed a positive result for flavonoids, tannins, anthraquinones, alkaloids, and terpenoids while the negative result for saponin (Table 1).
“+” and “-” indicate the presence and absence of phytochemicals respectively.
Table 1: Result of phytochemical screening of A. elegans leaf skin
There are various factors that determine the presence or presence of phytochemicals. In the present study, the leaf skin of A.elegans has been tested with methanol. The presence of biologically active constituents has been investigated. These constituents have various applications mainly medicinal and industrial applications in the genus Aloe. The presence of phenolic compounds in the plants like flavonoids has pharmacological and biochemical actions viz., antioxidant, anti-allergic, anti-inflammatory, hepatoprotective, anti-carcinogenic, anti-viral, and antithrombotic activities [26, 27]. They exist widely in the plant kingdom and displayed a positive correlation between increased consumption of flavonoids and reduced risk of cardiovascular and cancer diseases [28]. Anthraquinones have wide medicinal applications such as antimicrobials, analgesics, [29], anti-inflammatories, varicella-zoster, herpes simplex type I and II, influenza, and pseudo rabies [30], and many others [31]. The phytochemicals such as tannins are used in anti-hemorrhoidal, hemostatic, and anti-diarrheal preparations [32]. Terpenoids such as triterpenes, sesquiterpenes, and diterpenes have been referred to as antibiotics, insecticidal, anthelmintic, and antiseptic in the pharmaceutical industry [22, 33]. Terpenoids are naturally occurring organic molecules found in all living organisms like plants. They have antibacterial properties. Terpenoids play an active role in wound healing, strengthen the skin, increase the concentration of antioxidants in wounds, and restore inflamed tissues by increasing blood supply [34, 35]. Alkaloids in plants have been extensively researched because of their biological activities. Studies on a number of these alkaloids have demonstrated that many of them have many pharmacological activities such as anticancer, antibacterial, antiviral, antioxidant, and antifungal [36].
Generally, the presence of phytochemicals/medicinally active constituents in Aloe species has the medicinal activities of wound healing and cell proliferation, intestinal absorption and purgative action, anti-inflammatory and immunomodulatory effects, hepatoprotective activity, antioxidant effect, antibacterial activity, antifungal activity, antiviral activity, antimalarial activity, anthelmintic activity, anticancer activity, antidiabetic activity, antihyperlipidemic activity, effect on estrogen status, antiulcer activity, treatment of cardiovascular disorders, skin use, anti-aging effect, antiallergic activity, effect on central and peripheral nervous systems [5, 37-40]. These constituents can show therapeutic effects whether in the form of crude extracts (synergetic effect) or by isolating a single compound and testing against diseases.
Most of the time investigations of Aloe leaf skins are underestimated and the skins are disposed of as waste materials. However, the leaf skin of the Aloe species is also rich in phytochemicals like other parts. The current phytochemical analysis of A. elegans leaf skin revealed the medicinally active constituents. The presence of flavonoids, tannins, anthraquinones, saponin, and terpenoids from methanol extracts was confirmed. Therefore, this result shows that the skin is a source of phytochemicals even if alkaloids are absent.
In another way, methanol can be used to isolate the presented compounds from A.elegans leaf skin. Based on the present finding, A.elegans might be taken into consideration for further study. Hence, more work should be studied to extract, isolate and characterize the presented phytochemicals. In addition to that, the biological activities of these compounds whether from extracts or by isolating them are another recommended work.
Declarations
Ethics approval and consent to participate
Not applicable
Consent for publication
Not applicable
Availability of data and materials
The data that used are included in this manuscript.
Competing interests
The author declares that he has no competing of interests
Funding
Not applicable
Authors' contributions
All parts were written by the corresponding author.
Acknowledgements
Not applicable
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
