Pediatric Pharmaceutical Care Services in Nigeria from 1980 - 2023: A Narrative Review Study

Research Article | DOI: https://doi.org/10.31579/2688-7517/204

Pediatric Pharmaceutical Care Services in Nigeria from 1980 - 2023: A Narrative Review Study

  • Achi James C 1
  • Ogbonna Brian O 2,3*
  • Adenola Ugochi A 2
  • Orji Richard 2
  • Anietoh Maureen U 2
  • Osuafor Nkeiruka G 4
  • Umeh Blessing I 2
  • Ezenekwe Lizette N 2
  • Nduka Ifeoma J 2
  • Ighorodje Austine E 5
  • Ejie Loveth 2
  • Nnamani Monica N 5
  • Eze S Amarachi 2
  • Ngozi Augustine O 6

1Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, Delta State University, Abraka, Nigeria
2Department of Clinical Pharmacy and Pharmacy Management, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University Awka, Anambra State, Nigeria
3Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, David Umahi Federal University of Health Sciences, Uburu, Ebonyi State, Nigeria
4Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, University of Abuja, Nigeria 
5Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, Madonna University Elele, River State, Nigeria
6Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmaceutical Sciences, Abia State University, Uturu, Abia State, Nigeria
 

*Corresponding Author: Ogbonna O Brian, Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, Madonna University Elele, River State, Nigeria

Citation: Achi James C, Ogbonna Brian O, Adenola Ugochi A, Orji Richard, Anietoh Maureen U, et al, (2024), Infectious disease, J. Pharmaceutics and Pharmacology Research, 7(8); DOI:10.31579/2688-7517/204

Copyright: © 2024, Ogbonna O Brian. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: 19 June 2024 | Accepted: 03 July 2024 | Published: 02 August 2024

Keywords: pharmaceutical care; pediatrics; pharmacist; children; healthcare services; outcome; nigeria; review

Abstract

Background: Pediatric pharmaceutical care is a new concept in the pharmacy profession. The knowledge of pediatric pharmaceutical care in Nigeria is limited, which may have negative consequences on pediatric pharmaceutical care and treatment efficacy and safety. In developed countries child healthcare is taking as first to non, as it is perceived that children are the future leaders, and as such all available pharmaceutical and financial resources are channeled into seeing that the best possible pharmaceutical care is rendered, watching out for best possible outcomes. While the concept of Pediatric pharmaceutical care is still in its infancy in Nigeria, the state and extent of Pediatric pharmaceutical care studies in health services remain largely unknown in Nigeria.

Objective: This study described pediatric pharmaceutical carestudiesin Nigeria.

Method: This study adopted narrative review in describing pediatric pharmaceutical care service studies in Nigeria. The study was a retrieved literature search conducted on computerized databases. Search terms were used singly, and in combination, using truncation where needed. Only studies carried out in Nigeria and written in the English Language from January 1980 to December 2023 were examined. Data obtained were subjected to descriptive statistics of frequency, percentage, and comparative assessment using the Oxford and Scottish Benchmarks for Study Standard. The study lasted from January to May 2024.

Result: A total of 11 articles were used for the study. Studies carried out in south-south had the highest incidence 4(36.36%) respectively, followed by South-west 3(27.27), South-east 2 (18.18). Nationwide, and north-west had the same number of articles selected 1(9.09%) respectively, apart from north-central and North-east 0(0.00%). The studies fell within the lower half of the Oxford and Scottish benchmarks for the hierarchy of study types. Which implies poor policy making and intervention, due to an ineffective healthcare system, and this may lead to a negative outcome on the patient health.

Conclusion: Most of the studies were majorly carried out in the Southern, western, and eastern parts of Nigeria. Systematic, narrative review and others of pediatric pharmaceutical care studies in the country were absent. Pediatric Pharmaceutical care activities fell within the lower half of two standard benchmarks for the hierarchy of studies.

Introduction

Children represent a significant proportion of the population requiring pharmacy services in a variety of hospital and community settings; as such, pharmacists play an essential role in pediatric care [1-3]. Due to advances in pediatric medicine, the increasing complexity of childhood diseases and unique dosing and pharmacokinetic challenges, there is growing need to educate pharmacists in basic pediatric competencies. Furthermore, it is estimated that the use of prescription medications among pediatric patients is substantial; according to the Centers for Disease Control and Prevention, 14–20% of patients under 19 years old surveyed in 2008 reported having used at least one prescription drug in the preceding month [4,5]. As a result, pharmacy curricula should emphasize a minimum level of pediatric pharmacotherapy competence; this could potentially help to lower the rate of pediatric medication errors [6].

The provision of pharmaceutical care to children can be challenging, especially with regards to the appropriate drug, dosage and route of administration. Because of their relative lack of chronic ailments, children usually require fewer medications compared to adults; this, compounded with the various ethical and logistical barriers to studying the effects of medications among children, means that there are very few medications licensed for use among children [7]. Medications without the proper marketing authorization are referred to as ‘unlicensed’, while off-label medications indicate licensed medicines which are prescribed or used in a manner not consistent with recommendations, for instance in terms of dose, route of administration or recommended age.

Also, allocation of pediatric pharmacy services is often extrapolated from analysis of both internal and external pharmacy services provided to an adult population, despite multiple studies, national organizations, and regulatory bodies that say providing safe pediatric pharmacy services poses unique challenges. More resources are required to prevent adverse drug events in the vulnerable pediatric population. Allotting pediatric pharmacy resources based on extrapolated adult census data per pharmacist or adult medication order per pharmacist grossly underestimates what is needed to provide safe, comprehensive pharmacy services to pediatric patients. Despite recommendations from numerous health care bodies, including The Joint Commission, the American Academy of Pediatrics (AAP), Pediatric Pharmacy Advocacy Group, and the American Society of Health-System Pharmacists, some hospitals that care for children have failed to establish robust pediatric pharmacy services [8-10].

According to the United Nations, 37.7% of the population in Jordan is under 14 years old. [11] Moreover, pharmacists in Jordan often act as primary care providers as, for financial reasons, they are often the first and only port of call for healthcare advice and medicine use by patients. Wazaify et al. also reported that pharmacists in Jordan often dispense non-prescribed medications, including antibiotics. [12] As such, it is imperative that pharmacists in Jordan have the necessary knowledge to provide safe and adequate care to pediatric patients, including the information needed to dispense medications and counsel pediatric patients or their guardians [13]. However, due to a lack of national guidelines regarding pediatric care, pharmacists often rely on knowledge received during their education and training. The present study aimed to explore the self-reported knowledge, attitudes and competency of final-year pharmacy students in Jordan regarding pediatric pharmaceutical care, including assessment, treatment and dosage. To the best of the authors’ knowledge, this is the first study to directly explore pharmacy students’ perceptions and attitudes regarding this topic.

Despite mounting evidence regarding the value of pharmaceutical care services, little is known about pharmaceutical care services on the pediatric population in Africa and Nigeria at large. Given this observation and the demonstrated need for pharmacists to provide and make pharmaceutical care services available to the delicate pediatric population, despite the challenges associated in delivering these services. Howbeit, it is important to understand that pharmaceutical care services are a unique aspect of pharmacy practice that benefits the patient with lots of positive outcomes. But there is a huge lacuna on delivering pharmaceutical care services to the pediatric population. Thus, this study presented an overview of pediatric pharmaceutical care services in Nigeria and generated information for intervention, and policymaking.

methods

Study Area: The study covered pediatric pharmaceutical care services carried out in Nigeria 

Review question: What is the extent and nature of pediatric pharmaceutical care services in Nigeria?

Study population and type of studies included: The search was carried out on PubMed and Google Scholar, for all pediatric pharmaceutical care studies. Manual search was done for studies that met the inclusion criteria. This ensured retrieval of relevant studies while focusing on the study objectives.

Eligibility criteria: 

Inclusion criteria 

• Studies published in English language 

• Peer-reviewed papers were eligible for inclusion 

• Pediatric pharmaceutical care studies conducted in Nigeria irrespective of the region 

• Studies with defined protocol and study design either experimental or non-experimental 

• Studies with no conflict of interest stated 

•Studies that provided other information that may help to understand pediatric pharmaceutical care services                                                   

• Studies with clearly stated and defined research design. 

Exclusion criteria

• Studies without a clearly defined period, duration, sample size, and location were discarded 

• Studies with methodological flaws 

• Studies with incomplete data. 

Study design: The study was a narrative overview of pediatric pharmaceutical care services in Nigeria.

Risk of Bias: The included studies were assessed for subjects and sampling selection bias, reporting bias before selection.

Condition and Domain studied: Pediatric pharmaceutical care studies and articles that described pediatric pharmaceutical care service activities in Nigeria. 

Data extraction was done in accordance with the standard reporting protocol for narrative reviews [14].

Information source: Search was conducted using Google Scholar and PubMed.

Data items and Summary Measures: The data synthesized were sought for study location, design, sample size, year of publication, inclusion criteria, exclusion criteria, year of publication, study instrument, title of publication. Articles that met the inclusion criteria irrespective of their year of publication were selected.

Context: The study covered pediatric pharmaceutical care services carried out in Nigeria.

Articles search process: The graphical illustration in the figure below (Fig.1) shows how the search was conducted.  The related keywords to the title of the study were used for the search. PubMed and Google Scholar were used to search for studies and articles on pediatric pharmaceutical care services in Nigeria published between 1980 and 2023. Additional words found appropriate and relevant to the title and objective of the study were utilized. A total of 455 articles were obtained, 155 came from PubMed and 300 articles from Goggle Scholar. These articles were assessed for eligibility based on the inclusion criteria.

Study period and duration: The study lasted from April to May, 2023 and covered peer-reviewed articles published from January 1980 to December, 2023.

Ethical approval: Ethical approval is not applicable here. However, only studies with ethical approval were included and utilized in the review process.

Data analysis: Data was summarized with descriptive statistics.

Study articles selection process: A total of 455 articles were obtained, 155 came from PubMed and 300 articles from Goggle Scholar. These articles were assessed for eligibility based on the inclusion criteria. Overall, 275 studies that fell outside the scope of Pediatric Pharmaceutical Care Services were discarded giving rise to 180 articles. On further screening, 120 articles with invalid and incomplete study designs were eliminated, and another 49 articles with incomplete follow-up data which gave rise to 11 studies used for the review.

Data extraction instrument, pilot testing, and data extraction process:

Data Extraction design was adapted from a similar study carried out in Nigeria by [15]. Data was extracted by careful consideration of the articles, elimination of irrelevant or incomplete ones that did not meet the study objective and criteria. The remaining data were analyzed and pilot tested. Five articles were used for the pilot test and they were not included in the study. Further modifications such as the arrangement of the date items logically and designing of the sheet into an appropriate table format were made to obtain the final instrument. The instrument was approved by an independent assessor after critiquing it by applying it to two independent studies before being used for the data collection.

Results

 

ReferenceTitleLocationDesign

Year

of publication

Sample sizeInclusionExclusionStudy instrument
[16]Management of acute diarrhea in children by community pharmacists in Lagos, NigeriaSouth-westDescriptive cross-sectional survey2014202Registered retail community PharmacistNon-Registered retail community PharmacistQuestionnaire, Data collection form
[17]
  1. Community Pharmacists' Knowledge and Attitudes towards Pediatric Pain Management in Nigeria

 

North-westDescriptive cross-sectional survey2021623Pharmacist who attended the 38th Annual National Conference of the Association of Community Pharmacists of Nigeria (ACPN)Pharmacist who attended the 38th Annual National Conference of the Association of Community Pharmacists of Nigeria (ACPN) and unwilling to participateQuestionnaire
[18]
  1. Drug pooling: A cost-saving strategy to enhance antibiotics availability for pediatric in-patient in Nigeria

 

South-eastMixed- method approach201953Caregivers of in-patient children, nurses, physicians and pharmacistsNon-Caregivers of in-patient children, nurses, physicians and pharmacistsFocus groups, interviews and medical records
[19]
  1. Bridging the gap in knowledge and use of antibiotics among pediatric caregivers: comparing two educational interventions
South- southProspective cross-sectional study202360Pediatric care giversNon-Pediatric care giverQuestionnaire  
[20]
  1. Incidence and cost estimate of treating pediatric adverse drug reactions in Lagos, Nigeria

 

South-westProspective observational study20112004 admitted childrenChildren admitted to the pediatric wards of the Lagos State University Teaching Hospital (LASUTH) in Nigeria, between July 2006 and December 2007.Children not admitted to the pediatric wards of the Lagos State University Teaching Hospital (LASUTH) in Nigeria, between July 2006 and December 2007.Prescriptions
[21]
  1. Knowledge and indulgence in substance abuse among adolescents in Anambra State, South-East Nigeria
South- eastA descriptive cross-sectional study2022285Adolescents aged 10 to 19 years recruited from an adolescent summer/long vacation camp in August of 2019 at OzubuluAdolescents aged below and above 10 to 19 years recruited from an adolescent summer/long vacation camp in August of 2019 at OzubuluQuestionnaire
[22]
  1. High levels of pre-treatment HIV drug resistance and treatment failure in Nigerian children

 

South-westObservational prospective cohort study201690-100Age ≤12 years, confirmed HIV-1 test (positive HIV antibody test if age >18 months, or a positive HIV nucleic acid polymerase chain reaction (PCR) test if age ≤18 months), eligibility for initiation of first-line ART according to national guidelines at that time (all HIV-infected children <2>5 years)HIV-2 co-infection, anticipated non-compliance with the protocol and current participation in another study or clinical trialQuestionnaire
[23]
  1. Prescribing pattern and antibiotic use for hospitalized children in a Northern Nigerian Teaching Hospital

 

Northern NigeriaA descriptive retrospective design20183908All eligible prescription orders for children below the age of 18 years that were on admission within the study periodPrescription orders that were not legibly written and considered not readable were not included, as well as those containing only intravenous infusions, consumable items, and vaccines. Any prescriptions without relevant client identity (age, registration number, and ward address).Profoma
[24]
  1. Factors influencing adherence to pediatric antiretroviral therapy in Portharcourt, South- South Nigeria

 

South-southA cross-sectional survey2013213Caregivers and their children that consented to be interviewedCaregivers and their children that never consented to be interviewedInterview
[25]
  1. Assessment of the knowledge and practice of pediatric pharmacy among hospital pharmacists in Delta State, Nigeria
South-southA cross-sectional survey201390Pharmacists working in the facilityPharmacists not working in the facilityQuestionnaire
[26]
  1. Drug prescribing and potential drug-drug interactions at the pediatric unit of a secondary health facility in Southern-Ijaw Local Government Area, Niger Delta Region, Nigeria
South-southA descriptive, cross-sectional, retrospective study2022227Pediatric patients in the facility within the specified time frameNon-Pediatric patients in the facility within the specified time frameCase note

Table 1: Evidence-based table of the characteristics of study articles

s/nGeopolitical zonesNo of Studies n (%)Study Focus
1North-east0 (0.00) 
2North-west1 (9.09)Knowledge, attitude towards pediatric pain, outcome
3North central0 (0.00) 
4South-east2 (18.18)Knowledge, cost and Antibiotic Stewardship in pediatric pharmaceutical care service
5South-south  4 (36.36)Knowledge, attitude on pediatric care, drug therapy problems, adherence, pediatric pharmacy practice
6South-west3 (27.27)Management, treatment, drug therapy problems and cost in pediatric pharmaceutical care services
7Nationwide1 (9.09)Antibiotic Stewardship in pediatrics, adherence
 Total11 (100) 

Table 2: Focus on studies on pediatric pharmaceutical care studies in Nigeria according to geopolitical zone distribution.

S/n Level of evidence

Definition  

 

n (%)
11ASystematic Review of RCTs0(0.00)
21BIndividual RCTs0(0.00)
32ASystematic review of cohort studies0(0.00)
42BIndividual cohort studies, Low quality RCT0(0.00)
52CEcological studies0(0.00)
63ASystematic review of case-control studies0(0.00)
73BIndividual case control studies0(0.00)
84Case series, poor quality cohort, and case-control studies11(100)
 Total 11(100)

Table 3: Assessment of Studies on pediatric pharmaceutical care studies in Nigeria based on Oxford Center for Evidence-Based Medicine’s Levels of Evidence from Highest to Lowest [27]

s/nStudy types according to hierarchyn (%)
1Systematic review and Meta-analysis0(0.00)
2Randomized Controlled Trials0(0.00)
3Nonrandomized intervention studies0(0.00)
4Observational studies11(100)
5Non-experimental studies0(0.00)
6Expert opinion0(0.00)
 Total11(100)

Table 4: Assessment of pediatric pharmaceutical care studies in Nigeria based on the Scottish Intercollegiate Guidelines Network for hierarchy of Study Type [28]

S/nPeriod of publication of studyNo of Studies n (%)
1≤20000 (0.00)
22001-20100 (0.00)
32011-202011 (100)
42021≤0 (0.00)
Total 11 (100)

Table 5: Periodic Distribution of pediatric pharmaceutical care studies in Nigeria

Discussion

An Overview of Pediatric Pharmaceutical Care Services in Nigeria

Pediatrics is the branch of medicine that deals with the medical care of infants, children, and adolescents. It is a critical component of healthcare due to the vulnerability of children to diseases and other health conditions. Children represent a significant proportion of the population requiring pharmacy services in a variety of hospital and community settings; as such, pharmacists play an essential role in pediatric care.

In Nigeria, healthcare has been a challenge due to various factors such as inadequate facilities, low funding, and a shortage of health care professionals. These and other challenges have led to poor healthcare outcomes, especially in the pediatric population. Children in Nigeria face numerous health challenges such as malnutrition, malaria, pneumonia, and diarrhea, which contribute to high morbidity and mortality rates. While there is still much work to be done, these efforts are a step in the right direction and offer hope for the future of pediatric healthcare in Nigeria.

But the present-day collaborative care model (pharmaceutical care) evolved from the USA [29-32]. Also, the practice of different models of pharmacy practice from the traditional model of dispensing to the newly introduced model of pharmaceutical care, ensures that pharmacists take responsibility for the medication care they provide to the patient, and this ensures collaborating with other healthcare personnel and most importantly with the physicians to ensure rational drug use.

Over the years, allocation of pediatric pharmacy services is often extrapolated from analysis of both internal and external pharmacy services provided to an adult population, despite multiple studies, national organizations, and regulatory bodies that say providing safe pediatric pharmacy services poses unique challenges. More resources are required to prevent adverse drug events in the vulnerable pediatric population. Allotting pediatric pharmacy resources based on extrapolated adult census data per pharmacist or adult medication order per pharmacist grossly underestimates what is needed to provide safe, comprehensive pharmacy services to pediatric patients [33, 34]. However, Observational studies were the best fit in accessing and analyzing the pediatric pharmaceutical service across various variables in Nigeria this corresponds to the distribution of the studies showing a higher incidence of non-experimental studies in the country. This could also be as a result of the relative ease in the conduct of an observational study than experimental studies.

Also, due to the reduced cost, manpower, and time employed for an experimental study. Most of the studies cited in the work were also carried out within the last decade as shown in table 1 and 5, recording 0 (0.00%) within the decade of 2001 to 2010 and the last following decade (2011-2020) recording 11 (100%) while the decade of 1980-2000 recording one cited work 0 (0.00%). This is largely because the concept of pediatric pharmaceutical care services evolved from the European countries [35], and it’s been gradually adopted by the Nigerian government when because it is a patient/goal-oriented model which was introduced within the last 2 decades and it has been gradually the healthcare system for Health Care Providers.

Description of the pediatric pharmaceutical care services and the extent and nature of work done in Nigeria 

Table 2 revealed the regional distribution of the articles and the study focus of each region. It showed that the highest number of studies were done in South-south 4 (36.36%) respectively, followed by the South-west 3 (27.27%), South-east 2 (18.18), and Nationwide and North-west 1(9.09%) of the country respectively, while North-east and North-central 0 (0.00%). The theme of the works conducted in South-east, South-west, and South-south comprised of the knowledge, attitude, adherence, drug therapy problems, cost and antibiotics stewardship in pediatric pharmaceutical care, while that of the North-west focused on knowledge and attitude towards pediatric pain and outcome, and nationwide focused more on adherence and antibiotic stewardship in pharmaceutical care services on the pediatrics.

Most of the works were done within South-east, South-west, South-south region possibly because the majority of the pharmaceutical schools and teaching hospitals are domiciled there and besides, it is easier to access your patients directly and deliver pharmaceutical care in these regions collaboratively with other health care providers due to less restriction to female genders as well as moral and societal impediments. The Nationwide studies also provided for comparative analysis between regions, states, and more within the year. 

Description of pediatric pharmaceutical care and comparisons of the studies to the oxford and Scottish benchmarks for the hierarchy of clinical 

As shown by Table 4 on the hierarchy of studies, observational studies were majorly all the number of records 11(100) %. Studies in the hierarchy other than nonrandomized intervention studies had no record as observational studies presumably were the best fit in accessing and analyzing the collaborative differentials across various variables.

Most of the studies cited were surveys carried out using questionnaires as the instrument of study, although the questionnaires were used directly on the respondents. A few of the studies involved pharmaceutical care but most of them were focused on pediatric care. As portrayed by Table 3 on the Evidence-based Medicine Evidence level, Case series, poor quality cohort, and case-control studies have the highest score of 11(73.68%) while ecological studies and the rest of the study with a 0% score. This shows that pediatric pharmaceutical care activities in Nigeria are poor. There is need for policy makers in the country to put into consideration the positive impact of the pediatric pharmaceutical care in patient outcome, and make better policies that can create a breeding-ground for better pharmaceutical care services. Future studies on pediatric pharmaceutical care that can meet up the benchmark for the hierarchy of studies is need to prompt an intervention in the healthcare system on pediatric pharmaceutical care that will affect the health of the pediatric patient positively.

Conclusion

Many of the articles cited were studies carried out on pediatric pharmaceutical carewithin the Nigerian healthcare system. Most of all the studies conducted were observational studies. There was no systematic review, meta-analysis, nor randomized clinical trial from all the articles used for this study. The studies fell short of the Oxford and Scottish benchmarks for the hierarchy of studies, which entails that studies that fall under systematic review, meta-analysis, and randomized control trials benchmark for the hierarchy of studies are strong studies because of their peculiarity, and specificity, studies below this benchmark for the hierarchy of studies are seen to be weak. The distribution of the studies recorded a higher incidence of the study conducted in South-east, South-west, and South-south as compared to the other various regions. However, the pediatric pharmaceutical care activities in Nigeria healthcare services are still at her infancy, as no one is interested in what happens between the pediatrics and pharmaceutical care services in the healthcare system, and this could be the reason why few articles were generated for the study. These studies are suggestive of a poor pediatric pharmaceutical care in Nigeria. 

Limitations

The possibility of omission due to search and search terms limitations. Some of the studies cited may have some level of bias that escaped elimination which could have an impact on the outcome of the study. The method of presenting tables and data in the present study was purposively chosen for simplicity and clarity even though they could be better presentation formats.

Conflict of interest

The authors have none to declare. 

Grant/Sponsorship

None.

Highlights (Learning Points)

1. No narrative review article was found which reviewed the pediatric pharmaceutical care services in Nigeria over the past four decades. 

2. The study articles on pediatric pharmaceutical care services cited since 2020 fell below the higher upper half of the Hierarchy of Study Type Standard Benchmark of Oxford and Scottish benchmarks. 

3. Majority of the studies on pediatric pharmaceutical care services in Nigeria were carried out in South-east, South-west, South-south regions. 

4. The theme of the works conducted in the South-east, South-west, South-south comprised ofthe impact of pediatric pharmaceutical care, knowledge, attitude, management, treatment, drug therapy problems, adherence and costwhile that of the nationwide focused more on the importance of pediatric pharmaceutical care on antibiotic stewardship and adherence. The studies in the North-west focused on knowledge, attitude, and outcome of pediatric pharmaceutical care, while north-east and north-central had no cited study.

5. The present work is a narrative overview of pediatric pharmaceutical care in Nigeria healthcare services. It reviewed a general overview of the pharmaceutical care activities on pediatrics, revealed the studies conducted on the subject matter, showed the level of the work done, and gave a comparison of the available studies with some standard benchmarks for the hierarchy of study type. It also gave recommendations and provided documented information for intervention.

References

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Baheci Selen

"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".

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Jesus Simal-Gandara

I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.

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Douglas Miyazaki

We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.

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Dr Griffith

I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.

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Dr Tong Ming Liu

I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.

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Husain Taha Radhi

I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.

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S Munshi

Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.

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Tania Munoz

“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.

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George Varvatsoulias

Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.

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Rui Tao

Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.

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Khurram Arshad

Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.

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Gomez Barriga Maria Dolores

The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.

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Lin Shaw Chin

Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.

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Maria Dolores Gomez Barriga

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.

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Dr Maria Dolores Gomez Barriga

Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.

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Dr Maria Regina Penchyna Nieto

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.

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Dr Marcelo Flavio Gomes Jardim Filho

Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”

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Zsuzsanna Bene

Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner

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Dr Susan Weiner

My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.

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Lin-Show Chin

My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.

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Sonila Qirko

My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.

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Luiz Sellmann