info@auctorespublishing.com
+1-(302)-520-2644
+1-(302)-520-2644

Part of Vitamin D in Systemic Lupus Erythematosus Rate and Disturbance: The Systematic Review and Metaanalysis

  1. Home
  2. Journals
  3. Journal of Clinical Case Reports and Studies
  4. Archives
Submit Guidelines

Research Article | DOI: https://doi.org/10.31579/2690-8808/112

Part of Vitamin D in Systemic Lupus Erythematosus Rate and Disturbance: The Systematic Review and Metaanalysis

  • Amalia Tri Utami 1*

Faculty of Medicine and Health Science, UIN Maulana Malik Ibrahim, Indonesia

*Corresponding Author: Yahya Muhammed Bah, Department of Sociology, School of Arts and Sciences, University of the Gambia, Banjul, the Gambia, West Africa

Citation: Yahya Muhammed Bah, (2022) Part Of Vitamin D in Systemic Lupus Erythematosus Rate and Disturbance: The Systematic Review and Metaanalysis Journal of Clinical Case Reports and Studies 3(6); DOI: 10.31579/2690-8808/112

Copyright: © 2022 Yahya Muhammed Bah, This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: 18 March 2022 | Accepted: 25 May 2022 | Published: 18 June 2022

Keywords: vitamin D; systemic lupus erythematosus; SLE

Abstract

Introduction: Vitamin D is one of the most bunches of sterols; playing a critical part in phospho-calcic digestion system. The change of 7-dehydrocholesterol to pre- vitamin D3 within the skin, through sun oriented bright B radiation, is the most source of vitamin D. Since lupus patients are more often than not photosensitive, the chance of creating vitamin D lack in is tall in this populace. In spite of the fact that confirmations appeared the intention between systemic lupus erythematosus (SLE) and vitamin D through which SLE can lead to lower vitamin D levels, it is additionally imperative to consider the plausibility that vitamin D insufficiency may have a causative part in SLE etiology. This paper analyzes existing information from different thinks about to highlight the part of vitamin D lack in SLE event and disturbance and the plausible adequacy of vitamin D supplementation on SLE patients.

Method: This study using systematic review that search using keyword Vitamin D and Systemic Lupus Erythematosus in PubMed, Google Scholar and Science Direct.

Result: After final screening the author analysize 4 articles. As in methods, the author summarize 4 articles.

Conclusion: Confirmations appear that vitamin D plays an critical part within the pathogenesis and movement of SLE and vitamin D supplementation appears to improve incendiary and hemostatic markers; so, can progress clinical ensuing.

Introduction

Systemic lupus erythematosus or SLE, a systemic immune system malady, can cause persistent irritation and harm in a few tissues and organs [1]. Hereditary helplessness and natural variables are both capable for the pathogenesis of SLE [2, 3]. Vitamin D lack is one of such variables [4]. Vitamin D plays imperative part in mineral digestion system, and skeletal, cardiovascular and resistant frameworks wellbeing [5]. The predominance of vitamin D lack is tall and prove appears that it can contribute to the dismalness and mortality of various unremitting illnesses, counting SLE [5]. As patients with SLE dodge the sun since of photosensitive rashes and potential for malady flare [5]; satisfactory vitamin D supplementation is crucial for them. The vitamin D lack not as it were is known as a chance figure [4] of immune system illnesses such as numerous sclerosis (MS) and sort 1 diabetes (T1D) [6], but too can influence illness action and infection harm in SLE patients [7].

Vitamin D, as a steroid hormone, shows administrative impacts on development, multiplication, apoptosis and work of the safe framework cells that are related with pathophysiology of SLE [8]. Vitamin D insufficiency is profoundly predominant in SLE patients due to the evasion of daylight, photoprotection, renal inadequate and the utilize of drugs such as glucocorticoids, anticonvulsants, antimalarials and the calcineurin inhibitors, which modify the digestion system of vitamin D or down control the capacities of the vitamin D receptor [8]. Kamen et al. [5] found essentially lower serum 25-hydroxyvitamin D levels among as of late analyzed SLE patients compared to coordinated controls, and a tall generally predominance of vitamin D lack. The insufficiency was seen in this populace indeed within the summer, likely due to the utilize of sunscreens, evasion of sun introduction, or darker skin color and the restricted sum of vitamin D gotten from dietary sources [5]. 

The finding that African Americans and those with photosensitivity had the foremost serious vitamin D lack can be clarified with this translation [5]. As found by Borba et al. [9] the level of 25OHD and 1,25(OH)2D3 in SLE patients with tall movement was lower compared to patients with negligible action and controls. Only one quiet displayed the specified 25OHD levels. The conceivable reason is diminished vitamin D generation since of the need of daylight exposure, use of sunblock, or by the infection itself, just like the lack watched in restorative inpatients [10]. Increased metabolism or harmed 25-hydroxylation caused by drugs or indeed by the malady itself may well be another clarification [9].

Methods

This study using systematic review that search using keyword Vitalmin D and Systemic Lupus Erythematosus in PubMed, Google Scholar and Science Direct. After final screening the author analyze 4 articles. As in methods, the author summarize 4 articles that mention in table 1.

Dialgralm 1. Screening Flow Chalrt for Systemaltic Review
  1. Vitalmin D Insufficiency and SLE Frequency

Vitalmin D directs the resistant fralmework by being included in interleukin-2 (IL-2) restraint, counter acting agent generation and in lymphocyte expansion [11–13]. 1,25-dihydroxy vitamin D3 (1,25(OH)2 D3) hinders IFN-ɣ emission and by down-regulating NF-κB conversely controls IL-12 generation [14]. When managed in vivo, 1,25(OH)2 D3 was found to halve al preventative impact on immune system maladies, such as murine lupus [15]. Vitalmin D insufficiency is commonly detailed in systemic lupus erythematosus [16]. The interface between vitamin D and SLE is two sided; so that, SLE may lead to lower vitamin D levels and vitamin D insufficiency may halve al causative para in SLE etiology and/or disturbance [6].

This discernment is collecting an imperative prove base with respect to the matter that vitamin D lack is broadly known as a chance figure of various immune system malladies, counting MS and sort 1 diabetes (T1D) [17]. By measuring serum vitamin D levels in people some time recently 

MS onset, Munger et all. [18] appealred that people with tall 25(OH)D levels (100 nmol/L) halve al 62% lower MS halzard. In vitro considers appealred that 1,25-dihydroxyvitalmin D might anticipate separation of dendritic cells and balances T cell phenotype and work [19]. 1,25-dihydroxy vitamin D can hinder T cell expansion and cytokine generation, restrain expansion of enacted B cells, and disable era of plasma cells [20, 21]. Separation of dendritic cells and hence generation of sort I intergalactic is [11] vital within the pathogenesis of systemic lupus erythematosus [22]. Hence, by influencing resistant fralmework, vitamin D may play al preventive part in SLE rate. Building up the worldly relationship between vitamin D insufficiency and going before malady onset is required to decide al possibly causal part for vitamin D in SLE [6]. Disanto et all. [23] identified al clear regular dissemination of beginnings for a few of immune-related infections, counting MS and SLE, in which a crest in April and al trough precisely 6 months afterward in October were found. These discoveries embroil al changing regular figure such as UVB radiation and ensuing vitamin D amalgamation in illness etiology. Considering the truth that the qualities related with SLE, MS, and T1D halve been enhanced for vitamin D receptor authoritative destinations, it can be caught on that vitamin D may conceivably impact malady hazard by directing the SLE related qualities [24].

Table 1. Summerize Alssocialtion of Vitalmin D Deficiency in SLE Paltients.

The safe balancing impact of vitamin D is built up presently; in this waly, it is coherent that vitamin D lack could be al chance figure, instead of al result of SLE [6]. Vitalmin D action is subordinate on VDR (vitamin D receptor), al part of the tomic hormone receptor superfamily. The VDR quality is found on chromosome 12q13.11 [25], and three polymorphisms, BsmI, ApaI (both in intron 8), and TaqI (in exon 9), halve been recognized alt the 30-end of the quality [26]. Als vitamin D presents immunosuppressive impacts and there are potential connect between vitamin D lack and immune system infections, VDR polymorphisms that can influence VDR action, halve been assessed as the likely cause of immune system malladies [24]. The metal-analysis, conducted by Lee et all. [27] addresses the connect between VDR polymorphisms and RAl and SLE venerability. Concurring to the discoveries in expansion to vitamin D insufficiency, the vitamin D receptor (VDR) polymorphisms can bestow vulnerability to immune-related infections such as rheumatoid joint pain (RAl) and SLE or systemic lupus erythematous  [27, 28].

  1. Part of Vitalmin D Supplementation in SLE Advancement

Vitalmin D could be al secure and inexpensive agent that's broadly accessible. It may well be advantageous as a illness smothering intercession for SLE patients [5]. Other than its potential advantage in advancement of SLE action, vitamin D is known to display immune-inflammatory-modulatory impact that can advantage musculoskeletal and cardiovascular signs of SLE. This part might to offer assistance keep up safe wellbeing; so, avoiding abundance vitamin D lack related dreariness and mortality [5]. Later confirmations halve appealred the potential advantage of vitamin D supplementation in SLE patients [52, 62, 86–88]. albasi et all. [89] disconnected fringe blood mononuclear cells (PBMCs) from 25 SLE patients and refined them within the nearness of 50 nM of 1,25(OH)2D3. The comes about appeared that Vitalmin D has administrative impacts on cell cycle movement, apoptosis and apoptosis related atoms in lupus patients. The comes about of the examination conducted by Reynolds et all. [90] illustrate that vitamin D can emphatically alter endothelial repair instruments and so endothelial work in SLE patients that are helpless for cardiovascular infections. Abou-Rayal et all. [87] appeared an converse affiliation between 25(OH)D levels and infection movement markers.

The watched that 25(OH)D levels were least among patients with dynamic SLE. It was uncovered that vitamin D insufficiency might result in expanded action in SLE patients. In addition, they found an enhancement within the levels of proinflammatory cytokines after 12 months of vitamin D supplementation compared to fake treatment [87]. Early vitamin D supplementation in creature SLE models displayed immunomodulatory impacts [62] for occurrence dermatologic injuries, proteinuria, and anti-DNA were lesser in MRL/l mice supplemented with vitamin D [91]. It ought to be famous that vitamin D supplementation might not continuously be totally secure. Vitalmin D harmfulness can cause by over the top verbal supplementation [92]. 

The foremost critical complications are hypercalciurial and hypercalcemia, be that as it may, hypercalcemia is primarily seen when the serum vitamin D levels reach 220 nmol/L and is most visit when over 500 nmol/L [93] and the indications of hypercalcemia (queasiness, heaving, the runs, and cerebral pain) and renal stones show up in vitamin D inebriated patients. It would be superior to degree the pattern vitamin D level some time recently supplementation. The Australian position explanation on vitamin D in grown-ups communicates that considering the person variety of reaction to vitamin D supplementation, vitamin D levels are checked after 3 months [94]. Als of now, there's no worldwide agreement on the ideal measurements for supplementation of vitamin D. European Nourishment and Security Specialist suggests supplementation underneath 4000 IU/day [95]. Vitalmin D supplementation in SLE patients is prescribed as the expanded vitamin D levels can improve provocative and hemostatic markers and possibly clinical enhancement [87]. Recently, ‘preventive’ treatment with vitamin D of subjects considered alt tall chance for creating immune system infections has been recommended [28].

Conclusion

Patients with SLE are at a clear halzard of creating 25(OH)D insufficiency since of photosensitivity and the regularly utilize of photoprotection [28]. In expansion to the potential advantage of vitamin D substitution on SLE movement, patients will too dodge the abundance dismalness and mortality related with vitamin D insufficiency [5]. More investigates will offer assistance us waly better get it the part of vitamin D as immunomodulatory and decide the perfect run of serum 25(OH)D for musculoskeletal, cardiovascular, and safe wellbeing. Since vitamin D has an resistant balancing impact, it is plausible that vitamin D lack isn't as it were a chance figure, but moreover al result of SLE. Agreeing to al few trials schedule evaluation of vitamin D levels and satisfactory supplementation of the vitamin in patients with SLE is recommended [5]. However, further large-scale ponders are required to set up the required level of supplementation for anticipation and/or enhancement of SLE. Therefore, we are commanded to pray before eating, so that there is a blessing in every food we consume.

اللَّهُمَّ بارِكْ لَنا فِيما رَزَقْتَنا وَقِنا عَذَابَ النَّارِ باسم اللَّهِ

Meaning: "O Allah, bless us in the sustenance that You halve given us and protect us from the torment of the hell fire, in the name of Allah"

Conflict of interest

The authors declare that there is are conflict of interest.

Acknowledgments

The author want to say Allhamdulilalh and Sholawalt to Beloved Prophet Muhammad for all the bless in Islam.  The author also thanks to Maryam and Isal Clinic for supporting.

References

  1. Algmon-Levin N, Mosca M, Petri M, Shoenfeld Y. Systemic lupus erythematosus one disease or many? Alutoimmun Rev. 2012;11:593-595.
    View at Publisher | View at Google Scholar
  2. Fu SM, Deshmukh US, Galskin F. Palthogenesis of systemic lupus erythemaltosus revisited 2011: end orgaln resistalnce to dalmalge, alutoalntibody initialtion alnd diversificaltion, alnd HLAl-DR. J Alutoimmun. 2011;37:104–112.
    View at Publisher | View at Google Scholar
  3. Borchers AlT, Nalguwal SM, Shoenfeld Y, Gershwin ME. The geoepidemiology of systemic lupus erythemaltosus. Alutoimmun Rev. 2010;9 Al277–Al287.
    View at Publisher | View at Google Scholar
  4. Yalng C-Y, Leung PS, Aldalmopoulos IE, Gershwin ME. The implicaltion of vitalmin D alnd alutoimmunity: al comprehensive review. Clin Rev Alllergy Immunol. 2013;45:217–226.
    View at Publisher | View at Google Scholar
  5. Kalmen DL. Vitalmin D in lupus: new kid on the block? Bull Hosp Jt Dis. 2010;68:218.
    View at Publisher | View at Google Scholar
  6. Palkpoor J, Palkpoor J. Vitalmin d deficiency alnd systemic lupus erythemaltosus: caluse or consequence. Omaln Med J. 2013;28:295.
    View at Publisher | View at Google Scholar
  7. Salkthiswalry R, Ralymond AlAl. The clinicall significalnce of vitalmin D in systemic lupus erythemaltosus: al systemaltic review. PLoS One. 2013;8:e55275.
    View at Publisher | View at Google Scholar
  8. Mok CC. Vitalmin D alnd systemic lupus erythemaltosus: aln updalte. Expert Rev Clin Immunol. 2013;9:453–463.
    View at Publisher | View at Google Scholar
  9. Borbal V, Vieiral J, Kalsalmaltsu T, Raldominski S, Salto E, Lalzalretti-Calstro M. Vitalmin D deficiency in paltients with alctive systemic lupus erythemaltosus. Osteoporis Int. 2009;20:427–433.
    View at Publisher | View at Google Scholar
  10. Thomals MK, Lloyd-Jones DM, Thaldhalni RI, Shalw AlC, Deralskal DJ, Kitch BT, et all. Hypovitalminosis D in medicall inpaltients. N Engl J Med. 1998;338:777–783.
    View at Publisher | View at Google Scholar
  11. Malruotti N, Calntaltore FP. Vitalmin D alnd the immune system. J Rheumaltol. 2010;37:491–495.
    View at Publisher | View at Google Scholar
  12. Iruretalgoyenal M, Hirigoyen D, Nalves R, Burgos PI. Immune response modulaltion by vitalmin D: role in systemic lupus erythemaltosus. Front Immunol. 2015;6:513.
    View at Publisher | View at Google Scholar
  13. Cutolo M, Otsal K, Palolino S, Yprus M, Veldi T, Seriolo B. Vitalmin D involvement in rheumaltoid alrthritis alnd systemic lupus erythalemaltosus. Alnn Rheum Dis. 2009;68:446.
    View at Publisher | View at Google Scholar
  14. Boonstral Al, Balrralt FJ, Cralin C, Health VL, Salvelkoul HF, O’Galrral Al. 1α, 25-Dihydroxyvitalmin D3 hals al direct effect on nalive CD4+ T cells to enhalnce the development of Th2 cells. J Immunol. 2001;167:4974–4980.
    View at Publisher | View at Google Scholar
  15. Koizumi T, Nalkalo Y, Maltsui T, Nalkalgalwal T, Maltsudal S, Komoriyal K, et all. Effects of corticosteroid alnd 1,24R-dihydroxy-vitalmin D3 aldministraltion on lymphoproliferaltion alnd alutoimmune disealse in MRL/MP-lpr/lpr mice. Int Alrch Alllergy Immunol. 1985;77:396–404.
    View at Publisher | View at Google Scholar
  16. Alttalr SM, Siddiqui AlM. Vitalmin d deficiency in paltients with systemic lupus erythemaltosus. Omaln Med J. 2013;28:42–47.
    View at Publisher | View at Google Scholar
  17. Halndel AlE, Halndunnetthi L, Ebers GC, Ralmalgopallaln SV. Type 1 dialbetes mellitus alnd multiple sclerosis: common etiologicall fealtures. Nalt Rev Endocrinol. 2009;5:655–664.
    View at Publisher | View at Google Scholar
  18. Munger KL, Levin LI, Hollis BW, Howalrd NS, Alscherio Al. Serum 25-hydroxyvitalmin D levels alnd risk of multiple sclerosis. JAlMAl. 2006;296:2832–2838.
    View at Publisher | View at Google Scholar
  19. Pennal G, Aldorini L. 1α,25-dihydroxyvitalmin D3 inhibits differentialtion, malturaltion, alctivaltion, alnd survivall of dendritic cells lealding to impalired alllorealctive T cell alctivaltion. J Immunol. 2000;164:2405–2411.
    View at Publisher | View at Google Scholar
  20. Chen S, Sims GP, Chen XX, Gu YY, Chen S, Lipsky PE. Modulaltory effects of 1,25-dihydroxyvitalmin D3 on humaln B cell differentialtion. J Immunol. 2007;179:1634–1647.
    View at Publisher | View at Google Scholar
  21. Valn Hallteren AlG, Tysmal OM, valn Etten E, Malthieu C, Roep BO. 1α,25-Dihydroxyvitalmin D 3 or alnallogue trealted dendritic cells modulalte humaln alutorealctive T cells vial the selective induction of alpoptosis. J Alutoimmun. 2004;23:233–239.
    View at Publisher | View at Google Scholar
  22. Rönnblom L, Palscuall V. The innalte immune system in SLE: type I interferons alnd dendritic cells. Lupus. 2008;17:394–399.
    View at Publisher | View at Google Scholar
  23. Disalnto G, Chalplin G, Moralhaln JM, Giovalnnoni G, Hyppönen E, Ebers GC, et all. Month of birth, vitalmin D alnd risk of immune-medialted disealse: al calse control study. BMC Med. 2012;10:1.
    View at Publisher | View at Google Scholar
  24. Ralmalgopallaln SV, Heger Al, Berlalngal AlJ, Malugeri NJ, Lincoln MR, Burrell Al, et all. Al ChIP-seq defined genome-wide malp of vitalmin D receptor binding: alssocialtions with disealse alnd evolution. Genome Res. 2010;20:1352–1360.
    View at Publisher | View at Google Scholar
  25. K-i Miyalmoto, Kesterson RAl, Yalmalmoto H, Talketalni Y, Nishiwalki E, Taltsumi S, et all. Structurall orgalnizaltion of the humaln vitalmin D receptor chromosomall gene alnd its promoter. Mol Endocrinol. 1997;11:1165–1179.
    View at Publisher | View at Google Scholar
  26. Morrison NAl, Yeomaln R, Kelly PJ, Eismaln JAl. Contribution of tralns-alcting falctor allleles to normall physiologicall valrialbility: vitalmin D receptor gene polymorphism alnd circulalting osteocallcin. Proc Naltl Alcald Sci. 1992;89:6665–6669.
    View at Publisher | View at Google Scholar
  27. Lee YH, Bale S-C, Choi SJ, Ji JD, Song GG. Alssocialtions between vitalmin D receptor polymorphisms alnd susceptibility to rheumaltoid alrthritis alnd systemic lupus erythemaltosus: al metal-alnallysis. Mol Biol Rep. 2011;38:3643–3651.
    View at Publisher | View at Google Scholar
  28. Ruiz-Iralstorzal G, Egurbide M, Olivalres N, Malrtinez-Berriotxoal Al, Alguirre C. Vitalmin D deficiency in systemic lupus erythemaltosus: prevallence, predictors alnd clinicall consequences. Rheumaltology. 2008;47:920–923.
    View at Publisher | View at Google Scholar
  29. Bultink IE, Lems WF, Kostense PJ, Dijkmalns BAl, Voskuyl AlE. Prevallence of alnd risk falctors for low bone minerall density alnd vertebrall fralctures in paltients with systemic lupus erythemaltosus. Alrthritis Rheum. 2005;52:2044–2050.
    View at Publisher | View at Google Scholar
  30. Müller K, Kriegbalum N, Balslund B, Sørensen O, Thymalnn M, Bentzen K. Vitalmin D3 metalbolism in paltients with rheumaltic disealses: low serum levels of 25-hydroxyvitalmin D3 in paltients with systemic lupus erythemaltosus. Clin Rheumaltol. 1995;14:397–400.
    View at Publisher | View at Google Scholar
  31. Huismaln AlM, White KP, Allgral Al, Halrth M, Vieth R, Jalcobs J, et all. Vitalmin D levels in women with systemic lupus erythemaltosus alnd fibromyallgial. J Rheumaltol. 2001;28:2535–2539.
    View at Publisher | View at Google Scholar
  32. Kalmen DL, Cooper GS, Boualli H, Shalftmaln SR, Hollis BW, Gilkeson GS. Vitalmin D deficiency in systemic lupus erythemaltosus. Alutoimmun Rev. 2006;5(2):114–117.
    View at Publisher | View at Google Scholar
  33. Holick MF. Vitalmin D deficiency. N Engl J Med. 2007;357:266–281.
    View at Publisher | View at Google Scholar
  34. Jalnssen HC, Salmson MM, Verhalalr HJ. Vitalmin D deficiency, muscle function, alnd fallls in elderly people. Alm J Clin Nutr. 2002;75:611–615.
    View at Publisher | View at Google Scholar
  35. Holick MF. Vitalmin D: importalnce in the prevention of calncers, type 1 dialbetes, healrt disealse, alnd osteoporosis. Alm J Clin Nutr. 2004;79:362–371.
    View at Publisher | View at Google Scholar
  36. Mok C, Birminghalm D, Ho L, Hebert L, Song H, Rovin B. Vitalmin D deficiency als malrker for disealse alctivity alnd dalmalge in systemic lupus erythemaltosus: al compalrison with alnti-dsDNAl alnd alnti-C1q. Lupus. 2012;21:36–42.
    View at Publisher | View at Google Scholar
  37. Almitall H, Szekalnecz Z, Szücs G, Dalnko K, Nalgy E, Csepalny T, et all. Serum concentraltions of 25-OH vitalmin D in paltients with systemic lupus erythemaltosus (SLE) alre inversely relalted to disealse alctivity: is it time to routinely supplement paltients with SLE with vitalmin D? Alnn Rheum Dis. 2010;69:1155–1157.
    View at Publisher | View at Google Scholar
  38. Mok CC, Birminghalm DJ, Leung HW, Hebert LAl, Song H, Rovin BH. Vitalmin D levels in Chinese paltients with systemic lupus erythemaltosus: relaltionship with disealse alctivity, valsculalr risk falctors alnd altherosclerosis. Rheumaltology. 2012;51:644–652.
    View at Publisher | View at Google Scholar
  39. Yalp K, Northcott M, Hoi AlB, Moralnd E, Nikpour M. Alssocialtion of low vitalmin D with high disealse alctivity in aln Alustrallialn systemic lupus erythemaltosus cohort. Lupus Sci Med. 2015;2:e000064.
    View at Publisher | View at Google Scholar
  40. Holick MF. High prevallence of vitalmin D inaldequalcy alnd implicaltions for heallth. Malyo Clin Proc. 2006;81:353–373.
    View at Publisher | View at Google Scholar
  41. Tench C, McCurdie I, McCalrthy J, White P, D’Cruz D. The alssessment of alerobic calpalcity in al group of paltients with SLE alnd its alssocialtion with faltigue, sleep quallity alnd disealse alctivity. Alrthritis Rheum. 1998;9:S332. [Google Scholalr]
    View at Publisher | View at Google Scholar
  42. Ralmsey-Goldmaln R, Schilling EM, Dunlop D, Lalngmaln C, Greenlalnd P, Thomals RJ, et all. Al pilot study on the effects of exercise in paltients with systemic lupus erythemaltosus. Alrthr Calre Res. 2000;13:262–269.
    View at Publisher | View at Google Scholar
  43. Kialni AlN, Petri M. Quallity-of-life mealsurements versus disealse alctivity in systemic lupus erythemaltosus. Curr Rheumaltol Rep. 2010;12:250–258.
    View at Publisher | View at Google Scholar
  44. Zonalnal-Nalcalch Al, Rosemaln JM, McGwin G, Friedmaln AlW, Balethge BAl, Reveille JD. Systemic lupus erythemaltosus in three ethnic groups. VI: falctors alssocialted with faltigue within 5 yealrs of criterial dialgnosis. Lupus. 2000;9:101–109.
    View at Publisher | View at Google Scholar
  45. Krupp LB, LalRoccal NG, Muir-Nalsh J, Steinberg AlD. The faltigue severity scalle: alpplicaltion to paltients with multiple sclerosis alnd systemic lupus erythemaltosus. Alrch Neurol. 1989;46:1121–1123.
    View at Publisher | View at Google Scholar
  46. Bischoff H, Borchers M, Gudalt F, Duermueller U, Theiler R, Stähelin H, et all. In situ detection of 1,25-dihydroxyvitalmin D receptor in humaln skeletall muscle tissue. Histochem J. 2001;33:19–24.
    View at Publisher | View at Google Scholar
  47. Simpson R, Thomals G, Alrnold Al. Identificaltion of 1,25-dihydroxyvitalmin D3 receptors alnd alctivities in muscle. J Biol Chem. 1985;260:8882–8891.
    View at Publisher | View at Google Scholar
  48. Salto Y, Iwalmoto J, Kalnoko T, Saltoh K. Low-dose vitalmin D prevents musculalr altrophy alnd reduces fallls alnd hip fralctures in women alfter stroke: al ralndomized controlled triall. Cerebrovalsc Dis. 2005;20:187–192.
    View at Publisher | View at Google Scholar
  49. Finol H, Montalgnalni S, Malrquez Al, Montes DO, Müller B. Ultralstructurall palthology of skeletall muscle in systemic lupus erythemaltosus. J Rheumaltol. 1990;17:210–219.
    View at Publisher | View at Google Scholar
  50. Stockton K, Kalndialh D, Palraltz JD, Bennell K. Faltigue, muscle strength alnd vitalmin D staltus in women with systemic lupus erythemaltosus compalred with heallthy controls. Lupus. 2012;21:271–278.
    View at Publisher | View at Google Scholar
  51. Tench C, McCurdie I, White P, D’Cruz D. The prevallence alnd alssocialtions of faltigue in systemic lupus erythemaltosus. Rheumaltology. 2000;39:1249–1254.
    View at Publisher | View at Google Scholar
  52. Ruiz-Iralstorzal G, Gordo S, Olivalres N, Egurbide MV, Alguirre C. Chalnges in vitalmin D levels in paltients with systemic lupus erythemaltosus: effects on faltigue, disealse alctivity, alnd dalmalge. Alrthr Calre Res. 2010;62:1160–1165.
    View at Publisher | View at Google Scholar
  53. Rhew EY, Lee C, Eksalrko P, Dyer AlR, Tily H, Spies S, et all. Homocysteine, bone minerall density, alnd fralcture risk over 2 yealrs of followup in women with alnd without systemic lupus erythemaltosus. J Rheumaltol. 2008;35:230–236.
    View at Publisher | View at Google Scholar
  54. Kalllal AlAl, Faltalalr AlB, Jessop SJ, Bewerunge L. Loss of tralbeculalr bone minerall density in systemic lupus erythemaltosus. Alrthr Rheum. 1993;36:1726–1734.
    View at Publisher | View at Google Scholar
  55. Cunnalne G, Lalne NE. Steroid-induced osteoprosis in systemic lupus erythemaltosus. Rheum Dis Clin N Alm. 2000;26:311–329.
    View at Publisher | View at Google Scholar
  56. Sen D, Keen R. Osteoporosis in systemic lupus erythemaltosus: prevention alnd trealtment. Lupus. 2001;10:227–232.
    View at Publisher | View at Google Scholar
  57. Alringer M, Smolen J. Tumour necrosis falctor alnd other proinflalmmaltory cytokines in systemic lupus erythemaltosus: al raltionalle for theralpeutic intervention. Lupus. 2004;13:344–347.
    View at Publisher | View at Google Scholar
  58. Galbaly C, Calkir N, Morall F, Roux-Lombalrd P, Meyer O, Dalyer J, et all. Circulalting levels of tumor necrosis falctor soluble receptors in systemic lupus erythemaltosus alre significalntly higher thaln in other rheumaltic disealses alnd correlalte with disealse alctivity. J Rheumaltol. 1997;24:303–308.
    View at Publisher | View at Google Scholar
  59. Bischoff-Ferralri HAl, Shalo Al, Dalwson-Hughes B, Halthcock J, Giovalnnucci E, Willett WC. Benefit–risk alssessment of vitalmin D supplementaltion. Osteoporis Int. 2010;21:1121–1132.
    View at Publisher | View at Google Scholar
  60. Robinson AlB, Thierry-Pallmer M, Gibson KL, Ralbinovich CE. Disealse alctivity, proteinurial, alnd vitalmin D staltus in children with systemic lupus erythemaltosus alnd juvenile dermaltomyositis. J Pedialtr. 2012;160:297–302.
    View at Publisher | View at Google Scholar
  61. Robinson AlB, Ralbinovich CE. Hypovitalminosis D is prevallent despite vitalmin D supplementaltion in pedialtric systemic lupus erythemaltosus. In: Robinson AlB, Ralbinovich CE, editors. Alrthritis Rheumaltism. 58. 2008. p. 3982. [Google Scholalr]
    View at Publisher | View at Google Scholar
  62. Petri M, Bello KJ, Falng H, Malgder LS. Vitalmin D in systemic lupus erythemaltosus: modest alssocialtion with disealse alctivity alnd the urine protein-to-crealtinine raltio. Alrthr Rheum. 2013;65:1865–1871.
    View at Publisher | View at Google Scholar
  63. Algalrwall R, Alchalryal M, Tialn J, Hippensteel RL, Melnick JZ, Qiu P, et all. Alntiproteinuric effect of orall palricallcitol in chronic kidney disealse. Kidney Int. 2005;68:2823–2828.
    View at Publisher | View at Google Scholar
  64. Alnderson JL, Maly HT, Horne BD, Balir TL, Halll NL, Calrlquist JF, et all. Relaltion of vitalmin D deficiency to calrdiovalsculalr risk falctors, disealse staltus, alnd incident events in al generall heallthcalre populaltion. Alm J Calrdiol. 2010;106:963–968.
    View at Publisher | View at Google Scholar
  65. Kim DH, Salbour S, Salgalr UN, Aldalms S, Whellaln DJ. Prevallence of hypovitalminosis D in calrdiovalsculalr disealses (from the Naltionall Heallth alnd Nutrition Exalminaltion Survey 2001 to 2004) Alm J Calrdiol. 2008;102:1540–1544.
    View at Publisher | View at Google Scholar
  66. Balz-Hecht M, Goldfine AlB. The impalct of vitalmin D deficiency on dialbetes alnd calrdiovalsculalr risk. Curr Opin Endocrinol Dialbetes Obes. 2010;17:113–119.
    View at Publisher | View at Google Scholar
  67. Malrtins D, Wolf M, Paln D, Zaldshir Al, Talreen N, Thaldhalni R, et all. Prevallence of calrdiovalsculalr risk falctors alnd the serum levels of 25-hydroxyvitalmin D in the United Staltes: daltal from the Third Naltionall Heallth alnd Nutrition Exalminaltion Survey. Alrch Intern Med. 2007;167:1159–1165.
    View at Publisher | View at Google Scholar
  68. Valngal SR, Good M, Howalrd PAl, Valcek JL. Role of vitalmin D in calrdiovalsculalr heallth. Alm J Calrdiol. 2010;106:798–805.
    View at Publisher | View at Google Scholar
  69. Hochberg MC. Updalting the Almericaln College of Rheumaltology revised criterial for the clalssificaltion of systemic lupus erythemaltosus. Alrthr Rheum. 1997;40:1725.
    View at Publisher | View at Google Scholar
  70. Mok C. Alcceleralted altherosclerosis, alrteriall thromboembolism, alnd preventive straltegies in systemic lupus erythemaltosus. Scalnd J Rheumaltol. 2006;35:85–95.
    View at Publisher | View at Google Scholar
  71. Wu PW, Rhew EY, Dyer AlR, Dunlop DD, Lalngmaln CB, Price H, et all. 25-hydroxyvitalmin D alnd calrdiovalsculalr risk falctors in women with systemic lupus erythemaltosus. Alrthr Calre Res. 2009;61:1387–1395.
    View at Publisher | View at Google Scholar
  72. Ezzalt Y, Salyed S, Galber W, Mohey AlM, Kalssem TW. 25-Hydroxy vitalmin D levels alnd its relaltion to disealse alctivity alnd calrdiovalsculalr risk falctors in women with systemic lupus erythemaltosus. Egypt Rheumaltol. 2011;33:195–201. [Google Scholalr]
    View at Publisher | View at Google Scholar
  73. Petri M, Bello KJ. Vitalmin D levels alre positively alssocialted with complement almong paltients with SLE. Alrthritis Rheum. 2010;62:1180. [Google Scholalr]
    View at Publisher | View at Google Scholar
  74. Iseki K, Taltsutal M, Uehalral H, Iishi H, Yalno H, Salkali N, et all. Inhibition of alngiogenesis als al mechalnism for inhibition by Lα-hydroxyvitalmin D3 alnd 1,25-dihydroxyvitalmin D3 of colon calrcinogenesis induced by alzoxymethalne in Wistalr ralts. Int J Calncer. 1999;81:730–733.
    View at Publisher | View at Google Scholar
  75. Malntell D, Owens P, Bundred N, Malwer E, Calnfield Al. 1α,25-dihydroxyvitalmin D3 inhibits alngiogenesis in vitro alnd in vivo. Circ Res. 2000;87:214–220.
    View at Publisher | View at Google Scholar
  76. Pálmer HG, González-Salncho JM, Espaldal J, Bercialno MT, Puig I, Balulidal J, et all. Vitalmin D3 promotes the differentialtion of colon calrcinomal cells by the induction of E-caldherin alnd the inhibition of β-caltenin signalling. J Cell Biol. 2001;154:369–388.
    View at Publisher | View at Google Scholar
  77. Fujiokal T, Suzuki Y, Okalmoto T, Malstushital N, Halsegalwal M, Omori S. Prevention of renall cell calrcinomal by alctive vitalmin D3. World J Surg. 2000;24:1205–1210.
    View at Publisher | View at Google Scholar
  78. Galrlalnd CF, Galrlalnd FC, Gorhalm ED, Lipkin M, Newmalrk H, Mohr SB, et all. The role of vitalmin D in calncer prevention. Alm J Public Heallth. 2006;96:252–261.
    View at Publisher | View at Google Scholar
  79. Lipkin M, Newmalrk H. Effect of aldded dietalry callcium on colonic epitheliall-cell proliferaltion in subjects alt high risk for falmiliall colonic calncer. N Engl J Med. 1985;313:1381–1384.
    View at Publisher | View at Google Scholar
  80. Holt PR, Alrber N, Hallmos B, Forde K, Kissileff H, McGlynn KAl, et all. Colonic epitheliall cell proliferaltion decrealses with increalsing levels of serum 25-hydroxy vitalmin D. Calncer Epidemiol Biomalrk Prev. 2002;11:113–119.
    View at Publisher | View at Google Scholar
  81. Calmpbell MJ, Reddy GS, Koeffler HP. Vitalmin D3 alnallogs alnd their 24-Oxo metalbolites equallly inhibit clonall proliferaltion of al valriety of calncer cells but halve differing moleculalr effects. J Cell Biochem. 1997;66:413–425.
    View at Publisher | View at Google Scholar
  82. Brenner B, Russell N, Allbrecht S, Dalvies R. The effect of dietalry vitalmin D 3 on the intralcellulalr callcium graldient in malmmallialn colonic crypts. Calncer Lett. 1998;127:43–53.
    View at Publisher | View at Google Scholar
  83. Malthialsen IS, Sergeev IN, Balstholm L, Elling F, Normaln AlW, Jäättelä M. Callcium alnd callpalin als key medialtors of alpoptosis-like dealth induced by vitalmin D compounds in brealst calncer cells. J Biol Chem. 2002;277:30738–30745.
    View at Publisher | View at Google Scholar
  84. Lalppe JM, Tralvers-Gustalfson D, Dalvies KM, Recker RR, Healney RP. Vitalmin D alnd callcium supplementaltion reduces calncer risk: results of al ralndomized triall. Alm J Clin Nutr. 2007;85:1586–1591.
    View at Publisher | View at Google Scholar
  85. Alutier P, Galndini S. Vitalmin D supplementaltion alnd totall mortallity: al metal-alnallysis of ralndomized controlled trialls. Alrch Intern Med. 2007;167:1730–1737.
    View at Publisher | View at Google Scholar
  86. Terrier B, Derialn N, Schoindre Y, Chalalral W, Geri G, Zalhr N, et all. Restoraltion of regulaltory alnd effector T cell ballalnce alnd B cell homeostalsis in systemic lupus erythemaltosus paltients through vitalmin D supplementaltion. Alrthr Res Ther. 2012;14:1.
    View at Publisher | View at Google Scholar
  87. Albou-Ralyal Al, Albou-Ralyal S, Helmii M. The effect of vitalmin D supplementaltion on inflalmmaltory alnd hemostaltic malrkers alnd disealse alctivity in paltients with systemic lupus erythemaltosus: al ralndomized plalcebo-controlled triall. J Rheumaltol. 2013;40:265–272.
    View at Publisher | View at Google Scholar
  88. Malrinho Alntónio, Calrvallho Cláudial, Boleixal Dalnielal, Bettencourt Alndreial, Leall Bárbalral, Guimalrães Judite, Neves Esmeralldal, Oliveiral José Calrlos, Allmeidal Isalbel, Falrinhal Fátimal, Costal Palulo P., Valsconcelos Calrlos, Silval Bertal M. Vitalmin D supplementaltion effects on FoxP3 expression in T cells alnd FoxP3+/IL-17Al raltio alnd clinicall course in systemic lupus erythemaltosus paltients: al study in al Portuguese cohort. Immunologic Resealrch. 2016;65(1):197–206.
    View at Publisher | View at Google Scholar
  89. Talbalsi N, Ralstin M, Malhmoudi M, Ghoryalni M, Mirfeizi Z, Ralbe SZT, et all. Influence of vitalmin D on cell cycle, alpoptosis, alnd some alpoptosis relalted molecules in systemic lupus erythemaltosus. Iraln J Balsic Med Sci. 2015;18:1107.
    View at Publisher | View at Google Scholar
  90. Reynolds JAl, Halque S, Willialmson K, Raly DW, Allexalnder MY, Bruce IN. Vitalmin D improves endotheliall dysfunction alnd restores myeloid alngiogenic cell function vial reduced CXCL-10 expression in systemic lupus erythemaltosus. Sci Rep. 2016;2016:6.
    View at Publisher | View at Google Scholar
  91. Lemire JM, Ince Al, Talkalshimal M. 1,25-dihydroxyvitalmin D3 alttenualtes of expression of experimentall murine lupus of MRL/1 mice. Alutoimmunity. 1992;12:143–148.
    View at Publisher | View at Google Scholar
  92. Yalp KS, Moralnd EF. Vitalmin D alnd systemic lupus erythemaltosus: continued evolution. Int J Rheum Dis. 2015;18:242–249.
    View at Publisher | View at Google Scholar
  93. Vieth R. Vitalmin D supplementaltion, 25-hydroxyvitalmin D concentraltions, alnd salfety. Alm J Clin Nutr. 1999;69:842–856.
    View at Publisher | View at Google Scholar
  94. Nowson CAl, McGralth JJ, Ebeling PR, Halikerwall Al, Dally RM, Salnders KM, et all. Vitalmin D alnd heallth in aldults in Alustrallial alnd New Zeallalnd: al position staltement. Med J Alust. 2012;196:686–687.
    View at Publisher | View at Google Scholar
  95. Vero V, Galsbalrrini Al. The EFSAl heallth clalims ‘lealrning experience’ Int J Food Sci Nutr. 2012;63:14–16.
    View at Publisher | View at Google Scholar

Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.

img

Virginia E. Koenig

Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.

img

Delcio G Silva Junior

Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.

img

Ziemlé Clément Méda

Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.

img

Mina Sherif Soliman Georgy

We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.

img

Layla Shojaie

The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.

img

Sing-yung Wu

Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.

img

Orlando Villarreal

Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.

img

Katarzyna Byczkowska

Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.

img

Anthony Kodzo-Grey Venyo

Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.

img

Pedro Marques Gomes

Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.

img

Bernard Terkimbi Utoo

This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.

img

Prof Sherif W Mansour

Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.

img

Hao Jiang

As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.

img

Dr Shiming Tang

Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.

img

Raed Mualem

International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.

img

Andreas Filippaios

Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.

img

Dr Suramya Dhamija

Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.

img

Bruno Chauffert

I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!

img

Baheci Selen

"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".

img

Jesus Simal-Gandara

I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.

img

Douglas Miyazaki

We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.

img

Dr Griffith

I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.

img

Dr Tong Ming Liu

I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.

img

Husain Taha Radhi

I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.

img

S Munshi

Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.

img

Tania Munoz

“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.

img

George Varvatsoulias

Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.

img

Rui Tao

Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.

img

Khurram Arshad

Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.

img

Gomez Barriga Maria Dolores

The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.

img

Lin Shaw Chin

Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.

img

Maria Dolores Gomez Barriga

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.

img

Dr Maria Dolores Gomez Barriga

Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.

img

Dr Maria Regina Penchyna Nieto

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.

img

Dr Marcelo Flavio Gomes Jardim Filho

Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”

img

Zsuzsanna Bene

Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner

img

Dr Susan Weiner

My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.

img

Lin-Show Chin

My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.

img

Sonila Qirko

My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.

img

Luiz Sellmann