Letter to Editor | DOI: https://doi.org/10.31579/2690-4861/083
1 Department of Pediatric Intensive Care Unit, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Joint Center for Infection and Immunity,Guangzhou, Medical University, 510623, Guangzhou, China.
2 The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
3 Department of Biological Sciences (DBS), National University of Medical Sciences (NUMS),Secretariat c/o Military Hospital, Adjacent to Armed Force Institute of Cardiology, Rawalpindi, Pakistan.
4 Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
*Corresponding Author: Saifullah Afridi, Ph.D. Department of Biological Sciences (DBS), National University of Medical Sciences (NUMS), Secretariat c/o Military Hospital, Adjacent to Armed Force Institute of Cardiology, Rawalpindi, Pakistan.
Citation: S Afridi and Daniel C. Hoessli (2020) Pakistani youth population is prone to SARS-CoV-2 (nCoVID-19) Infection. International Journal of Clinical Case Reports and Reviews. 5(1); DOI:10.31579/2690-4861/083
Copyright: © 2020 Saifullah Afridi, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 23 September 2020 | Accepted: 23 December 2020 | Published: 30 December 2020
Keywords: Keywords
Abstract
The novel coronavirus (nCOVID-19) with potential for human-to-human transmission at an exponential rate across the globe has been shown in numerous reports. According to WHO declaration COVID-19 is a global emergency with over 40 million infections that could cause 1-5 million deaths. Currently Pakistan is acutely facing this key challenge with lockdown and casualties. On February 25, 2020, the (COVID-19) first case was reported in Karachi (Sindh) from a pilgrim and rapidly spread throughout Pakistan. As of October 25, 2020, a total of 320,211 cases have been confirmed in the 4 Pakistani provinces, the capital Islamabad and the two autonomous. The predicted numbers of infections up to November 10 should be around 335,000-350,000 with 5000-10,000 severe and 1000-3000 critical cases [2-3].Though the available COVID-19 strain sequences from three autonomous regions Gilgit Baltistan (GB), Karachi (Sindh) and Khyber Pakhtunkhwa (KPK), Pakistan show 95-99% similarity with the Chinese original COVID-19 strains4-5. However, the current available Pakistani epidemiological data show substantially different patterns from the world COVID-19 trends(Fig.1A-C) by infecting 50-60 % of 18-49-year age individuals predominately with an alarming proportion of 35-45 % of younger people (18-39 years) with male dominancy (82-88 % male /12-18 % female),(Fig.1B-D). Similarly, different patterns of provinces epidemiological data, i.e., KPK high mortality rate 40 ± 2 % with lowest 13 ± 2 % recovery vs other regions (Fig.1A) shows diverse COVID-19. On the other hand, the death rate 12 ± 2 % in (10-49-year youth) vs 84 ± 2 % (50-80+year old) (Fig.1E), suggesting youth as a COVID-19-gun showlder to hit old.
Beside nemours reasons, here we list some key factors affecting COVID-19 infections in Pakistan, i.e.,[1] Existence of different COVID-19 strains due to mutation or different Pakistanis returning from abroad (Fig.1A). [2] A massive 60% of young Pakistani getting infected (Fig.1B-C). [3] More exposure due to promiscuous activities (businesses, social gatherings, migrant workers, travelers, and transporters. [4] Social ignorance among the young of the world COVID-19 transmission trends. [5] Bad habits of sleep, fast-food, and smoking. Now we urgently need to consider these unusual aspects of COVID-19 in Pakistan and take all precautionary measures as early as possible.
Conflict of interest: On behalf of all my team, we have no conflict of interest to declare.
Funding Source: No funding were granted
Ethical Approval: Approved by National Command Operation Center (NCOC-Pakistan) for COVID-19 data.
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