Short Communication | DOI: https://doi.org/10.31579/IJBR-2022/065
1 Intensive Care Unit, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil
2 Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil
3 Cardiac Surgery Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil
*Corresponding Author: Tania Leme da Rocha Martinez, Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil.
Citation: André L.V. Gasparoto, Anita L R Saldanha, Tania L.R. Martinez, Ana P.P. Margeotto. et.all. (2022) Outcomes of Intensive Care Units Covid-19 Patients with and Without Previous Use of Acetylsalicylic Acid. International J. of Biomed Research. 2(3): DOI: 10.31579/IJBR-2022/065
Copyright: © 2022 Tania Leme da Rocha Martinez, This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 01 February 2022 | Accepted: 04 February 2022 | Published: 08 February 2022
Keywords: COVID-19; aspirin, D-dimer; mortality
Pandemic COVID-19 infection is known to enhance prothrombotic conditions in affected patients. Thrombotic complications occur at high rates in hospitalized patients with COVID-19, yet the impact of intensive antithrombotic therapy on mortality is uncertain. COVID-19 is a respiratory disease that results in a prothrombotic state manifesting as thrombotic, microthrombotic and thromboembolic events. As a result, several antithrombotic modalities have been implicated in the treatment of this disease. In other words, the knowledge that thrombotic changes in fibrin networks contribute to increased cardiovascular risk in COVID-19 affected patients. Given that aspirin modulates the fibrin network, we aimed to determine if aspirin therapy associates with changes in D-Dimer values, aiming at the chance of fibrin clots in patients on aspirin treatment. The other parameters studied for this comparison were mechanical ventilation, time of hospitalization, need for dialysis therapy and mortality. A number of 306 patients in these conditions was evaluated for all the variables mentioned. Univariate analysis for previous use of aspirin did not significantly affect D-Dimer values nor the other parameters studied.
ASA: Acetylsalicylic Acid
ICU: Intensive Care Unit
The aim of this work was to evaluate whether patients with COVID-19 hospitalized in the Intensive Care Unit (ICU) under previous use of acetylsalicylic acid (ASA) (regardless of the reason) had D-dimer values already evaluated, also need for mechanical ventilation, time of hospitalization, need for dialysis therapy and deaths, lower rates than those who did not use this class of drug. Anticoagulant and antiplatelets uses, either single or combined, have been questioned in various research works [1-5].
The methodology used was retrospective and non-interventional analysis of the ICU database directed to patients with COVID-19.
Of the 306 patients evaluated, the results showed that 60% were male and 27 patients used ASA (8.8%). In this group, the median age was 68 (35-96 years), the mean D-dimer at admission was 4720 ng/dl, 20 of them required mechanical ventilation (84%), 12 of dialysis therapy (44%), the mean length of ICU stay was 14 days and total of 25 days. The death rate was 37% (10 patients). In the group that did not use ASA (91.2%), the median age was 62 (18-96 years), the mean D-dimer at admission was 3352 ng/dl, 239 of them required mechanical ventilation (86%), 110 for dialysis therapy (39%), the mean length of ICU stay was 13 days and total of 22 days. The death rate was 33% (91 patients).
In conclusion, in this sample, it is evident that the previous use of ASA through this univariate analysis did not significantly affect the initial value of D-dimer, in the need for mechanical ventilation, dialysis therapy, hospitalization time and deaths.
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