Outcome of Different Endoscopic Endonasal Flaps

Research Article | DOI: https://doi.org/10.31579/2692-9562/160

Outcome of Different Endoscopic Endonasal Flaps

  • Sameh M Zamzam

Lecturer of Otolaryngology, Cairo University. Egypt.

*Corresponding Author: Sameh M Zamzam, Lecturer of Otolaryngology, Cairo University. Egypt.

Citation: Sameh M. Zamzam, (2026), Outcome of Different Endoscopic Endonasal Flaps, Journal of Clinical Otorhinolaryngology, 8(2); DOI:10.31579/2692-9562/160

Copyright: © 2026, Sameh M Zamzam. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Received: 21 May 2026 | Accepted: 29 May 2026 | Published: 15 June 2026

Keywords: nasoseptal flap; middle turbinate flap; inferior turbinate flap; lateral wall flap

Abstract

Introduction: Endoscopic endonasal surgeries have been evoluted in the last two decades, it has an advanced and expanded role in many anterior & middle and posterior skull base diseases like CSF rhinorrhea, pituitary lesions. Reconstruction of the dura after these kinds of surgeries is remaining a big challenge for rhinologists. This is a review article aiming to discuss the different endoscopic endonasal pedicled flaps and their outcome.

Methods: Online searching for articles in English on https://pubmed.ncbi.nlm.nih.gov, https://scholar.google.com, https://www.researchgate.net, https://onlinelibrary.wiley.com.

Results: Fifty-five articles have been found fulfilling the criteria needed for data collection for outcome of different types of flaps in different journals, 54 articles published from 2000 to 2022 and just one article published in 1988.

Conclusion: Endonasal flaps give surgeons many solutions for reconstruction of the cranial base after extended endonasal skull base surgeries, they carry the advantages of being nearby, carry their blood supply, easy to harvest and no cosmetic drawbacks. Little complications like crustations, hyposmia and some degree of nasal obstruction may be noted.

Introduction

Endoscopic endonasal surgeries have been evoluted in the last two decades, nowadays this entity of surgeries is not limited for just dealing with enlarged turbinates, sinusitis or inflammatory polyps but also it has more advanced and expanded role in many anterior & middle and posterior skull base diseases like CSF rhinorrhea, pituitary lesions and even more extensive tumors like chordoma and craniopharyngioma. [1,2]

This evolution was aided by many facilities like angled instruments, high resolution cameras and monitors which help in more precise visualization and good dealing with the pathology. Also, the navigation system helps surgeons to be aware of the anatomy to avoid injury of important structures. This also leads to development of a teamwork between rhinologists and neurosurgeons work via two or four handed techniques. [3]

Reconstruction of the dural defects after these kinds of surgeries still a big challenge for rhinologists, anciently they used the extra nasal pedicled structures as transfrontal peri cranial

flaps and trans pterygoid temporoparietal flaps or even external fascial grafts from lateral aspect of thigh to reconstruct the anterior and middle cranial base dural defects. These were associated with co-morbidity & much cosmetic drawbacks and the surgical technique was very difficult. [4-6]

Recently, rhinologists invented techniques to use the intra nasal lining mucoperiosteum and mucoperichondrium as a pedicled flap to reconstruct the dural defects or to cover a bare bone. Aided by adding fat or adhesive synthetic material between the flap and the defect or supporting the flap by gel foam or surgical, another limited local use of the endonasal flaps is to repair small septal perforations. [7,8]

This is a review article aiming to discuss the different endoscopic endonasal pedicled flaps and their outcome in reconstructing cranial base and septal perforation.

Methods

Keywords used for online searching were: nasoseptal flap, middle turbinate flap, inferior turbinate flap, lateral wall flap, posterior septal flap, choanal atresia, septal perforation, grafts, skull base defect, extended endonasal, pituitary adenoma, CSF leak, chordoma, craniopharyngioma.

Articles dealing with patients with describing their demographic data, lesions and outcome of reconstruction were included in this article, also articles demonstrating cadaveric dissection were included to describe the techniques of harvesting the flaps.

Online searching for recent articles in English on https://pubmed.ncbi.nlm.nih.gov, https://scholar.google.com, https://www.researchgate.net, https://onlinelibrary.wiley.com. other languages were excluded

 

Results

Fifty-five articles have been found fulfilling the criteria needed for data collection for this article in different journals, 54 articles published from 2000 to 2022 and just one article published in 1988.

Discussion

Different types of endonasal flaps have been found in literature were discussed regarding their techniques and outcome.

1-Nasoseptal flap (NSF) - Hadad Bassagasteguy Flap (HBF)

A study by Hadad et al used the nasoseptal posterior pedicled flap, based on nasoseptal branch of posterior septal artery from sphenopalatine which is a branch of internal maxillary artery. After decongesting the nasal cavity with xylometazoline and saline/ adrenaline they did out fracture and lateralization of the inferior turbinate with resection of the middle turbinate to allow proper visualization of the entire nasal septum and to allow easy moving and manipulation of the pedicled flap and instruments. A sagittal incision is done in the mucoperichondrial and mucoperiosteum layers inferiorly just above the maxillary crest and another similar incision is done superiorly just below the olfactory mucosa by 0.5 cm to avoid its injury, the two incisions connected anteriorly then dissection of the mucoperichondrial and mucoperiosteal layers from anterior to posterior with keeping the posterior-inferior attachment for vascularization (figure 1). Then flap is rotated into the postnasal space and elevated to cover the target defective area, vigorous torsion or twisting should be avoided to prevent devascularization of the flap, this flap could be refashioned according to the size and shape of the defect, it services to cover defects in anterior, middle and posterior cranial fossae. The flap is supported by inflated Foley’s catheter. [1]

The huge donor site cartilage is now exposed and liable for crust formation or infection, some authors preferred to cover it as possible by using the mucosa of the resected middle turbinate supported by silicone splint for 14 days. Others used the reverse posterior nasoseptal flap. [2]

They used this flap with 44 cases including twenty cases of pituitary adenoma, nine cases of post traumatic and spontaneous CSF leak, five cases of meningiomas, one case of neuroblastomas, five cases of clival chordomas and one case of craniopharyngiomas, only 2 cases (5%) showed postoperative intermittent CSF leak. [1]

Figure 1: Cadaveric Dissection illustrates the outlines of the nasoseptal flap 2

A study by Wardas et al has applied the nasoseptal flap on 23 skull base patients, seven cases of pituitary macro adenomas, seven cases of chordomas, two cases of Rathke's cleft cysts, two cases of petroclival meningioma, two cases of craniopharyngioma, one case of fibrous dysplasia, one case of neurinoma and they reported one failure case (3%) of persisting CSF leakage after removing a chordoma. [3]

This is compared with a higher percentage of post operative CSF leak in another study by Kassam et al, they entailed twenty-five cases with skull base surgery and reconstructed by nasoseptal flap, [11] cases of pituitary adenoma, 4 cases of chordoma, 4 cases of meningioma, 2 cases of neuroblastoma,2 cases of CSF leak and 2 cases of malignant neoplasm, they reported postoperative CSF leakage in 8 patients (30%). [4 ]

A study by Luginbuhl et al included 16 cases of CSF rhinorrhea reconstructed by the nasoseptal flap, they reported failure in one case (6%). 9 A study by Zanation et al, included larger number of cases, they included 70 cases of pituitary macroadenomas and meningiomas and malignant neoplasm were reconstructed after removal of the lesion by nasoseptal flap, with failure in 4 cases (5%). [10]

Nearly the same with Lui et al have entailed 93 cases of CSF leak reconstructed by the nasoseptal flap, 3 cases only showed post operative leakage (3%). [11]

A study by Garcia-Navarro et al was conducted on 21 cases of pituitary adenomas, meningiomas and craniopharyngiomas, the defect was reconstructed by nasoseptal flap, they reported failure in 4.5%. [12]

Another study by Barger et al included 21 patients with pituitary adenoma reconstructed with nasoseptal flap, only one case showed postoperative CSF leak (5%). [13]

A huge number of cases were included in a study by Thorp et al, they included 144 cases of different pathologies between pituitary adenomas, chordomas, meningiomas, CSF leaks and malignant tumors, they reported failure rate in 3 cases only (2%) after reconstruction using nasoseptal flap. [14]

A study by Cavallo et al included 25 cases, 9 meningiomas, 8 craniopharyngiomas, 6 pituitary macro adenomas, one pituicytoma and one Rathke’s cleft cyst, they reported failed reconstruction in one case (4%). [15] 

Also, a study by Conger et al, entailed 509 cases of extended skull base surgery, only 83 reconstructed by nasoseptal flap with failure rate 4%. [16]

Hadad Bassagasteguy nasoseptal Flap carries the advantages being large in surface area gives up to 20 cm2, could be refashioned according to the defect, well vascularized, could reconstructs two adjacent defects. It may be limited in use in patients with nasal septal problem like perforations due to heroin & cocaine addiction or cold frosting weather, previous nasal septal surgery or granulomatous disease and tumors invading the nasal septum, also sphenopalatine artery ligation & posterior septectomy and sphenoid surgery considered a limitation for using the Hadad Bassagasteguy nasoseptal Flap. Little drawbacks were reported in the form of olfactory changes (3%) & synechia and crust formation. [4-7,17]

2-Modifications of Nasoseptal flap 

2-1-Rescue Nasoseptal flap

Nasoseptal flap is used to reconstruct the teared dura in skull base defects, CSF leakage couldn’t be anticipated in each patient, on the other hand the flap has some drawbacks as crust formation, synechia & olfactory changes and septal cartilage infection or necrosis. If there is no defect no need for reconstruction and in small defect surgeons can use fat or mucosal grafts. Upon this it’s preferred not to harvest the nasoseptal flap in each patient. Other authors preferred to do what’s named by rescue nasoseptal flaps which means the surgeon starts to harvest the nasoseptal flap at the beginning of surgery and returning it to the septum if not needed for reconstruction. [6]

 2-2-Re-use of nasoseptal flap

The nasoseptal flap could be reused in recurrent cases of benign lesion as meningioma and pituitary adenomas, it is preferred to be the same surgeon of the primary surgery, it is important to precisely know the operative details and mapping of the primary surgery and to know the side of the pedicle of the nasoseptal flap if the surgical details were not available doppler could be used to detect the side of the pedicle. Technique entails separation of the pedicle from the edges of the defect or from the recurrent benign lesion, repositioning of the flap, removing the recurrent lesion then reconstruction the defect. This kind of modification couldn’t be helpful in malignant lesion. [2]

A study by Zanation et al included 12 revision cases with re-use of the nasoseptal flap with success rate 100%. [2]

2-3-Extending nasoseptal flap including the nasal floor

In case of extensive dural defects surgeons may need to extend the nasoseptal flap to reconstruct the defect, this extended flap includes the nasal floor mucoperiosteal layer with the nasoseptal flap. Technique is similar to routine nasoseptal flap but the incision starts posteriorly at the septum just below the floor of sphenoid downward to floor passing laterally between the hard and soft palate till reach the inferior surface of inferior turbinate, then the incision extended anterior in sagittal plane below the inferior turbinate preserving the inferior meatus till reach the level of the head of inferior turbinate then the incision runs on the floor medially to reach the septum then the incision runs upward on the anterior part of the septum till the olfactory mucosa then extends backwards to the face of sphenoid sinus, then dissection is done preserving the vascular pedicle at posterior part of the septum above the choana, healing takes about 8 weeks for re-epithelialization. [8]

2-4-Extending nasoseptal flap including the nasal floor and inferior turbinate

For more extended flap, like the previously described technique but the incision passes laterally above the inferior turbinate preserving the nasolacrimal duct opening to include the mucoperiosteal layer of the floor and inferior turbinate with the nasoseptal flap, it gives a surface area up to 28 cm2. [8,17]

2-5-360o nasoseptal flap including nasal floor and lateral nasal wall

In this modification, the lateral incision extends to include the middle and superior turbinates mucoperiosteum, it’s technically difficult & time consuming and associated with high incidence of nasolacrimal duct opening stenosis. [8]

A study by Moon et al included 5 cases of CSF rhinorrhea, 2 cases needed an extended nasoseptal flap with inferior turbinate flap only and 3 cases needed an extended nasoseptal flap with lateral wall flap with no post operative CSF leak, one case complicated with nasolacrimal duct opening stenosis and treated by Dacryocystorhinostomy (DCR). [8]

2-6-Double (bilateral) nasoseptal flap

It is preferred to be done by two teams, a team for each side for harvesting the flaps and for reconstruction of the dural defect, in this modification, the surgeon start with right side harvesting the flap with removal of the vomer and sphenoid rostrum, the contralateral flap should be harvested along the line of removed vomer and rostrum. [18]

A study by Kim et al included 17 bilateral nasoseptal flap out of 92 cases of nasoseptal flap and contralateral rescue flap, success rate 100%. [18]

2-7-Reverse nasoseptal flap (reverse Hadad flap)

Using a contralateral anteriorly based pedicled nasoseptal flap to cover the doner side of the original Hadad flap, this reverse flap is rotated posteriorly 180o, it is beneficial when posterior septectomy is extended anteriorly, this gives the length to the contralateral flap to cover the donor side. [19]

A study by Kasemsiri et al, included 47 skull base lesions of variable pathologies, they did nasoseptal flap for reconstruction with reverse flap to cover the donor site, one case showed failure (2%). [19]

The following table 1 entails outcome of different studies used nasoseptal flaps and its modifications in reconstruction skull base defects.

3-Middle turbinate flap (MTF)

In this entity of endonasal pedicled flap the mucoperiosteum of both medial and lateral surface of the middle turbinate is dissected with preserving the vascular supply, it gives up to 5.5 cm2 surface area and it is suitable to cover defects in fovea ethmoidalis and planum sphenoidale and to less extend sellar defect, this was firstly described on 6 cadaveric dissection (twelve middle turbinate flaps). [20]

Technique of harvesting this flap includes a vertical in the head of middle turbinate after proper decongesting the nose the incision extends horizontally and posterior on its medial surface just below cribriform plate of ethmoid, good precise dissection of the mucoperiosteal layer is done, then removing the bone of middle turbinate in piecemeal manner to prevent its avulsion and CSF leak, dissecting the lateral surface mucosa and may include mucosa over lacrimal bone, the mucosa will be like an open book, preserve the posterior attachment which carries the middle turbinate branch of sphenopalatine artery (figure 2). [20]

Figure 2: A diagram illustrates technique of harvesting the middle turbinate flap 20

A study by Simal-Julian et al, has applied middle turbinate flap on 10 cases, 8 pituitary macroadenoma and 2 CSF rhinorrhea at anterior cranial base, they reported 100% success rate.

21 Another use in a study by Chen et al, authors have used the pedicled middle turbinate flap to reconstruct the surgical bed after endoscopic nasopharyngeal resection of 18 patients with recurrent nasopharyngeal carcinoma after failed chemoradiotherapy, this is carrying the advantage to cover the prevertebral muscle and to protect the petroclival segment of the internal carotid artery, on the other hand it may prevent early detection of recurrence, they reported failure of reconstruction in 3 cases (16%). [22]

A study by Elmorsi et al conducted on 31 patients of CSF rhinorrhea from anterior cranial fossa, they used a septal graft supported by middle turbinate flap, they reported failure in 4 cases (13%).[23]

Another different indication in the study by Hanci et al, not included cranial base defects, they used the middle turbinate flaps to repair septal perforations in 31 cases, they reported failure in 2 patients (6.5%). [24]

Tamura et al have reported a study of 3 cases of anterior cranial base pathology, 2 cases of spontaneous CSF leak and a case of Schwannoma with 

no postoperative CSF leakage after reconstruction by middle turbinate flap. 25 Another study by Amin et al, middle turbinate flap was conducted on twenty-five cases of CSF leak after endoscopic transsphenoidal pituitary surgery, they reported failure in one case (4%), they also reported that the surface area of this flap can reach to 9.5 cm2. [26]

Wang et al have included 4 cases, 2 pituitary, 1 craniopharyngioma and 1 spontaneous CSF leak, all cases were reconstructed by using fascia lata graft aided by middle turbinate flap with success rate 100%. 27 on the other hand a study by Manimaran et al conducted on 13 cases of anterior cranial base non tumorous lesions, 10 cases of CSF leak, 3 cases of meningocele, they reported failure rate in 3 cases (23%). [28]

A recent study by Carnevale et al, middle turbinate flap was conducted on 25, 7 of them with gasket seal technique, they reported postoperative leak in one case who did gasket seal technique, failure rate 3 %. [29] Another recent study by Kento et al on one case of spontaneous CSF rhinorrhea from cribriform plate of ethmoid and fovea ethmoidalis reconstructed by middle turbinate flap with no post operative complications or failure. [30]

The following table 2 entails outcome of different studies used middle turbinate flaps in reconstruction skull base defects.

4-Inferior turbinate flap

Posterior pedicled Inferior Turbinate flap (PITF)

In this type of flaps surgeons preserve the mucoperiosteum of both sides of inferior turbinate, technique includes proper decongesting the nose, vertical incision on the anterior end of inferior turbinate, the incision passes in sagittal direction towards nasopharynx, this helped by gentle medialization of the inferior turbinate for proper visualization of lateral surfaces. Then dissection of the mucoperiosteal layer of the inferior turbinate is done with preserving the posterior attachment which carries the vascular pedicle containing the inferior turbinate branch from the sphenopalatine artery, the bony turbinate is removed (figure 3). This is more suitable to cover defects in clivus and to less extend sellar defects and it provides about 4.5 cm2. [31]

Figure 3: A cadaveric illustration of anterior dissection of both sides of inferior turbinate mucoperiosteum 31

 A study by Fortes et al included 4 cases, 2 cases of clival chordoma, one case of clival basilar artery aneurysm, one case of pituitary macroadenoma, were reconstructed by inferior turbinate flap with success rate 100%. [31]

In a study by Yib et al, they reported two cases of revision endoscopic transsphenoidal pituitary surgery with utilized nasoseptal flaps in the prior surgeries, scarifying both old nasoseptal flaps was done and new reconstruction with posterior pedicled inferior turbinate flap with no postoperative leak. 32 The same in the study by Boetto et al, two revision cases of clival chordoma, they used the inferior turbinate flap in the new reconstruction after utilized nasoseptal flaps in prior surgeries, no post operative leak. [33]

An old study by Vuyk et al used the posterior pedicled inferior turbinate flap to repair anterior small septal perforations in 31 cases, this surgery required a second stage to section the posterior pedicle of the flap after requiring its vascularity from the recipient site. This study reported failure in 10 cases to cover the septal perforation (33%). [34] Another study by Friedman et al, used this flap in septal perforations in 10 cases, reported failure in 3 cases (30%). [35]

4-2-Anterior pedicled Inferior Turbinate flap (AITF)

In this flap the incision started from posterior end of the inferior turbinate with preserving the pedicle anteriorly carrying the vascular branch from anterior ethmoidal artery. More suitable to reconstruct the anterior skull base defects. [3] A study by Gil et al, seven cases of anterior skull base reconstruction using the anterior pedicled inferior turbinate flap, 4 of these 7 cases were supported with nasoseptal flap due to wide defects, authors reported no post operative CSF leak.[36]

The following table 3 entails outcome of different studies used inferior turbinate flaps in reconstruction skull base defects and septal perforations.

5-Lateral wall flaps

5-1-Posterior pedicled lateral nasal wall flap (PLNW)

Technique starts with proper decongesting the nasal cavity, followed by middle meatal antrostomy with preserving the mucoperiosteum on lacrimal bone anterior to uncinate process as it will be included in the flap, a vertical incision is done anterior to inferior turbinate extends upward, a second posterior vertical incision is done in front of the Eustachian tube on medial pterygoid plate, both incision connected to each other by horizontal incision below the inferior turbinate and include a portion of nasal floor mucoperiosteum, dissection started with elevation of the mucoperiosteum of both sides of the inferior turbinate and lateral nasal wall with preserving the middle turbinate, the flap is posterior pedicled (figure 4), suitable for sellar and clival defects, it provides about 13 cm2 surface area. [37,38]

Figure 4: A diagram illustrating the posterior pedicled lateral nasal wall flap 38

A study by Lavigne et al included 24 cases, 13 chordomas, 6 pituitary adenomas, 3 meningiomas, 1 neuroblastoma, 1 chondrosarcoma, reconstructed by lateral nasal wall flap, they reported failure in 6 cases (24%). 37 Another study by Rivera-Serrano et al has included four cases of middle and clival cranial fossa defects, they used the lateral nasal wall flap with no failure rate, and what is worth to mention that the authors called it Carrau-Hadad Flap (C-H flap). [39]

A study by Alobid et al included three large septal perforations, they reported failure rate 16?tween incomplete repair and post operative nasal obstruction. [40]

 5-2Anterior pedicled lateral nasal wall flap (ALNW)

Same technique as posterior pedicled lateral wall flap but the pedicle would be anterior in front of the middle turbinate (figure 5). [41]

Figure 5: A diagram illustrating the anterior pedicled lateral nasal wall flap 41

A study by Hadad et al included three case of anterior cranial base lesion, two cases of neuroblastomas and one case of meningoencephalocele, reconstructed by anterior pedicled lateral nasal wall flap, with no post operative failure, it is worth to mention that the authors called it Hadad Bassagasteguy 2 Flap (HB 2 flap). [42]

A different study by Langdon et al included one case of nasal carcinoma, plastic reconstruction of the nasal skeleton is aided by anterior pedicled lateral nasal wall flap. [41]

The following table 4 entails outcome of different studies used lateral wall flaps in reconstruction skull base defects & septal perforations and external nasal skeleton.

Table 4: Outcome of lateral nasal wall flap in different studies

6-Anterior ethmoidal artery based septal flap (AEA flap) (Castel Nuovo flap)

Mainly used for repairing anterior septal perforations, based on a pedicle of anterior ethmoidal artery branches. Technique started by proper decongestion of the nasal cavity and refreshing the edge of septal perforation, 

a vertical incision is done on the septum just behind the perforation, a second vertical incision is done on the septum 1 cm behind the level of axilla of middle turbinate, the two incisions connected to each other including the nasal floor mucoperiosteum, then dissection and anterior rotation to cover the septal hole (figure 6). [43]

Figure 6: A diagram illustrates the fashioning of anterior ethmoidal artery based septal flap in repairing septal perforations 43

Four studies by Castel Nuovo et al, Santamaria-Gadea et al, Cavada et al, Alobid et al included 11, 6, 13, 2 patients of septal perforations in order, all showed no failure rate. [43-46] On the other hand a study by Atallah et al included 14 patients with failure rate 28.6%. [47]

A different study by Elhassan et al, they used the AEA flap in recontraction the frontal sinus defects instead for septal perforation, the study included 3 

cases, one case of CSF leak from posterior frontal wall, one case of meningocele, one case of frontoethmoidal osteoma with 100% success rate. [48]

The following table 5 entails outcome of different studies used anterior ethmoidal artery base septal flaps in reconstruction skull base defects and septal perforations.

Table 5: Outcome of anterior ethmoidal artery septal flap in different studies

7-Vomer-Rostrum flap

A very recent study by Goates et al has been published few days ago describing what is called vomer-rostrum flap, it’s a limited posterior septal flap, the authors used it on four patients, 2 cases of fungal ball and 2 cases of sphenoiditis, one of them underwent 2 prior sphenoidotomy. This flap aims to limit restenosis of sphenoid ostium by covering the hyperostotic bone by mucosal flap. Technique started with ethmoidectomy and sphenoidotomy, the incision started the rostrum of sphenoid then passes anteriorly to the septum then descent on the septum to reach the level just above the vomer bone, dissection is done with removal the bony rostrum and vomer, wide sphenoidotomy is completed with lining the ostium and the cavity with this flap, the study reported success in all patients with no restenosis after following up 6 months. [49]

8-Posterior septal flap in surgery of choanal atresia (swinging door flap)

Technique entails a vertical incision on the posterior part of the septum just anterior to atretic choana from above downward and extends to nasal floor until reach the lateral nasal wall (L-shaped), the flap then dissected with keeping upper and lateral attachment (figure 7). The aim is to line the newly developed tunnel and to limit restenosis. [50]

Figure 7: An endoscopic view illustrates the use of posterior septal flap after repairing choanal atresia 50

A study by Stamm et al included this flap on 33 patients of choanal atresia, 10 (30%) cases showed restenosis after 1 year follow up. [50] Another study by Nour et al, included 14 neonates of choanal atresia managed by using this flap aided by stenting, with no restenosis on long term follow up.[51]

Adegboyega et al, they included 12 cases, 5 of them showed restenosis (41%). 52 On the other hand a study by Wormald et al on 17 cases managed by the flap without stenting, no cases showed restenosis on long term follow 

up.[53] The same with Mladina et al, used this flap on one case 14 years old, with no restenosis. [54] A study by Tomoum et al included 72 patients divided into 2 groups, 42 managed by flap without stenting and 30 managed by stent without flap, restenosis was lower in the 1st group (21%) comparing to that of the 2nd group (33%). [55]

The following table 6 entails outcome of different studies used posterior septal flaps in reconstruction after choanal atresia surgery.

Table 6: Outcome of swinging door posterior septal flap in different studies

Although this article is a review to demonstrate different types of endonasal flaps and their outcome, it is worth to mention other extra nasal distant flaps were and still being used inside the nasal cavity, usually require both endoscopic and open approaches, radial artery based lipofascial forearm flap has been mentioned in literature as a method of trans nasal skull base reconstruction, it needs a multidisciplinary team, time consuming, needs to access the neck vessels subcutaneously through Caldwell-Luc antrostomy to get vascularity. A prior trial was to use the anterolateral thigh flap carries cosmetic complications and difficult techniques, other nearby flap like pericranial, temporoparietal and Oliver palatal flaps were used before using the endonasal mucosal lining for reconstructing cranial base defects. [56,57]

It’s also worth to mention that the use of endonasal flap usually aided by other materials, the materials may be allografts like fascia Lata graft from 

lateral aspect of the thigh to lie between the defect and flap (gasket seal closure) also fat tissue from anterior abdominal wall or lateral aspect of the thigh is used. Literature also mentioned the 3F technique (Fat + Fascia + Flap) for better sealing of the defect, other synthetic materials were also used as fibrin glue or surgical.

 For better covering and sealing a huge surface area defects many authors have to used more than one endonasal flap e.g., combined Nasa septal flap with middle turbinate flap. [5,9,12,15,16]

The following table 7 entails summary of outcome of different endoscopic endonasal flaps in this study’s articles

N/A: Not Available

Table 7: Summary of outcome of different endoscopic endonasal flaps in this study’s articles

Conclusion

Endonasal flaps give surgeons many solutions for reconstruction of the cranial base after extended endonasal skull base surgeries, they carry the advantages of being nearby, carry their blood supply, easy to harvest and no cosmetic drawbacks. Little complications like crustations, hyposmia and some degree of nasal obstruction may be noted.

Still there is a challenge in some cases who have generalized nasal mucosal diseases like granulomas or Mucor mycosis or hypo perfused nasal mucosa like in cocaine addicts or sever cold weather countries; in such patient it may be difficult to use the endonasal cavity mucosa for reconstruction.

References

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Perlat Kapisyzi

Dear Reader: We have published several articles in the Auctores Publishing, LLC, journal, Clinical Medical Reviews and Reports in recent years (CMRR). This is an ‘open access’ journal and the following are our observations. From the initial invitation to submit an article, to the final edits of galley proofs, we have found CMRR personnel to be professional, responsive, rapid and thorough. This entire process begins with Catherine Mitchell, Editorial Coordinator. She is simply outstanding, and, I believe, unparalleled in her capacity. I cannot imagine a more responsive and dedicated Editorial Coordinator. As I read the dates and timing of her correspondence with us, it seems that she never sleeps. I hope Auctores Publishing, LLC, appreciates her efforts as much as these authors do. Thank you to Auctores Publishing, LLC, to the Editorial Staff/Board, and to Catherine Mitchell from a grateful author(s).

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Dr Gary Merrill

Dear Maria Emerson, Editorial Coordinator of - Journal of Clinical Research and Reports. ''I am pleased to provide this testimonial following the publication of our recent case report in this journal. The peer review process was rigorous, constructive, thorough, and conducted in a timely manner. The reviewers’ comments were thoughtful, detailed, and highly constructive, contributing substantially to the refinement, clarity, and scientific robustness of our manuscript. The process was conducted with professionalism and academic integrity throughout. The support provided by the editorial office was exemplary. Communication was consistently prompt, clear, and courteous at all stages of the submission and publication process. The editorial team demonstrated a high level of organization and responsiveness, ensuring that all queries were addressed efficiently and that the process remained transparent and well-coordinated. The overall quality of the journal is reflected in its strong editorial standards, commitment to scientific excellence, and dedication to publishing clinically meaningful research. It has been a privilege to publish our work in this journal, and we would welcome the opportunity to contribute further in the future.'' Best wishes from, Dr. Efstratios Trogkanis, Cardiologist.

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Dr Efstratios Troganis

Dear Grace Pierce, Editorial Coordinator of the journal IJCCR, I had a very positive experience with Auctores - Journal throughout the publication process. The Editorial Team was highly responsive, professional, and supportive at every stage. I would like to extend my sincere thanks to the Editor: Grace Pierce, for her guidance and assistance. The peer-review process was smooth and constructive, helping improve the quality of my work. I would gladly recommend Auctores Journal to fellow researchers and authors. Dr. SABITA SINHA, Medical Oncologist, MD (Electro Homeopathy).

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Dr SABITA SINHA

Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.

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Dr Ted Christopher

International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.

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Joel Yat Seng Wong

Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.

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Dr Mamoun Magzoub

Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.

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Baciulescu Laura

Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal

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Christoph Maurer

Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.

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Dr Elena Salvatore

Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed

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Mahmoud Kamal Moustafa Ahmed

Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.

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Dr Meng-JouLe

Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell

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Dr Andriy Sinelnyk

I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.

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Edouard Kujawski

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.

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Dr Matteo Bonori

Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti

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Dr Claudio Ligresti

Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.

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Dr Chiara Giuseppina Beccaluva

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.

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Dr Aline Tollet

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.

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Dr Ravi Shrivastava

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora

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Dariusz Ziora

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.

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Dr Jelle Lettinga

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.

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Dr Walter F Riesen

Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.

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Dr Rakhi Mishra

Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.

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Hala Al Shaikh

Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD

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Dr Eric S Nussbaum

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.

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Dr Victor Olagundoye

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.

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Dr Farahnaz Fallahian

Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.

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Dr Oleg Golyanovski

To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina

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Dr Elvira Farina

My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.

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Gertraud Teuchert-Noodt

We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.

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Dr David Vinyes

Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.

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Dr Anyuta Ivanova

I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.

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Dr Farooq Wandroo

"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".

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Dr Shweta Tiwari

To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.

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Dr Tewodros Kassahun Tarekegn

I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.

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Cristina Berriozabal

Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."

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Thomas Urban

I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.

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Zhao Jia

My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.

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Luiz Sellmann

My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.

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Sonila Qirko

My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.

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Lin-Show Chin

Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner

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Dr Susan Weiner

Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”

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Zsuzsanna Bene

Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.

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Dr Maria Regina Penchyna Nieto

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.

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Dr Maria Dolores Gomez Barriga

Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.

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Maria Dolores Gomez Barriga

The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.

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Lin Shaw Chin

Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.

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Gomez Barriga Maria Dolores

Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.

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Khurram Arshad

Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.

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Rui Tao

“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.

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George Varvatsoulias

Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.

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Tania Munoz

I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.

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S Munshi

I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.

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Husain Taha Radhi

I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.

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Dr Tong Ming Liu

We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.

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Dr Griffith

I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.

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Douglas Miyazaki

"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".

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Jesus Simal-Gandara

I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!

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Baheci Selen

Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.

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Bruno Chauffert

Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.

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Dr Suramya Dhamija

International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.

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Andreas Filippaios

Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.

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Raed Mualem

As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.

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Dr Shiming Tang

Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.

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Hao Jiang

This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.

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Prof Sherif W Mansour

Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.

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Bernard Terkimbi Utoo

Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.

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Pedro Marques Gomes

Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.

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Anthony Kodzo-Grey Venyo

Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.

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Katarzyna Byczkowska

Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.

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Orlando Villarreal

The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.

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Sing-yung Wu

We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.

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Layla Shojaie

Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.

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Mina Sherif Soliman Georgy

Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.

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Ziemlé Clément Méda

Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.

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Delcio G Silva Junior

Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.

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Virginia E. Koenig