AUCTORES
Globalize your Research
Review Article | DOI: https://doi.org/10.31579/2766-2314/109
1 Plant Resources Study Group, Graduate Program in Natural Resources, Mato Grosso do Sul State University (UEMS), CP 351 79804-970, Dourados, Mato Grosso do Sul, Brazil.
2 Electrochemistry Study Group, Graduate Program in Natural Resources, Mato Grosso do Sul State University (UEMS), CP 351 79804-970, Dourados, Mato Grosso do Sul, Brazil.
*Corresponding Author: Etenaldo F. Santiago, Plant Resources Study Group, Graduate Program in Natural Resources, Mato Grosso do Sul State University (UEMS), CP 351 79804-970, Dourados, Mato Grosso do Sul, Brazil.
Citation: Pamela K. F. Silv, Simone Y. Fernandes, Debora de Araujo, Montcharles S. Pontes, Etenaldo F. Santiago, (2023), Natural Compounds as Active Ingredients for Potential New Bioherbicides: Towards Sustainable Weed Control, J, Biotechnology and Bioprocessing, 4(5); DOI: 10.31579/2766-2314/109
Copyright: © 2023, Etenaldo F. Santiago. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 20 July 2023 | Accepted: 31 July 2023 | Published: 08 August 2023
Keywords: allelochemicals; plant extracts; germination; natural compounds; bioherbicides
Plants have a great diversity of species and metabolic complexity. In the environment, they can interact between species by releasing chemical compounds, known as allelochemicals. This has aroused interest in the agricultural area due to the demand for environmentally friendly products, which cause less risk to human health and to the surroundings of cultivated areas. In this review we report results of plant extracts rich in allelochemicals that have herbicidal potential, since they alter the physiological responses of plants, being the percentage of germination, antioxidant activity and effect on the photosynthetic apparatus. This evidence strengthens the improvement of natural compounds as herbicidal active principles, as substitutes for chemical pesticides. Since the application of bioherbicides in agricultural crops are the subject of research and future applications in the field.
Associated with increase in urban population, we have a need to increase the food production (Satterthwaite et al., 2010). New technologies are developed for increase the food quality and food production; however, a concern raises about the environmental impact of these technologies to natural ecosystems. Nowadays, the production challenge based on sustainable principle depends on the collaborative efforts for understand the functioning of ecological production systems, aiming to maintenance of the relationship among production, organisms and natural environment (Mensah and Casadevall 2019).
Currently, pesticides are the major inputs used for food production in agricultural activity, these compounds have important bioactivity (Ngegba et al., 2022), specially, biocidal activity against living organisms that cause damages to cultivated plant species. Among the pesticides (agrochemicals), herbicides are the most used class of active compounds, based on synthetically formulated product. Herbicides are used to inhibits growth and development of weeds, causing weed organism death or controlling their development (Holt et al., 2013). Thus, decrease the competition of crop plants with alien weed species. Additionally, as example of commercial formulations used as herbicide we have glyphosate, 2,4-D, paraquat, atrazine, trifluralin and others, with distinct modes of action.
Since its discovery, herbicides represent a great leap in agricultural activity, increase significantly the plant productivity (Holt et al., 2013). According to their mode of action, herbicides could be classified in two basic categories: post-emergent those whose effective activity occurs on developed plants and pre-emergent herbicidesshowed its activity as inhibit seed germination (Holt et al., 2013; Sherwani et al., 2014).
Associated with the increased useof conventional pesticides in agriculture and their recognized risks to human health and the environment, alternative inputs that allow and increase food production to ensure food security are desirable (FAO 2017).
Environmentally friendly products for weed control, has a grow demand in the last decades. Bioherbicidesor biopesticides are products based on natural substances as an active ingredient, among their sources we have plants or plant compounds, they stand out due to the high production of biomolecules that inhibit/reduce seed germination and development of weed plants. Additionally, studies with focus on increasing and diversifying its applicationhas increased greatly in recent years (Hasan et al., 2021). Bioherbicides have some advantages over synthetic herbicides, such as their specific performance based on plant allelopathic responses, less resistance, and environmentally friendly behavior (Archana et al., 2022).
In this context, essential oils (EOs) produced by diverse plant tissues and species, may present a great bioherbicide action depending on the plant species source, usually aromatic plants (i.e., rosemary (Salvia rosmarinus), lemongrass (Cymbopogon citratus), eucalyptus (Eucalyptus spp.) present secondary metabolites associated with plant resistance or defense mechanism to pest and predators (Ootani et al., 2013; Lima 2020). These metabolites present a great potential to act as novel natural herbicides. Thus, considering the relevance of design novel ecofriendly agrochemical inputs, the present study shows environmentally sustainable alternatives in potential pre-emergent bioherbicides for control seed germination are presented.
The term plant allelopathy refers to the interaction between plants that receive or release compounds (called allelochemicals) that influence plant growth, being stimulus or inhibition responses (Hickman et al., 2021). Exploring the mode of action of allelopathic plant compounds and their application in agriculture can help in the implementation of sustainable systems. This application can be carried out by extracting allelochemicals from plants and applied to the target species, being great substitutes for synthetic pesticides. Seed germination inhibition responses, low plant growth and lower residue levels are found after use (Polechonska et al., 2020).
The allelochemical compounds of plants that influence the reduction of plant parameters gain prominence in the economic sector and are soon called botanical bioherbicides (Scavoand Mauromicale 2021). Bioherbicides have some advantages over synthetic herbicides, such as specificity in their performance, pathogens develop less resistance to microbial products, and respect for the environment, as they are produced naturally (Fernández and Juncosa 2002).
Among the parts of the plant, the leaves were described as the main organs for the extraction of allelopathic compounds, which were treated as a crude extract without necessarily having described the major compounds, the essential oils extracted by hydrodistillation or others, such as maceration, extraction by solvent. Although other parts of plants such as seeds, roots, stems, among others show allelopathic behavior, the extraction of compounds from the leaves is the most common way to obtain these products, since the leaves are usually easier to access for the practice of collection (Zanfano et al., 2022).
Table 1: Plant species and their parts with potential use for bioherbicide
3.1. Inhibition of seed germination
The large-scale use of agrochemicals causes environmental and human health risks. This has aroused the need for investments in technologies that make the production of agricultural systems more efficient. In this sense, research involving the interaction of active principles of plants with pesticide potential has shown promising results (Pacheco and Buzea, 2018; Prata et al., 2018), also stand out as an environmentally friendly alternative (Table 2).
Table 2: Seed germination response exposed to bioherbicide extracts
Percentage germination (%G); control (C); treatments (T).
In view of this, another indispensable parameter to be investigated is the toxicity of the constituents of natural products to non-target organisms and human health, especially if the purpose is its use as a more environmentally friendly pesticide, that is, a biopesticide.The term biopesticide should be interpreted as a technological mechanism, from plant derivatives, microorganisms or biochemical substances that aim to reduce, eliminate and/or control target organisms (pests), implying a different technique from conventional agricultural practices with industrial agrochemicals (Ferraz et al., 2021).
The use of essential oils in agriculture also stands out as an agent for controlling pathogens and invasive plants, as these compounds inhibit seed germination and/or the development of other plants that are nearby (Werrie et al., 2020; Maes et al., 2021). Study species Brassica pekinensis, Lactuca sativa, Oryza sativa, Portulaca oleracea, Oxalis corniculata and Setariaviridis showed reduction and/inhibition in germination when exposed to aqueous extract, pure ethanol and ethanol/water from Artemisia argyi leaves (Li et al., 2021). Results by Setyowati et al. (2021), describe the bioherbicidal activity of Sorghum root extract with effect of reducing the germination of Oryza sativa and Vigna radiata.
Considering the diversity of flora (especially tropical flora), compounds with properties for applications such as bioherbicides are produced, however, most of them lack certification to reach the level of production. This can be verified by the registration of active ingredients used in commercialized biopesticide products, which is prepared by the United States Environmental Protection Agency.
3.2. Enzymatic inhibition
Among the effects on plants caused by the application of EOs are the changes in enzymatic activity (Zhao et al., 2017). These changes of increase or decrease in enzyme activity occur due to the mechanism of recognition of stress compounds in plant metabolism. According to Fu et al. (2017), reactive oxygen species (ROS) are the first signaling for abnormalities in
plant metabolism. Initially, the oxygen produced by the photosynthetic reaction can be converted to reactive forms such as superoxide ion (O2), singlet oxygen (O2), peroxide ion (O2), hydrogen peroxide (H2O2) and hydroxyl radical (HO) during electron transfer reactions (Apel and Hirt, 2004). It is important to define that the low content of ROS perform a signaling function to the damage caused by oxidation in plant cells. However, high ROS contents (oxidative burst) are harmful to seeds, leading to irreversible phytotoxicity such as loss of phospholipids, imbalance of fatty acids and disruption of plasma membranes (Hasanuzzaman et al., 2020).
The ROS cleaning mechanism in plants includes enzymatic and non-enzymatic activity and their action occurs in specific cellular compartments. Non-enzymatic detoxification includes the action of flavonoid, phenolic and carotenoid compounds linked to primary defense against biotic and abiotic stresses, in addition to being directly linked to light stress (Santos et al., 2020).
The enzymatic defense of ROS includes the action of superoxide dismutase (SOD), catalase (CAT), peroxidase (POD) and peroxidase ascorbate (APX). Based on the process of formation and defense of ROS, a sophisticated interaction between reactive molecules and antioxidant enzymes acts. As the formation of superoxide ion (O2) is associated with damage to the plasma membrane (Gomes and Garcia, 2013), consequently, the control occurs through the enzyme superoxide dismutase (SOD), which catalyzes the reaction transforming O2 into molecular oxygen. (O2) and hydrogen peroxide (H2O2). However, the reaction promoted by SOD generates another ROS that is even more harmful to germination, with H2O2 being linked to membrane deterioration by the association of O2 molecules on fatty acids. The activated enzymes catalase (CAT) and peroxidase (POD) act in the detoxification of H2O2. The loss of CAT and POD activity is related to cellular deterioration, that is, lipid peroxidation occurs and, therefore, leads to loss of germinal potential. As soon as the H2O2 continues in the intercellular medium, it triggers the enzyme ascorbate peroxidase (APX) that uses the H2O2 electron oxidation reaction medium that results in the release of H2O (Kurutas, 2015; Moraldes and Bosch, 2019) (Figure 1).
Studies are reported in the literature on the effect of oils on plant enzyme activity. (Benchaa et al., 2018; Gharsan et al., 2022). Han et al. 2021, points out that the antioxidant activity of SOD and POD enzymes were reduced in seeds of Poa annua, Setaria viridis, Amaranthus retroflexus and Medicago sativa species exposed to different concentrations (0.25; 0.50; 1; 2; 5 mg mL1) of Ambrosia artemisiifolia L. essential oil, therefore, the analysis of the enzyme activity of plants exposed to EOs provides reliable answers, in order to attribute reliability in the data set to obtain a new bioherbicide.
Figure 1: Mode of action of antioxidant enzymes in the presence ROS.
3.3. Effect on photosynthesis
Plant compounds act directly on the photosynthetic apparatus, altering the photosynthesis yield, pigment content and consequently plant development (Travaini et al., 2016; Radhakrishnan et al., 2018; Hasan et al., 2021). Such compounds present in plant extracts are classified by phenolics, flavonoids, alkaloids, terpenoids (Altemimi et al., 2017). Therefore, understanding the interaction of bioactive compounds in the photosynthetic apparatus strengthens its importance for new formulations of bioherbicides (Jinxin etal., 2022).
Results by Al-Johani et al. (2013), show that extracts of Chenopodium murale inhibited photosynthesis of Hordeum vulgare plants and significantly reduced the chlorophyll content. Chlorophyll a and chlorophyll b content were reduced in plants of Raphanus sativus variety sativus treated with aqueous extract of Hypericum perforatum (Hypericaceae) (Godlewska et al., 2021).The application of extracts from roots of Helianthus annuus L. in sinapis alba seeds decreased the parameters of maximum fluorescence (Fm) and initial fluorescence (Fo)(Pula et al., 2020).
In view of this, the chlorophyll fluorescence technique helps in the investigation of the effects of plant extracts and is advantageous to fill knowledge gaps, since the advance in the management of crop groups requires increasingly friendly sources with the environment. Study by Carvalho et al. (2016), investigated the site of interaction of plant extracts Plucheasagittalis, and leaves of Cecropia palmata and Brachiaria brizantha in photosystem ii of Spinacea oleracea through chlorophyll a fluorescence, the level of Fm decreased in treated plants, while control plants maintained optimal levels of fluorescence.
The application of synthetic herbicides has been increasing the population's concern for a healthier diet and better environmental quality, with this the search for alternative inputs has been growing in the market. Therefore, allelopathic effects related to plants´ bioactive secondary compounds have shown promising results as bioherbicides are considered less aggressive to the environment and non-target organisms. Although the idea of substituting completely the conventional agrochemical pesticides for biopesticides seems to be in a distant future, the use of these natural compounds is reality, especially for organic systems of production. However, the incorporation of biopesticides for use in large-scale agriculture needs to break some barriers since the tradition of farms using agrochemicals with faster and visible results, the market power of the agricultural inputs companies, the gaps of knowledge about natural compounds and target organisms, and other challenges. Finally, despite the difficulties, natural compounds generate some commercial and environmental perspectives, since their use is considered a sustainable method. Studies are still needed on the subject, to facilitate the creation of methods to integrate these compounds in the production chain, reducing costs, as well as inducing consumers to give preference to agrochemical pesticide-free food, also contributing to the incorporation of technology in agricultural production systems, an important step to Brazil in front of the challenger of reducing to zero deforestation until 2030 allied to the increase in food production.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
