AUCTORES
Globalize your Research
Case report | DOI: https://doi.org/10.31579/2578-8949/182
1Assistant Prof of Neurology, Department of Internal Medicine Department, Faculty of Medicine, Thamar University, Yemen
2Department of Clinical Pharmacy, Wenzhou Medical University, Wenzhou, Zhejiang, PR, China
*Corresponding Author: Khaled Saleh, Assistant Prof of Neurology, Department of Internal Medicine Department, Faculty of Medicine, Thamar University, Yemen
Citation: Khaled Saleh; Ali Ahmed Al-Zaazaai, (2024), Tanning Melanotan Jabs and Nasal Spray: Safe or Not? Dermatology and Dermatitis, 11(3); DOI :10.31579/2578-8949/182
Copyright: © 2024 Khaled Saleh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly Cited.
Received: 23 November 2024 | Accepted: 05 December 2024 | Published: 20 December 2024
Keywords: metronidazole; hepatic encephalopathy
Metronidazole is a widely used drug in day-to-day gastro-enterology practice. It is prescribed for conditions like Crohn’s disease, intra-abdominal abscess, infection with Helicobacter pylori, hepatic encephalopathy, and Recurrent Pyogenic Cholangitis (RPC) [1]. Metronidazole is fairly safe and well tolerated but can induce toxicity of the central nervous system, which is also referred to as metronidazole-induced encephalopathy [2].
Metronidazole is a widely used drug in day-to-day gastro-enterology practice. It is prescribed for conditions like Crohn’s disease, intra-abdominal abscess, infection with Helicobacter pylori, hepatic encephalopathy, and Recurrent Pyogenic Cholangitis (RPC) [1]. Metronidazole is fairly safe and well tolerated but can induce toxicity of the central nervous system, which is also referred to as metronidazole-induced encephalopathy [2]. Three types of symptoms have been reported: seizures, cerebellar dysfunction, and acute changes in mental status. These symptoms can develop alone or in combination [2]. Brain MRI on T2-weighted FLAIR images reveals abnormalities, most commonly within the cerebellar dentate nuclei and corpus callosum. The third cerebral ventricle was sandwiched by bilateral cerebellar dentate nuclei, taking the form of a “chestnut.” The abnormality within the cerebellar dentate nuclei has thus been termed the “Chestnut Sign” in Japan, where several cases of metronidazole-induced encephalopathy have been reported [3].
A 50-year-old male patient presented with progressively worsening difficulty in talking, imbalance during walking, mental confusion, headache, and weakness over the past 3 days
The patient had a known case of decompensated alcohol-related cirrhosis of the liver with ascites, portal hypertension, and a history of recurrent hepatic encephalopathy.
At the presentation, his medical history showed that he had been using metronidazole (500 mg three times daily) for more than a year. On examination, he was inicteric and afebrile. The patient was drowsy with mild mental confusion but was easily arousable and oriented in time, place, and person.
Neurologic examination revealed dysarthria, bilateral horizontal gaze nystagmus, positive Romberg's sign, positive bilateral finger nose test, wide base stance and gait, and impaired tandem walking suggestive of cerebellar-type ataxia. Asterixis was absent. Laboratory parameters on admission were normal.
Neurotoxicity is one of the most important adverse effects of
metronidazole therapy. The exact mechanism of metronidazole toxicity has not yet been elucidated [1]. Rao and Mason report that catecholamine neurotransmitters reduce the efficacy of 5-nitroimidazole drugs such as metronidazole and generate both semiquinone and nitroanion radicals [4]. These radicals are proposed to cause nervous tissue damage. Because of the reversibility of the MR imaging changes, the cause of the changes is most likely due to “axonal swelling with increased water content”, not axonal demyelination [5]. Metronidazole can cause irreversible neurotoxicity to the supratentorial white matter, and the mechanism of encephalopathy may differ from that of cerebellopathy. In addition, it can be inferred that MRI including DWI may have a role in diagnosis and the prediction of the prognosis of metronidazole-induced encephalopathy [6]. MR imaging findings exhibit typical abnormalities. High signal intensities in the globus pallidus on T1-weighted images have been established as a characteristic finding on MR images in chronic hepatic encephalopathy, and recent data have shown that white matter abnormalities can also be detected [7]. However, cerebellar lesions have rarely been observed in MRI studies, and there are a few reports describing abnormal T2 high signal intensities in superficial and deep cerebellar white matter including the brachium pontis in patients with acquired hepa- to cerebral degeneration [8]. In Mulcahy's study, the cerebellar lesions were the only demonstrated lesion on MR imaging [9]. A case report presented a patient with metronidazole-induced encephalopathy with contrast-enhanced lesions followed by permanent damage in the form of cystic changes [10].
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
