AUCTORES
Globalize your Research
Research Article | DOI: https://doi.org/10.31579/2693-7247/060
1 Department of Chemistry, AUEC (A), Visakhapatnam.
2 Department of Chemistry, MVR College, Visakhapatnam, Andhra Pradesh 530026, India.
3 Department of Chemistry, St. JOSEPHS COLLEGE FOR WOMEN (A), Gnanapuram.
*Corresponding Author: Venkata Kishore, Department of Chemistry, AUEC (A), Visakhapatnam, India.
Citation: V Kishore, T Rao, A Deepthi, N Annapurna. (2021). Method Development of an Analytical Procedure for the Determination of Clofarabine in Pharmaceutical Formulations. J. Pharmaceutics and Pharmacology Research. 4(5); DOI: 10.31579/2693-7247/060
Copyright: © 2021 Venkata Kishore, This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 25 November 2021 | Accepted: 08 December 2021 | Published: 13 December 2021
Keywords: clofarabine; RP-HPLC; method development; validation; ICH guidelines
A novel, simple and economic high performance liquid chromatography (HPLC) method has been developed for the estimation of Clofarabine in bulk and tablet dosage form with greater precision and accuracy.The method was validated as per ICH guidelines. Validation studies demonstrated that the proposed HPLC method is simple, specific, rapid, reliable and reproducible. Hence the proposed method can be applied for the routine quality control analysis of Clofarabine in bulk and tablet dosage forms. All the components of the system are controlled using SCL-10Avp System Controller. Data acquisition was done using LC Solutions software.
For many years, the Southern Research Institute has had a programme, supported by the US National Cancer Institute, searching for new nucleoside anticancer drugs. In the early 1980s, two adenine-containing nucleosides, now known as fludarabine (Fludara; Berlex Oncology) and cladribine (Leustatin; Ortho Biotech) were in clinical trials. At the time, it was not clear whether either drug would gain approval by the FDA because some concerns were raised during preclinical and clinical development of these agents. Both drugs were susceptible to glycosidic bond cleavage with fludarabine subject to some phosphorylase cleavage and cladribine subject to both hydrolytic and enzymatic cleavage [1].
Clofarabine administered intraperitoneally had significant activity against a wide variety of human tumourxenografts implanted subcutaneously in athymic nude or severe combined immune deficiency mice [2]. Moderate to excellent sensitivity to tumour growth delays were seen in all eight human colon tumours, three out of four human renal tumours, all four non-small-cell lung tumours, and all three prostate tumours. This spectrum of widespread anticancer activity has been confirmed by other investigators in human tumourxenograft models in mice [3]. The anticancer activity of clofarabine was dose- and schedule-dependent, and greater antitumour activity was associated with more frequent administration [4].Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5'-triphosphate metabolite, which inhibits the enzymatic activities of ribonucleotide reductase and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA [5-7].
Acute leukaemia is the most common paediatric cancer, with acute lymphoblastic leukaemia (ALL) and acute myelogenous leukemia (AML) being the two most common types. In the United States alone, ~2,000 children are diagnosed each year with ALL and 500 with AML [8]. Successful treatment of paediatric ALL and AML involves intensive, multi-cyclic therapy with multiple drugs that have various mechanisms of action and dosing regimens [9-10]. Such intense, cyclic treatment regimens with many different agents have reported a projected 5-year disease-free survival of 70% for paediatric patients with ALL and a complete response (CR) rate of 90% in certain forms of childhood acute leukaemia [11].
In this regard and view of the need for a suitable analytical HPLC method for routineanalysis of Clofarabinein formulations.Attempts were made to developsimple, precise and accurate analytical methods for estimation of Clofarabineand extend it for their determination in formulation.
The aim of the method is to develop an analytical procedure for the determination of Clofarabine in Pharmaceutical Formulations. The analytical procedure for determination of Assay in finished product of Clofarabine Injection, 1mg/mL is an In-House procedure.
The method shall be validated for the following parameters:
Precision
Specificity
Intermediate Precision
Accuracy
Robustness
Stability of Analyte in solution
System Suitability of overall validation study.
Instrumentation,Chromatographic Conditions & Method:
The Chromatographic system consisted of a Shimadzu Class VP Binary pump LC-10ATvp, SIL-10ADvp Auto sampler, CTO-10Avp Column Temperature Oven, SPD-10Avp UV-Visible Detector. All the components of the system are controlled using SCL-10Avp System Controller. Data acquisition was done using LC Solutions software.
The mobile phase consisted of 85:15 (v/v) of buffer solution and acetonitrileoperated on isocratic mode. The flow rate is 1.0 ml/min. Chromatographic Estimation of Clofarabinewas performed onInertsil ODS-2 (150 x 4.6) mm, 5µm column. The wavelength of detection is 263 nm. The injection volume is 25µL.
Chromatographic conditions
A High Performance liquid chromatography equipped with UV detector and an auto sampler or its equivalent
Column : Inertsil ODS-2 (150 x 4.6) mm, 5µm
Detection wavelength : 263 nm
Flow rate : 1.0 mL / min
Injection volume : 25µL
Run time : 10 min
Column temperature : 40°C
Sample cooling rack : 25°C
Standards
Clofarabine working standard.
Preparation of Buffer Solution
Dilute 1.0 mL of Glacial acetic acid in 1000 mL of water and mix.
Preparation of Mobile phase
Mix buffer solution and acetonitrile in 85:15 (v/v) portion, sonicate well.
Preparation of Diluents
Methanol 0.9% sodium chloride
Preparation of 0.9% Sodium Chloride Solution
Weigh and transfer accurately 0.9 g of sodium chloride into 100 mL volumetric flask dissolve and make up to the volume with water.
Preparation of Blank
Dilute 1.0 mL of methanol in 10 mL volumetric flask and make up to the mark with 0.9 % sodium chloride solution.
Preparation of Standard Solution
Weigh and transfer about 30 mg of Clofarabine standard in a 50 mL volumetric flask. Add about 10 mL of methanol and sonicate to dissolve. Make up to the volume with methanol and mix well. Transfer 5 mL of above solution in to 50 mL volumetric flask, dilute and make up to the volume with 0.9% sodium chloride solution.
Note:Standard solutions are stable up to 48 hrs at both room temperature and 2-8°C.
Preparation of Test Solution
Transfer 3.0 mL of sample solution into 50 mL volumetric flask. Add 5.0 mL methanol and 30 ml of 0.9% sodium chloride and mix well. Dilute up to the mark with 0.9% sodium chloride solution.
Note:Test solutions are stable up to 48 hrs at both room temperature and 2-8°C.
Procedure
Separately inject each solution into the chromatographic system in the following order.
Blank - Single injection
Standard solution - Five injections
Test solution - Two injections
Standard solution bracketing - Single injection.
Experimental:
Intermediate Precision
Intermediate precision expresses within-laboratories variations such as different days, different analysts, different columns, different equipment’s etc. Ruggedness incorporates the concept described under the terms “Intermediate Precision” as defined in USP <1225>.
Intermediate precision is established by doing same exercise as system and method precision by different analyst on different day using different column and different equipment. The same Lot/Batch of standard and sample were used within the laboratory. The results of Intermediate Precision are tabulated in below table. Comparison of Method Precision and Intermediate Precision result is summarized in the table below.
Acceptance Criteria:
The result meets the acceptance criteria and found comparable, indicates that the method is precise and rugged with respect to analyst to analyst, day to day, column to column and equipment to equipment for its intended use.
The robustness of an analytical procedure is a measure of its capacity to remain unaffected by small, but deliberate variations in method parameters and provides an indication of its reliability during normal usage. Robustness study is performed by analyzing the standard at different conditions. The results obtained with altered conditions are compared against results obtained under normal chromatographic conditions.
Variation in Flow Rate (± 0. 2 mL/min.)
The standard was carried out by varying the flow rate of mobile phase to 0.8 mL/min. and
1.2 mL/min. in place of actual flow rate 1.0 mL/min. The results are summarized in the below table. Typical chromatogram of Robustness for variation in flow rate (0.8 mL/min and 1.2 mL/ min) is exhibited below.
Variation in Column Oven Temperature (± 2°C)
The standard was carried out by varying the column oven temperature of 38°C and 42°C in place of actual column oven temperature 40°C. The results are summarized in the below table. Chromatogram of Robustness for variation in Column Oven Temperature (38°C and 42°C) is exhibited below.
Variation in Organic composition (142.5 and 157.5)
The standard was carried out by varying the Organic composition 142.5 mL and 157.5 mL in place of actual the 150mL. The results are summarized in the below table. Chromatogram of Robustness for variation in the Organic composition (142.5 mL and 157.5 mL) is exhibited below.
Acceptance Criteria:
The System suitability defined in test procedure should meet in each condition.
System suitability of overall validation study
The System suitability is an integral part of analytical procedure. The tests are based on the concept that the equipment, analytical operations and samples to be analyzed constitute an integral system that can be evaluated as such. The system suitability results are tabulated in the below Table.
The analytical procedure for Assay is validated and found suitable for its intended use and it meets the acceptance criteria for:
Specificity:
No Interference should be observed at the retention time of peak in the chromatograms obtained from the diluent and the placebo solution.
Forced Degradation:
The method is specific and stability indicating for its intended use.
Linearity:
The analytical procedure is linear within the concentration range from 50 % to 150 % (30.24µg/mL to 90.72µg/mL) for Clofarabine peak
Intermediate Precision:
The method is precise and rugged with respect to analyst to analyst, day to day, column to column and equipment to equipment for its intended use.
Accuracy:
The analytical test procedure is accurate for its intended use.
Robustness:
The test method is robust enough as demonstrated by altering the Flow rate, Column oven temperature and Organic composition.
Stability of analyte in solution:
The Standard solution is stable up to 48 hours and sample solution is stable up to 48 hours at room temperature and 2-8°C for Clofarabine peak.
The data for each validation characteristic described in this report meets the acceptance criteria with respect to Specificity, Forced degradation, Stability of analyte in solution, Linearity, Precision, Intermediate Precision, Accuracy and Robustness.
The validation results reveal that the analytical procedure is suitable for determination of Assay in ClofarabineInjection, 1mg/mL. The method is stability indicating for determination of Assay of Clofarabine in Clofarabine Injection, 1mg/mL.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
