info@auctorespublishing.com
+1-(302)-520-2644
+1-(302)-520-2644

Medicinal Plants for The Treatment of Obesity

  1. Home
  2. Journals
  3. International Journal of Clinical Case Reports and Reviews
  4. Archives
Submit Guidelines

Review Article | DOI: https://doi.org/10.31579/2690-4861/294

Medicinal Plants for The Treatment of Obesity

  • Tahreem Riaz 1
  • Muhammad Akram 1
  • Umme Laila 1
  • Ibrahim M. Hamouda 2,3*

1 Department of Eastern Medicine, Government College University Faisalabad Pakistan.

2 Professor of Dental Biomaterials, College of Dentistry, Umm Alqura University, Makkah, KSA.

3 Professor of Dental Biomaterials, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.

*Corresponding Author: Ibrahim M. Hamouda, Professor of Dental Biomaterials, College of Dentistry, Umm Alqura University, Makkah, KSA.

Citation: Riaz T., Akram M., Laila U., Ibrahim M. Hamouda, (2023), Medicinal plants for the treatment of Obesity. International Journal of Clinical Case Reports and Reviews. 13(2); DOI: 10.31579/2690-4861/294

Copyright: © 2023 Ibrahim M. Hamouda, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Received: 08 February 2023 | Accepted: 15 February 2023 | Published: 23 February 2023

Keywords: obesity; therapeutic plants; anti-obesity mechanism; weight loss; dietary supplements

Abstract

A persistent increase in morbidity indicators has been connected to the global epidemic of obesity; it is regarded as a societal issue & poses significant health dangers. Synthetic medications and surgery are examples of therapeutic approaches; both have high prices and potentially dangerous side effects. Plant-based drugs provide an alternative strategy. Traditional uses of medicinal plants are one of the options for treating obesity, and they help with the development and research of obesity phytotherapy. In this review, we provided information regarding plant species along with their mode of action used for the effective treatment of obesity. It was revealed that the species in the catalogue had anti-obesity properties, including actions to slow down the absorption of fat, reduce enzymatic activity, mediate lipid levels, and boost the effects of lipolysis, which were primarily linked to phenolic compounds. For species with phenolic compounds in their chemical components, more thorough botanical, chemical, pre-clinical, and clinical research are especially required. The safe therapy for obesity may involve taking standardized medicinal plant extracts. The effectiveness of some plant combinations for medical purposes, however, may be reduced, and they may also have unanticipated negative effects

Introduction

The increasing intake of high-calorie meals is the primary cause of obesity, which is regarded as a global epidemic as well as an energetic imbalance. Inactivity, environmental and social changes, particularly those affecting bargaining power and education levels, as well as the impact of others on food consumption are additional contributors [1-4]. Diabetes, osteoarthritis, dyslipidaemias, and musculoskeletal problems, including endometrial, breast, and colon cancer, are all linked to obesity [5]. Additionally, clinically apparent cardiac risk factors associated with obesity include hypertension, glucose intolerance, insulin resistance, and a high body mass index [6, 7]. Since 1980, the rates of morbidity and death have risen [8,9], making them a social issue that has attracted institutional and governmental attention [10]. Children under five who were obese numbered close to 42 million in 2013. In 2014, there were approximately than 1.9 billion overweight individuals, of whom and over 600 million were obese.

Correct diagnosis is essential to selecting the optimal course of treatment for obesity [11]. There are many integrative and complementary therapies, including diet plans, exercise, surgery, behavioural therapy, lifestyle changes, and medication-assisted treatments for hypnosis, drug addiction, acupuncture, or the utilisation of therapeutic plants [12, 13]. 

Because they are non-invasive, pharmacological approaches are advised for the obese person's treatment. Medications such as sibutramine, fluoxetine, sertraline, orlistat, and topiramate are among those that are advised [14]. However, since they could exacerbate the clinical picture in people with cardiovascular problems, these should be used with extreme caution.

Many people turn to alternative remedies when conventional medical treatments for chronic conditions are ineffective and ultimately dangerous. Plant-based medicines that may promote satiety, a quicker pace of weight reduction, and a higher metabolism are included in these treatments. Currently, dietary supplement-based weight loss treatments are common, indicating that ethno pharmacology & phytotherapy may be effective weight loss and preventive methods.

Plants are used medicinally because of ethno botanical and ethno pharmacological research that examines their potential for curing and preventing a wide range of illnesses. These methods draw on common knowledge, hence the conventional has grown in significance to science. Such methods also aid in the choice of study species & the creation of phototherapeutics drugs based upon ethno pharmacological research [15, 16].

In this respect, species of plants have evolved crucial for producing isolated & extract chemical components that are the basis for the creation of medicines for obesity. To ensure solid, secure, and dependable outcomes, all the factors that identify a plant as an unconventional treatment option for the treatment of illnesses must be systematically evaluated or the creation of treatment solutions, which take into consideration the cultural, social, environmental, & economic disparities between nations, evidence-based public policies, must be developed. Setting constraints for that goal and fostering knowledge exchange amongst producers, researchers, developers, and businesses are both facilitated by translational research.

Based upon the aforementioned factors, Species of plants are listed in this study which have been ethno pharmacologically mentioned as prospective remedies for obesity. These plants also possess the pharmacological potential to be turned into phototherapeutic drugs. The goal is to direct future ethno pharmacological, pre-clinical, and clinical research in the pursuit of therapeutic alternative treatments and the advancement of public health.

Anti-obesity mechanism of therapeutic plants

1. Inhibition of enzymes

Treatment for obesity has included targeting the inhibition of dietary fat breakdown and absorption. In order for triglycerides to be broken down into mono & diglycerides and smaller fatty acids that the body can absorb, it is known that the most significant enzyme, known as PL (Pancreatic Lipase), is involved. Researchers and medical professionals agree that a PL inhibitor can lessen fat breakdown, which in turn reduces fat assimilation and absorption. In obese patients, this can simulate a reduction in calorie consumption and aid in preventing further weight gain.

Due to research showing that obese people have higher levels of lipoprotein lipase (LPL), the therapy of obesity has also included targeting this enzyme. As LPL catalyses the dissolution of blood triglycerides to release free fatty acids (FFA), which increases the buildup of triglyceride in adipose tissue, suppression of LPL is envisaged to lower assimilation of FFA and assist in the control of obesity [43]. Treatment for type 2 diabetes mellitus is mostly focused on inhibiting the enzymes responsible for metabolism and digesting of carbohydrates. Because carbs make up the majority of calories consumed by humans in their meals, it could also be taken into account and relevant in study on obesity. These enzyme inhibitors reduce postprandial hyperglycemia by slowing down carbohydrate metabolism, which delays hydrolysis of glucose to triacylglycerol in adipose tissue [44].

2. Inhibition of adipogenesis

The primary energy reserve in both humans and animals is called white adipose tissue (WAT), and this is where extra energy is kept in the form of triglycerides. The equilibrium of such a process determines how well energy intake and output are balanced, which is known as metabolic homeostasis and regulates body weight. Rapid weight gain has been caused by an imbalance in energy consumption and energy expenditure. In contrast to peripheral tissues like the muscles & adipose tissue, the centralized nervous system, especially the hypothalamus, controls and coordinates energy consumption and expenditure. It has been suggested that a sophisticated network of both long- and short-term signals controls how much energy is consumed. These signals, which include neuropeptides that regulate hunger and metabolism known as orexigenic and anorexigenic neuropeptides, are absorbed by the hypothalamus [45, 46].

Triacylglycerols are recruited to make up for the shortage of energy during periods of energy restriction or hunger. One of the main causes of the predominance of obesity in the modern society is believed to be an overabundance of WAT [47]. The process of forming additional adipocytes from precursor cells, which leads to an increase in the volume of the adipocyte, is known to be involved in the expansion of adipose tissue. The development of anti-obesity-associated bioactivities has been linked to therapies that control adipocyte size and number, expression of signals related to energy balance, and inhibition or increase of particular adipokines [48].

3. Appetite suppression

In order to create long chain fatty acids from acetyl coenzyme A and malonyl-CoA, fatty acid synthase (FAS) is known to catalyse a reductive reaction. It has been demonstrated that FAS inhibition can lower food consumption & body mass in mice given FAS inhibitors. As a result, FAS inhibition is a prospective treatment goal to reduce appetite & promote lose a lot of weight [49].

Numerous plants & the compounds they produce have been demonstrated to inhibit FAS, which has a detrimental effect on appetite. Green tea's epigallocatechin gallate was discovered to be a potent inhibitor of chicken liver FAS by both irreversible slow binding and reversible quick binding. Similar to known FAS inhibitors like cerulenin and the synthetic FAS inhibitor C75, the inhibitory effects were equivalent to those of these substances [50].

Medicinal plants with anti-obesity activity

In medicine and as nutritional supplements, natural plant compounds are frequently used. Natural products are nearly as old as living itself because they have been used from the beginning of human civilization on this planet. Recent years have seen a significant increase in interest in dietary phytochemicals as potential treatments for weight loss and health enhancement. Natural compounds have long been a prolific source for the development of new medications due to their diversity in chemical composition and capacity to act on a variety of biological targets, and these drugs are used in the majority of alternative and complementary systems. Plant medicines with numerous phytochemical combinations may have a synergistic impact by acting on many biological targets, providing benefits above therapies that just use one component. The following table represent anti-obesity potential of some medicinal plants with their mechanism of action.

Table: Medicinal plants with anti-obesity mechanism.

Conclusion

According to several in vivo investigations on the effectiveness of anti-obesity herbal remedies, they might work by promoting thermogenesis, reducing lipogenesis, boosting lipolysis, stifling appetite, and lowering lipid absorption. Different outcomes may result from using isolated or combined anti-obesity medicinal plant remedies. In conclusion, consuming single medicinal plants through food may be safer and more effective than consuming concoctions made from multiple medicinal plants. These results corroborate the advice of health organisations to regularly consume vegetables and particular herbs like curcumin, capsicum, ginger, & green tea. It is important to keep raising awareness of anti-obesity medication use and enticing obese people to take it, along with an improved exercise routine & a nutritious diet. Further research in the fields of chemistry, biology, and medicine is required to determine whether some medicinal plants, especially which are used as spices & condiments, can reduce and treat human obesity. Such anti-obesity information would be helpful for food & medication producers when novel goods are produced, as well as for governments in regulating food stuffs as a strategy to encourage and improve public health.

References

  1. Cohen-Cole E, Fletcher JM. (2008). Is obesity contagious? Social networks vs. environmental factors in the obesity epidemic. J Health Econ. 27:1382–1387.
    View at Publisher | View at Google Scholar
  2. Hardy LL, Mihrshahi S, Gale J, Nguyen B, Baur LA, et al. (2015). Translational research: are community-based child obesity treatment programs scalable? BMC Public Health. 15:652.
    View at Publisher | View at Google Scholar
  3. McLaren L. (2007). Socioeconomic status and obesity. Epidemiol Rev. 29:29–48.
    View at Publisher | View at Google Scholar
  4. Maalik A, Khan FA, Mumtaz A, Mehmood A, Azhar S, et al. (2014). Pharmacological applications of quercetin and its derivatives: a short review. Trop J Pharm Res J Cit ReportsScience Ed. 13:1561–1561.
    View at Publisher | View at Google Scholar
  5. Weir MR. (2009). The obesity paradox: impact of obesity on the prevalence and prognosis of cardiovascular diseases. Postgrad Med. 121:164–165.
    View at Publisher | View at Google Scholar
  6. Klein G, Kim J, Himmeldirk K, Cao Y, Chen X. (2007). Antidiabetes and anti-obesity activity of Lagerstroemia speciosa. Evid Based Complement Altern Med. 4:401–407.
    View at Publisher | View at Google Scholar
  7. Ogden CL, Kit BK, Fakhouri THI, Carroll MD, Flegal KM. (2014). The epidemiology of obesity among adults. GI Epidemiol Dis Clin Methodol Second Ed. 394–404.
    View at Publisher | View at Google Scholar
  8. Organization WWH. (2016). No Title. Obes Overweight. 1.
    View at Publisher | View at Google Scholar
  9. Harvey JR, Ogden DE. (2014). Obesity treatment in disadvantaged population groups: where do we stand and what can we do? Prev Med (Baltim), 68:71–75.
    View at Publisher | View at Google Scholar
  10. Yanovski SZ. (2011). Obesity treatment in primary care-are we there yet? N Engl J Med. 365:2030–2031.
    View at Publisher | View at Google Scholar
  11. Dickel ML, Rates SM, Ritter MR. (2007). Plants popularly used for losing weight purposes in Porto Alegre, South Brazil. J Ethnopharmacol. 109:60–71.
    View at Publisher | View at Google Scholar
  12. City INNEWY. (2008). Special Article. J Med. 346:982–987.
    View at Publisher | View at Google Scholar
  13. Apovian CM, Aronne LJ, Bessesen DH, McDonnell ME, Murad MH, et al. (2015). Pharmacological management of obesity: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 100:342–362.
    View at Publisher | View at Google Scholar
  14. Liu J, Lee J, Hernandez MAS, Mazitschek R, Ozcan U. (2015). Treatment of obesity with celastrol. Cell. 161:999–1011.
    View at Publisher | View at Google Scholar
  15. Albuquerque UP De, Hanazaki N. (2006). As pesquisas etnodirigidas na descoberta de novos fármacos de interesse médico e farmacêutico: fragilidades e pespectivas. Rev Bras Farmacogn. 16:678–689.
    View at Publisher | View at Google Scholar
  16. de Albuquerque UP, Monteiro JM, Ramos MA, de Amorim EL. (2007). Medicinal and magic plants from a public market in northeastern Brazil. J Ethnopharmacol. 110:76–91.
    View at Publisher | View at Google Scholar
  17. S. I. Koo, and S. K. Noh. (2007). Green tea as inhibitor of the intestinal absorption of lipids: potential mechanism for its lipid-lowering effect. The Journal of Nutritional Biochemistry. 18 (3): 179-183.
    View at Publisher | View at Google Scholar
  18. H. Okuda, L. Han, Y. Kimura et al. Anti-Obesity Action of Herb Tea. (Part 1). Effects or Various Herb Teas on Noradrenaline-Induced Lipolysis in Rat Fat Cells and Pancreatic Lipase Activity. Japanese Journal of Constitutional Medicine. 2001, 63 (1/2): 60-65.
    View at Publisher | View at Google Scholar
  19. T. Hsu, A. Kusumoto, K. Abe et al. Polyphenol-enriched oolong tea increases fecal lipid excretion. European journal of clinical nutrition. 2006, 60 (11): 1330-1336.
    View at Publisher | View at Google Scholar
  20. F. Martins, T. M. Noso, V. B. Porto et al. Maté tea inhibits in vitro pancreatic lipase activity and has hypolipidemic effect on high-fat diet-induced obese mice. Obesity. 2009, 18 (1): 42-47.
    View at Publisher | View at Google Scholar
  21. S. A. Kang, K. Hong, K. H. Jang et al. Altered mRNA expression of hepatic lipogenic enzyme and PPARα in rats fed dietary levan from Zymomonas mobilis. The Journal of Nutritional Biochemistry. 2006, 17 (6): 419-426.
    View at Publisher | View at Google Scholar
  22. S. Jun, E. Jung, D. Kang et al. Vitamin C increases the fecal fat excretion by chitosan in guinea‐pigs, thereby reducing body weight gain. Phytotherapy Research. 2010, 24 (8): 1234-1241
    View at Publisher | View at Google Scholar
  23. K. Ishihara, S. Oyaizu, Y. Fukuchi et al. A soybean peptide isolate diet promotes postprandial carbohydrate oxidation and energy expenditure in type II diabetic mice. The Journal of nutrition. 2003, 133 (3): 752-757.
    View at Publisher | View at Google Scholar
  24. S. Haaz, K. Fontaine, G. Cutter et al. Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update. Obesity reviews. 2006, 7 (1): 79-88.
    View at Publisher | View at Google Scholar
  25. A. T. Roberts, C. K. Martin, Z. Liu et al. The safety and efficacy of a dietary herbal supplement and gallic acid for weight loss. Journal of medicinal food. 2007, 10 (1): 184-188.
    View at Publisher | View at Google Scholar
  26. H. Maeda, M. Hosokawa, T. Sashima et al. Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice. J. of Agricultural and Food Chemistry. 2007, 55 (19): 7701-7706
    View at Publisher | View at Google Scholar
  27. H. Maeda, M. Hosokawa, T. Sashima et al. Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochemical and biophysical research communications. 2005, 332 (2): 392-397.
    View at Publisher | View at Google Scholar
  28. H. Maeda, T. Tsukui, T. Sashima et al. Seaweed carotenoid, fucoxanthin, as a multi-functional nutrient. Asia Pac J Clin Nutr. 2008, 17 (S1): 196-199.
    View at Publisher | View at Google Scholar
  29. D. E. Walsh, V. Yaghoubian, and A. Behforooz. Effect of glucomannan on obese patients: a clinical study. Int J Obes. 1984, 8 (4): 289-293
    View at Publisher | View at Google Scholar
  30. J. H. Kim, D. H. Hahm, D. C. Yang et al. (2005). Effect of Crude Saponin of Korean Red Ginseng on High Fat DietInduced Obesity in the Rat. Journal of pharmacological sciences. 97 (1): 124-131.
    View at Publisher | View at Google Scholar
  31. F. Lei, X. N. Zhang, W. Wang et al. (2007). Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. Int J Obes (Lond). 31 (6): 1023-9
    View at Publisher | View at Google Scholar
  32. W. J. Pasman, J. Heimerikx, C. M. Rubingh et al. (2008). The effect of Korean pine nut oil on in vitro CCK release, on appetite sensations and on gut hormones in post-menopausal overweight women. Lipids in Health and Disease. 7 (10): 7-10
    View at Publisher | View at Google Scholar
  33. S. Smyth, and A. Heron. (2006). Diabetes and obesity: the twin epidemics. Nature Medicine. 12 (1): 75-80.
    View at Publisher | View at Google Scholar
  34. H. J. Kim, I. Y. Bae, C. W. Ahn et al. (2007). Purification and identification of adipogenesis inhibitory peptide from black soybean protein hydrolysate. Peptides. 28 (11): 2098-2103.
    View at Publisher | View at Google Scholar
  35. J. Udani, M. Hardy, and D. C. Madsen. (2004). Blocking carbohydrate absorption and weight loss: a clinical trial using Phase 2™ brand proprietary fractionated white bean extract. Alternative medicine review. 9 (1): 63-69.
    View at Publisher | View at Google Scholar
  36. S. Ambati, J. Y. Yang, S. Rayalam et al. (2009). Ajoene exerts potent effects in 3T3‐L1 adipocytes by inhibiting adipogenesis and inducing apoptosis. Phytotherapy Research. 23 (4): 513-518.
    View at Publisher | View at Google Scholar
  37. H. Maeda, M. Hosokawa, T. Sashima et al. (2006). Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. International journal of molecular medicine. 18 (1): 147-152.
    View at Publisher | View at Google Scholar
  38. N. Bai, K. He, M. Roller et al. (2008). Active compounds from Lagerstroemia speciosa, insulin-like glucose uptakestimulatory/inhibitory and adipocyte differentiation-inhibitory activities in 3T3-L1 cells. Journal of agricultural and food chemistry. 56 (24): 11668-11674.
    View at Publisher | View at Google Scholar
  39. G. Klein, J. Kim, K. Himmeldirk et al. (2007). Antidiabetes and anti-obesity activity of Lagerstroemia speciosa. Evidence Based Complementary and Alternative Medicine. 4 (4): 401-408.
    View at Publisher | View at Google Scholar
  40. F. Van Heerden. (2008). Hoodia gordonii: A natural appetite suppressant. Journal of Ethnopharmacology. 119 (3): 434-437.
    View at Publisher | View at Google Scholar
  41. C. L. Hsu, and G. C. Yen. (2007). Effects of capsaicin on induction of apoptosis and inhibition of adipogenesis in 3T3- L1 cells. Journal of agricultural and food chemistry. 55 (5): 1730-1736.
    View at Publisher | View at Google Scholar
  42. J. Ahn, H. Lee, S. Kim et al. (2010). Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/β-catenin signaling. American Journal of Physiology-Cell Physiology. 298 (6): C1510- C1516.
    View at Publisher | View at Google Scholar
  43. A. L. Woollett, D. C. Beitz, R. L. Hood, and S. Aprahamian. (1984). An enzymatic assay for activity of lipoprotein lipase, Analytical Biochemistry, vol. 143, no. 1, pp. 19–25,
    View at Publisher | View at Google Scholar
  44. N. D. Yuliana, M. Jahangir, H. Korthout, Y. H. Choi, H. K. Kim, et al. (2011). Comprehensive review on herbal medicine for energy intake suppression, Obesity Reviews, vol. 12, no. 7, pp. 499–514.
    View at Publisher | View at Google Scholar
  45. S. Barcelo-Batllori and R. Gomis, Proteomics in obesity research, Proteomics, vol. 3, no. 2, pp. 263–278.
    View at Publisher | View at Google Scholar
  46. G. Morton, D. E. Cummings, D. G. Baskin, G. S. Barsh, and M. W. Schwatz. (2009). Central nervous system control of food intake and body weight, Nature, vol. 443, no. 7109, pp. 289–295, 2006.
    View at Publisher | View at Google Scholar
  47. F. M. Gregoire, C. M. Smas, and H. S. Sul. (1998). Understanding adipocyte differentiation, Physioligical Reviews, vol. 78, no. 3, pp. 783–809.
    View at Publisher | View at Google Scholar
  48. S. Rayalam, M. A. Della Fera, and C. A. Baile. (2008). Phytochemicals and regulation of the adipocyte cycle, The Journal of Nutritional Biochemistry, vol. 19, no. 11, pp. 717–726.
    View at Publisher | View at Google Scholar
  49. T. M. Loftus, D. E. Jaworsky, G. L. Frehywot et al., (2000). Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors, Science, vol. 288, no. 5475, pp. 2379–2381.
    View at Publisher | View at Google Scholar
  50. X. Wang and W. Tian, (2001). Green tea epigallocatechin gallate: a natural inhibitor of fatty acid synthase, Biochemical and Biophysical Research Communication, vol. 28, no. 5, pp. 1200–1206.
    View at Publisher | View at Google Scholar

Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.

img

Virginia E. Koenig

Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.

img

Delcio G Silva Junior

Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.

img

Ziemlé Clément Méda

Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.

img

Mina Sherif Soliman Georgy

We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.

img

Layla Shojaie

The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.

img

Sing-yung Wu

Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.

img

Orlando Villarreal

Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.

img

Katarzyna Byczkowska

Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.

img

Anthony Kodzo-Grey Venyo

Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.

img

Pedro Marques Gomes

Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.

img

Bernard Terkimbi Utoo

This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.

img

Prof Sherif W Mansour

Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.

img

Hao Jiang

As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.

img

Dr Shiming Tang

Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.

img

Raed Mualem

International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.

img

Andreas Filippaios

Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.

img

Dr Suramya Dhamija

Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.

img

Bruno Chauffert

I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!

img

Baheci Selen

"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".

img

Jesus Simal-Gandara

I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.

img

Douglas Miyazaki

We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.

img

Dr Griffith

I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.

img

Dr Tong Ming Liu

I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.

img

Husain Taha Radhi

I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.

img

S Munshi

Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.

img

Tania Munoz

“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.

img

George Varvatsoulias

Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.

img

Rui Tao

Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.

img

Khurram Arshad

Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.

img

Gomez Barriga Maria Dolores

The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.

img

Lin Shaw Chin

Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.

img

Maria Dolores Gomez Barriga