AUCTORES
Globalize your Research
Research article | DOI: https://doi.org/10.31579/2578-8868/225
1Neurosurgery Department, MUSTAPHA PACHA University Hospital, Algiers, Algeria
2Neurosurgery Department ALI AIT IDIR Hospital Health Establishment, Algiers, Algeria
*Corresponding Author: K.Badache, Neurosurgery Department, MUSTAPHA PACHA University Hospital, Algiers, Algeria
Citation: K.Badache, N. Habchi, F /Z. Bendib, F.Bouchnaki, W. Abdelaoui et all. (2022). Management of Choroid Plexus Papillomas. J. Neuroscience and Neurological Surgery. 11(2); DOI:10.31579/2578-8868/225
Copyright: © 2022 K.Badache, This is an open-access article distributed under the terms of The Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Received: 10 December 2021 | Accepted: 27 December 2021 | Published: 03 January 2022
Keywords: choroid plexus papillomas; intraventricular tumor and surgical excision
Introduction: Choroid plexus papillomas are rare neuroepithelial tumors found primarily in children. It represents less than 1% of all central nervous system tumors.
Materials and methods: A retrospective study including 14 patients with choroid plexus papilloma tumors were performed at the Neurosurgery Department in Ait IDDIR Health Hospital Establishment between January 2010 and December 2017. In each case, diagnosis was made clinically and confirmed radiologically and histo-pathologically. All patients were operated.
Results and discussion: The mean age was 26 years (ranged 3 months –48 years) .In our department, we grouped together 14 cases of choroid plexus papilloma tumors. For mortality we had one case who died during surgery, survival rate for 04 years is 100% .We had not recurrence during the study period.All patients had intracranial hypertension (HIC) without neurological deficit and benefited from brain CT, MRI and an Angiography. The location of the tumor was: Lateral ventricle, Fourth ventricle, Third ventricle. All patients underwent surgical excision with or without ventriculo-peritoneal shunt.
Conclusion: Choroid plexus papillomas are rare neuroepithelial tumors, typically considered benign lesions, derived from the choroid plexus and appear like cauliflower.
Choroid plexus papillomas (CPP) are a rare neuroepithelial tumors found primarily in children.
It represents less than 0.5-1% of all central nervous system tumors. They represent 2-5% of CNS tumors in children [1].
CPPs are benign tumors that grow slowly. They correspond to growths and appear as reddish, papillomatous tumors (compare to cauliflowers) [2].
Materials and Methods
Between January 2010 and December 2017, 14 cases of patients with Choroid Plexus tumors were treated, these are 9 male patients and 5 female (sex ratio: 1.8: 1) whose Age: 3 months - 48 years (average age: 26). We have 10 children / 4 adults.Localization to the lateral ventricles was found in 58% (8 cases), fourth ventricle at 21% (3 cases), at the third ventricle in 14% (2 cases) and in the cerebellar ponto angle 7% (1 case).Clinical manifestations are represented by an intracranial hypertension syndrome in 80% of cases (headache, nausea, vomiting), It may be a Macrocrania (tense fontanelle) 21% of cases, signs of cerebral focalizations are observed in only 7% of cases (signs of deficiency), Cerebellar Ataxia including 14% of cases, Deafness in 7% of cases, Intra-ventricular haemorrhage 7% of cases and cries of epilepsy in 14% of cases.Complementary examinations are based on CT event, all of our cases benefited from this rapid examination allowing a definite diagnosis (figures 1, 2 and 3). MRI allowed us to better appreciate the tumor morphology and its extension through the ventricle (figure 4). Angiography identifies the vascularization (a process highly vascularized by the choroidal arteries), Echo trans fontanel was performed for children under 10 months. Figure 1, 2 and 3Surgical excision was performed in all cases allowing the tumor to be removed iin total in 65%, subtotal 35% of cases. Ventriculoperitoneal bypass by pre and post operative valve in 68%.The operative consequences were presented by a transient neurological motor deficit 2/3 cases which is due to a cortectomy (intraventricular PCP), an intraventricular hematoma in1 case, an aphasia in 1 case, a persistent Hydrocephaly in 2 cases, an infection and fistula of the CSFin 4 cases, Cognitive impairment in 1 case, Ascites in 1 case due to the ventriculo-peritoneal derivation and in whom subsequently a ventriculoatrial derivation was performed.The survival time is 36 months, we observed no recurrence in the case of total excitation during the study period and in the event of subtotal excitation the cerebral MRI was performed every 6, the recurrence is 14% of cases. Mortality in one per-operative case, Survival for 5 years is 100%NO RECURRENCE in cases of total EXERSE during the study period.
Choroid plexus papillomas is a rare, benign, intraventricular tumor, very common in children very rare in adults, 2-5% of pediatric brain tumors (1and 2). It is considered as rare, benign, intraventricular tumor.The lateral ventricles, readily the ventricular junction, rarely the 3rd ventricle and the ponto-cerebellar angle. The localization at the level of the 4th ventricle is especially encountered in adults [4].In our series these tumors are located in the regions where the choroid plexuses are usually located, i.e. the lateral ventricles (50%), the 3rd ventricle (5%) and the 4th ventricle (40%). More rarely, they develop at the level of the pontocerebellar angle.The first case was discovered by chance during an autopsy of a child who died of broncho-pneumopathy in 1833 by Guèrard, the first surgical excision was performed by Dandy in 1927, in 1933 Masson succeeded in performing a surgical excision with success. .The increase in intracranial pressure is the most frequent symptom most often due to obstruction of the CSF outflow pathways, disorder of CSF resorption and CSF hypersecretion by sustained tumor hyperproduction by several authors (Milhoart demonstrates that hyperproduction before the operation and markedly decrease after surgery); some Hydrocephalus which persists after surgery (1 case in our series).Cerebral meningeal hemorrhage from the tumor (highly vascularized tumor). Hence the importance of a cerebral angiography in our series allows the identification of vascularization (a process highly vascularized by the choroidal arteries) 21% of cases.Computed tomography (CT) and R.M.N have helped a lot in the diagnosis and in the treatment strategy; on CT Tumor aspect:, intraventricular process, intensely enhanced hyperdense, NMR: very important modalityUnfortunately, in our 71% of the cases, the form of a clearly contoured polylobed process with intraventricular extension (lateral ventricle, ventricular hub, fourth ventricle) was not available in all cases in our series.Treatment is surgical: all patients have undergone surgical excision with or without DVP, surgical excision should be as complete as possible.Surgical life depends on tumor location, the trans-frontal-Trans-cortical route has been useful for third ventricular lesions.
According to several authors (H. Yettou, JCMarchall) the frontal Trans cortical route is facilitated by the intra ventricular approach, the anatomical landmarks of the third ventricle, the interventricular foramen, the choroid plexus, thalamo -striated vein the section of this will allow the direct approach by the interthalamo-trigonal approach. the temporo-occipital pathway is indicated for Tumors which sit at the level of the ventricular crossroads through the T1 -T2 groove if the tumors sit at the Parieto-occipital level the surgical approach will be through P1 -P2, for tumors of the fourth ventricle the approach is the sub-occipital median way and if the tumors sit at the level of the ponto-cerebellar angle the approach is under the lateral occipital retroauricular, the drainage of hydrocephalus is done either by an external drainage at the time of the intervention (intraoperative) or by internal drainage through ventriculo-peritoneal drainage before surgical excision.The anatomo-pathological study of choroid plexus tumors shows macroscopically a Cauliflower appearance, a very vascular globular papillary mass of reddish color sometimes pinkish gray of variable size with an insertion on the choroid plexus by cons microscopically the histological appearance of the choroid plexus, an epithelium made up of a single layer of cubic or columnar cells with a basophilic nucleus with numerous villi. Davis described villous hypertrophy as gross hypertrophy.-Selective embolization will be helpful in reducing the degree of vascularity and may facilitate total resection [3].-The use of tractography, fMRI, and neuronavigation may minimize the risk of postoperative neurologic deficits when the tumor is near / in meaningful areas of the brain [4].
Choroid plexus papillomas are intraventricular lesions, histologically benign but highly vascular. The choice of surgical approach differs depending on the location of the lesion.Total resection offers good prognosis.Adjuvant therapies are not necessary. Total surgical exercise should be the goal in each case.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
