Life-Saving Procedure Cervical Cleavage Protects Precious Pregnancies in Particular

Case Report | DOI: https://doi.org/10.31579/2578-8965/318

Life-Saving Procedure Cervical Cleavage Protects Precious Pregnancies in Particular

  • Suresh Kishanrao

Family Physician & Public Health Consultant Bengaluru, India.

*Corresponding Author: Suresh Kishanrao, Family Physician & Public Health Consultant Bengaluru, India.

Citation: Suresh Kishanrao, (2026), Life-Saving Procedure Cervical Cleavage Protects Precious Pregnancies in Particular, J. Obstetrics Gynecology and Reproductive Sciences, 10(5) DOI:10.31579/2578-8965/318

Copyright: © 2026, Suresh Kishanrao. This is an open-access article distributed under the terms of The Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Received: 14 August 2026 | Accepted: 24 August 2026 | Published: 31 August 2026

Keywords: Septate uterus, CI= Cervical incompetency, MicroTSE = Microsurgical Testicular Sperm Extraction, ICSI= intracytoplasmic sperm injection, IVF=

Abstract

Cervical incompetency is a condition when the cervix of the uterus opens too early during pregnancy without pain or contractions. Main Causes of this condition are a) genetic- born with a weak or differently shaped uterus, b) connective tissue disorders, c) Injury from a previous birth and d) past surgery on the cervix. The condition is diagnosed by an ultrasound test to check the length of the cervix. The problem is fixed conservatively first by giving Progesterone to help keep the uterus calm, close monitoring, of all high-risk pregnancies. If that fails a small stitch put in the cervix to keep it closed until the fetus is 37 weeks old. 

Pregnancies of women in their mid-30s brings, or any uterine problems like septate uterus unique social and emotional advantages like emotional maturity and financial stability, alongside important biological considerations regarding fertility decline and health risks that require mindful medical tracking and prenatal care. Having a baby through IVF in mid-30s helps beat natural fertility decline. Egg quality and quantity drop fast after age 35. IVF increases the chances of getting pregnant. Women aged 35 to 37 have higher live birth rates with IVF than older age groups

This problem usually manifests in the second trimester. It can lead to early birth or loss of the baby. Common Signs include mild pelvic pressure, low back pain, cramps in the belly, change in vaginal discharge, light spotting. 

Materials and Methods: This article tries to address the problem of Cervical incompetency management through two precious cases of pregnancies. The most recent one, a rare case in New Delhi, India, an IVF twin pregnancy where the first twin was delivered following early cervical dilation at 19 weeks. An emergency cervical cerclage combined with high cord ligation and antibiotics allowed the remaining twin's pregnancy to successfully continue for over 17 weeks, culminating in a delivery past viability in a lady who continued the pregnancy and delivered through cesarean section in 37th week. The second case is also precious as the primigravida was lost due to septal uterus and cervical incompetence in early second trimester, followed by Cervical cleavage, conceiving delivering after about 18 months.

Introduction

Pregnancy refers to a time when a woman has fetus (one or multiple) developing in uterus. It most often happens after sexual intercourse, but it can also happen through assisted reproductive technologies (ARTs). A "precious pregnancy" is a medical and emotional term for a pregnancy that is heavily anticipated, achieved after a long struggle with infertility, or conceived via fertility treatments like IVF [2]. It also involves uterine problems like septate uterus, bicornuate uterus, uterine fibroids, endometrial polyps etc., cervical incompetency, advanced maternal age, higher medical risks like diabetes or pregnancy induced hypertension, & severe anemia needing extra specialized monitoring and management [3]. There is also higher likelihood of premature birth or needing a C-section delivery. Managing demands scheduled prenatal screenings & tests to identify adverse health conditions early.

Cervical incompetency is a condition when the cervix of the uterus opens too early during pregnancy without pain or contractions. This problem usually starts in the second trimester. It can lead to early birth or loss of the baby. Common Signs include mild pelvic pressure, low back pain, cramps in the belly, change in vaginal discharge, light spotting. Main Causes of this condition are a) genetic- born with a weak or differently shaped uterus, b) connective tissue disorders, c) Injury from a previous birth and d) past surgery on the cervix. The condition is diagnosed by an ultrasound test to check the length of the cervix. It is fixed by a small stitch put in the cervix to keep it closed. Progesterone is given to help keep the uterus calm, close monitoring, and regular visits with a high-risk pregnancy [3,4,5,6,7].

Pregnancy in a woman's mid-30s brings unique social and emotional advantages like emotional maturity and financial stability, alongside important biological considerations regarding fertility decline and health risks that require mindful medical tracking and prenatal care. Having a baby through IVF in mid-30s helps beat natural fertility decline. Women aged 35 to 37 have higher live birth rates with IVF than older women in their 40s. IVF cuts down the months of trying to get pregnant naturally. IVF twins most often result from the transfer of multiple embryos into the uterus, giving the couple double joy, just a miracle. IVF and other advanced fertility treatments make up under 2% of total overall annual births (25 million) out of a total 28 million pregnancies in 2026 in India. Assisted reproduction accounts for a vastly higher share about 30% to 40% of all multiple births nationwide due to multi-embryo transfers, a precautionary practice by the IVF centers in Inda. 

This article is based on two precious case reports, one very rare, almost like a miracle as the first baby of IVF twins at 19 weeks of pregnancy in January 2026 due to CI followed by cervical cleavage and continuation of the pregnancy leading to the second live birth through cesarean section 127 days after in May 2026. The second baby was also precious as the mother had both septal uterus and cervical incompetence during primigravida that had to be terminated, following cervical cleavage and septal resection was done and she delivered the second gravida to a baby- girl in August 2025.

Case Report:

Case 1 in Delhi: A woman aged 34 years with pregnancy of 19 weeks through IVF was brought to a private hospital in Delhi with severe lower abdominal pain [9]. An ultrasound showed that her cervix was opening too early. Her history revealed that her pregnancy had taken years to achieve as her husband was cancer survivor and chemotherapy had reduced his sperm count. The couple had undergone Micro-TESE, a surgical procedure to retrieve sperm from the testicles, followed by ICSI where a single sperm was injected directly into an ovum. The twins were Monozygotic where one embryo splits into two, which happens slightly more often in IVF than in natural pregnancy after long and difficult journeys.

By the time woman reached the hospital, labour had started. In such cases most gynecologists place a vaginal stitch at the external opening of the cervix. When the dilatation is progressed as was in this case vaginal stitch fails. The correct place to halt early labour is internal OS of the cervix, which can be reached either by Laparoscopy or Laparotomy or opening the abdomen. The Gynecologist decided to do Laparoscopic Cerclage which is stitching the cervix to prevent it from opening too early.

Procedure: Under general anesthesia the first twin was delivered prematurely as it had no life. The placentas did not separate and removing it would have triggered labour and risked the life of the other twin. The umbilical cord of the deceased twin was tied, left the placenta inside and did cerclage, The stitch held and labour stopped. The patient stayed in the hospital for a month, receiving appropriate antibiotics and monitoring. After discharge also she had blood tests & ultrasound every fortnight. The pregnancy slowly stabilized & retained placenta began functioning normally for the surviving twins, until completion of 37 weeks. In May 2025 the cervical cerclage was removed around the 37th week of pregnancy & she delivered a healthy baby girl weighing 3.27 Kg by cesarean section, both mother and Baby went home healthy. Today the girl is about a year old and healthy. 

Case 2: Ms. Shilpa, aged about 28 yrs., gave a pleasant message saying she was pregnant, completing 14 weeks on 19 October 2023. She and her husband Kiran were classmates in MPH course and had become very close to this author during 2020-2022. In the first scanning a septate uterus was identified and placenta was lying low, therefore classified as high-risk pregnancy. It was being managed conservatively with close antenatal monitoring. Then she had spotting after a week. Another scan on 22 November identified Cervical incompetence and single umbilical artery were diagnosed, for which she was given a cervical stitch on 22 November. During the cervical Cerclage surgeon found a membrane tear and mild leakage of amniotic fluid and were told that saving baby had hardly 50% chance. Anyway, stitch was put in, but for the next 2 days there was continued leakage despite being on antibiotics and full bedrest. Finally, a scan on 24th November showed no amniotic fluid and placenta previa with no chance of survival of the bay, as the heartbeat was very weak. Therefore, an MTP was done on 7 December 2023, and a surgical correction via Hysteroscopic Septal Resection. Fortunately, she became pregnant in late 2024 and gave birth to a baby girl in August 2025 without thanks to the Cervical Cerclage done in 2023 without any problem and baby would be celebrating first birthday on 25th August 2026.  

Discussions:

Human pregnancy lasts about 40 weeks (280 days) from the last menstrual period and is divided into three trimesters. Parturition (childbirth) is the active process of delivering the foetus and placenta, triggered by complex hormonal signals between the mother, foetus, and placenta. First Trimester of pregnancy (Weeks 1–13) includes fertilization, implantation of the blastocyst, organogenesis, and high human chorionic gonadotropin (hCG) levels. Second Trimester (Weeks 14–27) involves rapid growth, refinement of organ systems, and active movement felt by the mother. Third Trimester (Weeks 28–40): Maximum foetal weight gain, maturation of the respiratory system, and preparation for birth. Hormonal Regulation of Pregnancy involve a) Progesterone, which keeps the uterine muscle relaxed and quiet during gestation b) Oestrogen counters progesterone late in pregnancy to increase uterine sensitivity c) Placenta Secretes hormones like hCG, human placental lactogen (hPL), relaxin, and oestrogens to support foetal growth and maternal metabolic adaptation.                   

The Process of Parturition (Labor) includes i) Initiation: Foetal cortisol & placental oestrogen rise while progesterone declines, stimulating prostaglandins and oxytocin receptors ii) First Stage (Cervical Dilatation): Regular uterine contractions start; the cervix thins (effacement) and opens fully to 10 cm iii) Second Stage (Expulsion): Strong maternal pushing & uterine contractions move the foetus through the birth canal for delivery iv) Third Stage (Placental): Uterine contractions continue briefly to separate and expel the placenta (afterbirth)

Some women have unusually weak cervix which may not be able to properly hold a baby in place during pregnancy. This is called an incompetent cervix or cervical insufficiency. Having an incompetent cervix can cause a woman to go into early labour, posing a risk or even fatal for the baby. A premature opening of the internal os of the cervix, leads to further dilatation and causes uterine activity leading to miscarriage or premature delivery.

Certain structural and tissue problems present from birth or developing later in life, like Congenital Septate uterus, Bicornuate or unicornuate uterus, Submucosal fibroids disrupt the womb or endometrium, Intrauterine adhesions and Endometrial polyps disrupt the main function of the uterus and contribute to second-trimester losses or recurrent miscarriages. Such problems too are identified only during first pregnancy through first trimester scans and give a scope to save precious babies. 

Indian demography in 2026 indicates that Estimated a) Total Population: ~1.46 to 1.47 billion, b) Total Fertility Rate (TFR): 1.9 births per woman, c) Estimated Crude Birth Rate: ~16.35 annual live births per 1,000 population d) Annual Live Births: ~24 million to 25 million newborns e) Total Pregnancies: ~28 million to 30 million (factoring in standard pregnancy wastage & loss ratios of 10%, i.e.  first- & second-trimester miscarriages roughly 7% + 3% MTPs) [10]

Though pregnancies in mid-30’s has benefits and Advantages of financial stability, due to better career establishment which provides a secure environment for a child. The parents too have greater patience, life experience, and preparedness to support mindful parenting. Pregnancies at this stage are usually well-planned and deeply desired.

In India, the chance of having twins with IVF is roughly 25% to 30% if two or more embryos are transferred as some doctors do and if both embryos attach to the womb, fraternal twins occurring is the single biggest factor for twins. If doctors transfer only one embryo, the chance drops to under 2%. Few couple’s request for a double embryo transfer, hoping to complete their family in one attempt or save money on repeat cycles, may also lead to twins. Rarely, a single transferred embryo splits inside the uterus after implantation (Monozygotic), due to advanced laboratory culture methods creating identical twins. Fertility drugs given before egg retrieval make the ovaries mature multiple eggs and IVF fertilizes them outside the body and putting back more than one created embryo drives the high twin’s rate [8].

Cervical incompetence gives few warning signs. Severe cramping or lower belly pain, Vaginal bleeding, leaking fluid or your water breaking Fever or bad-smelling discharge as was in both of our cases. Many reach a hospital only after labour process has advanced as was in both cases. Women with second semester loss, preterm labour, IVF pregnancies or twin gestations should have cervical length scans every two weeks from 12 week onwards. A vaginal swab to check for infections is also recommended in high-risk cases.

Cervical Cleavage surgery: Cervical cerclage or cervical stitch is a treatment used during pregnancy to sew the cervix shut with a strong stitch or band, between 11 & 24 weeks of pregnancy to prevent pregnancy loss / early birth in women with a weak or short cervix [7]. 

Cervical cerclage is surgical procedure in which stitches or surgical tape are used to close the cervix opening. It is a common treatment for cervical incompetency and helps to ensure that the baby stays in the uterus for the appropriate amount of time. The cervical cerclage will keep the cervix closed until around 37-38 weeks of pregnancy, when the doctor will remove the cerclage and allow labor to naturally begin.

Types of Procedure: 1. Transvaginal Cerclage: The most common method. The doctor places the stitch through the vagina using a speculum. 2. Transabdominal Cerclage: A less common method. The doctor places a band high around the cervix through an incision in the abdomen or Laparoscopic approach. Three types of cervical cerclage procedures in Inda are:

McDonald Cerclage: This is by far the most common type of cervical cerclage. The cervical opening is cinched shut with traditional surgical stitching between 16 to 18 weeks and the stitch is removed around week 37. 

Procedure: The bladder having been emptied, the cervix is exposed and grasped by Allis' or Babcock forceps. A purse string suture of No. 4 Mersilk on a Mayo needle is inserted around the exo-cervix as high as possible to approximate to the level of the internal os. This is at the junction of the rugose vagina and smooth cervix. Five or six bites with the needle are made, with special attention to the stitches behind the cervix. These are difficult to insert and must be deep. The stitch is pulled tight enough to close the internal os, the knot being made in front of the cervix and the end left long enough to facilitate subsequent division.

Shirodkar Cerclage: with this method the stitching is done in the walls of the cervix rather than the opening. This is a more difficult procedure compared to the traditional McDonald method, but the deeper level of the sutures is believed to reduce the risk of infection. This is permanent & will be in for all future pregnancies. The original technique is described below:

I. A strip of fascia lata 1/4 inch wide and 4 1/2 inches long, is removed from the outer side of the thigh, and each end of this strip is transfixed with a linen suture. 

2. The cervix is pulled down, a transverse incision is made above the cervix as in anterior colporrhaphy, and the bladder is pushed well up above the internal os. 

3. The cervix is then pulled forward, toward the symphysis pubis, and a vertical incision is made in the posterior vaginal wall, again at and above the internal os, going only through the vaginal wall. 

4. Through the right and left corner of the anterior incision an aneurysm needle is passed between the cervix and the vaginal wall until its eye comes out of the posterior incision. 

5. The linen attached to each end of the fascia is passed through the eye of the aneurysm needle, and the right end of the fascia is pulled retro-vaginally forward into the anterior incision. The same thing is done from the left side.

Abdomen Cerclage: the cervix is stitched shut at the very top of the cervical opening (internal OS) as was done in our first case). This method is permanent and is usually only done in cases where conventional cerclage methods are not viable. This procedure is often indicated because doing the cerclage vaginally is difficult because of the degree of funneling, cervical dilatation or effacement. This type is chosen, if a prior cervical cerclage had failed.

Cervical cerclage places a stitch at the right anatomical level and usually allows women to continue normal activity with fewer restrictions. Elevating foot end of the bed or strict bed rest is advocated unlike in vaginal cerclage is not required. Most such women can work from home or even take light tasks with a long rest after lunch.

Resting for a few days to a week or more depending on individual risk is advised. Patients must avoid sexual intercourse, tampons, and heavy lifting. The stitch is usually cut and removed around 36 to 37 weeks of pregnancy so that patients can deliver safely. Transabdominal stitches are left in place, requiring a C-section for delivery. 

Cervical cerclage is usually performed during the third month of pregnancy, or between 12-14 weeks. Early detection of the problem is key to preventing further issues later in the pregnancy. Some women may need a cervical cerclage later in pregnancy due to a sudden problem of the cervix shortening or opening, called as emergent cerclage. If a woman ends up needing an emergent cerclage, this is usually a sign that future pregnancies will face the same problem.

Laparoscopic cervical cerclage: Laparoscopic cervical cerclage is a minimally invasive surgery where a non-absorbable stitch is placed around the top of the cervix to prevent second-trimester miscarriages or premature birth caused by a weak cervix. This surgery is done in cases of failed vaginal cerclage, or when a standard vaginal stitch did not work in past pregnancies or when the cervix is too short, scarred, or damaged from prior procedures Key Steps of the Procedure Anesthesia: a) Performed using general anesthesia b) Small incisions (ports) are made in the abdomen for a camera and fine tools iii) The tissue near the bladder and uterine blood vessels is gently moved to expose Isthmus- the lower part of the uterus, iv) A strong, non-absorbable tape or suture is tied securely around the upper cervix. Most patients go home within 24 to 48 hours and resume light activities within a few days. Delivery later in pregnancy requires a C-section as was in our Delhi case report [11]

In few cases, there could be some side effects that range from mild to severe such as i) Premature contractions leading to miscarriage or labour ii) Vaginal bleeding iii) Cervical dystocia, or the cervix’s inability to dilate properly during labor iv) Rupture of membranes v) Cervical infection as indicated by Foul smelling vaginal discharge and high fever vi) Cervical laceration vii) Nausea and vomiting from anesthesia.

Summary:

Some women are known to have what’s called an incompetent cervix or cervical insufficiency). This means that a woman’s cervix is unusually weak and may not be able to properly hold a baby in place during pregnancy. Having an incompetent cervix can cause a woman to go into early labor, which can be risky or even fatal for the baby. In such patients there is a premature opening of the cervix’s internal os and causes uterine activity, leading to miscarriage in early second semester or premature birth.

A more conservative approach opted initially in such patients would involve bedrest in supine position at a slight incline with her feet elevated.

Cervical cerclage is surgical procedure in which stitches or surgical tape are used to close the cervix opening. It is a common treatment for cervical incompetency and helps to ensure that the baby stays in the uterus until around 37-38 weeks of pregnancy, when the cerclage is removed and allows labor to naturally begin. An abdominal cerclage is also an option to treat cervical insufficiency. This procedure is standard treatment for women with an incompetent cervix with success rates of 80-90% and rarely has any type of complications. 

References

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Dr Aline Tollet

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.

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Dr Ravi Shrivastava

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora

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Dariusz Ziora

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.

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Dr Jelle Lettinga

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.

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Dr Walter F Riesen

Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.

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Dr Rakhi Mishra

Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.

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Hala Al Shaikh

Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD

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Dr Eric S Nussbaum

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.

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Dr Victor Olagundoye

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.

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Dr Farahnaz Fallahian

Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.

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Dr Oleg Golyanovski

To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina

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Dr Elvira Farina

My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.

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Gertraud Teuchert-Noodt

We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.

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Dr David Vinyes

Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.

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Dr Anyuta Ivanova

I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.

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Dr Farooq Wandroo

"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".

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Dr Shweta Tiwari

To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.

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Dr Tewodros Kassahun Tarekegn

I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.

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Cristina Berriozabal

Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."

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Thomas Urban

I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.

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Zhao Jia

My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.

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Luiz Sellmann

My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.

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Sonila Qirko

My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.

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Lin-Show Chin

Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner

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Dr Susan Weiner

Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”

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Zsuzsanna Bene

Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.

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Dr Maria Regina Penchyna Nieto

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.

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Dr Maria Dolores Gomez Barriga

Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.

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Maria Dolores Gomez Barriga

The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.

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Lin Shaw Chin

Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.

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Gomez Barriga Maria Dolores

Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.

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Khurram Arshad

Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.

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Rui Tao

“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.

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George Varvatsoulias

Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.

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Tania Munoz

I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.

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S Munshi

I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.

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Husain Taha Radhi

I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.

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Dr Tong Ming Liu

We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.

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Dr Griffith

I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.

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Douglas Miyazaki

"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".

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Jesus Simal-Gandara

I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!

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Baheci Selen

Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.

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Bruno Chauffert

Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.

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Dr Suramya Dhamija

International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.

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Andreas Filippaios

Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.

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Raed Mualem

As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.

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Dr Shiming Tang

Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.

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Hao Jiang

This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.

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Prof Sherif W Mansour

Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.

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Bernard Terkimbi Utoo

Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.

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Pedro Marques Gomes

Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.

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Anthony Kodzo-Grey Venyo

Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.

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Katarzyna Byczkowska

Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.

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Orlando Villarreal

The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.

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Sing-yung Wu

We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.

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Layla Shojaie

Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.

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Mina Sherif Soliman Georgy

Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.

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Ziemlé Clément Méda

Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.

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Delcio G Silva Junior

Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.

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Virginia E. Koenig