AUCTORES
Globalize your Research
Review ariticle | DOI: https://doi.org/10.31579/2690-1897/219
Grodno State Medical University, Gorkogo St, Grodno, Republic of Belarus
*Corresponding Author: Elizaveta I Bon, Grodno State Medical University, Gorkogo St, Grodno, Republic of Belarus.
Citation: Maksimovich N.Ye, Flurik S.V, Dremza I.K, Bon E.I, Sitko A.D, Otlivanchik N.I, (2024), Indicators of Changes in Motor and Emotional Tests in A State of Ethanol Intoxication, J, Surgical Case Reports and Images, 7(9); DOI:10.31579/2690-1897/219
Copyright: © 2024, Bon E.I. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 10 September 2024 | Accepted: 27 September 2024 | Published: 11 October 2024
Keywords: motor and emotional tests; ethanol intoxication
Alcohol intoxication refers to a clinically dangerous condition caused by recent alcohol consumption, in which alcohol and its metabolites accumulate in the bloodstream faster than they can be metabolized by the liver. Alcohol has a range of effects on the central nervous system at different doses. Acute effects include Wernicke's encephalopathy, traumatic brain injury, memory loss, seizures, stroke, and hepatic encephalopathy. We observe an increase in the mobility of rats after the introduction of alcohol and its sharp decline after the introduction of grapefruit juice.
As for the number of short and long washings, as well as the "climbing" and "rering" stands, their number, after the introduction of alcohol, decreases somewhat, and after the introduction of grapefruit juice, also continues to decrease.
Alcohol intoxication refers to a clinically dangerous condition caused by recent alcohol consumption, in which alcohol and its metabolites accumulate in the bloodstream faster than they can be metabolized by the liver [9]. Alcohol has a range of effects on the central nervous system at different doses. Acute effects include Wernicke's encephalopathy, traumatic brain injury, memory loss, seizures, stroke, and hepatic encephalopathy [10]. When alcohol is consumed orally, ¼ of it is absorbed in the stomach and ¾ in the upper part of the small intestine. Through the mucous membrane of the stomach and intestines, most of the alcohol, or more precisely ethanol, enters directly into the blood, and then through the portal vein system into the liver. [3] In our body, 90-98% of the alcohol consumed is oxidized and processed; from 2 to 10% of it is excreted unchanged with exhaled air, with urine, feces, with saliva and through the skin with sweat. 90-98% of the alcohol consumed is metabolized in the liver. In small quantities, ethanol is broken down in other organs. [3] Alcohol oxidation occurs in three ways: with the participation of the enzyme alcohol dehydrogenase, with the help of catalase and with the help of cytochromes. [8] The oxidation reaction of ethanol with the participation of alcohol dehydrogenase occurs in the presence of the coenzyme nicotinamide acetyl dinucleotide (NAD) with the subsequent formation of acetic acid aldehyde. With the participation of the enzyme acetaldehyde dehydrogenase, acetaldehyde is converted into acetic acid.[11] The reaction can occur in both directions. Both enzymes work only in the presence of NAD, which converts them into an active oxidized form. [1] NAD itself is restored during the oxidation of these enzymes. Acetic acid burns during subsequent oxidation to carbon dioxide and water with the release of energy.[2] The first stage of alcohol oxidation to the formation of acetaldehyde is five times slower than the second stage of oxidation to the formation of final products. [7] If the first occurs mainly in the liver, then the second stage can proceed intensively in many tissues of the body: in the liver, kidneys, and brain. When small doses of alcohol are consumed, about 90% is oxidized by alcohol dehydrogenase in the liver and about 10% by catalase. This type of reaction occurs in cells that have cytochrome systems and depends on the concentration of alcohol in the tissues.[8] The third type of oxidation occurs with the participation of the microsomal ethanol-oxidizing system (MEOS).[6] The introduction of large doses of alcohol causes an excess of reduced forms of pyridine nucleotides NADH and NADPH and a deficiency of oxidized forms of NAD and NADP. This triggers the oxidation and reduction reactions of cytochromes of the p450 family during the first stage of xenobiotic detoxification in the liver.[5] Cytochrome P450 has many isoforms - isoenzymes, of which more than a thousand have already been isolated. They play an important role in the oxidation of numerous endogenous and exogenous compounds, including ethanol. The cytochrome P450-dependent microsomal ethanol-oxidizing system plays an insignificant role in the metabolism of small amounts of ethanol, but is significantly induced by its excess and acquires significant significance with its abuse.[9] Enormous importance in this system is given to the 6 main isoforms directly responsible for the metabolism of ethanol in the body. Among them: CYP2E1, CYP1A2, CYP3A4, CYP2C (exists in 4 variations, 3 of which are involved in the elimination of ethanol: CYP2C9, CYP2C8, CYP2C19). Let's consider the actions of each of them. [13] Cytochrome P450 2E1 (CYP2E1) is a key enzyme in the microsomal pathway of ethanol oxidation. CYP2E1 is unevenly distributed in the liver acini. Enzyme expression, both constitutively and after induction, such as with ethanol, is restricted to the centrilobular region of the liver, specifically the three to four hepatocyte layers most proximal to the central vein. After induction, CYP2E1 concentrations in these layers are approximately 0.1 mM. CYP2E1 has a higher Km for ethanol oxidation (8-10 mM) in hepatocytes compared to alcohol dehydrogenase (0.5-2.0 mM), and therefore metabolizes approximately 10-20% of ethanol at low blood alcohol concentrations (10 mM); with an increase in its level (40-70 mM) or after CYP2E1 induction, the proportion of ethanol metabolized by CYP2E1 can increase to 60%. Also, in a number of experiments to identify the effect on ethanol excretion, it was found that the average value of CYP2E1-dependent ethanol oxidation is twice as high as the total activity of CYP1A2 and CYP3A4, which indicates the primary role of CYP2E1 in ethanol metabolism in human liver microsomes.[7]. Cytochrome P450 1A2 (CYP1A2) is the next most important enzyme in microsomal ethanol oxidation. The participation of CYP1A2 in ethanol oxidation in the liver has been confirmed experimentally in rats, and subsequently in humans. It has been established that the CYP1A2 gene is constitutively expressed in the liver. The Km value for CYP1A2 in ethanol oxidation is 62.6 mM, which is significantly higher than that of CYP2E1, indicating its lower affinity for ethanol compared to the CYP2E1 isoform. However, the Vmax value of purified CYP1A2 (39.9 nmol/min) is higher than that of CYP2E1, indicating more efficient operation of CYP1A2 at high ethanol concentrations. [7,11]. Cytochrome P450 3A4 (CYP3A4) is the most abundant CYP enzyme in the liver, involved in the metabolism of endogenous compounds and xenobiotics, including ethanol. CYP3A4 accounts for approximately 30% of the total cytochrome P450 pool, while CYP2C9 accounts for ~20%, CYP1A2 for ~15%, and CYP2E1 for ~10%. CYP3A4 (in addition to CYP2E1 and CYP1A2) makes a significant contribution to the metabolism of ethanol to acetaldehyde. [7,12] Cytochrome P450 2C (CYP2C) is the most common in the liver after CYP3A4. Using recombinant human CYP and selective inhibitors on human liver microsomes, the participation of its isoforms in ethanol oxidation was proven. The human CYP2C subfamily includes four isoforms ranked in descending order of their relative abundance in liver tissue: CYP2C9 (50%), CYP2C8 (26%), CYP2C19 (16%), CYP2C18 (8%). The CYP2C18 isoform does not participate in ethanol metabolism. [7,12]. Despite the pleasant taste and color of grapefruit juice, it still has negative effects on the liver, especially on the same cytochrome P450 isoforms that were discussed earlier. These effects are caused by the chemicals contained in the juice, which are quite abundant both in the pulp and in the peel. Furanocoumarins (molecules based on one five-membered ring with oxygen - furan, and coumarin - two linked six-membered rings, one of which includes one oxygen atom, and the other is attached by a double bond) in citrus fruits suppress the action of the cytochrome P450 3A4 enzyme, irreversibly binding to it. Restoring the enzyme activity by 50% requires at least a day, and by 100% - at least 3 days. They can also prevent the cell from assembling new molecules of this protein according to the "instructions" translated into RNA form. Grapefruit juice reduces the level of cytochrome P450 3A4 by 47% in four hours, which enhances the effect of a number of drugs taken in the next 24 hours. It is important to note that under the influence of furanocoumarins, the amount of 3A4 decreases primarily in the enterocytes of the upper third of the duodenum. However, with excessive juice consumption (more than 500 ml per day), the amount of 3A4 decreases in the liver as well. [12]. Naringin, which gives grapefruit a bitter taste, has a similar effect, also on cytochrome 1A2, although it works weaker alone than in a mixture with other substances in citrus juice. Particular attention should also be paid to the group of flavonoids, the amount of which is especially high in the peel and outer layers of the fruit pulp. [14] Flavonoids that have a blocking effect mainly on CYP2C9, CYP2C19 and CYP2C8 include naringenin and dihydroxybergamottin. Naringin, naringenin and dihydroxybergamottin have a blocking effect exclusively on the liver isoforms of the enzyme. However, all of these substances (including furanocoumarin) act on the principle of complementarity, binding to specific sites of the corresponding isoform of the enzyme.[15]
Six rats were injected intraperitoneally with ethyl alcohol solution at a dose of 0.5 mg/kg. After 15 minutes, the "open field" test was used to study motor disorders and changes in the emotional state of rats with alcohol intoxication. After this test, 2 ml of freshly squeezed grapefruit juice was injected through a gastric tube and the "open field" test was repeated. "Open field" test. The test is carried out on a flat surface, divided into 36 squares, fenced along the perimeter. In the "open field" they determine the time of the animal's exit from the center of the site, where it is placed at the beginning, activity in the horizontal and vertical planes of space, grooming (washing). In the "open field" it is possible to observe violations of motor activity by registering discoordination, the disappearance of voluntary movements or their limitation. The motor activity of animals in the horizontal plane includes running in different directions, walking in a circle. In this case, the participation of all the rat's limbs in the movement is assessed. One crossed square is taken as a unit of movement during visual registration of activity. Grooming can be short - in the form of quick circular movements of the front paws around the nose and whiskers, and long - washing the eyes, the area behind the ears, the entire head, paws, sides, back, anogenital area, tail. The motor activity of rats in the vertical plane is represented by two types of stances: climbing (ascending) - the animal's hind legs remain on the floor surface, and the front ones rest against the wall of the "open field", and rearing (from "rear" - "to stand on end") - the front limbs remain suspended. The obtained data were subjected to statistical processing and entered into the table:
Groups | Test «open field» | ||||
| Distance traveled (cm) in 5 min | Muscle strength (dough holding time, min) | Number of washes | Number of racks «climbing» | Number of racks «rering» | |
| Control | 340 (300;380) | 282,5 (265;290) | 2(2;3) | 7(6;8) | 5,5(5;6) |
| Alcohol | 135* (100;160) | 175* (170;180) | 1(0;1)* | 2(0;3)* | 2(2;3)* |
| Alcohol and grapefruit juice | 35(25;45)*# | 60(0;120)*# | 1(0;2) | 1(0;2)* | 0(0;1)*# |
| A day after the introduction of alcohol | 285*# (275;300) | 250# (220;270) | 1(1;2) | 5(5;6)*# | 4(3;4)* |
| One day after the introduction of alcohol and grapefruit juice | 225*# (195;250) | 192* (170;200) | 1(0;1)* | 3(2;4)* | 2(1;3)* |
* - p<0>
# - p<0>
Indicators of changes in motor and emotional tests in a state of ethanol intoxication at a dose of 1 g/kg and in ethanol intoxication at the same doses with the introduction of 2 ml of grapefruit juice into the stomach.
Thus, we observe an increase in the mobility of rats after the introduction of alcohol and its sharp decline after the introduction of grapefruit juice.
As for the number of short and long washings, as well as the "climbing" and "rering" stands, their number, after the introduction of alcohol, decreases somewhat, and after the introduction of grapefruit juice, also continues to decrease.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
