General Practitioners Always Refer Their Patients to “dr. Macguffin”: Conceptualization of Referral in General Medicine

Review article | DOI: https://doi.org/10.31579/2639-4162/343

General Practitioners Always Refer Their Patients to “dr. Macguffin”: Conceptualization of Referral in General Medicine

  • Jose Luis Turabian

Specialist in Family and Community Medicine. Health Center Santa Maria de Benquerencia. Regional Health Service of Castilla la Mancha (SESCAM), Toledo, Spain.

*Corresponding Author: Jose Luis Turabian Health Center Santa Maria de Benquerencia Toledo, Spain.

Citation: Jose L. Turabian, (2026), General Practitioners Always Refer Their Patients to “dr. Macguffin”: Conceptualization of Referral in General Medicine, J. General Medicine and Clinical Practice, 9(5); DOI:10.31579/2639-4162/343

Copyright: © 2026, Jose Luis Turabian. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Received: 02 March 2026 | Accepted: 19 March 2026 | Published: 24 March 2026

Keywords: referral and consultation; general practice; practice patterns, physicians; interprofessional relations; secondary care; continuity of care in primary health systems; doctor-patient relationships

Abstract

This article presents a personal viewpoint proposing that the general practitioner's referral to a hospital specialist must be considered conceptually as "MacGuffin." Film director Alfred Hitchcock popularized both the term "MacGuffin" and the technique, which designates a plot device that motivates the characters and the development of a story, but which is actually irrelevant in itself. A MacGuffin functions simply as a plot element that captures the viewer's attention or drives the narrative of a work of fiction. By conceptually considering the General Practitioner's referral to a hospital specialist as a MacGuffin, referal becomes a relational and management tool that fosters patient trust, while continuity of care remains the primary care physician's responsibility. Referral as a "MacGuffin" (the seemingly insignificant element that drives the plot) means that the technical objective of the referral (the consultation itself) is secondary; the essential element is not just the referral to the specialist, but the shared decision-making process. Referral to a specialist is not so much a system for facilitating diagnosis and biomedical treatment, but rather a tool for shaping the doctor-patient relationship. This perspective defines medical referral not as the end of the care process or as a mere bureaucratic formality, but as a strategic tool—a "MacGuffin," in cinematic terms—that serves to strengthen the relationship between the family doctor and the patient, ensuring continuity of care.

Introduction

There is a general trend in healthcare systems toward mandatory electronic referrals, after which the specialist decides whether to offer the patient an appointment. This situation raises several interesting questions about referrals from general practitioners (GP) to hospital specialists [1]. The fundamental problem with this situation probably lies in the misinterpretation of the concept of referral in general practice. During medical school, little is taught about the mechanics of effectively referring patients through the healthcare system, nor about positioning oneself as a specialist within the system to obtain adequate access to appropriate patients [2]. GPs' referral of patients to specialists cannot be explained in biomedical terms alone. It seems necessary to take into account the fact that referral is a sensitive topic for GP, involving emotionally charged interactions and relationships with patients, colleagues, specialists, and supervisors [3]. Certainly, what GPs—and patients—fear is that we will lose the right to refer. And it is true that there are many reasons to refer a patient. Referral is a more complex medical act than it appears when trying to understand its underlying causes. Hospital specialists always have reasons to categorize referrals as inappropriate [4]. But, there’s no such thing as an unnecessary referral [5].

A key focus in recent studies is the justification for referrals. Research suggests that the vast majority (over 90%) of referrals are justified, even though overall rates vary [6]. The concept of inappropriate referral held by primary care physicians includes meanings beyond simply referring a heath problem what can be resolved [7]. It is also unclear whether lower referral rates reflect a lack of service provision or less overuse of hospital services [8]. There is wide variation in referral rates (sometimes up to tenfold) among GPs, driven by factors such as population demographics, patient expectations, GP experience, and local capacity, rather than solely clinical quality. There is considerable heterogeneity not only in the threshold for referral but also in which physicians will receive referrals [2].

It has not yet been demonstrated that referring more or less implies better or worse quality of practice in primary health care. This assertion is supported by research indicating that referral rates are influenced by a complex, varied, and often unproven set of factors, rather than solely by clinical quality. While policymakers often view high referral rates as inefficient and low rates as potentially risky, evidence suggests that the appropriateness of the referral is more critical than the volume [9, 10].

Higher referral rates can sometimes indicate proactive, high-quality practice, such as that of a GP with a particular interest in identifying more complex or rare conditions. Conversely, lower rates do not always indicate better care; they could be due to a lack of access to specialists. Reducing unnecessary care has been proposed to prevent harm and lower costs, but studies show that attempting to force lower referral rates can increase patient risks as well as reduce them. Research suggests that, rather than focusing solely on reducing or increasing the number of referrals, it is more effective to focus on improving the quality of the referral itself—specifically, ensuring that it is appropriate, necessary, and well-documented [11]. In this context, a different approach to referral from GP to hospital specialist is proposed, which proves to be more beneficial for the patient, the GP, and the healthcare system.

Methodology

This article that is a personal viewpoint; it aims to reflect on, conceptualize, and propose, based on a selected narrative review and the author's experience, the true meaning of referral from the GP to the hospital specialist.

Discussion

I propose understanding and conceptualizing derivation as a "MacGuffin ." The film director and producer Alfred Hitchcock popularized both the term "MacGuffin" and the technique, with his films "Number Seventeen" (1932) and "The 39 Steps" (1935) being early examples of the concept [12]. This is an expression coined by Alfred Hitchcock that designates a plot device that motivates the characters and the development of a story, and which in reality lacks relevance in itself. A MacGuffin simply functions as a plot element that captures the viewer's attention or drives the plot of a work of fiction. The word comes from this story: ¿Two men are on a train and one of them says to the other, “What’s that package in the luggage compartment above your head?" The other replies, "Ah, that's a McGuffin." The first man insists: “What’s a McGuffin?” and his traveling companion replies: “A MacGuffin is a device for hunting lions in Scotland.” “But there aren’t any lions in Scotland,” the first man retorts. “Then that thing over there isn’t a MacGuffin,” the other responds [13].

Hitchcock once described the MacGuffin as: “The device, the gimmick, if you will, or the papers the spies are after… The only thing that really matters is that in the picture the plans, documents, or secrets must seem to be of vital importance to the characters. To me, the narrator, they’re of no importance whatsoever” [14]. Hitchcock sometimes joked that “in the studio we have a certain MacGuffin who is the element that takes care of all the dirty work of the plot” [13] giving it a personality of its own. To paraphrase Hitchcock, we could say that "in general medicine we have a hospital specialist, a certain Dr. MacGuffin, who takes care of all the dirty work of healthcare." Referral as a "MacGuffin" (the seemingly insignificant element that drives the plot) means that the technical objective of the referral (the consultation itself) is secondary. The essential element is not just referring the patient to a specialist, but the shared decision-making process. The referral acts as a bridge that activates specialized care without severing the link with primary care. The patient perceives that their GP is concerned with finding the best option, while maintaining responsibility for their overall health. Even after the patient is referred, the GP continues follow-up, integrating specialist reports for consistent, long-term care. The referral, managed as a "MacGuffin," prevents the patient from feeling abandoned or disoriented within the system, ensuring timely communication and information exchange [15, 16].

By understanding referral as a MacGuffin, we redefine the role of the primary care physician. In this framework, the referral is not the "end" of the process, but rather the catalyst that allows us to delve deeper into the patient's life story. The referral is a narrative engine. Referral becomes a relational and management tool that fosters patient trust and confidence [17]. Referral to a specialist is not so much a system for facilitating biomedical diagnosis and treatment, but rather a tool for shaping the doctor-patient relationship: The type of doctor-patient relationship creates a context for intervention. The doctor-patient relationship is a diagnostic and treatment tool. It is not merely a means to an end, but a central therapeutic component and an intervention tool in itself. It is important to remember that the most frequently used medicine by primary care physicians is the doctor themselves [18-23].

If we accept that referral is a MacGuffin, the focus shifts from the specific pathology to the patient's journey: it is a pretext for listening. Sometimes, the referral request is the "Trojan horse" that the patient uses to express fears or uncertainties that they cannot verbalize otherwise. It reinforces trust: when referring, the GP does not disengage, but acts as an expert guide who decides when it is necessary to incorporate additional support staff, always maintaining control of the patient's evolution (continuous care). Being aware of the “MacGuffin” in the patient's medical record and carefully crafting it to meet their needs can improve the natural course of illness/health, strengthen patient motivation, and increase the impact of medical intervention. This scenario highlights the role of “Continuing Care.” When the referral itself is something secondary (when it is a MacGuffin), longitudinality shines through. A physician who understands their patient's social, family, and emotional context can use that consultation to: 1) Filter out the noise: Interpret what the specialist says in the patient's language; 2) Manage expectations: Prevent the patient from placing unrealistic hopes on a diagnostic test; and 3) Maintain continuity of care: Ensure that, whatever happens in the hospital, the patient always has a safe place to return to. Thus, the family physician/GP is not the one who knows everything, but rather the one who knows the person who has everything [24-31].

The referral, considered as a MacGuffin, facilitates the return to the center: the specialist provides the specific technique or diagnosis, but it is the family physician who integrates that information into the patient's life, giving meaning or context to the "return" of the consultation; translating the specialist's response into something meaningful for the patient. One cannot be an expert in all areas of medicine, so the role of the GP is often to seek things out or ask a specialist and then contextualize the specialist's response for the patient within their situation [32]. In other words, the patient's journey begins and ends with the GP [33]. This perspective helps combat professional burnout, transforming a sometimes frustrating bureaucratic act -referral- into a clinical act full of symbolic meaning. Understanding the referral from the GP not only as an administrative act, but as a key relational element between doctor and patient, is an effective strategy for preventing professional exhaustion by fostering a relationship of trust, continuity, and person-centered care [34].

Referrals are often perceived as a "loss of control" or a therapeutic failure. Understanding them as a relational element allows them to be reinterpreted as an act of shared care, where the family doctor/GP remains the central figure in the care process, ensuring the patient receives the best possible care at the right time, thus reducing the emotional burden and maintaining a sense of absolute responsibility.

This strengthens the bond and builds trust. A well-managed referral, explained and perceived by the patient as part of their care process (and not as a mere consultation), reinforces trust in the family doctor. When the patient feels their doctor cares about their overall well-being and guides them appropriately to the specialist, the relationship is strengthened, reducing frustration for both parties. This concept of referral as a MacGuffin also helps physicians manage the "difficult patient" or complex case: Family physicians/GPs often face cases with a complex psychosocial burden that generate high anxiety and a risk of burnout. Referral, viewed as a relational support tool, helps to share the patient's complexity, alleviating the feelings of emotional exhaustion and depersonalization characteristic of burnout. Studies indicate that meaningful relationships with patients protect against burnout. By approaching referral as a proactive action, physicians maintain their sense of purpose and professionalism, avoiding depersonalization and the abandonment of personal fulfillment. Furthermore, it achieves a reduction in administrative and clinical stress: Although high referral rates can be a symptom of burnout, strategic and well-communicated referrals help to better manage time and patient expectations, thus reducing the pressure on healthcare services [35].

A warm handoff between physicians in a referral relationship reinforces the patient's trust in our judgment, helps build the patient's relationship with the referring physician, and sets the stage for more effective care [36]. The best predictors of a completed referral are a long-standing relationship with the primary care physician (37). Increased continuity of care decreases referral to specialist care [38].

And what happens if the specialist rejects the referral? Is it possible to do general medicine without referrals? Is it possible to write a story, even a mystery story, without a MacGuffin? Hitchcock once responded: "Certainly. It's possible to build a two-masted schooner without a keel, but the ship will be much harder to sail and may be prone to rolling over unexpectedly. Furthermore, even if the MacGuffin is never brought on stage, the odds are that it's there, hovering around just out of sight, directing the actions of the main characters and snickering in the wings." [14].

In summary, conceptually considering the GP referral to a hospital specialist as a MacGuffin is beneficial for primary health care (TABLE 1). The referral becomes a relational and management tool that fosters patient trust, while continuity of care remains the responsibility of the primary care physician. The interface between primary and specialist care is complex, but specialist care is embedded within (is a subsystem of) primary health care, and the key element of diagnosis and treatment is GP-patient relationship. The referral to a specialist is not so much a system to facilitate biomedical diagnosis and treatment, but rather a tool to shape the doctor-patient relationship. This perspective defines the medical referral not as the end of the care process or as a mere bureaucratic formality, but as a strategic tool—a "MacGuffin," in cinematic terms—that serves to strengthen the relationship between the family physician/GP and the patient, guaranteeing continuity of care. Viewing referrals as a relational extension of care—and not simply as a bureaucratic process—helps physicians maintain emotional balance, feeling supported by the healthcare network and maintaining a human connection with the patient. The patient's journey begins and ends with the primary care physician.

ElementReferral as a ProcedureReferral as a MacGuffin
Objetivo"Getting rid of" the problem or complying with protocolStrengthening the therapeutic alliance
Role of the General PractitionerAdministrative / Referrer.Uncertainty manager and companion.
OutcomeFragmentation of careContinuity of care and a holistic vision
PatientA number on a waiting listThe protagonist of a coordinated story

                              Table 1: Benefits Of Conceptualizing And Focusing On Referral As A Macguffin Versus As A Bureaucratic Procedure

References

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I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.

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Cristina Berriozabal

To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.

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Dr Tewodros Kassahun Tarekegn

"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".

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Dr Shweta Tiwari

I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.

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Dr Farooq Wandroo

Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.

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Dr Anyuta Ivanova

We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.

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Dr David Vinyes

My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.

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Gertraud Teuchert-Noodt

To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina

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Dr Elvira Farina

Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.

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Dr Oleg Golyanovski

Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.

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Dr Farahnaz Fallahian

Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.

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Dr Victor Olagundoye

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD

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Dr Eric S Nussbaum

Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.

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Hala Al Shaikh

Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.

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Dr Rakhi Mishra

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.

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Dr Walter F Riesen

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.

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Dr Jelle Lettinga

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora

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Dariusz Ziora

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.

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Dr Ravi Shrivastava

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.

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Dr Aline Tollet

Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.

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Dr Chiara Giuseppina Beccaluva

Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti

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Dr Claudio Ligresti

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.

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Dr Matteo Bonori

I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.

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Edouard Kujawski

Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell

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Dr Andriy Sinelnyk

Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.

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Dr Meng-JouLe

Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed

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Mahmoud Kamal Moustafa Ahmed

Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.

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Dr Elena Salvatore

Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal

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Christoph Maurer

Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.

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Baciulescu Laura

Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.

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Dr Mamoun Magzoub

International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.

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Joel Yat Seng Wong

Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.

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Dr Perlat Kapisyzi

Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.

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Dr Ted Christopher

Dear Grace Pierce, Editorial Coordinator of the journal IJCCR, I had a very positive experience with Auctores - Journal throughout the publication process. The Editorial Team was highly responsive, professional, and supportive at every stage. I would like to extend my sincere thanks to the Editor: Grace Pierce, for her guidance and assistance. The peer-review process was smooth and constructive, helping improve the quality of my work. I would gladly recommend Auctores Journal to fellow researchers and authors. Dr. SABITA SINHA, Medical Oncologist, MD (Electro Homeopathy).

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Dr SABITA SINHA

Dear Maria Emerson, Editorial Coordinator of - Journal of Clinical Research and Reports. ''I am pleased to provide this testimonial following the publication of our recent case report in this journal. The peer review process was rigorous, constructive, thorough, and conducted in a timely manner. The reviewers’ comments were thoughtful, detailed, and highly constructive, contributing substantially to the refinement, clarity, and scientific robustness of our manuscript. The process was conducted with professionalism and academic integrity throughout. The support provided by the editorial office was exemplary. Communication was consistently prompt, clear, and courteous at all stages of the submission and publication process. The editorial team demonstrated a high level of organization and responsiveness, ensuring that all queries were addressed efficiently and that the process remained transparent and well-coordinated. The overall quality of the journal is reflected in its strong editorial standards, commitment to scientific excellence, and dedication to publishing clinically meaningful research. It has been a privilege to publish our work in this journal, and we would welcome the opportunity to contribute further in the future.'' Best wishes from, Dr. Efstratios Trogkanis, Cardiologist.

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Dr Efstratios Troganis

Dear Reader: We have published several articles in the Auctores Publishing, LLC, journal, Clinical Medical Reviews and Reports in recent years (CMRR). This is an ‘open access’ journal and the following are our observations. From the initial invitation to submit an article, to the final edits of galley proofs, we have found CMRR personnel to be professional, responsive, rapid and thorough. This entire process begins with Catherine Mitchell, Editorial Coordinator. She is simply outstanding, and, I believe, unparalleled in her capacity. I cannot imagine a more responsive and dedicated Editorial Coordinator. As I read the dates and timing of her correspondence with us, it seems that she never sleeps. I hope Auctores Publishing, LLC, appreciates her efforts as much as these authors do. Thank you to Auctores Publishing, LLC, to the Editorial Staff/Board, and to Catherine Mitchell from a grateful author(s).

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Dr Gary Merrill