Short Communication | DOI: https://doi.org/10.31579/2766-2314/165
Anupam Chanda. Head Packaging and Polymer Science Technologist (PG). Principal Consultant: Bioxytran Inc, MA, Boston, USA.
*Corresponding Author: Anupam Chanda, Head Packaging and Polymer Science Technologist (PG). Principal Consultant: Bioxytran Inc, MA, Boston, USA.
Citation: Anupam Chanda, (2025), Eye drop bottle and Cap design problems, Polymer compatibility problems with product and Leachable issues from Bottle Label, J, Biotechnology and Bioprocessing, 6(5); DOI:10.31579/2766-2314/165
Copyright: © 2025, Anupam Chanda. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 03 September 2025 | Accepted: 16 September 2025 | Published: 30 September 2025
Keywords: adolescents; alcohol; smoking; socioeconomic status, substance abuse
Addiction affects all socioeconomic groups. Little consensus exists regarding the relationship between socioeconomic status (income, wealth, and parental education) and substance use alcohol use, smoking, and marijuana use). Youth from low-income families face unique stressors that can increase the risk of substance abuse which can have substantial adverse outcomes.
Leakage and discolouration of Eye drops are very frequent and market complaint in
USA market. In this Article I will try to explain these issues in three different steps like: Eye drop bottle and Cap design problems, Polymer compatibility problems with product and Leachable issues from Bottle Label.
Structure of the CAP:
Position of the SPIKE should be at the center of the Cap that it exactly places on top of the Nozzle. Else first-time spike will pierce the nozzle but from next time on wards it will place outside the tip of the nozzle and product leakage observe.
Height of the SPIKE is most important to avoid product Leakage.
Rigidity of the SPIKE is most important.
Discolouration of Product observed
After analyzing of the bottle polymer this has been observed quantity of the pigments are more compare to the standard.
Excess pigments slowly leach with the product.
After analyzing the polymer this has also been observed quantity of Additives are more and which was leached and mix with product and discoloration observed.
Polymer Leachables are Polybutylene terephthalate (PBT) is a widely used polyester plastic in medical device and MDI valve components.
PBT oligomers and other residuals or degradants can be similarly leached from the valve components fabricated from this material.
Impact of Leachables in Drugs
Increased Toxicity
Interfere Assay
“Ph ‘change.
Bottle Label
Multiple inks, coating and adhesive are using during label printing.
Printed Label Leachables are Phtoinitiators 1-benzoylcyclohexanol and 2- hydroxyl-2-methylprophenone from ink used on labels of HDPE and glass bottles were found to migrate into a solid product.
Adhesive Leachabels are Particulates Protein and Peptide Aggregation
Case Study: UV Curable Printing INK
For an extractables from a device component the AET (μg/g) can be determined using Equation 1: Equation 1
AET = SCT. Dt
Dd m
Dd- Doses per day
Dt- Total Labelled doses
m - mass of component
The AET (μg/device) for a drug delivery device (e.g. an MDI) can be determined from Equation 2:
AET = SCT. Dt
Dd
Dd- Doses per day
Dt- Total Labelled doses
Infrared Spectrum of a Heptane Extract of a Polycarbonate Component
TDS-GC/MS of polymeric material Photolysis of triaryl sulfonium salts
GC-MS Chromatogram of a Heptane Extract of a Polystyrene Component
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