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Research Article | DOI: https://doi.org/10.31579/2690-1919/471
Kenya Medical Training College, Kenya.
*Corresponding Author: Salim Omambia Matagi, Kenya Medical Training College, Kenya.
Citation: Hashem Shams MM, Ibtehal Mamdouh Hamdy, (2025), Evaluation of Quality of Life Associated with Pediatrics Transfusion-dependent Thalassemia- A cross-sectional study, J Clinical Research and Reports, 18(5); DOI:10.31579/2690-1919/471
Copyright: © 2025, Maiada Mahmoud Hashem Shams. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 03 January 2025 | Accepted: 17 February 2025 | Published: 27 February 2025
Keywords: loneliness; isolation; alone; social isolation; depression; mental health; rest ; intervention
Objectives: Thalassemia is a common blood disorder that may impact the patients quality of life wherefore, we conducted this study to evaluate the quality of life of pediatrics lived with transfusion dependent thalassemia in north Sinai-Egypt.
Design: A cross sectional study, questionnaire-survey form (PedsQL™ 4.0 GCS) was conducted by the children parents.
Setting: The study was conducted in the blood transfusion department at al-Arish general hospital. Which is responsible for all transfusion dependent thalassemia patients in North Sinai.
Patients: parents of 32 children were questioned. children were selected using simple random sampling technique from September 2022 to June 2023. 18 females (56.3%) and 14 males (43.7%).
Results: Children's HRQOL was measured by 23 items in this concise and multidimensional scale. The present study mean total score (46.9 ± 13.5) was lower than that of a study conducted in Egypt 2014 (63.74 ± 13.2) which indicate a lower quality of life The mean physical, Psychosocial health, Emotional, social, and school functioning scale are 42.4±17.5, 49.3± 12.8, 49.3±12.8, 54.7± 12.7, 59.4± 18.5, 33.9±13.4. The largest total scale in the group who have children 8–12 years 50.6± 6.4.
Most scales exceeded the minimum reliability standard of 0.70. Internal consistency reliability for the Total Scale Score (α = 0.92), Physical Health Summary Score (α = 90), Psychosocial Health Summary Score (α = 0.87), Emotional functioning score (α = 0.55), Social functioning (α = 90) and School functioning (α = 0.67).
Statistically significant correlation between social functioning and all other subscales, with a Pearson moment correlation coefficient of r ≥ 0.50 and a p-value ≤ 0.05. Additionally, a strong and statistically significant correlation was found between school functioning and physical functioning with a Pearson moment correlation coefficient of r =0.60 and p <.001, while a moderate and statistically significant correlation was observed between the emotional functioning scale and physical functioning as well as school functioning, with a Pearson moment correlation coefficient of r = 0.4 and a p-value of less than 0.05.
Conclusions: The study findings reveals the negative impact of thalassemia on the physical, Psychosocial health, Emotional, social and school functioning which in return affect negatively on their quality of life. School functioning was the most affected domain this call for a steps and efforts in order to improve. A planned teaching program updated education sessions should be conducted aiming to direct the patients, family and school how to cope with thalassemia, how to connect in order to improve the quality of life of thalassemia children patients, in addition facilitate their life.
Thalassemia is chronic disease that have no cure; management were improved recently but; preliminary study found that thalassemia have negative impact on the quality of life especially in developing countries. Consequences like Physical deformities; growth retardation; and delayed puberty are all possible. so we aimed to assess the quality of life; especially it is poorly understood in Egypt and there has been minimal research about the influence of thalassemia and its complications on the quality of life. When the impact of quality of life assessed it help in developing policy to deal with.
Thalassemia is the world's most common genetic illness that is passed down the generations.(1) It is an inherited blood disorder in which the body produces abnormal and inadequate globin chain hemoglobin.it is divided into alpha- (α-) thalassemia and beta- (β-) thalassemia.(2) 90 years ago, severe thalassemia was first described by cooly and lee. According to the spectrum of severity, thalassemia was classified as thalassemia major (TM), thalassemia intermedia (TI), and thalassemia minor.(3,4) It was classified as transfusion-dependent and non-transfusion dependent Regarding the need for regular blood transfusion.(5) Geographically, thalassemia is a major public health issue across the Mediterranean, the Middle East, and the Indian subcontinent, as well as Southeast Asia.(6,7) Around 300 million people globally are carriers, with 55 million living in Southeast Asia.(8) Worldwide, around 270 million carriers of hemoglobin disorder and thalassemia, about 30% of them are beta carriers. Annually, between 300,000 and 400,000 babies are born with dangerous hemoglobin disorders 90% of them are in low-middle income countries.(9–13) In Egypt beta thalassemia major is the most common hemoglobinopathy disease.(14,15)
Physical deformities, growth retardation, and delayed puberty are all possible consequences of thalassemia. Thalassemia affects physical appearances, such as bone abnormalities and short height, which contribute to low self-esteem. (16–18) Thalassemia major affects patients' appearance by producing physical abnormalities and delayed puberty, as well as affecting their self-esteem. people with thalassemia major are prone to bone discomfort and gastrointestinal pain, respectively, while hemosiderosis in the endocrine glands causes short stature. (19,20) Heart failure, cardiac arrhythmia, liver disease, endocrine difficulties, and infections are associated with thalassemia complications. (21–23) resulting in a lower quality of life. (24–26)
A patient with thalassemia major can be summarized as "a patient who has no chance of getting a job, getting married, or having children". (27) According to WHO (1996), Quality of Life is defined as an individual’s perceptions of their position, specifically in terms of culture and systems of values in which the person’s life and in relation to their goals, expectations, standards, and concerns.(28) Previously stated, thalassemia may have a negative influence on the quality of life.(27,29,30).
Because children are less able to express their concerns and are more vulnerable than adults, assessing QOL in children is critical for providing appropriate care, as it aids in detecting the disease's and treatment's effects on children.(31,32) Furthermore, according to a recent study, children's QOL can be utilized as a predictor of health-care expenses and can also be used to identify at-risk groups of children who should receive proactive care coordination.(33,34) A better knowledge of the elements that influence QOL in children and adolescents with thalassemia should lead to the development of more appropriate clinical, psychological, and social support programs to improve treatment results, particularly in terms of QOL
The effects of thalassemia major and its consequences on quality of life are poorly understood in Egypt and There has been minimal research into the influence of thalassemia and its complications on the quality of life(35) Thus, in our study, we aim to study the quality-of-life of patients with transfusion-dependent thalassemia in pediatrics using PedQl questionnaire. This is an important issue as it not only impacts the individual themselves but also the community and society.
Study aims and objectives.
We conducted this study aiming to determine and measure the quality of life of patients with thalassemia who live with chronic blood transfusion physically, socially, and psychologically.
Methodology
Study design, Populations, setting, and sampling technique.
An observational cross-sectional study was conducted by questioning the parents of the participated 32 children who routinely receive their blood transfusion in AGH and included in the study. The study done in the blood transfusion department at al-Arish general hospital. The selection of the study participants done through simple random sampling technique from September 2022 to June 2023. No patient was refused the questionnaire.
Inclusion criteria: Transfusion dependent thalassemia patients of pediatrics 3-18 years old. patient with other comorbidities and complications.
Exclusion criteria: Patients who refused to perform the study questionnaire and refused to participate.
Study tool:
A structured questionnaire-survey form (PedsQL™ 4.0 GCS) in English that translated into Arabic to be easily understood. The PedsQL 4.0 Generic Core Scales consisted of 4 scales: (i) Physical Functioning (eight items); (ii) Emotional Functioning (five items); (iii) Social Functioning (five items); and (iv) School Functioning (five items) , A 5-point Likert scale is utilized across the parent proxy-report (0 = never a problem; 1 = almost never a problem; 2 = sometimes a problem; 3 = often a problem; 4 = almost always a problem). The items are reverse-scored and transformed into a 0–100 scale (0 = 100, 1 = 75, 2 = 50, 3 = 25, 4 = 0). Therefore, higher scores on the PedsQL 4.0 indicate better HRQOL. The scores for each scale are calculated by adding up the item scores and dividing them by the number of items answered, so that higher PedsQL 4.0 total scores reflect better HRQOL.
A trained study research instigator meat with the children’s parents to start the interview. Enough time were given to all parent to answer the questionnaire. Each parent answers the questionnaire separately in their specific questionnaire paper. All questionnaires were computerized to be ready for data analysis.
All the data were analyzed using R software. The categorical variables were presented by frequency and percentage. While the continuous variable described by mean with standard deviation.The Physical Health Summary Score (eight items) is the same as the Physical Functioning Subscale. To compute the Psychosocial Health Summary Score, consisting of 15 items, the mean is calculated by adding up the item responses and dividing by the number of items answered in the Emotional, Social, and School Functioning Subscales.We calculated Cronbach's alpha coefficient to determine the scale's internal consistency and reliability. Satisfactory reliability was defined as 0.70 or greater. To assess the feasibility of administering PedsQL 4.Generic Core Scales, and the percentage of missing values was calculated.We assessed the intercorrelation between the scales using Pearson's product-moment correlation coefficient, The correlation is classified as small (0.10-0.29), medium (0.30-0.49), and large (0.50), p <0>
A total of 32 parents of the participated children were surveyed. Gender distribution among children were 18 females (56.3%) and 14 males (43.7%). They were 3 to 18 years old. The PedsQL™ 4.0 demonstrated a 100% response rate, without any missing responses. This supports the questionnaire's feasibility, and indicates that parents are capable and willing to provide high-quality data on their child's HRQOL and
| Question | N (%) |
| PHYSICAL FUNCTIONING (problems with…) | |
| 1-Walking 100 meters | |
| Almost never | 2 (6.2%) |
| Sometimes | 22 (68.8%) |
| Often | 4 (12.5%) |
| almost always | 4 (12.5%) |
| 2-Running | |
| Almost never | 0(0%) |
| Sometimes | 20 (62.5%) |
| Often | 8 (25%) |
| almost always | 4 (12.5%) |
| 3-Participating in sports activities or exercise | |
| Almost never | 2 (6.2%) |
| Sometimes | 16 (50%) |
| Often | 6 (18.8%) |
| almost always | 8 (25%) |
| 4-Lifting something heavy | |
| Almost never | 2 (6.2%) |
| Sometimes | 18 (56.3%) |
| Often | 4 (12.5%) |
| almost always | 8 (25%) |
| 5-Taking a bath or shower by him or herself | |
| Never | 6 (18.8%) |
| Almost never | 16 (50%) |
| Sometimes | 4 (12.5%) |
| Often | 2 (6.2%) |
| almost always | 4 (12.5%) |
| 6-Having aches or pains | |
| Never | 4 (12.5%) |
| Almost never | 8 (25%) |
| Sometimes | 14 (43.8%) |
| Often | 2 (6.2%) |
| almost always | 4 (12.5%) |
| 7- Having aches or pains | |
| Almost never | 10 (31.3%) |
| Sometimes | 16 (50%) |
| Often | 2 (6.2%) |
| almost always | 4 (12.5%) |
| 8-Feeling tired | |
| Sometimes | 12 (37.5%) |
| Often | 12 (37.5%) |
| almost always | 8 (25%) |
| EMOTIONAL FUNCTIONING (problems with…) | |
| 9-Feeling afraid or scared | |
| Never | 8 (25%) |
| Almost never | 6 (19%) |
| Sometimes | 12 (38%) |
| Often | 6 (19%) |
| 10-Feeling sad | |
| Never | 4 (12%) |
| Almost never | 8 (25%) |
| Sometimes | 8 (25%) |
| Often | 12 (38%) |
| 11-Feeling angry | |
| Never | 2 (6.2%) |
| Almost never | 2 (6.2%) |
| Sometimes | 18 (56%) |
| Often | 6 (19%) |
| almost always | 4 (12%) |
| 12-Trouble sleeping | |
| Never | 8 (25%) |
| Almost never | 14 (44%) |
| Sometimes | 10 (31%) |
| 13-Worrying about what will happen to him or her | |
| Never | 8 (25%) |
| Almost never | 14 (44%) |
| Sometimes | 4 (12%) |
| almost always | 6 (19%) |
| SOCIAL FUNCTIONING (problems with…) | |
| 14-Getting on with other children | |
| Never | 10 (31%) |
| Almost never | 10 (31%) |
| Sometimes | 2 (6.2%) |
| Often | 6 (19%) |
| almost always | 4 (12%) |
| 15-Other children not wanting to be his or her friend | |
| Never | 12 (37.5%) |
| Almost never | 10 (31.25%) |
| Sometimes | 6 (18.75%) |
| Often | 2 (6.25%) |
| almost always | 2 (6.25%) |
| 16-Getting teased by other children | |
| Never | 10 (31.25%) |
| Almost never | 12 (37.5%) |
| Sometimes | 4 (12.5%) |
| Often | 6 (18.75%) |
| 17-Not being able to do things that other children his or her age can do | |
| Never | 4 (12%) |
| Almost never | 6 (19%) |
| Sometimes | 16 (50%) |
| Often | 6 (19%) |
| 18-Keeping up when playing with other children | |
| Never | 8 (25%) |
| Almost never | 14 (44%) |
| Sometimes | 6 (19%) |
| Often | 4 (12%) |
| School functioning | |
| 19-Paying attention in class | |
| Almost never | 2 (6.2%) |
| Sometimes | 16 (50%) |
| Often | 10 (31%) |
| almost always | 4 (12%) |
| 20-Forgetting things | |
| Almost never | 4 (12%) |
| Sometimes | 16 (50%) |
| Often | 10 (31%) |
| almost always | 2 (6.2%) |
| 21-Keeping up with school activities | |
| Almost never | 6 (19%) |
| Sometimes | 10 (31%) |
| Often | 12 (38%) |
| almost always | 4 (12%) |
| 22-Missing school because of not feeling well | |
| Never | 2 (6.2%) |
| Almost never | 2 (6.2%) |
| Sometimes | 4 (12%) |
| Often | 18 (56%) |
| almost always | 6 (19%) |
| 23-Missing school to go to the doctor or hospital | |
| Sometimes | 4 (12%) |
| Often | 19 (60%) |
| almost always. ++ | 9 (28%) |
Table 1 represents Frequency and percentages of the participants responses for the different questions in subscales in PedsQL™ 4.0 questionnaire.
The mean total scale in the whole sample is 46.9 ± 13.5, The largest total scale in the group who have children 8–12 years 50.6± 6.4. The mean physical, Psychosocial health, Emotional, social, and school functioning scale are 42.4±17.5, 49.3± 12.8, 49.3±12.8, 54.7± 12.7, 59.4± 18.5, 33.9±13.4. Most scales exceeded the minimum reliability standard of 0.70. Internal consistency reliability for the Total Scale Score (α = 0.92), Physical Health Summary Score (α = 90), Psychosocial Health Summary Score (α = 0.87), Emotional functioning score (α = 0.55), Social functioning (α = 90) and School functioning (α = 0.67).
| 2–4 Years (toddler) | 5–7 years (Young child) | 8–12 years (child) | Total | Cronbach's alpha α | ||||||
| N=2 | N=20 | N=10 | N=32 | |||||||
| N of items | Mean | SD | Mean | SD | Mean | SD | Mean | SD | ||
| Total score | 23 | 48.3 | 0.7 | 44.9 | 16.3 | 50.6 | 6.4 | 46.9 | 13.5 | 0.92 |
| Physical scale | 8 | 34.3 | 0 | 40 | 21.5 | 48.7 | 3.3 | 42.4 | 17.5 | 0.9 |
| Psychosocial health scale | 15 | 55.8 | 1.2 | 47.5 | 14.4 | 51.6 | 10.1 | 49.3 | 12.8 | 0.87 |
| Emotional functioning scale | 5 | 65 | 0 | 54.5 | 10.1 | 53 | 17.8 | 54.7 | 12.7 | 0.55 |
| Social functioning scale | 5 | 65 | 0 | 55.5 | 20.5 | 66 | 14.3 | 59.4 | 18.5 | 0.9 |
| School functioning scale | 5 | 37.5 | 3.5 | 32.5 | 15.7 | 36 | 9 | 33.9 | 13.4 | 0.67 |
Table 2: presents the means and standard deviations of the PedsQL 4.0 Generic Core Scales and the internal consistency for parent proxy-report.
| Physical functioning | Emotional functioning | Social functioning | School functioning | |
| Physical functioning (r) | 1 | 0.41 | 0.84 | 0.60 |
| P value | 0.019* | <.001* | <.001* | |
| Emotional functioning (r) | 0.41 | 1 | 0.73 | 0.40 |
| P value | 0.01 | <.001* | .022* | |
| Social functioning (r) | .840 | 0.73 | 1 | 0.61 |
| P value | <.001* | <.001* | <.001* | |
| School functioning (r) | 0.60 | 0.40 | 0.61 | 1 |
| P value | <.001* | .022* | <.001* |
Table 3: shows the Intercorrelations between and among PedsQL 4.0 Generic Core Scales subscales. Table 3 demonstrates a robust and statistically significant correlation between social functioning and all other subscales, with a Pearson moment correlation coefficient of r ≥ 0.50 and a p-value ≤ 0.05. Additionally, a strong and statistically significant correlation was found between school functioning and physical functioning with a Pearson moment correlation coefficient of r =0.60 and p <.001, while a moderate and statistically significant correlation was observed between the emotional functioning scale and physical functioning as well as school functioning, with a Pearson moment correlation coefficient of r = 0.4 and a p-value of less than 0.05.
Figure 1: shows Intercorrelations between and among PedsQL 4.0 Generic Core Scales subscales, the darker blue circles denotes positive stronger correlation, the lighter blue circles less strong positive correlation (moderate )
A common Mediterranean hemoglobinopathy passed down the generation 90 years ago called thalassemia instigate us to investigate. Indeed, Healthcare organizations looking forward to improve patient’s quality of life and find ways to evaluate. Absolutely, Quality of life is valuable, meaningful, and should be taken into consideration. Wherefore, we surveyed 32 parents of children aged 3-18 years old to investigate their quality of life using PedsQL questionnaire in North Sinai which is considered a Mediterranean region.
Those patients receiving blood transfusion monthly to treat thalassemia during a period of the research. The study population divided into (56.3%) females and (43.7%) males. A 100% response rate of the parent on the questionnaire indicate their intense to improve on quality of life of their children. The present study mean total score (46.9 ± 13.5) was lower than that of a study conducted in Egypt 2014 (63.74 ± 13.2) which indicate a lower quality of life.(36)
Per contra, it is higher than the result of a study conducted on Iranian patients, their quality of life was (12.96±2.67).(37) Qol questionnaire consisted of 4 scales and 23 items The 4 scale was Physical Functioning (eight items);Emotional Functioning (five items); Social Functioning (five items); and School Functioning (five items). In the most literature studies physical and school functioning domains were the most affected.(38,39) .And also, by comparing the category of quality of life each other's we found that school functioning, 33.9±13 is the lowest QOL score category followed by physical health quality of life 42.4±17.5 while social functioning has the best scoring 59.4± 18.5 followed by emotional functioning 54.7± 12.7.
Ali, Hongally, a study conducted in Riyadh, KSA considered that the quality of life was socially not disrupted because of the attention and support that given to the children, making them in a good social life. (40)(41)(26) This may be due to disease complications increased as children get aged, resulting in decreased feeling of Discrimination. (36) Relatively looks like a study conducted in Egypt in which school and physical functioning the most affected. (36) Another study conducted in Iran results in low physical functioning comparing to the other categories.(37)
Additionally, a study conducted to compare west bank region and Gaza show decreases in school and physical functioning (42) Moreover, Physical functioning of the present study was (58.46 ± 18.09), lower than a study conducted in Gaza and west bank (58.06) and (63.01) respectively.(42,43)
Previous study conducted in Egypt addressed low quality of life of Transfusion dependent thalassemia, and patients usually suffer from chronic repeated transfusion and hospital admission which interrupt different life aspects socially, physically, and attendances to school. (44)
In a study conducted in Egypt a transfusion dependent patient shows lower quality of life than non-transfusion dependent patient. (44) A study conducted on Patients Attending the Hematology Outpatient Clinics at Cairo University Hospital patients aged ≥17 years assessed for QoL, and the study shows that qol were compromised and intervention to improve QoL was needed .(45)Another study conducted in developing countries in which thalassemia patients’ quality of life was immensely affected and stress were over their social, psychological, and emotional life also affect their career and education. (46–48)
The impact of age on quality-of-life scoring was determined in this study. It is shows as previewed in table 3 when children get older the physical health get better but emotional functioning worsen. In a study conducted in Gaza and western bank region physical and school functioning worsens by age while social functioning improved by age. as shown in table 3 there is a statistically significance correlation between social functioning and all other subscales, with a Pearson moment correlation coefficient of r ≥ 0.50 and a p-value ≤ 0.05
Additionally, a strong and statistically significant correlation was found between school functioning and physical functioning with a Pearson moment correlation coefficient of r=0.60 and p<.001, while a moderate and statistically significant correlation was observed between the emotional functioning scale and physical functioning as well as school functioning, with a Pearson moment correlation coefficient of r = 0.4 and a p-value of less than 0.05. (49,50) Ali SS21 also observed that thalassemia patients had significantly higher scores in the social domain.(55) This finding was not consistent with studies by Pruthi, Naderi, and Ishtiaq. (48) .
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I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
