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Research Article | DOI: https://doi.org/10.31579/2693-2156/034
* Cardiothoracic Surgery Department, Minia University, El Minya, Egypt. Madinah Cardiac Center, King Fahd Hospital, Madinah, Saudi Arabia.
*Corresponding Author: Yasser Mubarak, Cardiothoracic Surgery Department, Minia University, El Minya, Egypt, Madinah Cardiac Center, King Fahd Hospital, Madinah, Saudi Arabia
Citation: Yasser Mubarak, (2022). Early Outcome of Mitral Valve Surgery comparing Minimally Invasive versus Standard Median Sternotomy Approach. J Thoracic Disease and Cardiothoracic Surgery, 3(2); DOI:10.31579/2693-2156/034
Copyright: © 2022, Yasser Mubarak. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 27 December 2021 | Accepted: 19 January 2022 | Published: 01 February 2022
Keywords: minimal invasive cardiac surgery; right mini-thoracotomy; minimal invasive mitral valve surgery; standard median sternotomy
Background: This study compares our experience of early outcome of mitral valve surgery (MVS) after minimally invasive (MI) versus standard median sternotomy (SMS) approach.
Objective: Minimal invasive mitral valve surgery (MIMVS) aims to avoid complications of SMS like; bleeding, postoperative pain, and sternal wound infection. It provides better cosmesis and early recovery. The aim of this study is to evaluate early clinical outcome of MIMVS.
Patient and Method: It is prospective comparative cohort study in adult patients with mitral valve disease who perform MVS using either MI or SMS. From January 2020 to December 2021, early outcome of MVS between [120 patients] MI group through right mini-thoracotomy (RMT) with CPB peripheral cannulation and [120 patients] SMS group are compared.
Result: Females are more in MIMVS (80%). ACC and CPB time are longer in MIMVS than SMS (118±15.5 vs 74.4±32.3, 155±28.5 vs 115±48.8). Tricuspid repair and left atrial appendage (LAA) occlusion are performed only in SMS. Blood loss is lesser in MIMVS (250 ± 60.6 ml) than in SMS (550 ± 230 ml). Blood transfusion required (0.1 ± 0.53) in MIMVS, and (0.9 ± 0.7) in SMS. Re-exploration for bleeding is required in (4) cases of SMS. Mechanical ventilation time is shorter in MIMVS (6.4 ± 1.3) than in SMS (12.4 ± 6.8). ICU duration and hospital stay are shorter in MIMVS than SMS (2±0.4 vs 3.5±1.3, 7.2±1.3 vs 12±0.5). Wound infections present in (20) cases of SMS. Spirometric studies in MIMVS reveal better postoperative pulmonary functions than SMS group. Pain Visual Analog Score at discharge is better in MIMVS (1.4 ± 0.6) than in SMS (8.5 ± 1.5). There is no hospital mortality in both groups.
Conclusion: Minimal invasive mitral valve surgery is a safe procedure and improves cosmesis and patient’s satisfaction.
Inspite of availability of minimally invasive cardiac surgery (MICS) technique for long time ago, most of cardiac surgeons remained reluctant to perform MICS. [1] Many obstacles included a learning curve and special instruments required. Also, it had disadvantages of longer cardiopulmonary bypass (CPB) time, difficult visualization and poor exposure of operative field. [2] Moreover, it carried a high risk of stroke because of inadequate deairing. [3] Poor exposure of the surgical field in MICS was present in patients with average body weight; obese patients were added more high surgical risk [4, 5].
MICS was introduced to overcome morbidity associated with standard median sternotomy (SMS). Its access achieved through right minithoracotomy (RMT). The advances in instruments and cannula systems had allowed surgeons to perform MICS easily. Moreover, there was a need to overcome limitations of increased CPB time, difficult deairing and added more complex surgery [4].
The advantages of smaller surgical incisions were including early recovery, less postoperative pain, better cosmesis and carried low risk of wound infection [5,6]. With MICS approach, high-risk patients might benefit more from limiting surgical trauma with this approach. [4] There are efforts to decrease incision length, enhanced recovery, and better patient’s satisfaction, without drawback on surgical techniques [7]. Improved cosmesis should not be only indication for MICS; however, it is a welcomed added benefit [4].
Other benefits of MICS included reduced blood loss, blood transfusion, and atrial fibrillation (AF), shorter intensive care unit (ICU) and hospital stays [2]. Minimal invasive mitral valve surgery (MIMVS) had been associated with mortality rates of 1.2% - 5.8% [6].
After approval by the local ethical committee of our centre 240 consecutive patients with mitral valve disease were prospectively included in the study from January 2020 to December 2021. All patients gave written informed consent after the study protocol and the potential risks associated with the procedure had been outlined in details. Patients who had undergone MIMVS compared with patients who had undergone SMS. The mitral valve was either (8) repaired or (112) replaced in (120) patients by means of MIMVS approach through RMT. MIMIVS was performed according to patients` acceptance and desire, if there were no contraindications. Demographics and preoperative patient data were summarized in (Table 1). Inclusion criteria were elective mitral valve surgery. Exclusion criteria were mitral surgery with other concomitant cardiac surgery, emergency and redo surgery, endocarditis, ischemic mitral regurgitation (IMR), low EF (less than 30%), chest wall deformity, previous thoracotomy or thoracic radiation, chronic obstructive pulmonary disease (FEV1 < 1 L), and liver or kidney failure.
Variables | MIMVS (n=120) | SMS (n=120) |
Age (Mean ± SD) | 42.6 ± 12.8 | 48.5 ± 13.4 |
Female gender | 80% | 20% |
Diabetes Mellitus | 3% | 2% |
Body Surface Area (Mean ± SD) | 1.7±0.1 | 1.67±0.1 |
Preoperative NYHA (Mean ± SD) | 3.50±0.5 | 3.2±0.6 |
AF | 25% | 30% |
LVEF % (Mean ± SD) | 53.8±16.2 | 56.8±9.8 |
PASP (mmHg) (Mean ± SD) | 48.9±18.7 | 43±15.3 |
Mitral Valve Pathology [case] Mitral stenosis Mitral insufficiency Mixed |
80 10 30 |
65 20 35 |
Tricuspid Regurgitation [case] Mild Moderate Severe |
90 23 7 |
80 20 20 |
AF: atrial fibrillation, MIMVS: minimal invasive mitral valve surgery, NYHA: New York Heart association, LVEF: left ventricular ejection fraction, PASP: pulmonary artery systolic pressure, SMS: standard median sternotomy
Table 1: Demographics and preoperative patient data
Patients for MIMVR should include careful history for relevant comorbidities, clinical examination, echocardiography, pulmonary function testing (PFT) and coronary angiography when indicated. Preoperative computed tomography aortography (CTA) provides valuable information regarding aortic aneurysm, tortuosity, atherosclerosis, and femoral artery suitability for cannulation.
Operative data were including CPB time, and aortic cross clamp (ACC) time, mortality and morbidity (stroke, prolonged ventilation, bleeding, renal failure, and wound infection) were recorded.
Sternal wound infection (SWI) are either superficial (SSWI) including skin and subcutaneous, or deep (DSWI) including sternal bone exposure with/out stability, necrotic bone, and heart exposure, with/out septicemia
Patients were positioned in a supine position with the right side of the chest slightly elevated Photo (1 2). External defibrillator pads were placed on the chest. Intraoperative trans-esophageal echo (TEE) was obtained for all the patients. CPB was performed through peripheral cannulation technique. Femoral artery was cannulated with a 16F - 18F arterial cannula, and femoral vein was cannulated with a 25F venous cannula through open technique. Two venous drainage cannulas were routinely used at our center; the anesthesiologist placed a wire in right internal jugular vein (IJV) before draping. The cannula for superior vena cava (SVC) was placed percutaneously from the neck. Cannulation for Bicaval cannulation was performed; the tip of the femoral cannula was positioned just below the junction of inferior vena cava (IVC) and right atrium.
The mitral valve is approached through RMT, and infra-mammary incision (5- 6 cm) is made. This incision is made (1-2 cm) inferior to the nipple in men and about (1cm) above the breast crease in women, with subsequent soft tissue dissection directed toward the chest wall to allow entry into the thoracic cavity through 4th intercostal space. The soft tissue retractor and metallic multiuse retractors allow optimal exposure Photo [3,4]. The pericardium was opened above and parallel to the right phrenic nerve to expose the roof of the left atrium extending from aorta to diaphragm. Exposure was enhanced by placing three stay sutures in the pericardium; small hooks (crochet) pulled the stay sutures outside chest. Poor exposure of operative field, due to high diaphragmatic dome, overcame by silk stay suture placed on the central tendon of the diaphragm and pulled out of chest. This stitch should not be released, but be tied tightly at the end of the operation, to avoid any oozing from diaphragm. A combined Y-shape cardioplegia/aortic vent catheter is placed into the ascending aorta. CPB was initiated with moderate hypothermia (32°C).Venous drainage is achieved with vacuum assistance of approximately - 40 mmHg. Chitwood clamp was then inserted through a separate stab. Carbon dioxide flow used to reduce retained intracardiac gas. A special atrial retractor used to obtain MV exposure. The surgeon should size the atrial retractor blade to properly elevate the intra-atrial septum anteriorly and slightly to the left. A stab incision is made over the right sternal margin, and the retractor handle is bluntly passed though skin, and then screwed to the blade which is manually introduced into the chest Photo [5]. When the heart was empty before releasing aortic cross-clamp, a ventricular pacing wire was placed. During deairing patient was in a deep Trendelenburg position, aggressive filling the heart, positive pressure ventilation, and confirmed by TEE. After discontinuing CPB and administering protamine, decannulation was performed. The purse string sutures were tied, and femoral artery was reinforced using 5/0 Prolene suture. The thoracotomy incision was closed in the routine manner. Photo [6,7] Careful hemostasis is crucial and should be checked before chest closure by dental mirror to avoid bleeding from chest wall. When the hemostasis secured, two 28Fr chest drains placed into the pericardium and right pleural space. The pericardium is closed with 2–3 single sutures.
The statistical analysis was performed using the SPSS software package (version 20.0; SPSS Inc., Chicago, IL, USA). The analyzed data were expressed as number (N), percentage (%), mean (M) and standard deviation (SD) or as proportions. P-value < 0>
Demographics and preoperative patient data of both groups were similar except, MIMVS was more common in female gender (80%). (Table 1) Also, intra-operative data in both groups were similar except, tricuspid repair in SMS group has significant p-value < 0>
Variable | MIMVS (n=120) | SMS (n=120) |
ACC time (min) | 118±15.5 | 74.4±32.3 |
CPB time (min) | 155±28.5 | 115±48.8 |
Mitral valve replacement [case] Mechanical valve Tissue valve | 112 100 12 | 110 100 10 |
Mitral valve repair [case]
| 8 | 10 |
Tricuspid repair [case] | 0 | 35 33 ring 2 Mini band |
ACC: aortic cross clamp, CPB: cardiopulmonary bypass, LAA: left atrial appendage
Table 2: Intra-operative data in both groups
In our study, postoperative data in both groups were showing more blood loss and more blood transfusion required (Figure 1), high rate of wound infection Photo (8), prolonged hospital stay, and more pain according to pain visual analog scale (VAS) at time of discharge in group SMS. (Table 3) Duration of mechanical ventilation, ICU, and hospital stay time were more in SMS group (Figure 2).
Variable | MIMVS(n=120) | SMS (n=120) |
Wound Infection Superficial Deep | 0 0 0 | 20 15 5 |
Pacemaker Implantation | 1 | 1 |
Blood loss (ml) in drains | 250 ± 60.6 | 550 ± 230 |
Blood Transfusion | 0.1 ± 0.53 | 0.9 ± 0.7 |
Re-exploration for bleeding | 0 | 4 |
Mechanical ventilation time (hours) | 6.4 ± 1.3 | 12.4 ± 6.8 |
ICU duration (days) | 2±0.4 | 3.5±1.3 |
Length of hospital stay (days) | 7.2±1.3 | 12±0.5 |
Pain (VAS) at discharge | 1.4 ± 0.6 | 8.5 ± 1.5 |
Length of Incision | 5-8 cm 6.2±1.3
| 15-20 cm 16.3±5.8 |
VAS: visual analog scale
Table 3: Post-operative data in both groups
Blood loss in MIMVS was (250 ± 60.6) vs (550 ± 230) in SMS group, which showed significant statistically difference. Wound infection was (9) cases of SMS. In SMS group, there were (15) cases superficial sternal wound infection (SSWI), and (5) cases deep sternal wound infection (DSWI) needed vacuum [VAC]. DSWI had sternal bone exposed but still stable with positive culture (Staph. Aureus). Photo (9)
In our study, preoperative PFT was done to all patients prior to surgery, during the morning in sitting position. The preoperative spirometric study showed no significant statistically difference between the two groups. (Table 4) Postoperative Spirometric study was performed to all patients on the 7th postoperative day (POD). In group MIMVS, spirometric study revealed that, PFT had no significant reduction after surgery denoting better postoperative PFT than SMS group (Table 5).
Variable | MIMVS (n=120) | SMS (n=120) |
FVC (L)
| 2.54 ± 0.67
| 2.91 ± 0.83 |
FEV1 (L)
| 2.15 ± 0.5
| 2.7 ± 0.6 |
FEV1/FVC | 89.14 ± 5.8 | 91.75 ± 3.8 |
FEV1: forced expiratory volume in one second, FVC: forced volume capacity
Table 4: Preoperative spirometric study in both groups.
Variable | MIMVS (n=120) | SMS (n=120) |
FVC (L)
| 2.19 ± 0.72 | 1.52 ± 0.36 |
FEV1 (L) | 2.02 ± 0.63
| 1.43 ± 0.38
|
FEV1/FVC | 90.83 ± 9.81
| 93.92 ± 7.27
|
FEV1: forced expiratory volume in one second, FVC: forced volume capacity
Table 5: Post-operative pulmonary functions in both groups.
Mitral valve replacement (prosthetic or bioprosthetic valve), and repair were similar in both groups. However, tricuspid repair (ring or mini-band) and left atrial occlusion were recorded only in SMS group. There were postoperative significant p-value of FVC and FEV1, however insignificant p-value of FEV1/FVC between both groups.
There were no hospital mortality and all patients were discharged with normal valve function according to postoperative echo. At most recent follow-up, all patients were in functional class I, with resumption of normal activity earlier than SMS group.
Some surgeons remained concerned about the risk of groin wound infection, and risk of vascular injury due to peripheral cannulation in MICS. [8] In our study, there was not any wound infection at cannulation site. There were no recorded wound infection, vascular or neurological complications because of good preoperative preparation of cases, proper learning curve, clinical history, and CT aortography.
Peripheral cannulation and retrograde arterial perfusion carried a risk of retrograde dissection, embolization, and ipsilateral limb ischemia and was associated with an increased risk of stroke in patients with severe peripheral vascular disease (PVD). [9,10] In our study, full clinical history, CT aortography, and with TEE guidance all those complications were avoided.
MIMVS through RMT was safe procedure as SMS approach in elderly [11]. In our study, patients aged (42.6 ± 12.8 years) in MIMVS group, however it is promising in all age groups when contraindications are absent.
MV repair through RMT provides a durable and safe alternative to SMS with benefits of improved cosmesis, reduced postoperative pain, less blood loss with fewer blood transfusions, low incidence of infection, shorter hospital stay, and faster return to activity [12]. It can be performed with the same incidence of mortality, and morbidity to SMS [13]. In our MIMVS group, 12 patients underwent mitral repair [9 with ring and 3 with mini-band] with good results with competent repair within 3-month follow up.
Some surgeons believed that RMT might be as painful as SMS. There were methods to reduce postoperative pain like, minimization of rib-spreading, and intercostal nerve block (INB) by bupivacaine injection [14]. In our study, Pain VAS at the time of discharge was better in MIMVS than in SMS with significant p-value (<0>
Patient selection was the first important step to prevent complications [14]. With time, despite a steep learning curve, surgeons expanded this approach to perform more complex procedures, and included patients with more comorbidity, and high body mass index (BMI). [16] Although, obese patients had more comorbidity, they did not have an increase in mortality during cardiac surgery. MIMVS in obese patients had a lower morbidity and mortality when compared with SMS. [17] In our study, there were no significant statistically difference in preoperative comorbidity conditions; DM (3% MIMVS, 2% SMS), BSA (1.7±0.1 MIMVS, 1.67±0.1 SMS), NYHA class (3.50±0.5 MIMVS, 3.2±0.6 SMS), AF (15 MIMVA, 18 SMS), EF (53.8±16.2 MIMVS, 56.8±9.8 SMS), and FEV1 (2.15 ± 0.5 MIMVS, 2.7 ± 0.6 SMS)
Hybrid PCI and MIMVS in patients with prior cardiac surgery is more advantageous than CABG and mitral valve surgery by SMS. [16] However, there were neither redo nor ischemic MR cases in our study.
Many surgeons and their patients are beginning to believe that smaller incisions are always better because of less pain, faster recovery, and more satisfactory cosmetic result. However, CPB, and total operative times are significantly longer 40% or more. Smaller incisions are more “patient friendly” for the surgeons [18]. In our study, length of incision was (6.2±1.3) in MIMVS, and (16.3±5.8) in SMS with significant p-value.
RMT approach was associated with less new-onset AF, pneumonia, respiratory failure, and acute renal failure, lower drain output, and fewer blood transfusions. [3] Chest drains output was (250 ± 60.6ml) in MIMVS, and (550 ± 230ml) in SMS, with significant p-value < 0>
MIMVS is a safe procedure associated with low operative mortality. In addition to improved cosmetics, it provides shorter ventilation time; shorter ICU and hospital stay, and earlier return to full activities [19]. Preoperative predictors of mortality included advanced age, DM, smoking, dialysis, lung disease, congestive heart failure, and PVD [3]. In our study, there was not any perioperative mortality. There was no significant p-value between both groups in mechanical ventilation time (6.4 ± 1.3 MIMVS, 12.4 ± 6.8 SMS), and ICU stay (2±0.4 MIMVS, 3.5±1.3 SMS). However, significant p-value (<0>
MIMVS in elderly patients yields a lower morbidity and mortality when compared with SMS and should be considered when such individuals require valve surgery. [20] In our study, both groups included adult age. Also, we excluded ischemic or redo cases which were common in elder.
MIMVS has been associated with mortality rates of 1.2% - 5.8%. Moreover, it is often associated with enhanced recovery and better patient satisfaction. [6] Today, MIMVS became preferred at many centers owing to less postoperative bleeding and AF, reduced incidence of wound infection, and shorter hospital stays, quicker recovery, and improved cosmesis [21]. In our center, patients asked to perform MICS for cosmesis, less painful, short hospital stay especially with era of covid-19.
Cardiac surgery has shown a progressive and increasing interest towards the development of MICS. It represents a significant change in the way cardiac surgeons treat their patients today. It brings new challenges to the surgeon as well as the anesthesiologist. However, it significantly demands learning curves for the team and technical challenges for the operating surgeons are commonly required. MIMVS is rapidly growing with excellent results comparable with SMS approach: it has set equivalent perioperative mortality and less pain, less wound infection, less blood loss, less transfusions and re-explorations for bleeding, shorter hospital stay, and faster recovery.
Minimally invasive mitral valve surgery has been proven a feasible alternative to standard median sternotomy approach with low early morbidity and short-term mortality.
Each group has small number of patients because of short time of the study. One center experience with some bias of selection of cases was presented. Inspite of that was prospective study, it was not randomized.
ACC: aortic cross clamp, AF: atrial fibrillation, BMI: body mass index, BSA: body surface area, DM: diabetes mellitus, DSWI: deep sternal wound infection, CPB: cardiopulmonary bypass, CABG: coronary artery bypass grafting, CTA: computed tomography aortography, ICU: intensive care unit, IVC: inferior vena cava, IJV: internal jugular vein, INB: intercostal nerve block, IMR: ischemic mitral regurge, LAA: left atrial appendage, FEV1: forced expiratory volume in one second, FVC: forced volume capacity, MI: minimal invasive, MICS: minimal invasive cardiac surgery, MIMVS: minimal invasive mitral valve surgery, MVS: mitral valve surgery, LOS: length of stay, PCI: percutaneous coronary intervention, PFT: pulmonary function test, POD: postoperative day, PVD: peripheral vascular disease, RMT: right minithoracotomy, SMS: standard median sternotomy, SSWI: superficial sternal wound infection, SVC: superior vena cava, TEE: transesophageal echo, VAS: visual analog scale
Ethics approval and consent to participate: - Patient confirms that have read and understood the information about the research as provided in the participant information sheet inside his file. The study has got the formal approval and permission from Heart Team Meeting Ethical Committee at MCC approval before to start the study. The study conformed to the principles of “Declaration of Helsinki” and the investigator followed the appropriate safeguards regarding the rights and welfare of the human participants that have been included in the performed study. Research Reference No. 2020 R103
It was obtained written consent from patients.
It is available from recording (paper and in computer system) files and data at Madinah cardiac center adult cardiac surgery department.
None to declare.
None.
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Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
