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Research Article | DOI: https://doi.org/10.31579/2690-8794/280
Assistant Vice President for Clinical Education Development
*Corresponding Author: Zarmina Chaudhry, Assistant Vice President for Clinical Education Development.
Citation: Zarmina Chaudhry, James Keane, Leonard B. Goldstein, (2025), Dual GLP-1 and GIP Receptor Agonists in Women with PCOS: A Comprehensive Review of Metabolic, Reproductive, and Psychiatric Outcomes, Clinical Medical Reviews and Reports, 7(6); DOI:10.31579/2690-8794/280
Copyright: © 2025, Zarmina Chaudhry. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 26 August 2025 | Accepted: 05 September 2025 | Published: 11 September 2025
Keywords: metabolic; reproductive; and psychiatric
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretin hormones secreted by the intestines in response to nutrient intake. These hormones enhance insulin secretion from pancreatic beta cells in a glucose-dependent manner (Campbell & Drucker, 2013; Nauck & Meier, 2018).
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretin hormones secreted by the intestines in response to nutrient intake. These hormones enhance insulin secretion from pancreatic beta cells in a glucose-dependent manner (Campbell & Drucker, 2013; Nauck & Meier, 2018). In addition, they inhibit glucagon secretion, delay gastric emptying, and promote satiety.
While their effects are short-lived due to rapid degradation by the enzyme dipeptidyl peptidase-4 (DPP-4), the physiological reach of GLP-1 extends beyond glucose regulation. Unlike GIP, which acts predominantly at the pancreatic level, GLP-1 receptors are widely expressed in the heart, gastrointestinal tract, adipose tissue, vagus nerve, and various brain regions. Consequently, GLP-1 is associated with neuroprotective and cardioprotective effects (Baggio & Drucker, 2007; Drucker, 2018).
This review presents a comprehensive analysis of dual GLP-1/GIP receptor agonists in women with PCOS.
The rapid rise of GLP-1 and dual GLP-1/GIP receptor agonists marks a significant evolution in the management of obesity and related metabolic disorders, including in populations such as women with polycystic ovary syndrome (PCOS), where metabolic, reproductive, and psychiatric domains intersect. PCOS is a heterogeneous endocrine disorder involving a complex interplay of metabolic derangements, reproductive dysfunction, and psychiatric comorbidities. Traditional treatments—namely metformin, lifestyle modification, and hormonal therapy—frequently fall short in comprehensively addressing these multifactorial challenges (Teede et al., 2018). In recent years, glucagon-like peptide-1 receptor agonists (GLP-1 RAs), and more recently dual GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptor agonists like tirzepatide, have emerged as promising pharmacologic agents with broad-spectrum potential (Chao et al., 2022; Jastreboff et al., 2022). This review collectively demonstrates tirzepatide’s ability to address the metabolic, reproductive, and psychiatric manifestations of PCOS, while also revealing key limitations, safety considerations, and psychosocial drivers of treatment interest.
Recent advancements in pharmacologic treatment for obesity have introduced dual GLP-1 and GIP receptor agonists as promising agents for women with PCOS, offering significant improvements in metabolic parameters such as insulin resistance, body weight, and cardiovascular risk profiles (Frias et al., 2021; Ghosal et al., 2023). However, while these agents demonstrate considerable efficacy, emerging clinical observations suggest that there are important real-world challenges that must be acknowledged, particularly in female populations with complex endocrine and psychiatric profiles (Tucker, 2025a; Bennett et al., 2023).
From a systems-level perspective, the expansion of access to endocrinology care is a critical factor in translating these pharmacologic advancements into equitable clinical outcomes. With over 70% of U.S. counties lacking an endocrinologist, endocrine-trained nurse practitioners (NPs) may play an essential role in managing complex conditions such as PCOS and safely prescribing and monitoring GLP-1/GIP agonists (Zhou et al., 2023). Programs like the one at Duke University provide a promising model for addressing the endocrine workforce shortage, especially in rural and underserved areas. Their integration into multidisciplinary care teams could also enhance screening for psychiatric comorbidities, a frequently under-recognized burden in women with PCOS (Lake et al., 2025; Moradi et al., 2023).
Together, these findings emphasize that while dual GLP-1/GIP agonists hold promise for improving a wide array of PCOS-related outcomes, their successful implementation will depend not only on clinical pharmacology but also on structural and educational investments in healthcare delivery.
Across nearly all studies reviewed, tirzepatide was consistently associated with substantial weight loss, improved insulin sensitivity, and favorable effects on adiposity and hepatic fat, both in PCOS and general metabolic populations. Sassin et al. (2023) conducted a retrospective study at Baylor College of Medicine showing that tirzepatide, when added to metformin, led to significantly greater weight loss in non-diabetic women with PCOS compared to metformin alone—producing an average reduction of 8.65 kg versus 1.09 kg and nearly doubling the likelihood of clinically meaningful weight loss, with 90% of combination-treated patients achieving weight loss compared to 56.5% in the metformin-only group.
Khan et al. (2024) provided mechanistic support for these findings using a preclinical PCOS rat model, demonstrating that tirzepatide combined with adropin reduced cardiac lipid accumulation and inflammation by modulating the AKT/GSK3β/NF-κB/NLRP3 pathway, suggesting a potential link between metabolic stress, inflammation, and impaired cardiac function in PCOS (Abo El-Magd et al., 2024).
Meta-analyses by Li et al. (2023) and Jayasena et al. (2023) demonstrated that GLP-1 receptor agonists significantly reduced BMI, body weight, fasting insulin, and insulin resistance (HOMA-IR), while also improving menstrual frequency and total testosterone levels in women with PCOS. Flannery et al. (2023) further emphasized tirzepatide's effectiveness on central adiposity and hyperinsulinemia—key contributors to the pathophysiology of PCOS.
In real-world clinical comparisons, Wu et al. (2025) demonstrated that tirzepatide significantly outperformed semaglutide in weight loss, HbA1c reduction, and treatment adherence in over 20,000 patients—solidifying its position as a first-in-class therapy. Moreover, Cheng et al. (2024) found tirzepatide matched or exceeded bariatric surgery in reducing hepatic fat and achieving glycemic control in obese patients, suggesting non-invasive alternatives for PCOS patients who are poor surgical candidates.
GLP-1/GIP receptor agonists may provide glycemic control without the renal limitations observed in other agents such as SGLT1/2 inhibitors. For instance, sotagliflozin efficacy is attenuated in patients with moderate-to-severe CKD, a concern for PCOS patients who may have overlapped metabolic syndrome (Tucker, 2025d). In contrast, tirzepatide has shown consistent efficacy regardless of baseline renal function.
Still, not all metabolic outcomes are without concern. Tucker (2025a) identified nutritional deficiencies, rapid fat loss, and “GLP-1 fatigue syndrome” in semaglutide/tirzepatide users, particularly among those taking medications without medical supervision. Dr. W. Timothy Garvey, an expert in obesity medicine, highlighted several underreported adverse outcomes at the 2025 AACE Annual Meeting, including fatigue syndrome, cognitive clouding, bone loss, and nutrient deficiencies in women on GLP-1 therapy—especially among those experiencing rapid or excessive weight loss (Tucker, 2025a). These complications are often not captured in clinical trials, underscoring the necessity of real-world data to fully inform safe clinical use.
Additionally, gastrointestinal symptoms such as abdominal pain, though less emphasized in trials, were found to be the most common side effect in real-world data, reported by nearly 60% of users (Tucker, 2025a). Particularly concerning is the potential for bone mineral density loss in postmenopausal women. While muscle loss is typically regarded as a physiologic outcome of weight reduction, Garvey and others argue that bone demineralization may be less reversible and could predispose individuals to fractures, especially in older female populations (Tucker, 2025a). However, emerging evidence suggests that semaglutide may offer a more favorable bone safety profile compared to surgical interventions. A retrospective cohort analysis presented at the same conference found a 26% lower fracture risk among semaglutide users compared to those undergoing sleeve gastrectomy, suggesting that GLP-1 receptor agonists may provide bone protection during weight loss (Tucker, 2025c).
This raises the hypothesis that GLP-1s may have unique bone-preserving properties, possibly due to suppression of osteoclast activity or modulation of osteoblast survival. Such data may influence treatment decisions in reproductive-aged women with PCOS who are at elevated fracture risk. These findings highlight the importance of structured oversight, especially in patients at risk for undernutrition or osteopenia.
Reproductive health parameters also improved with incretin therapy, though data remain more limited. Vani et al. (2024) emphasized that GLP-1 RAs improve oocyte quality, luteal phase adequacy, and endometrial receptivity, thereby enhancing fertility potential in women with PCOS. A meta-analysis by Santos et al. (2024) specifically evaluated GLP-1 receptor agonists in women with PCOS and obesity. The findings demonstrated significant reductions in luteinizing hormone (LH), testosterone, and the LH/FSH ratio—hallmarks of hyperandrogenism—alongside improved menstrual cyclicity. These hormonal improvements are particularly encouraging, as they support the role of GLP-1 agonists in restoring ovulatory function and enhancing fertility.
Similarly, Li et al. (2023) found that GLP-1 RAs significantly improved menstrual regularity and insulin sensitivity while promoting weight loss. These reproductive improvements likely result from both direct neuroendocrine modulation and indirect effects via weight reduction and improved metabolic homeostasis.
Palomba et al. (2020) provide additional support for GLP-1–based interventions, particularly liraglutide, in enhancing fertility outcomes in obese women with PCOS. The authors emphasized that weight loss induced by GLP-1 RAs not only improves insulin sensitivity but also restores ovulatory cycles, thereby improving chances of conception. This dual benefit—metabolic and reproductive—underscores the potential of GLP-1 RAs to serve as an integrated therapeutic strategy in PCOS management, bridging metabolic correction and fertility restoration.
Case series such as Adewale & Gagner (2024) explored GLP-1 RA use in post-bariatric surgery patients experiencing weight regain, with tirzepatide showing more potent weight reductions than semaglutide. These findings open new opportunities for reproductive restoration even after surgical interventions.
However, patient motivation for initiating therapy often includes goals beyond fertility. Qualitative studies (Keller et al., 2025; Bartkoski et al., 2025) revealed that many women, particularly younger patients, seek GLP-1 medications due to body image dissatisfaction rather than medical necessity—raising important ethical questions about overprescription and potential for disordered eating.
The sociocultural aspect was addressed by Lake et al. (2025), who found that body image dissatisfaction was strongly correlated with interest in GLP-1 medications, independent of BMI. This has major implications for adolescent and young adult women with PCOS, a group already at risk for disordered eating and psychiatric distress.
Psychiatric and behavioral outcomes are increasingly recognized as integral to PCOS care. Moradi et al. (2023) found that women with PCOS report significantly higher food craving scores—especially in the emotional and external eating domains—compared to controls. These cravings were strongly correlated with body mass index (BMI), suggesting a feedback loop between disordered eating behavior and obesity in PCOS. GLP-1/GIP receptor agonists, which slow gastric emptying and act on hypothalamic satiety centers, may attenuate maladaptive eating patterns and support behavioral health in this population. Chao et al. (2022) and Moradi et al. (2023) revealed that GLP-1 RAs also help reduce hedonic eating, emotional food cravings, and reward dysregulation—which may indirectly influence fertility by stabilizing weight and hormonal rhythms.
GLP-1 RAs’ psychiatric effects are complex and, at times, contradictory. Zhou et al. (2023) showed that liraglutide reversed depression-like behavior in rats previously exposed to antipsychotics, suggesting a neuromodulatory benefit possibly mediated through HPA axis and BDNF modulation. GLP-1 RAs like liraglutide have shown potential to reverse depression-like behaviors in rat models following long-term antipsychotic exposure, suggesting central nervous system effects relevant to PCOS patients with coexisting mood disorders. The psychiatric dimensions of PCOS also warrant attention. In a preclinical model, Zhou et al. (2023) demonstrated that liraglutide reversed depressive-like behaviors and metabolic abnormalities induced by long-term antipsychotic use in rats. The reversal was linked to reductions in hippocampal inflammation and improvements in insulin sensitivity—suggesting that GLP-1 RAs may exert central nervous system benefits relevant to PCOS patients with coexisting mood disorders.
This is echoed in reviews proposing that GLP-1 RAs may exert antidepressant-like properties. These findings were echoed in human populations by Bennett et al. (2023), who conducted qualitative interviews with adults treated with GLP-1 RAs and found improvements in mood, self-esteem, and body image—though some participants reported emotional blunting and anxiety. These results emphasize the psychiatric duality of GLP-1 therapy, suggesting benefits for emotional regulation alongside potential risks that require clinical oversight.
Conversely, case reports such as Manoharan and Madan (2024) highlight the need for caution, as they described a patient with pre-existing psychiatric illness who experienced worsening depression and suicidal ideation after initiating semaglutide—symptoms that resolved upon discontinuation of the drug. Similarly, a population-based study by Douros et al. (2024) noted a slightly elevated risk of anxiety and suicidal ideation in GLP-1 RA users compared to controls. This highlights the need for mental health monitoring in patients using GLP-1 agents, especially those with pre-existing psychiatric histories. A qualitative study by Wilkenson et al. (2024) documented emotional blunting, social withdrawal, and psychological detachment in GLP-1 RA users with obesity or type 2 diabetes. Additionally, Hertel et al. (2023), using a large population-based study, found a slightly elevated risk of depression and suicidal behavior in patients with obesity using GLP-1 agonists, warranting continued psychiatric monitoring. These findings align with a 2024 cohort study by Mohammadifard et al., which found a small but statistically significant increase in depression and anxiety risk among obese patients using GLP-1 RAs, although the absolute risk remained low. Bartkoski et al. (2025) highlighted particular psychiatric vulnerability among adolescents, stressing the need for age-specific safety monitoring. Screening tools like PHQ-9, SCOFF, and the Columbia Depression Scale may be useful adjuncts when initiating GLP-1/GIP therapy in these groups.
Further nuance comes from Lah et al. (2025) and Brown et al. (2024), who reported improved mood, self-esteem, and mental clarity in some patients—but also emerging patterns of emotional detachment, fatigue, and hyperfixation on weight. “Fatigue syndrome,” described as a combination of low energy, weakness, and cognitive fog, has been identified in approximately 10% of patients experiencing rapid weight loss (Tucker, 2025a). This may have particular relevance for women with PCOS, who already demonstrate elevated rates of depression, anxiety, and disordered eating. In the absence of structured nutritional counseling and functional monitoring, the pharmacologic gains of GLP-1/GIP agonists may come at a cost to overall well-being. Another area of concern is the proliferation of online prescribing platforms that bypass essential clinical evaluation. This shift away from individualized care limits the clinician’s ability to risk-stratify, educate, and monitor patients—components that are especially important in populations with complex hormonal and psychiatric needs (Tucker, 2025e). These findings emphasize the need for a multidisciplinary, patient-centered approach to prescribing GLP-1/GIP receptor agonists in women with PCOS. While their metabolic and reproductive benefits are well-documented, attention must also be given to patient safety, psychiatric outcomes, and long-term physical functioning. Future research should focus on identifying at-risk subgroups, developing nutritional support protocols, and integrating mental health screening into weight-loss pharmacotherapy. The variability in mental health outcomes suggests that GLP-1 RAs should not be viewed as purely beneficial or harmful, but rather as medications requiring close psychiatric surveillance. Conversely, Pyo et al. (2023) proposed a potential antidepressant benefit, noting that GLP-1 RAs may modulate dopamine and serotonin systems via AMPK activation in the brain.
Future Directions
Several studies underscore how metabolic, reproductive, and psychiatric domains intersect. Improvements in body composition and insulin resistance often correlate with menstrual normalization and enhanced mood. However, when expectations are appearance-driven, treatment may lead to disordered eating, emotional detachment, or inappropriate continuation despite adverse effects.
Tucker’s Medscape reports (2025a, 2025b, 2025e) provide crucial real-world context, flagging concerns such as unsupervised online prescribing, long-term safety unknowns, and disparities in access. Meanwhile, alternative hormonal agents such as crinecerfont—a corticotropin-releasing factor receptor-1 (CRF1) antagonist—may one day complement incretin therapy in androgen-dominant PCOS subtypes, though data remains preliminary. Crinecerfont, currently used in congenital adrenal hyperplasia (CAH), reduces glucocorticoid burden and normalizes androgen excess—two mechanisms highly relevant to PCOS pathophysiology. Phase 3 trials in both children and adults demonstrated improved reproductive hormone profiles and reduced need for supraphysiologic steroid dosing, which may enhance fertility outcomes in affected women (Tucker, 2025e).
Similarly, findings from a two-year follow-up study on palopegteriparatide in hypoparathyroidism showed sustained improvements in renal and skeletal function. Although this agent is not directly related to PCOS treatment, it illustrates the value of hormone replacement strategies in long-term endocrine disorders and the need for individualized, physiology-based approaches (Tucker, 2025b).
Taken together, these studies suggest that GLP-1 and dual GLP-1/GIP receptor agonists—especially tirzepatide—represent a paradigm shift in PCOS management. They hold potential to address not only metabolic and reproductive dysfunction, but also certain psychiatric features of the syndrome. However, this enthusiasm must be tempered by the need for individualized treatment plans, routine psychiatric screening, and PCOS-specific clinical trials to better define long-term safety, efficacy, and optimal patient selection.
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I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
