Diseases as a legacy of the Great Oxidative Event, or how mitochondria became pathogenic and sweating became healing
Yuri Pivovarenko
Research and Training Center ‘Physical and Chemical Materials Science’ Under Kyiv Taras Shevchenko University and NAS of Ukraine, Kiev, Ukraine.
*Corresponding Author: Yuri Pivovarenko, Research and Training Center ‘Physical and Chemical Materials Science’ Under Kyiv Taras Shevchenko University and NAS of Ukraine, Kiev, Ukraine.
Citation: Yuri Pivovarenko, (2024), Diseases as a legacy of the Great Oxidative Event, or how mitochondria became pathogenic and sweating became healing, J. Cancer Research and Cellular Therapeutics, 8(5); DOI:10.31579/2640-1053/206
It is shown here that the appearance of oxygen gas in the earth's atmosphere turned mitochondria into sources of uncompensated hydrogen ions, pathogenic for humans. It seems that understanding this can be fundamentally important for doctors seeking to identify the origin of human diseases. At the same time, it seems that it is precisely this understanding that allows perceiving sweating, in which hydrogen ions are removed from the human body, as a universal therapeutic means, in particular an antitumor means.
Introduction
At the outset, it is worth making a few comments regarding the relationship between the evolution of the Earth's atmosphere and the evolution of cellular life on Earth. So, it is now believed that the atmosphere of ancient Earth was quite rich in hydrogen gas and carbon dioxide, but did not contain any oxygen gas at all (Figure 1, left).
Figure 1. This is a diagram that shows current views on the evolution of the Earth's atmosphere [1 – 3].
Apparently, all this gives reason to conclude that the ancient waters, in which cellular life is believed to have originated no later than 4 billion years ago [4 – 10], were also rich in hydrogen and carbon dioxide and also did not contain oxygen. This, in turn, suggests that the disappearance of hydrogen and carbon dioxide gas from the earth’s atmosphere and, as a consequence, from the earth’s water bodies, led to the disappearance of conditions most suitable both for the emergence of the first cells and for their life activity. However, the fact that cellular life forms have survived to this day indicates that ancient cells found a means to compensate for this disappearance. Given this, the fact that the mitochondrial Krebs cycle is a powerful producer of both atomic hydrogen and molecular carbon dioxide (Figure 2) deserves attention.
Figure 2. This is a Russian-language diagram of the Krebs cycle, which turned out to be most suitable for this article; the suitability of this diagram lies in the fact that it is free of many details that obscure the fact that the main mitochondrial products are atomic hydrogen and carbon dioxide [11].
Pairs of hydrogen atoms released in the reactions of the Krebs cycle are enclosed in circles; it is now believed that these hydrogen atoms are targeted to reduce FAD and NAD, in accordance with [12, 13].
Carbon dioxide molecules, also released in the reactions of the Krebs cycle, are enclosed in squares.
So, it is likely that it was the absorption of mitochondria that allowed ancient cells to bring the gas composition of their cytoplasms closer to the gas composition of ancient waters. It is also likely that it was precisely this absorption that allowed ancient cells to retain the restorative properties of their cytoplasm, which are believed to have been characteristic of both the ancient Earth’s atmosphere and ancient Earth’s waters [4].
Apparently, it is worth noting here that the latter assumption is based on the electron-donating properties of hydrogen gas in aqueous media (Figure 3, left).
Figure 3. This is a diagram of an air-hydrogen electrochemical cell. This diagram shows that the negative electrization of water occurs when it is bubbled with hydrogen gas (left), while the positive electrization of water occurs when it is bubbled with air (right); respectively, the red arrows indicate the movement of electrons from a compartment containing an aqueous solution bubbled with hydrogen gas to a compartment containing an aqueous solution bubbled with air [11].
At the same time, it was precisely this absorption of mitochondria that allowed ancient cells to enrich their cytoplasms with carbon dioxide and, therefore, reproduce the buffering properties of ancient reservoirs in them [14]; this is apparently confirmed by the fact that the buffering properties of biological fluids of modern mammals, including humans, are still based on the buffering properties of aqueous solutions of carbon dioxide generated in the Krebs cycle (Figure 2) [15 – 17].
Thus, there is enough reason to assume that the mitochondria absorbed by ancient cells initially performed a purely compensatory, rather than bioenergetic, function. At the same time, there is no doubt that it was precisely this compensatory function that mitochondria were able to perform only before the appearance of oxygen gas in the earth’s atmosphere (Figure 1, right), called the Great Oxidative Event [18 – 20]. So, it was the simultaneous appearance of gaseous oxygen in the cellular environment that undoubtedly transformed mitochondria from a means of maintaining a favorable gas composition of the cell cytoplasm into sources of superoxide anions [21 – 24] and, in parallel, hydrogen ions (Figure 4):
O2 + H● → O2– + H+ (1).
Figure 4. This is a typical diagram of a working mitochondrion: during oxidative phosphorylation, molecular oxygen is converted into superoxide anions and hydrogen atoms into protons, which are released by mitochondria (according to [12, 13]).
Apparently, it is worth noting here that it is precisely this parallelism that allows comparing mitochondria after the Great Oxidative Event with real air-hydrogen electrochemical cells (Figure 3). One way or another, it was the Great Oxidative Event that transformed mitochondria not only into sources of ATP (Figure 4), but also into sources of substances that are now considered the root causes of many human diseases, including senile and cancer [25 – 45]. Since a person cannot help but breathe, and it is impossible to remove mitochondria from his cells, this state of affairs seems insoluble, at least from an ordinary point of view. With that in mind, it's worth discussing why sweating might solve this problem.
Discussion
In beginning this discussion, one should also take into account the exceptionally high hydration capacity of positively charged water (that is, water enriched with uncompensated protons) [46], due to which it is able to overhydrate both human tissues and cells, thereby promoting numerous
diseases, in particular tumor growth [36, 40 – 43, 47, 48]; it seems that the fact that positively charged water dissolves even graphite (Figure 5), which is considered water-insoluble [14], should be considered as convincing confirmation of the exceptionally high hydration capacity of such water.
So, the appearance of molecular oxygen in the Earth’s atmosphere (Figure 1, right) determined the ability of mitochondria to create proton gradients (Figure 4), on which cellular bioenergetics is believed to be largely based [12, 13, 49 – 53], and at the same time pathogenic superoxide anions and protons (1). Thus, a situation arose in which mitochondria simultaneously became sources of both cellular energy and human diseases.
Thus, the Great Oxidation Event posed a truly Hamletian question to many forms of highly organized life: to be or not to be? (Apparently, it is worth recalling here that the cells of all multicellular organisms, including humans, contain mitochondria [54].)
Figure 5. This is a solution obtained by vigorously shaking graphite powder with positively charged water. It is noteworthy that sediment does not appear in this solution for many years (it is worth taking into account that graphite is considered insoluble in water [14]).
Fortunately, the electromagnetic forces of the Earth, which cause the evaporation of exclusively p ositively charged water, that is, water whose positive charge is provided by uncompensated protons [46, 55, 56], are able to resolve this seemingly intractable situation. To understand this, you should read, that these electromagnetic forces are so powerful that they can even separate water vapour into positively charged, which moves upward, and negatively charged, which moves downward, as in clouds (Figure 6).
Figure 6. Cloud polarization: the top of a typical cloud is positively charged and the bottom of a typical cloud is negatively charged [17, 55, 56].
Given all this, it seems unsurprising that sweating is not so much a means of cooling the human body as a means of ridding it of excess protons, the root cause of a number of diseases, including cancer. Therefore, in particular, intense sweating, especially at night, should be considered not so much as a sign of cancer, but as a means of cancer patients’ bodies to fight it. At the same time, the proposed perception of sweating appears to be prompting a reconsideration of the nature of the anticancer effects of agents such as radiation therapy and chemotherapy that increase sweating in cancer patients. At the same time, it is precisely this perception of sweating that allows perceiving the fever of cancer patients as a means by which their bodies increase their temperature and thereby activate sweating. Obviously, all this explains why fever is a common accompaniment of cancer [57 – 63]. Anyway, all these considerations can be useful to those proponents of anticancer hyperthermia who seek to explain its therapeutic effects [64 – 66].
Apparently, all these considerations allow concluding that unimpeded sweating is an important means of maintaining human health, in particular, a means of preventing cancer. Therefore, cotton underwear and cotton bed linen, which absorb sweat well, can be considered as medicinal, in particular, anti-cancer agents.
Accordingly, the difficulty sweating can be considered the cause of numerous human diseases, including cancer. Given this, antiperspirants that effectively prevent sweating should be considered pathogenic agents, in particular carcinogenic [67].
Conclusion
Although the approach proposed here, essentially evolutionary, is unusual for doctors, it seems completely justified. Thus, it is the proposed approach that allows doctors to perceive a number of modern human diseases, including cancer, as a legacy of the Great Oxidative Event and, in particular, allows them to explain why mitochondria and clean air have become potentially harmful to people, and sweating has become healing.
If all of the above seems too paradoxical, it is useful to remember the health and longevity of the highlanders. So, it seems that both the health and longevity of these people are due to the low pressure of mountain air, which causes both rarefaction of the inhaled air and easier sweating (the latter is due to the fact that low atmospheric pressure promotes evaporation water [68, 69].
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I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
Husain Taha Radhi
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery.
The peer review process, support from the editorial office, and quality of the journal are excellent.
The manuscripts published are of high quality and of excellent scientific value.
I recommend this journal very much to colleagues.
S Munshi
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
Tania Munoz
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
George Varvatsoulias
Dear editorial department:
On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal.
Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner.
I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality.
Sincerely,
Rui Tao.
Rui Tao
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Khurram Arshad
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
Gomez Barriga Maria Dolores
The peer reviewers process is quick and effective, the supports from editorial office is excellent,
the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Lin Shaw Chin
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project.
I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality.
We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Maria Dolores Gomez Barriga
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions,
I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients."
I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dr Maria Dolores Gomez Barriga
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing.
¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dr Maria Regina Penchyna Nieto
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions,
The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed.
The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dr Marcelo Flavio Gomes Jardim Filho
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing!
"I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Zsuzsanna Bene
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
Dr Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin.
The peer reviewers process is quick and effective, the supports from editorial office is excellent,
the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
Lin-Show Chin
My experience publishing in Psychology and Mental Health Care was exceptional.
The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work.
The editorial team was highly supportive and responsive, making the submission process smooth and efficient.
The journal's commitment to high standards and academic rigor makes it a respected platform for quality research.
I am grateful for the opportunity to publish in such a reputable journal.
Sonila Qirko
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional.
I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
Luiz Sellmann
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Zhao Jia
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery,
"The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
Thomas Urban
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient.
The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
Cristina Berriozabal
To Dear Erin Aust,
I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable.
Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free.
I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
Dr Tewodros Kassahun Tarekegn
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
Dr Shweta Tiwari
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication.
This journal certainly publishes quality research articles.
I would recommend the journal for any future publications.
Dr Farooq Wandroo
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
Dr Anyuta Ivanova
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
Dr David Vinyes
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
Gertraud Teuchert-Noodt
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice!
I declare that I am absolutely satisfied with your work carried out with great competence
in following the manuscript during the various stages from its receipt,
during the revision process to the final acceptance for publication.
Thank
Prof. Elvira Farina
Dr Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’
I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).”
The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent.
I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation.
Sincerely and best wishes,
Dr. Oleg Golyanovskiy.
Dr Oleg Golyanovski
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care.
" The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them."
Warm regards,
Susan Anne Smith, PhD.
Australian Breastfeeding Association.
Dr Susan Anne Smith
Dear Jessica Magne,
Editorial Coordinator,
Clinical Cardiology and Cardiovascular Interventions,
Auctores Publishing LLC.
I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable.
Best wishes from,
Farahnaz Fallahian.
Dr Farahnaz Fallahian
Dear Maria Emerson,
Editorial Coordinator,
International Journal of Clinical Case Reports and Reviews,
Auctores Publishing LLC.
I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support.
Yours sincerely
Dr. Victor Olagundoye.
Dr Victor Olagundoye
Dear Ashley Rosa,
Editorial Coordinator,
International Journal of Clinical Case Reports and Reviews.
Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals
Best wishes from,
Susan Anne Smith, PhD.
Australian Breastfeeding Association.
Dr Susan Anne Smith
Dear Agrippa Hilda,
Editorial Coordinator,
Journal of Neuroscience and Neurological Surgery.
The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper.
Thank you so much!
Eric Nussbaum, MD
Dr Eric S Nussbaum
Dr Hala Al Shaikh
This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Hala Al Shaikh
Dear Erin Aust,
Editorial Coordinator,
Journal of General Medicine and Clinical Practice.
We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work.
Best wishes By,
Dr. Rakhi Mishra.
Dr Rakhi Mishra
Dear Jessica Magne,
Editorial Coordinator,
Clinical Cardiology and Cardiovascular Interventions,
Auctores Publishing LLC.
The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal.
Kind regards
Walter F. Riesen
Prof. Dr. Dr. h.c. Walter F. Riesen.
Dr Walter F Riesen
Dear Ashley Rosa,
Editorial Coordinator,
International Journal of Clinical Case Reports and Reviews,
Auctores Publishing LLC.
Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article.
With regards,
Dr. Jelle R. Lettinga.
Dr Jelle Lettinga
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies,
I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries.
Best Regards,
Dariusz Ziora
Dariusz Ziora
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
