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Research Article | DOI: https://doi.org/10.31579/2692-9406/230
1. School of Pharmacy, MIT Vishwaprayag University, Solapur, Maharashtra, India.
2. D.S.T.S. Mandal’s College of Pharmacy, Jule Solapur, Maharashtra, India.
3. School of Health Sciences and Technology, Dr. Vishwanath Karad MIT World Peace University Kothrud, Pune, Maharashtra, India.
*Corresponding Author: Shrishail M Ghurghure, School of Pharmacy, MIT Vishwaprayag University, Solapur, Maharashtra, India.
Citation: Shrishail M Ghurghure, Trupti Gaikwad, Rudramuni Kore, Chandrasekhar D Bobade., (2025). Development of Teneligliptin Polymeric Nanocarriers for Antidiabetic Therapy: Formulation and Evaluation., J, Biomedical Research and Clinical Reviews, 11(2) DOI: 10.31579/2692-9406/230.
Copyright: © 2025 Shrishail M Ghurghure. This is an open-access article distributed under the terms of The Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 25 September 2025 | Accepted: 02 October 2025 | Published: 14 October 2025
Keywords: teneligliptin; diabetes mellitus; nanoparticles; nanoprecipitation; drug release kinetics
The present study focuses on the formulation and evaluation of Teneligliptin-loaded nanoparticles by using the nanoprecipitation method to enhance the solubility of teneligliptin and therapeutic efficacy in the management of Type 2 Diabetes Mellitus. The nanoparticle prepared by using ethyl cellulose and polyvinyl alcohol was employed as polymer and stabilizer, respectively, to prepare nine different batches F1 to F9 were prepared. The nanoparticles were characterized for total drug content, entrapment efficiency, particle size, zeta potential, surface morphology, FT-IR, DSC and XRD study. Drug content among the formulations ranged from 90.94 % to 99.06 %, and entrapment efficiency varied between 93.95 % and 99.17 %. Particle size analysis revealed a range of 194.80 nm to 268.50 nm, while zeta potential values spanned from −11.25 mV to −26.90 mV, indicating good colloidal stability. In vitro drug release studies conducted over 60 minutes showed cumulative release ranging from 44.18 % to 76.74 %. Batch F7 shows excellent results optimal characteristics, including the highest drug content (99.06 %), entrapment efficiency (99.17 %), and favourable particle size distribution. In vitro drug release studies revealed that F7 exhibited the maximum cumulative drug release (76.74 % at 60 minutes), following Korsmeyer–Peppas kinetics indicative of anomalous (non-Fickian) diffusion. These findings suggest that Teneligliptin nanoparticles, particularly formulation F7, offer a promising approach for improved drug delivery and bioavailability in diabetic therapy.
Diabetes is a metabolic disorder characterized by high levels of glucose in the blood, resulting from either inadequate insulin secretion or the body's inability to use insulin effectively. The primary forms of diabetes mellitus include Type 1 Diabetes Mellitus (T1DM), commonly called insulin-dependent diabetes; Type 2 Diabetes Mellitus (T2DM), also known as non-insulin-dependent diabetes; and Gestational Diabetes Mellitus (GDM), which arises during pregnancy.[1]
Type 1 diabetes mellitus, often referred to as insulin-dependent diabetes, typically affects children and young adults under 30 years of age, although it can also appear later in life. This form of diabetes arises when the insulin-producing beta cells in the pancreas, specifically within the islets of Langerhans, are destroyed, usually due to an autoimmune reaction or unidentified factors. Because the body can no longer produce insulin, individuals with type 1 diabetes must rely on insulin therapy as their primary treatment.[2]
In recent times, type 2 diabetes mellitus has increasingly been diagnosed in overweight children, even though it has typically been seen in adults above 30 years of age. Known as non-insulin-dependent diabetes mellitus (NIDDM), this condition develops when the body becomes resistant to insulin and there is a comparatively reduced production of insulin.[3]
Gestational diabetes mellitus (GDM) refers to a form of glucose intolerance that first appears during pregnancy. It is more frequently seen in women who are overweight or have a genetic predisposition to diabetes. Proper treatment to control blood sugar levels is crucial to reduce the likelihood of complications in the baby.[4]
Diabetes affects multiple organ systems in the body and, if not properly controlled, can lead to serious health issues over time. These health problems are typically divided into two categories: microvascular and macrovascular complications. Microvascular complications arise from damage to small blood vessels and include conditions like nerve damage (neuropathy), kidney damage (nephropathy), and eye damage (retinopathy).[5] Macrovascular complications include conditions like heart disease, stroke, and peripheral vascular disease. In cases of peripheral vascular disease, injuries or bruises may heal slowly, which can lead to the development of gangrene and, in severe situations, may necessitate amputation.[6]
1.1 Nanoparticles:
Nanoparticles (NPs) are tiny solid carriers used in drug delivery systems, generally ranging in size from 10 to 1000 nm. These carriers may be either biodegradable or non-biodegradable, and the drug can be incorporated by dissolving, encapsulating, entrapping, or binding it within the nanoparticles structure. The term "nanoparticles" includes two main types: nanospheres and nano capsules. In nano capsules, the drug resides in a central oily or aqueous core enclosed by a membrane, while in nanospheres, the drug is evenly dispersed throughout the particle matrix. Nanotechnology presents innovative opportunities in healthcare, particularly in areas where conventional therapies are limited. [7]
The main goals in designing nanoparticles for drug delivery include controlling their size, modifying their surface properties, and optimizing the release pattern of the active drug. These strategies help ensure targeted delivery, precise dosing, and sustained therapeutic effect at the intended site of action.[8]
Teneligliptin is an oral antidiabetic drug used in managing type 2 diabetes mellitus. It belongs to the class of DPP-4 (Dipeptidyl Peptidase-4) inhibitors. These medications work by boosting the effects of incretin hormones, which promote insulin secretion following meals and decrease glucose generation in the liver. This combined mechanism aids in regulating blood sugar levels effectively.[9] The main aim of the present study was the preparation of nanoparticles using polymers like Ethyl Cellulose at different concentrations by Nanoprecipitation method.
2.1. Materials:
Teneligliptin was purchased from Toronto Research Chemicals Mumbai, and all other polymers like Polyvinyl Alcohol (PVA), Ethyl Cellulose, Methanol, Dichloromethane (DCM), and Distilled Water were purchased from Rajesh Chemical Mumbai.
2.2. Method:
Utilizing a variety of polymers, the nanoprecipitation technique was employed to create Teneligliptin drug nanoparticles. Teneligliptin drug nanoparticles were prepared using the nanoprecipitation technique with a variety of polymers. Initially, an aqueous solution was prepared by weighing the required amount of Polyvinyl Alcohol (PVA) into a dry beaker. A measured quantity of distilled water was gradually added to the beaker containing PVA, and the mixture was stirred using a magnetic stirrer at 1800 rpm for approximately 6 hours until the PVA was completely dissolved. Separately, an organic solution was prepared by accurately weighing 20 mg of Teneligliptin and transferring it into a dry beaker. To this, 10 ml of methanol was added to dissolve the drug, followed by the gradual addition of 10 ml of dichloromethane (DCM). The required amount of ethyl cellulose was then weighed and added to the same beaker containing the Teneligliptin, methanol, and DCM mixture. This organic phase was then slowly injected into the prepared aqueous phase under continuous stirring at 1800 rpm for about 5 hours to allow nanoparticle formation via the nanoprecipitation process. The resulting suspension was kept in a refrigerator overnight to facilitate the settling of particles. The formed nanoparticles were then filtered using Whatman filter paper, collected, and dried. The method of Preparation is shown in Figure 1.
Figure 1: Preparation of Nanoparticles by Nanoprecipitation Method
2.3 Characterization of Optimized Teneligliptin Nanoparticles:
2.3.1. Total Drug Content (TDC)
An amount of polymeric nanoparticles equivalent to 5 mg of the drug was dissolved in methanol and stirred at 600 rpm for duration of 3 hours. The drug concentration in the resulting supernatant was then analyzed using a UV-visible spectrophotometer.[10]
2.3.2. Entrapment Efficiency (EE)
Polymeric nanoparticles containing an equivalent of 5 mg of drug were dispersed in 2 ml of distilled water and subjected to ultracentrifugation at 10,000 rpm for 30 minutes at a temperature of 5°C. After centrifugation, the supernatant was carefully removed. The drug entrapment within the nanoparticles was calculated by subtracting the quantity of drug found in the supernatant from the total drug initially used in the formulation process.[11] The determination of entrapment efficiency was repeated three times per sample. The percentage drug entrapment was calculated using the following equation:
2.3.3. Particle Size Analysis
The particle size of the formulation was evaluated by appropriately diluting the sample and analyzing it using a Zetasizer (Malvern Instruments). This method allowed for the determination of the formulation’s particle size.[12]
2.3.4. Scanning electron microscopy
The surface characteristics of Teneligliptin nanoparticles were examined using a scanning electron microscope (SEM), model S-3700N. SEM is an analytical technique that utilizes a focused beam of electrons to scan the surface of a sample, generating a highly magnified image. This technique provides a two-dimensional visualization and offers insights into the sample’s surface structure and elemental composition. [13,14]
2.3.5. FT-IR Spectroscopy
FTIR analysis was performed to assess potential chemical interactions between the drug and polymer. The samples were examined over a spectral range of 400 to 4000 cm⁻¹ using a Bruker Alpha-II instrument with a carbon black reference. To enhance signal intensity and minimize moisture interference, the detector was purged thoroughly with dry helium gas.[15]
2.3.6. Differential Scanning Calorimetry (DSC)
The physical form of the active pharmaceutical ingredient (API) within the nanoparticles was assessed using differential scanning calorimetry (DSC), employing a Mettler Toledo DSC-250 instrument. The sample was subjected to a heating rate of 100 °C per minute, with the temperature range set from 25 °C to 300 °C. The analysis was conducted under a nitrogen atmosphere, maintaining a nitrogen purge flow rate of 20 mL per minute.[16]
2.3.7. X-Ray Diffraction (XRD) Study
X-ray diffraction analysis of the powdered samples was performed using a Bruker D8 Advance X-ray diffractometer (USA) with Cu Kα radiation, operating at 40 kV and 25 mA. The scanning was conducted over a 2θ range of 10° to 60°. Diffraction patterns were obtained for both pure Teneligliptin and its solid nanoparticle formulation.
2.3.8. Zeta Potential Analysis
The surface charge of the nanoparticles was analysed using a Horiba Scientific instrument. One millilitre of the nanoparticle sample was taken and diluted with double-distilled water. To avoid agglomeration, the diluted sample was subjected to ultrasonication for five minutes using a bath sonicator. After this treatment, the zeta potential was measured by placing the sample in a transparent cuvette.[17]
2.3.9. In vitro drug release
An In-vitro drug release study was conducted to examine the release kinetics of polymeric nanoparticles under sink conditions. The evaluation of drug release from the nanoparticles was performed using a USP Type II dissolution apparatus (Electro lab) operating at 50 rpm. The nanoparticle formulations were tested in distilled water as the dissolution medium an hour. At predetermined time intervals, 5 mL samples were withdrawn, filtered using Whatman filter paper No. 41, and appropriately diluted. The drug content in the samples was then analysed using UV spectrophotometry.[18]
2.3.10. Stability study
Stability testing was conducted on the optimized batch, which exhibited the highest entrapment efficiency, drug release, and drug content. The formulation was stored using a Remi SC-6 Plus stability chamber under two temperature conditions: 25°C and 40°C. Under ICH guidelines, drug content was analysed after 45 and 90 days to assess any changes in the nanoparticle parameters.[18]
3.1 Total Drug Content:
The drug content of Teneligliptin nanoparticles was evaluated for all nine formulation batches (F1 to F9) to assess the total amount of drug within the nanoparticulate system. The results, shown in Figure 2, reveal that the drug content varied between 90.94% to 99.06%, indicating effective drug loading across all formulations. Among all the batches, F7 exhibited the highest drug content 99.06%, while F2 recorded the lowest 90.94%.
Figure 2: Percent (%) Drug content report of formulation F1 to F9
3.2 Entrapment Efficiency
The entrapment efficiency of all nanoparticle formulations ranged from 93.95% (F2) to 99.17% (F7). The highest entrapment was observed in batch F7, indicating superior formulation parameters. The consistently high EE values across all batches reflect the robustness and reliability of the preparation method used for Teneligliptin nanoparticles, it is shown in figure 3.
Figure 3: Percent Entrapment Efficiency report of Formulations F1 to F9.
3.3 Particle Size Analysis
Using a Horiba scientific instrument, the mean averaged particle size of the Teneligliptin nanoparticle has been determined. The size of each particle was determined using the scattering of dynamic light, and 0.3 ml of the substance was put into the viewing unit for examination. At room temperature, the size of particles was analyzed at a scattering angle of 90°C. The enormity has been converted to a size and shape distribution by combining 3 parallel measurements obtained while waving in Brownian motion. The particle size analysis of Teneligliptin nanoparticles across batches F1 to F9 was found to be within the range of 194.80 to 268.50 as shown in Figure. 4 and 5.
Figure 4: particle size report of formulation F1 to F9
Figure 5: Particle Size Report of Optimized Batch F7.
3.4 Zeta Potential Analysis:
The net charge on particles was measured with the help of a Horiba scientific device. 1 ml of NP was collected and then diluted with double-distilled water. The scattered underwent a five-minute ultra-bath sonicator treatment to prevent agglomeration. Zeta potential had been determined following the extraction of the sample from the transparent cuvette. The Zeta potential of each batch of solid TG nanoparticles has been determined. The produced batches of NP were found to have a zeta potential ranging from 11.25 to -26.90 mV. As shown in Table 1 and Figure 6.
| Batch | Zeta Potential (mV) |
| F1 | -15.90 |
| F2 | -13.60 |
| F3 | -15.20 |
| F4 | -14.90 |
| F5 | -13.50 |
| F6 | -12.20 |
| F7 | -11.60 |
| F8 | -12.60 |
| F9 | -11.50 |
Table 1: Zeta potential report of formulation batches F1 to F9
Figure 6: Zeta Potential Report of Optimized Batch F7
3.5 Scanning Electron Microscopy
The Teneligliptin appeared as smooth surfaced, irregularly shaped and crystalline in nature. NP was observed to be small-sized, spherical in shape and porous in nature as shown in Figure. 7.
Figure 7: SEM Photographic Images of Optimized Batch F7.
3.6 FT-IR Spectroscopy
The FTIR analysis was conducted to confirm the chemical integrity of Teneligliptin and to investigate any possible interactions between the drug and the excipients used in the formulation of its nanoparticles. The characteristic absorption bands of pure Teneligliptin were identified and compared with those of the nanoparticle formulation and individual excipients. Overall, the FTIR analysis confirms that Teneligliptin retains its chemical integrity upon formulation into nanoparticles, with no significant structural modifications. The slight shifts and the appearance of new peaks in the formulation spectrum suggest successful encapsulation and physical interactions with the excipients, without any chemical incompatibility or degradation of the drug. The FTIR spectra and its detail shown in figure 8, 9 and the interpretation data shown in table 2.
Figure 8: FTIR Spectra of Teneligliptin.
Figure 9: FTIR Spectra of Optimized Batch F7.
| Functional Group | Absorbance Frequency Region (cm⁻¹) | Pure Teneligliptin | Teneligliptin Nanoparticles |
| N–H Stretching | 3350–3500 | 3338.61 | 3476.55 |
| C–H Stretching | 3000–2850 | 2938.09, 2926.15 | 2975.50, 2874.06 |
| C=O Stretching | 1750–1700 | 1744.87 | |
| C–N Stretching (Primary amine) | 1390–1250 | 1342.15, 1252.56 | 1384.37 |
| C–O Stretching | 1300–1000 | 1172.66 – 1020.72 | 1102.24 |
| Aromatic C=C / C=N Stretching | 1600–1450 | 1603.10, 1507.17 | 1622.24 |
| C–Cl Stretching | 785–540 | 717.66, 480.49 | 577.62, 554.20, 486.09 |
Table 2: Data Interpretation of FTIR Spectra.
3.7 Differential Scanning Calorimetry (DSC):
DSC thermograms revealed a sharp endothermic peak at 231.10 °C for the TG sample, indicating high crystallinity and thermal stability. In contrast, the F7 formulation displayed a broader, lower-intensity peak at 177.99 °C with significantly reduced enthalpy, suggesting decreased crystallinity and possible drug amorphization. These thermal shifts confirm improved drug-excipient miscibility in F7, supporting its potential for enhanced solubility and bioavailability. The DSC thermogram for pure drug and optimized batch F7 is shown on figure 10 and 11.
Figure 10: DSC Thermogram of Pure Drug (Teneligliptin)
Figure 11: DSC Thermogram of Optimized Batch F7
3.8 X-Ray Diffraction (XRD) Study:
The XRD pattern of pure Teneligliptin displays a broad peak around 20° 2θ, indicating its predominantly amorphous nature. In contrast, the optimized formulation F7 shows distinct and sharp peaks at 10.68°, 17.63°, 20.28°, and 25.60°, suggesting the presence of crystalline structures. The appearance of these peaks in F7 confirms a transformation from the amorphous state to a more crystalline form, likely due to interactions with excipients or processing conditions during formulation, It is shown in figure 12 for pure drug and optimized batch F7 in Figure 13
Figure 12: XRD Spectra of Pure Drug (Teneligliptin).
Figure 13: XRD Spectra of Optimized Batch F7.
3.9. In Vitro Drug Release:
The in vitro drug release profiles of nine different formulations (F1 to F9) were studied using a dissolution test conducted over 60 minutes. The cumulative percentage of drug release was recorded at 5-minute intervals and is presented in the table 3:
| Time (min) | F1 | F2 | F3 | F4 | F5 | F6 | F 7 | F8 | F9 |
| 5 | 15.00 | 16.15 | 17.31 | 18.46 | 19.62 | 20.77 | 26.05 | 21.92 | 21.27 |
| 10 | 16.23 | 17.48 | 18.72 | 19.97 | 21.22 | 22.47 | 28.18 | 23.72 | 23.01 |
| 15 | 17.45 | 18.80 | 20.14 | 21.48 | 22.83 | 24.17 | 30.32 | 25.51 | 24.75 |
| 20 | 18.00 | 19.38 | 20.77 | 22.15 | 23.54 | 24.93 | 31.26 | 26.31 | 25.52 |
| 25 | 20.45 | 22.03 | 23.60 | 25.18 | 26.75 | 28.32 | 35.53 | 29.89 | 29.00 |
| 30 | 28.36 | 30.55 | 32.73 | 34.91 | 37.09 | 39.28 | 49.26 | 41.45 | 40.21 |
| 35 | 35.45 | 38.18 | 40.91 | 43.64 | 46.37 | 49.10 | 61.58 | 51.82 | 50.27 |
| 40 | 37.50 | 40.38 | 43.27 | 46.16 | 49.04 | 51.93 | 65.13 | 54.80 | 53.17 |
| 45 | 39.13 | 42.15 | 45.16 | 48.17 | 51.18 | 54.19 | 67.97 | 57.20 | 55.49 |
| 50 | 40.91 | 44.06 | 47.20 | 50.35 | 53.50 | 56.65 | 71.05 | 59.79 | 58.00 |
| 55 | 42.95 | 46.26 | 49.56 | 52.87 | 56.18 | 59.48 | 74.61 | 62.78 | 60.90 |
| 60 | 44.18 | 47.58 | 50.98 | 54.38 | 57.78 | 61.18 | 76.74 | 64.57 | 62.64 |
Table 3: In-Vitro Drug Release Study of all Batches
The in-vitro dissolution study confirmed that the nanoparticle formulations significantly improved the dissolution rate of Teneligliptin. Among all the tested formulations, F7 was identified as the most promising, with the highest cumulative drug release. These findings suggest that formulation F7 may offer enhanced bioavailability and is suitable for further pharmacokinetic and in-vivo evaluations.
3.10 In-Vitro Drug Release Kinetics:
The in vitro drug release behaviour of nine different formulation batches (F1–F9) was assessed 60-minute period. All formulations showed a time-dependent increase in drug release, with batch F7 achieving the highest cumulative release of 76.74% at the end of the study, identifying it as the most effective formulation. To investigate the underlying release mechanism and kinetics, the data were fitted to five established kinetic models: Zero-order, First-order, Higuchi, Hixson–Crowell, and Korsmeyer–Peppas. The suitability of each model was determined through various statistical parameters, including the coefficient of determination (R²), Akaike Information Criterion (AIC), Model Selection Criterion (MSC), along with kinetic parameters such as the rate constant (k) and release exponent (n).
Table 4 Regression Coefficient (R²) Values of Drug Release Data Obtained from Various Kinetic Models and "n" Value (Diffusional Exponent) According Korsmeyer 's-Peppas. The detail kinetics release data shown in table 4 and Figure 13.
| Drug Kinetic Modeling | |||||||||||
| Formulation | Zero Order | First Order | Higuchi | Hixson Crowell | Korsmeyer Peppas | ||||||
| R2 | k0 | R2 | k1 | R2 | kH | R2 | kHC | R2 | n | kKP | |
| F1 | 0.8611 | 0.848 | 0.9175 | 0.011 | 0.9333 | 5.513 | 0.9038 | 0.003 | 0.9521 | 0.637 | 3.343 |
| F2 | 0.8611 | 0.913 | 0.9208 | 0.012 | 0.9333 | 5.937 | 0.9071 | 0.004 | 0.9521 | 0.637 | 3.601 |
| F3 | 0.8611 | 0.979 | 0.9240 | 0.013 | 0.9333 | 6.361 | 0.9103 | 0.004 | 0.9521 | 0.637 | 3.858 |
| F4 | 0.8611 | 1.044 | 0.9268 | 0.014 | 0.9333 | 6.786 | 0.9135 | 0.004 | 0.9521 | 0.637 | 4.115 |
| F5 | 0.8611 | 1.109 | 0.9294 | 0.016 | 0.9333 | 7.210 | 0.9165 | 0.005 | 0.9521 | 0.637 | 4.373 |
| F6 | 0.8611 | 1.174 | 0.9315 | 0.017 | 0.9333 | 7.634 | 0.9195 | 0.005 | 0.9521 | 0.637 | 4.630 |
| F7 | 0.8611 | 1.473 | 0.9350 | 0.024 | 0.9333 | 9.575 | 0.9307 | 0.007 | 0.9521 | 0.637 | 5.807 |
| F8 | 0.8611 | 1.240 | 0.9332 | 0.018 | 0.9333 | 8.057 | 0.9223 | 0.005 | 0.9521 | 0.637 | 4.886 |
| F9 | 0.8611 | 1.202 | 0.9323 | 0.018 | 0.9333 | 7.816 | 0.9207 | 0.005 | 0.9521 | 0.637 | 4.740 |
Table 4: In-Vitro Drug Release Kinetics
The Korsmeyer–Peppas model best described drug release across all formulations, with a high R² of 0.9521, lowest AIC, and highest MSC values, indicating an anomalous (non-Fickian) diffusion mechanism. The average release exponent (n ≈ 0.637) suggests that a combination of diffusion and polymer matrix relaxation/erosion controls the release. Zero-order kinetics showed the poorest fit, while First-order, Higuchi, and Hixson–Crowell models fit moderately but were inferior to Korsmeyer–Peppas. Among batches, F7 exhibited the highest release rate constant (k = 5.807) and the most favorable statistical parameters, confirming its rapid and controlled drug release via a balanced non-Fickian mechanism, making it the optimal formulation for further development.
Figure 14: In-Vitro Release Profile of the Formulations F1 to F9.
3.11 Stability Studies:
Stability testing was conducted on the optimized nanoparticle batch, which exhibited high entrapment efficiency, drug content, and drug release. The formulation was stored under two temperature conditions—25°C and 40°C—to evaluate stability. As per ICH guidelines, drug content was analyzed at 45 and 90-day intervals to assess any variations in entrapment efficiency, drug release, and drug content. The outcomes are presented in Table 5. The nanoparticles remained stable throughout the testing period under the specified conditions, confirming compliance with ICH stability standards. The stability data of optimized batch is shown in table 5.
| Storage condition | Entrapment Efficiency (%) | Drug Content (%) | % Drug Release at 1 hr. | ||||||
| Initial | 45 Days | 90 Days | initial | 45 Days | 90 Days | Initial | 45 Days | 90 Days | |
| 25°C | 99.17 | 98.75 | 98.43 | 99.06 | 98.60 | 98.10 | 76.74 | 75.87 | 75.20 |
| 40°C | 99.17 | 98.58 | 98.09 | 99.06 | 98.25 | 97.85 | 76.74 | 75.55 | 74.93 |
Table 5: Stability Study of NP of Optimized Batch F7.
It is concluded that the prepared nanoparticles of Teneligliptin were evaluated for all the parameters, including drug content, entrapment efficiency, particle size, zeta potential, morphological analysis, thermal and crystallinity studies, and in vitro drug release behavior. The results demonstrated successful formulation of nanoparticles using the nanoprecipitation method with Ethyl Cellulose as the polymer. Among the nine batches developed (F1–F9), formulation F7 was identified as the optimized batch due to its superior performance, showing the highest drug content (99.06 %), entrapment efficiency (99.17 %), optimal particle size (194.80 nm), and maximum drug release (76.74 % at 60 minutes). Zeta potential values indicated stable colloidal dispersion, and characterization techniques (SEM, FT-IR, DSC, XRD) confirmed the formation of stable nanoparticles with modified physicochemical properties. Drug release followed the Korsmeyer–Peppas kinetic model, suggesting a controlled, non-Fickian mechanism. Stability studies confirmed that the optimized formulation remained stable under ICH storage conditions over 90 days. Therefore, the developed Teneligliptin nanoparticles, particularly batch F7, represent a promising approach for enhancing solubility, bioavailability, and therapeutic efficacy in the management of Type 2 Diabetes Mellitus.
Not Applicable.
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Authors thank to Principal and Management of D.S.T.S. Mandal’s College of Pharmacy, Jule, Solapur, for their continuous Support to carry out this research work.
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Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.
Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.
Dear Grace Pierce, Editorial Coordinator of the journal IJCCR, I had a very positive experience with Auctores - Journal throughout the publication process. The Editorial Team was highly responsive, professional, and supportive at every stage. I would like to extend my sincere thanks to the Editor: Grace Pierce, for her guidance and assistance. The peer-review process was smooth and constructive, helping improve the quality of my work. I would gladly recommend Auctores Journal to fellow researchers and authors. Dr. SABITA SINHA, Medical Oncologist, MD (Electro Homeopathy).
