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Research Article | DOI: https://doi.org/10.31579/2690-4861/1072
Health Care Analysis Center, Renatech Co., Ltd., 4-19-15 Takamori, Isehara, Kanagawa 259-1114, Japan.
*Corresponding Author: Naoyuki Okamoto, Health Care Analysis Center, Renatech Co., Ltd., 4-19-15 Takamori, Isehara, Kanagawa 259-1114, Japan.
Citation: Naoyuki Okamoto, Shunsuke Fujimoto, Takuya Shimizu, Mitsuhiro Ueda, Seiichi Inagaki, (2026), Development of A "Cancer Risk" Screening Method Based on Differences in The Balance of Trace Element Concentrations in The Blood Using ICP-MS with A Case-Control Study Approach: Metallo-Balance Method, International Journal of Clinical Case Reports and Reviews, 35(1); DOI:10.31579/2690-4861/1072
Copyright: © 2026, Naoyuki Okamoto. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 23 March 2026 | Accepted: 03 April 2026 | Published: 07 April 2026
Keywords: trace elements, serum, cancer risk, screening, positive predictive value, case-control study
Cancer control is a pressing issue in many countries, and preventing cancer deaths through early detection and treatment is extremely important.
This study conducted a case-control study focusing on trace element concentrations in blood to develop a low-cost, highly accurate, and patient-friendly screening method. Serum samples were collected from 2,912 cancer patients and 5,814 members of the general population. A "risk diagnosis" method was developed using binary logistic regression analysis based on serum concentrations of 17 elements measured using ICP-MS. Efficacy was evaluated using sensitivity, specificity, and AUC. In addition, the incidence of cancer within one year after blood collection was investigated among 7,993 participants in the test period of this method and evaluated using positive predictive values.
The analysis results showed high sensitivity and specificity, with AUCs ranging from 0.737 to 0.993, indicating effective discrimination. Furthermore, the positive predicted values were higher than the theoretical predicted values for pancreatic and prostate cancer in men, and similar to the theoretical predicted values for stomach and colorectal cancer in women.
These results indicate that this method can predict "cancer risk" with high accuracy and is an effective tool for cancer detection.
According to Globocan's 2020 report, approximately 20 million people worldwide are diagnosed with cancer each year, and approximately 10 million dies from it. The importance of cancer prevention activities is emphasized in countries around the world, including Japan. These measures can be broadly divided into three categories. Primary prevention aims to reduce the risk of cancer through lifestyle improvements, secondary prevention aims to reduce the risk of death through early detection and treatment of cancer, and tertiary prevention aims to alleviate pain and improve the quality of life for cancer patients [1]
In Japan, cancer control is primarily implemented as secondary prevention, with active screening for five sites: stomach, colorectal, lung, breast, and cervical cancer [2]. In other countries, screening for stomach and lung cancer is not implemented in most countries, and screening mainly focuses on colorectal, breast, and cervical cancer. Japan's colorectal cancer screening rate is low at 24.9%, lower than South Korea's 34.1% and the United States' 52.1%. Similarly, Japan's breast and cervical cancer screening rates are lower than those of South Korea, the United States, and the United Kingdom, posing a significant challenge [3]. Japan aims to achieve a screening rate of over 50% for all cancers, but is currently far from this goal. According to a study by Takeda et al. [4], reasons for not undergoing cancer screening include "I don't think it's necessary because I go to the clinic regularly," "I've been tested before," "I have a health checkup," "I don't have time," and "I'm anxious about the test." These results suggest that awareness of cancer risk is insufficient or that the benefits of cancer screening are not widely recognized.
Currently, cancer screening methods include direct observation and palpation (palpation, endoscopy, etc.) and methods for visualizing the inside of the body (X-ray, CT scan, MRI, PET scan, etc.). However, visual and palpation methods are limited to the body surface and organs of the digestive tract, imaging diagnostics are expensive and difficult to interpret, and there are problems such as radiation exposure to patients and stress caused by fear and anxiety about undergoing examinations, which has resulted in low screening rates and low patient numbers. Therefore, in recent years, the focus has been on developing new diagnostic methods using bodily fluids such as blood, urine, and saliva, which are called "liquid biopsies," and research is being conducted with the aim of early detection of diseases [5].
We have started research focusing on trace element concentrations in blood. The reason for focusing on trace elements is that while some are essential for living organisms, many have unknown functions or have been reported to have beneficial functions, and it has been suggested that excess or deficiency can inhibit normal biological responses and cause disorders and diseases. Numerous cases have been reported, including anemia due to iron deficiency [6], osteoporosis due to calcium deficiency [7], Minamata disease due to excess organic mercury [8], Keshan disease due to selenium deficiency [9], decreased zinc levels in schizophrenia [10], and decreased magnesium levels and increased phosphorus and calcium levels in heart failure [11]. Regarding cancer, breast cancer patients have been reported to have low serum zinc levels and high calcium, copper, iron, and magnesium levels [12], and breast cancer patients [13] and ovarian cancer patients [14] have also been reported to have high copper/zinc ratios. It has been reported that kidney cancer patients have high cadmium and lead concentrations and low zinc, iron, and manganese concentrations [15]. Furthermore, lung cancer patients have high copper and copper/zinc ratios, but low zinc and iron concentrations [16]. These reports suggest that serum trace element concentrations in diseased patients differ from those in the general population. Focusing on this, we have been developing a new cancer risk diagnostic method for colorectal cancer (men and women), prostate cancer, and breast cancer using blood trace element concentration balances measured by inductively coupled plasma mass spectrometry (ICP-MS) [17]. In this paper, we report the results of our previous study, in which we increased the number of cases and cancer sites to improve the accuracy of our cancer risk estimation method for each cancer site (called the metallobalance (MB) method) and confirmed its reliability through follow-up surveys for practical application.
1. Case and Control Serum Samples
Case serum samples were collected from cancer patients who were hospitalized and treated at Kanagawa Prefectural Cancer Center and Chiba Prefectural Cancer Center during the 10-year period from April 2005 to March 2015. The cancer sites in the collected serum were six sites in men (stomach, colorectal, lung, liver, pancreas, prostate) and nine sites in women (stomach, colorectal, lung, liver, pancreas, breast, cervix, uterine body, ovary), which have high cancer incidence/mortality rates in Japan [3]. Patients were informed by their attending physicians about the provision of serum and other samples for medical research and the use of medical information for research, and provided written informed consent to participate in this study. After admission and examination, blood was collected from the cubital vein in the early morning in a fasting state, converted to serum, and stored at -80°C. A total of 2,912 serum samples was provided from cancer patients. The breakdown was 272 cases of stomach cancer (140 men, 132 women), 455 cases of colon cancer (271 men, 184 women), 427 cases of lung cancer (269 men, 158 women), 140 cases of liver cancer (110 men, 30 women), 277 cases of pancreas cancer (143 men, 134 women), 279 cases of prostate cancer, 461 cases of breast cancer (185 women), 295 cases of uterus cancer, and 121 cases of ovarian cancer.
The control group consisted of 5,814 individuals (2,181 men and 3,633 women) who underwent health checkups at 15 clinics in seven prefectures across Japan between April 2016 and March 2018, had no history of cancer, provided written consent to donate blood for this study. To confirm the diagnostic accuracy of the "cancer risk" prediction formula for six sites in men and nine sites in women derived from this case-control study, a total of 7,993 people (2,949 men and 5,044 women) who underwent this test over a two-year period from April 2019 to March 2021 at the same 15 facilities that cooperated in this study and gave written consent to a follow-up were surveyed by mail to confirm their cancer status within one year after the test. Confirmation of cancer status was confirmed by submitting a copy of the doctor's diagnosis certificate.
Blood samples (6 ml) from the control and follow-up groups were collected from a cubital vein in the morning at the clinic from participants who had skipped breakfast. After collection, the blood was left at room temperature for 60 minutes, then centrifuged at 3,000 rpm for 10 minutes. The serum was collected and stored in a refrigerator. A few days after collection, the collected serum was sent to the testing center by refrigerated delivery and stored at -80°C until trace element analysis was performed.
2. Study Design
In a previous report [17], we developed a diagnostic method for cancer risk. In this study, we conducted a new case-control study by increasing the number of subjects and cancer site. The study flow is shown in Figure 1. The case and control samples used in the analysis were randomly divided into two groups based on gender and cancer site, with one group serving as training data and the other as validation data. Discriminant analysis was performed on the training data, and based on the discriminant equations derived for gender and cancer site, the individual case and control data assigned to the validation data were substituted into each discriminant equation to verify their discriminant ability. After validation, the case and control data from the training and validation data were combined to increase the number of subjects, and a binomial logistic regression analysis was performed. We aimed to put the newly derived regression equation into practical use as a cancer risk estimation equation.
Figure 1: Case-Control Flow Two-Fold Cross-Validation
This MB test estimates cancer risk by categorizing the discriminant value calculated from the discriminant equation for each cancer site into four levels (A, B, C, D, with cancer risk increasing from A to D). The classification was determined using the discrimination value and sensitivity when the specificity was set to 80% for A and BCD, 95% for AB and CD, and 99% for ABC and D. By inputting the concentration data of 17 elements in the blood collected from new examinees into the cancer site-specific discrimination formula, it became possible to make an ABCD classification for six sites in men and nine sites in women.
3. Measurement and Analysis of Trace Element Concentrations
Trace element concentrations in serum were measured in a cleanroom using inductively coupled plasma mass spectrometry (ICP-MS) after nitric acid pretreatment. Based on the results of preliminary trials, 17 elements were selected for measurement (sodium (Na), magnesium (Mg), phosphorus (P), sulfur (S), potassium (K), calcium (Ca), iron (Fe), cobalt (Co), copper (Cu), zinc (Zn), arsenic (As), selenium (Se), rubidium (Rb), strontium (Sr), molybdenum (Mo), silver (Ag), and cesium (Cs)) whose measurements were stable and reproducible.
The validity of the discriminant equation obtained from the case-control study was evaluated using sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) [18,19]. The discriminant equation was validated by calculating the predictive value TP (true positive) in the case group and the predictive value TN (true negative) in the control group using validation data. Statistical analysis was performed using Excel Statistics (BellCurve, Japan) and SPSS Ver. 24 (IBM, USA).
4. Reagents and Measurement Methods
ICP-MS (Agilent 7800; Agilent Technologies, Santa Clara, CA, USA) was used for the measurement of trace elements. The reagents used for ICP-MS measurements were 61% nitric acid solution/30% hydrogen peroxide solution (Kanto Chemical, Tokyo, Japan), XSTC-622B (ICP-MS mixed standard solution; SPEX CertiPrep, Metuchen, NJ, USA), atomic absorption spectroscopy standard solutions (Na, Mg, P, S, K, Ca, Be, Te; Kanto Chemical, Tokyo, Japan), and ICP-MS metal standard solutions (Y, Rh; AccuStandard, Inc. New Haven, CT, USA). All containers used for the measurements (sample storage bottles, sample bottles, micropipette tips) were made of polypropylene to prevent leakage of trace elements. Furthermore, all containers were washed with ultrapure water (18.00 MΩ·cm or higher) and nitric acid to remove contamination from trace elements.
Table 1 shows the number of serum samples used in the analysis by gender and age group. Table 2 shows the results of the discriminant analysis using the training data and the validation data. The discriminant analysis results showed that the sensitivity, specificity, and AUC for gastric cancer in men were 0.734, 0.907, and 0.901, respectively, and for gastric cancer in women were 0.783, 0.889, and 0.949, respectively. High sensitivity, specificity, and AUC were also obtained for other cancer sites. Furthermore, the accuracy of the discriminant equation was evaluated by calculating true positives (TP) and true negatives (TN) using the validation data. TP ranged from 0.7 to 0.85 for both men and women, and true negatives ranged from 0.8 to 0.95 for both men and women (Table 2).
Based on these results, a new binomial logistic regression analysis was performed using all data. The resulting ROC curves and AUCs (95% confidence intervals) are shown in Figure 2. Similar to the results of the discriminant analysis using the training data, the AUC was approximately 0.9 for both men and women for all cancer sites, demonstrating reliable discrimination results. Figure 3 compares the concentrations of the 17 measured elements by gender and cancer site in a radar chart. This chart shows the ratio, with the average value of the 17 elements in the control group taken as 1.0. Looking at all cancer sites, Co, Cu, As, Mo, and Ag tended to be high in both men and women, while Fe, Zn, Rb, and Cs tended to be low. Furthermore, even for elements with high or low values, differences in patterns were observed when looking at them by gender and cancer site.
| Gender | Age- class | Control | Cancer case | ||||||||||
| Colorectal | Stomach | Lung | Liver | Pancreatic | Prostate | Brest | Cervical | Uterine | Ovarian | Total | |||
Male | 20- | 78 | 1 | - | - | - | - | 1 | |||||
| 30- | 243 | 5 | 1 | 5 | 2 | 2 | - | - | - | - | 15 | ||
| 40- | 530 | 24 | 4 | 8 | 9 | 11 | 1 | - | - | - | - | 57 | |
| 50- | 477 | 64 | 27 | 40 | 21 | 22 | 29 | - | - | - | - | 203 | |
| 60- | 496 | 105 | 50 | 77 | 95 | 63 | 115 | - | - | - | - | 505 | |
| 70- | 329 | 69 | 47 | 109 | 103 | 43 | 125 | - | - | - | - | 496 | |
| 80- | 28 | 4 | 11 | 29 | 35 | 2 | 9 | - | - | - | - | 90 | |
| Total | 2181 | 271 | 140 | 269 | 265 | 143 | 279 | - | - | - | - | 1367 | |
Female | 20- | 178 | 1 | - | 4 | 5 | 10 | ||||||
| 30- | 448 | 3 | 4 | 2 | 2 | - | 61 | 20 | 8 | 8 | 108 | ||
| 40- | 895 | 11 | 11 | 8 | 7 | - | 119 | 51 | 47 | 22 | 276 | ||
| 50- | 962 | 41 | 15 | 22 | 5 | 23 | - | 43 | 39 | 96 | 36 | 320 | |
| 60- | 767 | 73 | 40 | 59 | 31 | 49 | - | 150 | 32 | 93 | 35 | 562 | |
| 70- | 364 | 53 | 47 | 55 | 58 | 44 | - | 70 | 25 | 44 | 18 | 414 | |
| 80- | 18 | 3 | 15 | 11 | 19 | 10 | - | 14 | 11 | 7 | 2 | 92 | |
| 90- | 1 | 1 | 1 | - | 2 | 4 | |||||||
| Total | 3633 | 184 | 132 | 158 | 116 | 134 | - | 461 | 185 | 295 | 121 | 1786 | |
Table 1: Number of controls and cancer patients by sex and age
Gender | Cancer sites | Training | Validation | ||||||||
| No. of control | No. of case | sensitivity | specificity | AUC | No. of control | No. of case | True positive | True negative | |||
Male | stomach |
1,089 | 64 | 0.734 | 0.907 | 0.901 |
1,092 | 76 | 0.763 | 0.922 | |
| colorectal | 134 | 0.769 | 0.904 | 0.912 | 137 | 0.701 | 0.929 | ||||
| lung | 120 | 0.767 | 0.923 | ||||||||
| 149 | 0.846 | 0.904 | 0.940 | ||||||||
| liver | 57 | 0.807 | 0.932 | 0.956 | 53 | 0.797 | 0.978 | ||||
| pancreas | 64 | 0.813 | 0.925 | 0.942 | 79 | 0.797 | 0.947 | ||||
| prostate | 119 | 0.798 | 0.841 | 0.892 | 160 | 0.688 | 0.851 | ||||
Female | stomach |
1,812 | 60 | 0.783 | 0.889 | 0.949 |
1,821 | 72 | 0.833 | 0.875 | |
| colorectal | 98 | 0.796 | 0.903 | 0.946 | 86 | 0.721 | 0.889 | ||||
| lung | 75 | 0.800 | 0.911 | 0.950 | 83 | 0.831 | 0.900 | ||||
| liver | 15 | 0.967 | 0.973 | 0.993 | 15 | 0.836 | 0.986 | ||||
| pancreas | 65 | 0.800 | 0.946 | 0.934 | 69 | 0.855 | 0.947 | ||||
| breast | 225 | 0.756 | 0.806 | 0.858 | 236 | 0.708 | 0.788 | ||||
| cervix | 97 | 0.742 | 0.859 | 0.872 | 88 | 0.750 | 0849 | ||||
| uterine | 157 | 0.783 | 0.880 | 0.915 | 138 | 0.717 | 0.874 | ||||
| ovary | 65 | 0.815 | 0.921 | 0.941 | 56 | 0.750 | 0.916 | ||||
Table 2 Cross-validation results
Binary logistic regression analysis using training data yielded high sensitivity, specificity, and AUC values ranging from 0.742 to 0.956 for both men and women, and for all cancer sites. Validation data was then fed into these gender-specific and cancer-site-specific discriminant functions to calculate positive and negative predictive values, both of which also yielded high results.
Figure 2: ROC curve and AUC from binary logistic regression analysis
The ROC curves are plotted according to the results of a binary logistic regression analysis performed using cases and controls, which combine the training and validation data. The left figure shows five cancer sites in men, and the right figure shows nine cancer sites in women. The numbers in the legend represent the AUC, and the numbers in parentheses represent the 95% confidence interval for the AUC..
Figure 3: Comparison of elemental concentrations by cancer site (control=1)
The radar charts show the ratios of the average values of 17 elements measured by ICP-MS in six cancer sites in men (left figure) and nine cancer sites in women (right figure), with the control average set to 1.0. In both men and women, Co, Cu, As, Mo, and Ag were higher than the control, while Fe, Zn, Rb, and Cs were lower. However, the ratio patterns of the 17 elements differed in both men and women depending on the cancer site.
Table 3 shows the elements with significant regression coefficients in the regression equation derived from the binomial logistic regression analysis using all data. Elements rated as + or ++ (Mg, Co, Cu, Mo) are highly correlated with cancer risk, while elements rated as - or -- (S, Zn, Rb) are presumed to be factors that reduce cancer risk. Because these significant regression coefficients differed by gender and cancer site, we were able to create discriminant equations for each cancer site.
| Elements | Male | Female | |||||||||||||
| Colon | Stomach | lung | Liver | Pancreas | Prostate | Colon | stomach | Lung | Liver | Pancreas | Breast | Cervix | uterine body | ovaries | |
| Na | ++ | - - | - - | ++ | - | - - | + | + | |||||||
| Mg | + | ++ | ++ | ++ | + | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ||
| P | ++ | ++ | ++ | + | |||||||||||
| S | - - | - - | - - | - - | - - | - - | - - | + | - - | - - | |||||
| K | - - | ++ | - - | - - | - - | - - | - - | ||||||||
| Ca | - - | - - | - - | ++ | ++ | ++ | ++ | ++ | |||||||
| Fe | ++ | - | + | + | - | - | - | - - | - - | ||||||
| Co | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ||||||||
| Cu | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ||||
| Zn | - - | - - | - - | - - | - - | - - | - - | - - | - - | - - | - - | - | |||
| As | ++ | + | + | ++ | ++ | + | ++ | ++ | |||||||
| Se | ++ | - - | + | ++ | + | ||||||||||
| Rb | - - | - - | - - | - - | - - | - | - - | - - | - - | ||||||
| Sr | - | - - | |||||||||||||
| Mo | + | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | |
| Ag | - | ++ | ++ | ||||||||||||
| Cs | - - | - - | - | - | - - | ||||||||||
Table 3: Significance of partial regression coefficients by gender and cancer site
The significance of the partial regression coefficients obtained from the final binary logistic regression analysis is shown. - and -- indicate a decrease in cancer risk at significance levels P<0>
To verify the accuracy and reliability of the MB test's ABCD assessment, a follow-up survey was conducted to confirm cancer onset one year after the date of examination. The cutoff value for cancer risk positivity was set at grade C or higher. The theoretical specificity was set at 95%. Among the 7,993 subjects in the follow-up survey (including those who underwent the test more than twice), the proportion of those diagnosed with CD was approximately 5%-10?pending on the cancer site. A mail-based follow-up survey was conducted for those diagnosed with a positive result, and approximately 70% responded. Table 4 shows the cancer onset status of the respondents by site. Taking male colorectal cancer as an example, the cutoff value for CD grade from the prediction formula yielded a specificity of 0.945, a sensitivity of 0.674, a false positive rate of 0.055, and a false negative rate of 0.326. Additionally, according to a Japanese government report, the annual incidence of colorectal cancer in men aged 20 to 79 is approximately 1 in 500. Therefore, of the 2,949 men who underwent the test, an estimated 5.9 (2,949/500) would have colorectal cancer and 2,943.1 would not. Based on this value, 3.98 (5.9 × 0.674) cancer patients would be classified as CD grade, and 161.87 (2,943.1 × 0.055) normal individuals would be classified as at high-risk group of cancer (CD grade). The theoretical positive predictive value of the CD grade would be 2.39% (3.98/ (3.98 + 161.87)). The actual positive predictive value of the follow-up survey was 0.8333 (2/240), less than 50% of the theoretical value, suggesting insufficient effectiveness. However, the predicted values for pancreatic cancer and prostate cancer in men exceeded the theoretical values, and those values for stomach cancer and colon cancer in women were shown to be almost equivalent to the theoretical values. It was also revealed that the positive predictive values for each site exceeded the incidence rate calculated from general population.
High-risk Cancer Site | Male | Female | ||||||||
No. of CD grade | No. of cancer | Positive predictive value (%) | Theoretical Predictive Value (%) | Incidence Rate (%) | No. of CD grade | No. of cancer | Positive predictive value (%) | Theoretical predictive value (%) | Incidence Rate (%) | |
| Gastric Ca. | 193 | 2 | 1.0363 | 1.5404 | 0.1250 | 424 | 2 | 0.4717 | 0.4995 | 0.0476 |
| Colorectal Ca. | 240 | 2 | 0.8333 | 2.3900 | 0.2000 | 448 | 7 | 1.5625 | 1.6320 | 0.1111 |
| Lung Ca. | 256 | 1 | 0.3906 | 1.1494 | 0.1250 | 251 | 0 | - | 0.8598 | 0.0588 |
| Pancreatic Ca. | 257 | 1 | 0.3891 | 0.3359 | 0.0333 | 214 | 0 | - | 0.5635 | 0.0244 |
| Prostate Ca. | 271 | 4 | 1.4760 | 0.8038 | 0.1429 | - | - | - | - | |
| Breast Ca. | - | - | - | - | 402 | 2 | 0.4975 | 1.0352 | 0.2000 | |
| Uterine Ca. | - | - | - | - | 238 | 1 | 0.4202 | 1.0048 | 0.0714 | |
Table 4. Results of a follow-up survey on cancer incidence one year after MB testing for those diagnosed with CD grade between April 2019 and March 2021
This table shows the results of a cancer incidence survey conducted within one year of testing for individuals diagnosed with CD in MB testing. The incidence rates in the table represent the average for Japanese individuals aged 20 to 79 in 2009. Based on this rate, the theoretically predictable cancer incidence rate for individuals diagnosed with CD was calculated, and the table also shows the rate at which cancer was actually confirmed (positive predictive value) from follow-up surveys of individuals diagnosed with CD.
It is estimated that one in two Japanese people will develop cancer and one in three will die from it [20]. Cancer control is an urgent issue in Japan, as it is in other developed countries around the world. The introduction of cancer screening for early detection and treatment is an important policy goal [21]. In particular, methods using bodily fluids such as blood, urine, and saliva are currently being developed because they are easy to administer and less burdensome to patients. Currently, tumor markers (e.g., CA125, CA19-9, CEA, SCC), PSA for prostate cancer, ABC screening for gastric cancer, and urinary NMP22 and CK8-18 for bladder cancer are being measured. However, due to insufficient accuracy, new cancer screening methods are being actively developed that measure microRNAs [22], nucleosomes [23], amino acids [24], and polyamines in blood, urine, and saliva [25]. In particular, in recent years, research has been conducted on the Multiple Cancer Early Detection (MCED) approach, which explores the possibility of identifying cancer sites through detailed examination of microRNAs in blood and urine [26,27,28]. This "cancer risk diagnostic method" using microRNAs in blood, urine, and saliva has been reported to demonstrate high sensitivity and specificity. However, although this MCED approach has high specificity, it has low sensitivity and is difficult to identify the location of cancer, so it is thought that its introduction as a cancer screening method is premature [29].
We have been working on developing a new "cancer risk" screening method using a stable trace element measurement method using ICP-MS. Of the 17 elements measured in this study, significant differences in concentrations were observed for many elements between the case and control groups. However, it is difficult to determine cancer risk by site based on individual elements alone. However, by creating discriminant equations for each cancer site using multivariate analysis, it became possible to calculate risk estimates for each site. Several studies have been published on the relationship between blood trace elements and cancer. Nakayama et al. [30] compared serum metallothionein, copper, and zinc levels in patients with chronic hepatitis, liver cirrhosis, and liver cancer, and reported that classification was possible with 80-90% sensitivity for each. Wu et al. [31] examined 13 elements in the serum of 25 breast cancer patients, 43 benign breast cancer patients, and 26 healthy individuals. They reported that Co, Ni, and Al were significantly higher in breast cancer patients, and logistic regression analysis revealed significantly higher levels of Cd, Mn, Fe, Cr, and Zn, enabling discrimination with a sensitivity of over 96%. Yasuda et al. [32] performed logistic regression analysis using 24 elements in hair samples from 124 solid cancer patients and 86 healthy individuals, reporting an AUC of 0.918 and significant results for I, As, Zn, Fe, Na, Se, K, and Mn. These findings, combined with the results of this study, indicate that cancer risk can be predicted based on differences in the balance of trace element concentrations in the blood. In this study, we improved the accuracy and reliability of the results by adding new case and control data to the data used in our previous report [17], resulting in a more reliable and accurate cancer risk screening method (MB test). As a result, the sensitivity, specificity, and AUC values of this MB test were high for all cancer sites. Furthermore, the positive predictive value calculated based on a one-year cancer incidence survey of high-risk participants was close to the theoretically calculated predictive value, and this value was 2 to 10 times the general incidence rate, indicating that this MB test is effective in diagnosing "cancer risk."
However, when elements like zinc exhibit diurnal fluctuations [33], many problems remain to be solved, including the presence of elements unsuitable for ICP-MS analysis (e.g., Mn, Ti, Sn), the presence of elements suspended in the atmosphere (e.g., Al) [34], differences in blood elemental concentrations based on age, place of residence, and race, and the timing of blood collection and storage/transportation methods [35]. Furthermore, there are very few reports on the mechanisms of interaction between multiple elements or the relationship between changes in elemental concentration balance and disease. Progress in these areas of research is eagerly awaited.
The MB test, a new "cancer risk diagnostic method" described in this report, has significant advantages: it does not require low-temperature storage, is less expensive than tests measuring proteins or RNA, and can estimate the risk of multiple cancer sites at once with a single annual blood sample. Therefore, it is appropriate to position it as a form of pre-cancer screening. This test will motivate people judged to be at high risk of cancer to actively and continuously undergo cancer screenings and health checkups, contributing to cancer prevention for many people.
The authors are affiliated with Renatech Co., Ltd., and some of their research results are patented. They also receive part of the research funding from Renatech, but this does not affect the results of this study.
Part of this research was supported by the Ministry of Economy, Trade and Industry's "Strategic Fundamental Technology Advancement Support Project" (No. 2831412036) for fiscal years 2016-2018, and was conducted as a collaborative project between Chiba Cancer Center, Kanagawa Cancer Center, and Renatech Co., Ltd. We would like to express our gratitude to the late Dr. Haruo Mikami and Dr. Hiroki Nagase of the Chiba Cancer Center and Dr. Yohei Miyagi of the Kanagawa Cancer Center for their generous cooperation in this research, as well as to all those involved at 15 clinics) in seven prefectures in Japan.
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Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.
Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.
Dear Grace Pierce, Editorial Coordinator of the journal IJCCR, I had a very positive experience with Auctores - Journal throughout the publication process. The Editorial Team was highly responsive, professional, and supportive at every stage. I would like to extend my sincere thanks to the Editor: Grace Pierce, for her guidance and assistance. The peer-review process was smooth and constructive, helping improve the quality of my work. I would gladly recommend Auctores Journal to fellow researchers and authors. Dr. SABITA SINHA, Medical Oncologist, MD (Electro Homeopathy).
Dear Maria Emerson, Editorial Coordinator of - Journal of Clinical Research and Reports. ''I am pleased to provide this testimonial following the publication of our recent case report in this journal. The peer review process was rigorous, constructive, thorough, and conducted in a timely manner. The reviewers’ comments were thoughtful, detailed, and highly constructive, contributing substantially to the refinement, clarity, and scientific robustness of our manuscript. The process was conducted with professionalism and academic integrity throughout. The support provided by the editorial office was exemplary. Communication was consistently prompt, clear, and courteous at all stages of the submission and publication process. The editorial team demonstrated a high level of organization and responsiveness, ensuring that all queries were addressed efficiently and that the process remained transparent and well-coordinated. The overall quality of the journal is reflected in its strong editorial standards, commitment to scientific excellence, and dedication to publishing clinically meaningful research. It has been a privilege to publish our work in this journal, and we would welcome the opportunity to contribute further in the future.'' Best wishes from, Dr. Efstratios Trogkanis, Cardiologist.
Dear Reader: We have published several articles in the Auctores Publishing, LLC, journal, Clinical Medical Reviews and Reports in recent years (CMRR). This is an ‘open access’ journal and the following are our observations. From the initial invitation to submit an article, to the final edits of galley proofs, we have found CMRR personnel to be professional, responsive, rapid and thorough. This entire process begins with Catherine Mitchell, Editorial Coordinator. She is simply outstanding, and, I believe, unparalleled in her capacity. I cannot imagine a more responsive and dedicated Editorial Coordinator. As I read the dates and timing of her correspondence with us, it seems that she never sleeps. I hope Auctores Publishing, LLC, appreciates her efforts as much as these authors do. Thank you to Auctores Publishing, LLC, to the Editorial Staff/Board, and to Catherine Mitchell from a grateful author(s).
