Design of a Plasmonic Refractive Index Sensor Based on the Amplifier System with two Plasmonic Waveguides and four Cavities with Different Dimensions and Coordinates

Review Article | DOI: https://doi.org/10.31579/2639-4162/113

Design of a Plasmonic Refractive Index Sensor Based on the Amplifier System with two Plasmonic Waveguides and four Cavities with Different Dimensions and Coordinates

  • Hamid Abbasi *

Atomoc and molecular of Physics group, faculty of basic science, University of Mazandaran, Babolsar.

*Corresponding Author: Hamid Abbasi, Atomoc and molecular of Physics group, faculty of basic science, University of Mazandaran, Babolsar.

Citation: Hamid Abbasi, (2023), Design of a Plasmonic Refractive Index Sensor Based on the Amplifier System with two Plasmonic Waveguides and four Cavities with Different Dimensions and Coordinates, J. General Medicine and Clinical Practice. 6(7); DOI:10.31579/2639-4162/113

Copyright: © 2023, Hamid Abbasi. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Received: 11 August 2023 | Accepted: 07 September 2023 | Published: 29 November 2023

Keywords: cerebral oximetry, complications of cardiac surgery

Abstract

In this research, we design a plasmonic refractive index sensor based on metal insulated metal waveguide (MIM) and examine it numerically. To design the structure of this sensor, we use five cavities with different dimensions and coordinates and two plasmonic waveguides. The resonant wavelengths and refractive index of the resonators are investigated and simulated by the finite difference time domain (FDTD) method. Due to the fact that the sensors and conduction characteristics of plasmonic waves are affected by the structure parameters, by changing the refractive index and changing the dimensions of the cavities, we can weaken or strengthen the passage coefficient in the resonant modes. As a result, we obtain the sensitivity coefficient, the competency digit (FOM) and the sensor quality coefficient. These plasmonic sensors with a simple frame and high optical resolution can be used to measure the refractive index in the medical, chemical and food industries, and due to the special correct distribution of resonances, they are highly sensitive to changes in the refractive index of the environment.

Introduction

Optical integrated circuits are one of the most important and practical tools in technology. To further exploit them and reduce barriers, compression of plasmonic structures began. These structures are made of metal and dielectric with dimensions below the excitation wavelength. Plasmonic science expresses the interaction of radiant electromagnetic waves on the surface of metals and their conducting electrons and has the ability to enclose electromagnetic waves at dimensions much smaller than the radiant wavelength in plasmonic structures. The term plasmon polariton is used to describe the cause of this married condition. Plasmonics are divided into two parts: (1) localized surface plasmons and (2) surface polariton plasmons, each of which is an application of metals and electromagnetic waves (in nanometer dimensions) in two-dimensional and one-dimensional structures. In localized surface plasmons (1), the oscillations of metal electrons and the intensification of plasmons are stimulated by the radiation beam, and the condition of the oscillation is that the frequency of the surface electrons is equal to the frequency of the radiation beam. The interaction of electromagnetic waves with excitation wavelength λ with a particle of size d can be studied in various numerical, analytical and semi-analytical methods. In this nano-volume, the electromagnetic field is compressed and modified. Also, small changes in the dielectric of this nanoparticle change the surface plasmon intensification, wavelength, absorbed and scattered beam, and the amount of these changes can be obtained by using optical characteristics. Plasmon Surface polaritons are electromagnetic waves that are coupled to surface free electrons in metals so that they can propagate longitudinally across the dielectric metal surface and have longitudinal polarization (P- polarized). One of the important applications of surface plasmon plasmon is to reduce the scattering of the electromagnetic field in optical waves and to confine the emission modes of the transverse electric field or the transverse magnetic field in the planes perpendicular to the direction of propagation. Surface plasmon amplification is an electromagnetic mode in which an electric field with TM polarization at the boundary between a metal surface and a dielectric material oscillates with paired electrons and two waves intensively occur, which increases the

field strength. Electrical and sensor performance correction. Plasmonic structures are divided into metal-dielectric-metal and dielectric-metal-dielectric structures to study the propagation of waves. The most important plasmonic components are based on the structure of passive devices (such as waveguides, couplers, filters, etc.) and active devices (such as amplifiers, amplifiers, switches, modulators, etc.) and will be simulated numerically. Inactive environments are isotropic and have only one refractive index. As a result, they are unsuitable for switches and sensors, but active environments are anisotropic, and we can change the refractive index and length by applying an external factor. Plasmonic nanosensor systems are key components of optical integrated circuits that need to be developed. Parameters such as high transmission efficiency, high-resolution, high-quality factor, optical stability, sensitivity enhancement and adjustability in a range of wavelengths should be considered in the structure of plasmon sensors. Obtaining and improving these parameters increases the speed of information processing in optically integrated circuits. In this research, arrays of metal- dielectric waveguides and plasmonic resonators (MIM) are simulated and analyzed to design and fabricate plasmonic sensors. The aim of this work is to achieve the desired parameters in plasmonic sensors and to improve and develop it. Is. Therefore, we change the geometry of the waveguides and resonators, the refractive index of the dielectric region, and the direction of coupling to achieve our goal. Plasmonic sensors are divided into three categories based on their geometric shape: (1) plasmonic converters in which flat nanofilm is used, (2) nano sensors with periodic nanowires, and (3) nano sensors containing single nanoparticles. In this research, changing the refractive index of the rims and changing the distance of the rims is used to improve the performance and adjust the plasmonic sensor systems.

Structural model and theory analysis

Each waveguide with any geometric shape has the ability to transmit waves and can limit their energy in one and two dimensions. This transition is interpreted by the wave equation. The geometry of a waveguide indicates its function, and the frequency of the transmitted wave determines the size of a waveguide. Maxwell's equations describe the shape of electromagnetic cross waves and the linear electricity equation describes the shape of sound waves. At longer wavelengths, wider wavelengths are guided, and at higher frequencies, narrower wavelengths are guided. Above a frequency range, the optical properties of metals are explained by the plasma model, which is the result of Maxwell's equations, and the electrons will be damped by collisions with the frequency υ = 1 / τ. For visible frequencies (microwave and far infrared), the spectrum of metals is very reflective and does not allow electromagnetic waves to propagate through them. At higher frequencies (near-infrared and visible from the spectrum) the field penetration and dissipation increase.

Then, at ultraviolet frequencies, the metals acquire dielectric properties and allow the propagation of electromagnetic waves with different degrees of attenuation. In the free electron model at high frequencies, the dielectric function tends to zero, and for noble metals, generalizing this model to a frequency range greater than the plasma frequency creates a polar environment. As a result, real metals are expressed by the greeting model:

ε )ω(= ε∞ - ωp2 / ω2+ iϒω  (1)

ω is the angular frequency, 

                                                                             Figure 1: Two-dimensional image of a plasmonic sensor

which consists of two waveguides and five cavities, one cavity in the middle of two waveguides, two cavities at a distance of 12 nm at the top and a cavity at a distance of 12 nm at the bottom of the middle cavity. A cavity is located on the left, at a distance of 10 nm from the waveguide. The input wave goes from the left waveguide to the cavities and after passing through them goes to the output waveguide. The height of the two waveguides is w1 = 50 nm. The middle cavity located in the middle of the two waveguides has a length of L1 = 262 nm and a height of W2 = 60 nm, which is located at a distance of 19 nm from the two waveguides. The lower cavity has a length of L2 = 100 nm and a height of W3 = 100 nm and the three upper cavities have a length of L3 = 100 nm, L4 = 100 nm and L5 = 30 nm and a height of W4 = 100 nm, W5, respectively. = 220 nm and W6 = 130 nm. Pin and Pout are the input wave and output wave measurement monitors, respectively, which are calculated by merging the natural component of the Poin Ting vector along the blurred lines. The transfer is calculated by T = Pout / Pin.

We consider the simulation bed as silver and the environment inside the cavities and waveguides as air. An electromagnetic field is generated by the excitation of a sensing element using light generated by SP that is concentrated on the metal surface. The refractive index of the MIM changes when the material under contact contacts the sensor. SPs are very sensitive to changes in refractive index in the vicinity of the surface. Refractive index changes can be related to SP by measuring changes in one of the properties of light (such as changes in λres, intensity, or phase). Because the wavelengths of the waveguides are smaller than the wavelengths of the light emitted, only the plasmonic TM state is present in the structure. According to Fig.1, the TM wave, which is used for SPP excited waves, starts propagating from the left waveguide and propagates in the waveguide, and its intensity decreases as it gets closer to the output port. Each amplifier reflects a certain amount of input wave. We see the distribution of the electric field in the resonant frequency of the simulated structure in Figure 2,  

                                                                                      which according to the figure, the maximum radiation in the middle cavity. When the field distribution in cavities is similar, energy loss is reduced. To achieve the maximum field distribution in the structure, all dimensions must be optimal, otherwise we must change the dimensions of the structure to achieve the maximum field distribution.

Fracture coefficient simulation and measurement methods

The proposed plasmonic resonance behavior is investigated numerically and theoretically. In the numerical approach to simulate the reflection spectrum and distribution of the optical field in the sensor structure, we use the time domain finite difference simulation (FDTD) method with perfectly matched layer boundary conditions (PML) because this method effectively reduces the numerical reflection. Gives. The uniform mesh sizes for the x and y directions are 8 and 8 nm, respectively, and the transmission line model is used to analyze the theory of structure. Two-dimensional simulation is performed, which is infinite in one dimension. The reason for this is to reduce the simulation time and achieve the desired result. The effective refractive index of a four-cavity sensor with a step of 0.01 from 1 to 1.2 in the wavelength range of 400 to 1500 nm has been calculated, which leads to a change in spectra and resonance wavelength. 

Figure 3 shows.

The first characteristic to be measured for a sensor is the S sensitivity, which is used to quantify the sensitivity of refractive index sensors:

S = Δ λ/ Δn (nm/RIU)   (2)

In this equation, Δλ is the change in resonance wavelength and Δn is the change in refractive index. In this simulation, we only change the refractive index of the middle cavity, and the refractive index of the other cavities is constant, which will make the sensor design more accurate and practical. According to Figure 3, 

                                                                             Figure 3: Transmission spectra of plasmonic refractive index sensor.

the sensor transmission spectra have two peaks, which according to Fig.4, have the highest sensitivity for the refractive index n = 1.19 (in mode2), which is equal to 1647 nm / RIU and the lowest value for the  refractive index n = 1.18 (In mode1) is equal to 0.

Figure 4: Resonance wavelength versus refractive index analysis.

Using Figure.4, we analyze the refractive index and the amount of change in each wavelength to design our desired sensor. According to this diagram, there is a relatively linear relationship between the two parameters of resonance wavelength and refractive index, and the TM resonance gradually shifts. Therefore, using Equation 2, the sensitivity of different wavelengths is obtained. Let (Figure.5).

                                                                                           Figure 5: Plasmonic sensor sensitivity coefficient diagram.

According to the figure, mode 2, which corresponds to the right peak of Fig.3, is more sensitive, and mode1, which corresponds to the left peak of Fig.3, has less sensitivity. Since sensitivity alone is not a measure of good performance for comparing different types of sensors, and light resolution is also very important for sensors, we need two more to measure the capabilities of a plasmonic sensor: Q quality factor and FOM suitability. Higher sensitivity reduces the FOM at the desired point. Obviously, increasing the length of the cavities can improve the sensitivity performance of the sensor with a smaller FOM size, which may result in a longer light path and more energy loss, respectively. The FOM merit is obtained from Equation (3):

FOM = S / FWHM (3)

Using Equation 3, we plot the FOM competency chart.

                                                                                                 Figure 6: Plasmonic sensor FOM competency diagram.

The quality coefficient is also obtained from Equation 4:

Q =   λres / FWHM    (4)

We see the quality coefficient diagram in Figure.7.

                                                                                         Figure 7: Quality factor diagram of Q plasmonic sensor.

Using Equation 4 and dividing the wavelength by FWHM, the quality coefficient Q is obtained and its value in the refractive index n = 1.19, which has the highest sensitivity coefficient, reaches 11.7935. Equations 2, 3 and 4 are the capabilities of measuring plasmon sensors obtained by changing the refractive index in the structure. Using these three equations, we draw the graphs of sensitivity coefficient, quality coefficient and competence. The remarkable thing about the proposed method is that its sensitivity coefficient is higher compared to previous sensors. As shown in Table 1, the proposed method offers better results compared to some similar articles. According to this table, the maximum sensitivity coefficient S among these papers belongs to the structure studied in this paper, which is equal to 1647 nm.

                                                                    Table 1: Comparison between proposed sensor specifications and similar articles.

Conclusion

Plasmonic refractive index sensor is a widespread issue and has become very popular in chemical and biological measurements because of a small change in the cavity refractive index that causes a large change in wave propagation properties. In this research, the latest developments in refractive index sensors based on two plasmonic waveguides and four cavities with different dimensions are highlighted. This sensor is considered because with a small change in the refractive index of the middle cavity causes a significant change in the propagation characteristics of the wave. Also, as a sensor, it requires both high sensitivity (S) and high competence number (FOM) to provide excellent performance with high optical resolution. For clarity of results and for better comparison, the refractive index of the structure is changed from 1 to 1.2 and the resonant wavelength is calculated at each stage. Due to its high-resolution resolution, this sensor can easily detect changes in the refractive index of 0.01 for materials with a refractive index between 1 and 1.2. These results and physical analysis due to the small configuration size, high FOM value and high sensitivity, can lead to further development of plasmonic waveguides in the field of loss reduction and excellent light control in plasmonic structures.

References

Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.

img

Virginia E. Koenig

Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.

img

Delcio G Silva Junior

Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.

img

Ziemlé Clément Méda

Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.

img

Mina Sherif Soliman Georgy

We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.

img

Layla Shojaie

The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.

img

Sing-yung Wu

Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.

img

Orlando Villarreal

Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.

img

Katarzyna Byczkowska

Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.

img

Anthony Kodzo-Grey Venyo

Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.

img

Pedro Marques Gomes

Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.

img

Bernard Terkimbi Utoo

This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.

img

Prof Sherif W Mansour

Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.

img

Hao Jiang

As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.

img

Dr Shiming Tang

Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.

img

Raed Mualem

International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.

img

Andreas Filippaios

Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.

img

Dr Suramya Dhamija

Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.

img

Bruno Chauffert

I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!

img

Baheci Selen

"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".

img

Jesus Simal-Gandara

I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.

img

Douglas Miyazaki

We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.

img

Dr Griffith

I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.

img

Dr Tong Ming Liu

I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.

img

Husain Taha Radhi

I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.

img

S Munshi

Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.

img

Tania Munoz

“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.

img

George Varvatsoulias

Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.

img

Rui Tao

Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.

img

Khurram Arshad