AUCTORES
Globalize your Research
Review Article | DOI: https://doi.org/10.31579/2693-7247/122
Aishwarya R&D 915, Hubtown Viva, Off Western Express Highway, Mumbai.
*Corresponding Author: Akhilesh Kumar Singh, Aishwarya R&D 915, Hubtown Viva, Off Western Express Highway, Mumbai.
Citation: Akhilesh Kumar Singh, Vishal, Vaneet Singh Thakur, Aarti Devi and Dayanidhi Pandey, (2023), Cushing Syndrome: A review and its treatment by emerging molecule Osilodrostat. J. Pharmaceutics and Pharmacology Research, 6(2); DOI:10.31579/2693-7247/122
Copyright: © 2023, Akhilesh Kumar Singh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 03 March 2023 | Accepted: 10 March 2023 | Published: 21 March 2023
Keywords: cushing syndrome; hypercortisolism; glucocorticoids; diabetes mellitus; dexamethasone; ketoconazole; osilodrostat
Cushing syndrome is mainly the Hypercortisolism state in our body which is due to many factors like inappropriate exposure of Glucocorticoids. It can be endogenous as well as exogenous depending upon the cause and responsible factors. Screening of Cushing syndrome includes procedures like UFC test, Low Dose DST, Low dose salivary cortisol levels. Diagnosis of the Syndrome involves the MRI of Pituitary gland, Overnight Dexamethasone test. Some of complications arising from this syndrome are excessive weight gain, Hypertension, Diabetes mellitus, decreased immune response, depression and Depression. Treatment of Cushing syndrome is done by various therapies like Pituitary surgery, adrenal surgery and medical treatment which involve use of various drugs for treatment. Osilodrostat has shown very impressive results in treatment of Cushing Syndrome as compared to other available options of drugs like Ketoconazole and Metyrapone. Further studies are to be done on Osilodrostat to conclude a perfect and permanent treatment of Cushing Syndrome.
Cushing’s syndrome is characterized by the excess levels of Cortisol in the body. Effect of cortisol can be seen on whole body tissues alone or at multiple sites in body. Excessive and inappropriate exposure of free circulating Glucocorticoids in the blood stream leads to the disease state called as Cushing Syndrome [1]. Complications in the Cushing syndrome include Hypertension, Metabolism related problems, some manifestations related to respiratory tract like asthma, Type –II Diabetes Mellitus, osteoporosis and rheumatoid arthritis [2]. Symptoms of Cushing syndrome include thinning of skin, body’s slow response to healing of injuries, unexpected weight gain, some other symptoms like fatigue, weakness and acne. We can categorize the Cushing Syndrome into two types: Endogenous and exogenous. Treatment of Inflammatory, neoplastic and autoimmune disorders may lead to exogenous cause of Cushing Syndrome. Endogenous cause of Cushing Syndrome can be associated with patients having history of uncontrollable Diabetes mellitus and cardiovascular diseases like Hypertension [3]. Cushing Syndrome can be categorized as: Adrenocorticotrophic Hormone (ACTH) dependent and Adrenocorticotrophic (ACTH) - Independent[4]. 80-85 percentage cases account for the ACTH-dependent mechanism of Cushing Syndrome, whereas only 15-20 percentage cases contribute for the ACTH- Independent endogenous Cushing Syndrome [4]. Diagnosis of Cushing Syndrome includes mainly by 2 screening tests: Late night salivary cortisol test, 24- Hour cortisol free test or low dose Dexamethasone test [5]. Osilodrostat can be used as a promising therapy option for treating Cushing Syndrome. Its mechanism of action is by inhibiting the cortisol biosynthesis in the adrenal cortex [6].
Some signs and symptoms associated with the Cushing Disease are:
The main purpose of screening tests is to check the increased level of cortisol in the body, Impaired ACTH negative feedback mechanism which in involved in Pituitary-Adrenal axis, loss of diurnal variation of ACTH and cortisol.
First line screening tests:
This test is used to indicate or to evaluate the free or unbound cumulative amount of free cortisol which is circulating in 24 hours in the blood stream. Three samples are to be collected in the 24 hours to measure the cortisol levels both bound and unbound. If the results of all three collected samples are in normal value, same or nearby to eachother, it is the indication of normal renal functioning. Thus there are no signs and symptoms of Cushing disease. Glomerular filtration rate (GFR), urinary creatinine level is used to identify the indication of cortisol production. GFR below 30 ml/min is the indication of decreased urinary cortisol excretion however, the production of cortisol is normal. Measurement, separation of Glucocorticoids and cortisol metabolites can be done by High Performance Liquid Chromatography (HPLC) method. Immunoassay methods (RIA, immunometric assays) are used to measure urinary cortisol levels.
The purpose of this screening test is to identify the unsuppressed dexamethasone despite of the cause of disease. 1 mg dose of dexamethasone is to be given to the patient on time 23:00 to 24:00 PM. Serum cortisol level is to be determined by the next day morning between 8:00 to 9:00 AM. Value of serum cortisol is to be determined and compared with standard values. If serum Cortisol levels exceed 1.8 mg/dl (50nmol/L), it is an indication of positive diagnosis of Cushing syndrome. Cortisol suppression is not seen in patients suffering from depression or obesity.
Cortisol concentrations reach maximum at midnight. Sample of patient was collected in late night 23:00 PM and evaluated for cortisol levels. It is a promising test for screening of Cushing disease.
Second line screening tests:
There is an abnormal increase in the serum cortisol level of patients suffering from Cushing Syndrome accompanied by lacking of approximately normal value of heart rhythm. Patient cortisol levels at midnight greater than1.8 µg/ml indicate presence of Cushing Disease.
In this test 0.5 mg of Dexamethasone is given to patient orally after every 6th hour. The serum sample is to be collected at morning time 9:00 AM till 48 hours. On the basis of Low dose CRH - DST test it can be stated that patients with Pseudo Cushing syndrome have less CRH release due to stress condition. In such patients a clear response to exogenous CRH stimulation after a specific dose of 0.5 mg of Dexamethasone is given. Plasma cortisol value greater than 1.4 µg/ dl indicate the presence of Cushing syndrome.
Diagnostic tests for cushing syndrome:
1.Magnetic resonance ivestigation (mri) of pituitary gland:
MRI is used to detect the presence or absence of pituitary adenomas. In radiological imaging, Macroadenomas can be seen, which indicates the presence of Cushing disease. Differentiation of normal pituitary tissues from pituitary adenomas can be done by MRI with contrast administration of 0.05 nmol/kg of Gadolinium [13].
2.Overnight dexamethasone test:
The purpose of this diagnostic test is to identify difference between ectopic Adrenocorticotrophic hormone secretion and Cushing syndrome. Procedure for this diagnostic involves the administration of 8mg of Dexamethasone at a single time at midnight around 23:00 PM or 2 mg after every 6 hours. Serum sample to be collected at morning 8:00 to 9:00 AM followed by identification of serum cortisol levels. Increase in the serum cortisol levels is the indication of ectopic source of ACTH, and low secretion indication of Confirmation of Cushing Syndrome [14].
Etiology of Cushing’s syndrome includes its two types: the endogenous and exogenous hypercortisolism. Most common cause of Cushing syndrome is exogenous type which is due to very long regular use of Glucocorticoids and it founds to be iatrogenic. Endogenous cause of Cushing syndrome can be categorized as ACTH Dependent and ACTH independent. In endogenous cause of Cushing syndrome there is an increase in the production of Cortisol by the Adrenal glands. Factors responsible for ACTH dependent endogenous Cushing syndrome are ACTH – secreting pituitary adenomas, ectopic ACTH secretion by neoplasm. Factors responsible for ACTH- independent Cushing syndrome are adrenal hyperplasia, adenoma, and carcinomas [15,16].
Treatment of Cushing syndrome includes three lines of treatment namely: First line of treatment, second line of treatment and third line of treatment. First line Treatment includes treatment algorithm and Pituitary surgery. Second line treatment includes Pituitary radiotherapy and Adrenal surgery. The third line or medical therapy includes various classes of medications for the treatment of Cushing Syndrome.
First line treatment:
Second line treatment:
If there is increase or no change in the increased cortisol levels in the patient with Cushing syndrome, additional treatment is to be given to patient to minimize the risk of complications regarding hypercortisolism. Hypersecretion of Cortisol in the body even after surgery is due to the remaining hidden tumor in the gland in cavernous sinus, in an ectopic parasellar region. In such conditions, there may be some treatment methods which can be employed which include repeat pituitary surgery, pituitary radiotherapy and adrenal surgery. Repeat pituitary surgery is done in cases where the imaging proof of residual tumor is seen in patient. There may be sometimes multimodal approach can be used to achieve best outcome and satisfactory results with patient compliance [20,21].
There are two methods employed for the Pituitary radiotherapy: The conventional radiotherapy (CRT) and stereotactic radiotherapy (SRT).
In CRT method, the delivery of ionizing radiation is done to the pituitary gland, the purpose of this method is to control the hormone hypersecretion and to stop the growth of tumor. LINAC is used to generate the photons and the CRT is given in multiple sessions according to the treatment schedule and need of patient. Dose of radiation generally ranges from 45-50 Gy at time. It can be higher or lower but maintaining a total dose of 1.8 to 3.0 Gy per fraction.
SRT method includes the delivery of ionizing radiations on the tumor surface directly to control the increased secretion and to diminish tumor growth. GK and LINAC SRS are used for this purpose which involves the delivery of focused radiation to the target in a single treatment [23].
Third line or Medical Treatment:
Medical treatment of Cushing syndrome includes the various classes of drugs as:
Use of osilodrostat for treatment of cushing syndrome:
Osilodrostat is an adrenal blocking agent, and it was initially used for the inhibition of Aldosterone production and to reduce the blood pressure. Basically Osilodrostat is an inhibitor of 11 β -Hydroxylase which contribute to the last step of Cortisol synthesis. Osilodrostat inhibits both CYP11B1 and CYP11B2. A study was carried out to differentiate between the effects of Ketoconazole, Metyrapone and Osilodrostat. It was found that Osilodrostat inhibits cortisol production in HAC15 cells, 18 times more potently than Ketoconazole and 2 times more significantly than Metyrapone [30]. In Phase I and Phase II studies found that the reduction rate of Cortisol levels in the patients by the use of Osilodrostat is very much significant than Ketoconazole and Metyrapone. Also the doses of Osilodrostat are much tolerated by the patients with very little or no side effects as compared to Ketoconazole and Metyrapone.
On the basis of literature study, it can be predicted that the treatment of Cushing Syndrome requires an immediate, promising and permanent solution. Screening and Diagnostic methods developed for the Cushing syndrome have a high level of accuracy and patient compliance. Despite of having variety of options for treatment like pituitary surgery and adrenal surgery, patients are more comfortable with medication therapy which is very limited in case of Cushing syndrome. The potency of treatment by drugs is very limited and takes very long time to cure causing no surety of successful treatment. Osilodrostat have been shown a great and promising option for treatment in Phase I and Phase II clinical studies. High dose of Osilodrostat is much tolerated in the patients as compared to other drugs like Ketoconazole and Metyrapone. More research is to be done in this direction so as to have a definite and sure treatment option despite of pituitary and adrenal surgery.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
