Short-Communication | DOI: https://doi.org/10.31579/2690-4861/151
*Corresponding Author: Mario Bendersky, Professor of Pharmacology, Cordoba State University, Derqui, Carlos Paz, Córdoba, Argentina.
Citation: M Bendersky. (2021). Confirmatory results about Spironolactone (S) Effects on AASI in Essential Hypertensive Patients: Short communication. International Journal of Clinical Case Reports and Reviews. 8(3); DOI:10.31579/2690-4861/151
Copyright: © 2021 Mario Bendersky, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 24 June 2021 | Accepted: 01 September 2021 | Published: 10 September 2021
Keywords: arterial stifness; spironolactone
Background: In previous studies we demonstrated that spironolactone 50 mg OD, added in hypertensive patients who do not normalize pressure with enalapril 10 mg in the morning, after 3 months reduces pressure and reduces arterial stiffness.
The objective of the present study was to analyze if this effect lasted up to 6 months, in a larger group of hypertensive patients. ABPM allows us to obtain Ambulatory Arterial Stiffness Index (AASI) through a mathematical formula. This index correlates well with Pulse Wave Velocity (PWV) and has shown good prognostic value in both normo and hypertensive populations: high AASI values, worse CV prognosis.
Hypertensives have shown increased arterial stiffness.
Enalapril (E) 10 mg in the morning is the commonest initial treatment in Argentine. After 30 days, in resistant to E hypertensives, it is used to add a second drug. Spironolactone (S) has antifibrotic properties, and has not enough studied in hypertensives in a short term treatment. Because these fact, we analize the effect of S add to E on AASI in patients with stage 1 essential hypertension treated 6 months with OD morning doses.
104 essential stage I hypertensives on E 10 mg at least 30 days were added with S: Aldo:Renine score <30>135 and/or 85 mmHg Mean age 64.2 years (54-68), 66 were male, BMI 29.3 (25-30). We added S 50 mg/d in OD morning dose for 6 months. Two 24-hour ABPM recordings (Spacelabs 90207) were performed pre and post-S, with at least 70 valid measurements each. A paired T-Test was used for statistical analysis and P<0>
Adverse events were mild, 18patients suffered headaches, kalemia increased from 4.10 to 4.50 mEq/l, and creatinine from 9.10 to 9.40 mg%, 6 patients presented mild dry cough.
In a basal study (E treated) AASI values were high (normal values are expected less then 0, 40 for this age) Spironolactone added to E, 50mg OD in the morning, during 6 months, induced a significant office and ambulatory BP decrease, and tends to reduce BP variability and heart rate. AASI was reduced to 0.36, within normal values, after 6 months of treatment.
Dear Editorial Team, Clinical Medical Reviews and Reports. My experience with the journal was highly positive. The peer-review process was rigorous, constructive, and completed in a timely manner. The reviewers provided valuable comments that helped improve the quality and clarity of our manuscript. The editorial office was professional, responsive, and supportive throughout all stages of the publication process. Communication was clear and efficient, and any questions were addressed promptly. Overall, I found the journal to maintain high scientific standards and an excellent publication workflow. I would be pleased to consider submitting future work to this journal. Best wishes from, Elena Popa.
It was my pleasure to submit my testimonial concerning the Reviewer Board of our Scientific Journal “Brain and Neurological Disorders”. The Reviewers focused on some modifications and their contribution was helpful. The ladies of our Editorial Office were also supported my efforts. It was my honor to have such a co-operation and I am looking forward for more collaboration.
Dear Grace Pierce, Editorial Coordinator of Journal of Clinical Research and Reports, Thank you for the speedy and efficient peer review process. I appreciate the fact that your peer reviewers do not take months to respond like with some other journals. I would also like to thank the editorial office for responding quickly to my questions. It is an excellent journal. I plan to submit more manuscripts in the future. Best wishes from, Robert W. McGee
Dear Grace Pierce, Editorial Coordinator of Journal of Clinical Research and Reports, Working with you and your team on our recent publication in JCRR has been a truly wonderful and enjoyable experience. The responses were prompt, and the reviewers were patient, constructive, and highly professional. One reviewer in particular gave me the feeling that a professor was carefully reading and commenting on my coursework, which was deeply touching. The entire process was straightforward and hassle‑free, with no tedious online forms to complete. I highly recommend this journal. Best wishes from, DR Aibing Rao, Head of R&D
I Appreciate the Opportunity to Share my Experience with the Journal of Clinical Research and Reports. The peer review process was timely and constructive, and the feedback provided helped improve the quality of our manuscript. The editorial office was professional, responsive, and supportive throughout the process, ensuring smooth communication and efficient handling of the submission. Overall, it was a positive experience collaborating with your team.
Dear Mercy Grace, Editorial Coordinator of Obstetrics Gynecology and Reproductive Sciences, We would like to express our gratitude for your help at all stages of publishing and editing the article. The editors of the magazine answer all the necessary questions and help at every stage. We will definitely continue to cooperate and publish other works in the Obstetrics Gynecology and Reproductive Sciences! Best wishes from, Alla Konstantinovna Politova,
