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Research Article | DOI: https://doi.org/10.31579/2690-8808/311
Department of Oral and Maxillofacial Surgeon, Head of Department, Position-11th Level, Anandaban Hospital.
*Corresponding Author: Bikash Desar, Department of oral and maxillofacial surgeon, Head of Department, Position-11th Level, Anandaban Hospital.
Citation: Bikash Desar, (2026), Clinical Evaluation of Platelet-Rich Fibrin for Alveolar Ridge Volume Preservation and Postoperative Pain Control After Tooth Extraction, J, Clinical Case Reports and Studies, 7(4); DOI:10.31579/2690-8808/311
Copyright: ©, 2026, Bikash Desar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 10 March 2026 | Accepted: 17 March 2026 | Published: 24 March 2026
Keywords: alveolar ridge preservation; platelet-rich fibrin; post-extraction socket; bone regeneration; postoperative pain
Background and Objectives:
Socket preservation aims to minimize alveolar bone resorption following tooth extraction in order to maintain ridge volume and contour for future prosthetic or implant rehabilitation. Platelet-rich fibrin (PRF), an autologous biomaterial rich in growth factors, has been proposed to reduce ridge resorption by promoting new bone formation and serving as a biological scaffold for tissue regeneration. Additionally, PRF may enhance wound healing and reduce postoperative discomfort. This study aimed to evaluate the effectiveness of PRF, alone and in combination with collagen, in preserving alveolar ridge dimensions in both the maxilla and mandible, and to assess its impact on post-extraction pain.
Methods:
Sixty patients requiring extraction of posterior teeth were randomly allocated into three groups: Group I (PRF; n = 20), Group II (PRF + collagen; n = 20), and Group III (control; n = 20). Extraction sockets were filled with PRF in Group I and PRF combined with collagen in Group II, while the control group received standard care without biomaterial placement. Cone-beam computed tomography (CBCT) was used to evaluate ridge height and width at baseline and at 3 months postoperatively. Postoperative pain was assessed at 24 hours, 3 days, and 7 days following extraction using the British Pain Society Numerical Rating Scale. Statistical analysis was performed using ANOVA and independent t-tests.
Results:
Comparative analysis revealed no statistically significant differences in ridge height or width among the three groups at the 3-month follow-up. However, both PRF alone and PRF combined with collagen significantly reduced short-term postoperative pain compared to the control group.
Conclusions:
Within the limitations of this study, PRF, whether used alone or in combination with collagen, did not demonstrate a significant advantage in preserving alveolar ridge dimensions compared to standard treatment. Nevertheless, both interventions were effective in reducing short-term postoperative pain, suggesting a potential clinical benefit in enhancing patient comfort following extraction.
Following tooth extraction, the alveolar socket undergoes physiological bone remodeling, resulting in a reduction of both ridge height and width. Evidence from the literature indicates that ridge width may decrease by approximately 29–63%, while ridge height may be reduced by 11–22?ter extraction. The most rapid and pronounced bone resorption typically occurs within the first three months post-extraction [1].
Dental implants have become a widely accepted and predictable option for prosthetic rehabilitation following tooth loss due to their durability, functionality, and favorable esthetic outcomes. However, successful implant placement depends largely on the availability of adequate bone volume and quality. Careful assessment of bone dimensions is therefore essential during treatment planning.
Although dental implants offer a reliable and effective solution for restoring both function and appearance, their long-term success requires the fulfillment of multiple clinical, biomechanical, and biological criteria [2,3]. Insufficient alveolar bone volume following extraction may compromise optimal implant positioning and stability, highlighting the importance of strategies aimed at preserving ridge dimensions.
According to Iasella et al. (2003), approximately 50–60% of alveolar bone volume is lost within the first three months following tooth extraction. These findings highlight the critical importance of the early post-extraction period in influencing alveolar bone healing and remodeling. Such resorption results in significant dimensional alterations of the alveolar ridge, affecting both height and width [4].
These dimensional changes may lead to esthetic concerns and create challenges for future prosthetic rehabilitation. He et al. (2009) described wound healing as a complex biological process and a natural defense mechanism aimed at preserving tissue integrity and maintaining overall homeostasis [5]. The physiological healing of the post-extraction socket involves a coordinated sequence of events, including blood clot formation, inflammatory response, cellular migration, angiogenesis, and bone formation. This dynamic process of bone resorption and apposition ultimately determines the final architecture of the healed ridge [6].
Socket preservation procedures are designed to minimize post-extraction bone resorption and maintain the volume and contour of the alveolar ridge. Preserving ridge dimensions is essential for facilitating future implant placement or prosthetic rehabilitation. Various techniques have been developed to prevent bone atrophy after tooth extraction, including socket preservation, guided bone regeneration, application of growth factors, immediate implant placement, and atraumatic surgical techniques [7–9]. However, certain bone grafting materials may require extended healing periods before sufficient new bone formation and graft integration occur [10].
Atraumatic extraction is a surgical approach aimed at minimizing trauma to surrounding hard and soft tissues, thereby preserving the integrity of the socket for future restorative procedures [11]. Among biologically based regenerative materials, platelet-rich fibrin (PRF), introduced by Dohan et al., has gained considerable attention. PRF is an autologous platelet concentrate rich in growth factors and is widely used in oral and maxillofacial surgery to enhance tissue healing. It is prepared from approximately 10 mL of the patient’s venous blood without the addition of anticoagulants or bovine thrombin, making it a fully autologous biomaterial. PRF consists of a dense fibrin matrix containing platelets, leukocytes, cytokines, and circulating stem cells. The growth factors embedded within this fibrin network are gradually released over 7–14 days, promoting angiogenesis, soft tissue regeneration, and bone healing. Numerous studies have reported that PRF accelerates epithelialization, improves soft tissue healing, and reduces postoperative pain and edema [12].
Socket preservation using biomaterials and autologous platelet concentrates, such as platelet-rich fibrin (PRF) and platelet-rich plasma (PRP), has been proposed as a strategy to enhance healing and reduce post-extraction bone resorption [13]. PRF, considered a second-generation platelet concentrate, promotes tissue regeneration and has been associated with improved early bone formation and enhanced structural organization of regenerated tissues. Unlike PRP, PRF is prepared without anticoagulants and forms a dense fibrin matrix rich in platelets, leukocytes, cytokines, and growth factors. It is obtained through simple centrifugation of autologous blood, making it a cost-effective and biologically favorable regenerative material [14].
Ridge preservation techniques, including the application of PRF, aim to limit post-extraction bone loss by providing a biological scaffold that supports angiogenesis, cellular migration, and new bone formation. In addition to its regenerative potential, PRF has been reported to reduce postoperative complications such as pain, edema, infection, dry socket, and trismus, thereby improving overall healing outcomes [15,16].
Maintaining alveolar ridge dimensions following tooth extraction is of paramount importance in modern dentistry, particularly for future implant placement and prosthetic rehabilitation. Continued research is essential to develop predictable techniques for preserving both hard and soft tissues, as dimensional alterations may compromise esthetic outcomes and functional restoration. Despite growing interest in PRF for ridge preservation, limited evidence exists regarding two important aspects: the evaluation of postoperative pain and the assessment of dimensional bone changes using three-dimensional cone-beam computed tomography (CBCT).
Therefore, the purpose of this study was to evaluate the effectiveness of platelet-rich fibrin (PRF), alone and in combination with collagen, in preserving alveolar ridge dimensions at extraction sites in both the maxilla and mandible, and to assess its impact on post-extraction discomfort. The null hypothesis stated that there would be no statistically significant difference between the use of PRF and standard treatment with respect to dimensional ridge changes or postoperative pain reduction at the extraction site.
This prospective clinical study was conducted at the Anandaban Tertiary Hospital.
All participants were fully informed about the study objectives, procedures, potential benefits, and associated risks. Written informed consent was obtained from each patient prior to participation. Sample size calculation was performed using G*Power software (version 3.1), considering 80% statistical power, a significance level (α) of 0.05, and an effect size of 1.2, resulting in 19 participants per group [17]. To account for potential dropouts, 20 patients were included in each group, yielding a total sample size of 60. A convenience sampling method was applied.
Patients requiring extraction of posterior teeth due to non-restorable conditions were randomly assigned into three groups (n = 20 per group):
Group I (PRF group): Teeth were extracted, and PRF was applied alone.
Group II (PRF + Collagen group): Teeth were extracted, and PRF was applied in combination with Collaplug® (Collagen Matrix, Inc., Oakland, NJ, USA).
Group III (Control group): Teeth were extracted without any adjunctive material.
Inclusion criteria consisted of systemically healthy patients aged 18–60 years who required extraction of posterior teeth for non-restorable reasons. Exclusion criteria included pregnant women, smokers, patients with known allergies, those undergoing chemotherapy or radiotherapy, and patients presenting with significant periapical lesions or periodontally compromised teeth.
All participants underwent a comprehensive clinical evaluation, including detailed medical and dental history, intraoral examination, and preoperative imaging using cone-beam computed tomography (CBCT) to assess the condition of the tooth and surrounding alveolar bone. Postoperative pain was assessed using the Numerical Pain Rating Scale (NPRS), ranging from 0 (no pain) to 10 (worst possible pain).
1.1. Surgical Procedures
Atraumatic Extraction:
All extractions were performed under local anesthesia using 2%lidocaine with 1:100,000 epinephrine. Atraumatic tooth extraction was carried out with dental forceps to minimize trauma to the surrounding alveolar bone and soft tissues. Following extraction, the socket was carefully debrided using bone curettes and sterile saline to remove any granulation tissue. The condition of the alveolar bone, particularly the buccal plate, was gently evaluated with a periodontal probe.
PRF Preparation:
Approximately 9–10 mL of venous blood was collected from each patient in plain tubes without anticoagulant. The samples were immediately centrifuged at 2,700 rpm (400×g) for 12 minutes. This process produced three distinct layers: the top layer of acellular platelet-poor plasma (PPP), the bottom layer of red blood cell (RBC) concentrate, and a central fibrin clot representing the PRF. The fibrin clot was carefully retrieved with sterile surgical tweezers, excess RBCs were removed, and the clot was compressed using a PRF metal box and piston to form a plug suitable for socket placement.
Socket Treatment:
Group I (PRF): The PRF plug was placed directly into the extraction socket, and the site was closed with figure-eight sutures.
Group II (PRF + Collagen): The PRF plug was placed in the socket, followed by a collagen plug (Collaplug®, Collagen Matrix, Inc., Oakland, NJ, USA) on top, and the site was sutured using a figure-eight technique.
Group III (Control): Patients underwent atraumatic extraction alone, without any additional biomaterial.
Postoperative Assessment and Follow-Up:
Pain levels were assessed at 24 hours, 3 days, and 7 days postoperatively using the British Pain Society Numerical Rating Scale (0 = no pain, 10 = worst possible pain). Follow-up examinations were conducted at 7 days, 1 month, and 3 months. At the 3-month follow-up, a second CBCT scan was performed to evaluate changes in alveolar ridge dimensions.
1.2. Statistical Analysis
The Shapiro–Wilk test was used to assess the normality of all continuous variables. Descriptive statistics, including means and standard deviations, were calculated for variables such as postoperative pain and ridge dimensions. Between-group comparisons were performed using one-way analysis of variance (ANOVA), and pairwise comparisons were conducted with independent t-tests where appropriate. Statistical analyses were carried out using SPSS version 22 (IBM-SPSS Inc., Armonk, NY, USA), and a p-value < 0.05 was considered statistically significant.
Alveolar Ridge Width:
Table 1 summarizes the mean ridge width values before and after treatment for the three study groups: control, PRF, and PRF combined with collagen. The table includes the mean ± standard deviation (SD) for each group at baseline and at the 3-month follow-up.
The control group showed a decrease in ridge width over the 3-month period.
Both the PRF and PRF + collagen groups demonstrated preservation of ridge width compared to the control group, although the differences were not statistically significant (p > 0.05).
Postoperative Pain:
Postoperative pain was assessed at 24 hours, 3 days, and 7 days using the Numerical Pain Rating Scale. Both the PRF and PRF + collagen groups reported lower pain scores at all time points compared to the control group, indicating a significant reduction in short-term postoperative discomfort (p < 0>
These results suggest that while PRF and PRF combined with collagen may not significantly alter ridge dimensions compared to standard treatment, they are effective in reducing postoperative pain in the short term.
| Group | Ridge Height Before | Ridge Height After | p-Value |
| Control group | 10.52 (SD 1.950) | 10.42 (SD 1.883) | 0.877 |
| PRF group | 10.02 (SD 1.040) | 9.82 (SD 1.020) | 0.595 |
| PRF + collagen group | 10.52 (SD 1.043) | 10.27 (SD 1.017) | 0.534 |
Table 1: Comparison of Alveolar Ridge Width Before and After Treatment Among Control, PRF, and PRF + Collagen Groups (Independent t-test)
PRF: Platelet rich fibrin; SD: Standard deviation.
The results presented in Table 1 indicate that there were no statistically significant differences in alveolar ridge width before and after treatment among the three groups, as all p-values were greater than 0.05. This suggests that neither PRF alone nor PRF combined with collagen had a significant impact on ridge width preservation compared to the control group over the 3-month follow-up period.
Table 2 presents the comparison of alveolar ridge height before and after treatment among the three groups: control, PRF, and PRF + collagen. For each group, the mean ridge height at baseline and at 3 months is reported along with the corresponding standard deviation (SD). The table also includes p-values derived from paired t-test analyses, indicating the statistical significance of changes in ridge height within each group over time.
The data from Table 2 allow for evaluation of the effectiveness of PRF and PRF + collagen in maintaining vertical ridge dimensions following tooth extraction.
| Group | Ridge Height Before | Ridge Height After | p-Value |
| Control group | 10.52 (SD 1.950) | 10.42 (SD 1.883) | 0.877 |
| PRF group | 10.02 (SD 1.040) | 9.82 (SD 1.020) | 0.595 |
| PRF + collagen group | 10.52 (SD 1.043) | 10.27 (SD 1.017) | 0.534 |
Table 2: Comparison of Alveolar Ridge Height Before and After Treatment Among Control, PRF, and PRF + Collagen Groups (Paired t-test)
PRF: platelet-rich fibrin; SD: standard deviation
The analysis of alveolar ridge height, as presented in Table 2, indicates that there were no statistically significant differences in ridge height before and after treatment within any of the three groups, as evidenced by all p-values exceeding 0.05. This suggests that neither PRF alone nor PRF combined with collagen had a significant effect on vertical ridge preservation over the 3-month follow-up period.
Table 3 summarizes the postoperative pain scores reported by participants in the three groups (control, PRF, and PRF + collagen) over the course of one week. Pain was assessed at three postoperative time points: 24 hours, 3 days, and 7 days. For each time interval, the mean pain score and corresponding standard deviation (SD) are presented. This analysis allows for evaluation of the effectiveness of PRF and PRF + collagen in reducing short-term postoperative discomfort following tooth extraction.
Table 3: Postoperative Pain Scores Among Control, PRF, and PRF + Collagen Groups Over One Week (Mean ± SD, ANOVA
PRF: platelet-rich fibrin; SD: standard deviation.
Across all groups, mean pain scores decreased progressively over time, reflecting the natural resolution of post-extraction discomfort. At 24 hours post-treatment, the control group reported the highest mean pain scores compared to the PRF and PRF + collagen groups. By 3 days post-treatment, both the PRF and PRF + collagen groups exhibited notably lower mean pain scores than the control group, suggesting an early benefit of PRF application in reducing postoperative discomfort.
At the 7-day follow-up, the differences in pain scores among the three groups became less pronounced, indicating that overall pain had subsided in all participants. These results suggest that both PRF and PRF + collagen were effective in reducing short-term postoperative pain, particularly within the first 3 days following tooth extraction, although the effect diminished over time as healing progressed.
This study evaluated the effects of platelet-rich fibrin (PRF) and PRF combined with collagen on alveolar ridge width, ridge height, and postoperative pain in patients undergoing alveolar ridge preservation following tooth extraction. Outcomes were compared to a control group receiving standard treatment.
Ridge Width:
The comparison of ridge width before and after treatment among the three groups is summarized in Table 1. In the PRF group, the mean ridge width decreased slightly from 11.09 ± 0.615 mm at baseline to 10.98 ± 0.589 mm at 3 months (p > 0.05). Similarly, in the PRF + collagen group, the ridge width changed minimally from 10.90 ± 1.024 mm at baseline to 10.84 ± 1.031 mm after treatment (p > 0.05). These results indicate that there were no statistically significant differences in ridge width preservation among the three groups over the 3-month period.
These findings are consistent with previous research, which demonstrated that ridge width exhibited a smaller change from baseline to 180 days in the PRF group compared to the control group (PRF: 0.75 ± 0.49 mm vs. Control: 1.36 ± 0.70 mm; p = 0.005), suggesting that PRF can reduce dimensional changes in the alveolar ridge [18]. Other studies assessing ridge contour at 5 mm from the crest reported a significantly greater preservation of ridge width with PRF treatment four weeks post-extraction compared to unassisted healing sockets [19–21].
Overall, while PRF and PRF + collagen did not produce statistically significant differences in ridge width in the current study, previous evidence suggests that PRF may contribute to clinically relevant reductions in alveolar ridge resorption over time.
Several studies included in meta-analyses have employed cone-beam computed tomography (CBCT) to quantify changes in alveolar ridge width, rather than solely assessing contour alterations. In these studies, sites treated with platelet-rich fibrin (PRF) generally exhibited reduced bone width resorption compared to naturally healing sockets; however, the differences were not statistically significant. Notably, a high degree of variability was observed across studies, highlighting inconsistencies in study designs and measurement protocols [22,23].
The primary goal of alveolar ridge preservation is to maintain the integrity of both hard and soft tissues following tooth extraction, thereby facilitating optimal implant positioning for future prosthetic rehabilitation. The selection of an appropriate preservation technique depends on patient-specific factors, the location of the extracted tooth, and the clinician’s judgment. Techniques such as socket preservation using bone grafts and immediate or early implant placement have been shown to minimize post-extraction bone loss and allow for predictable implant placement [8].
Specifically, two studies investigating dimensional changes of the alveolar ridge following PRF application alone reported that PRF significantly reduced horizontal ridge resorption as early as 8 weeks post-extraction [19,23]. These findings support the potential of PRF as a biological adjunct in ridge preservation, although variability in outcomes underscores the need for standardized protocols and further research to as long as 6 months post-surgery. Notably, both studies utilized multiple PRF clots or membranes, with Alzahrani et al. [19] employing two membranes and Temmerman et al. [23] using three to seven membranes. The quantity of clots or membranes and the cor- responding blood volume could influence the clinical outcome by potentially modulating the cellular environment within the socket [24].
Furthermore, some studies employed only a single PRF clot, whereas others utilized multiple clots or membranes, which may influence the extent of ridge preservation [19]. Marenzi et al. reported improved soft tissue healing at 7, 14, and 21 days post-extraction; however, the clinical interpretation of these findings is limited due to the variability of healing indices used across studies [25].
Carmagnola et al. observed a greater reduction in both alveolar ridge width and height when no preservation procedures were applied, highlighting the importance of ridge preservation techniques in maintaining post-extraction bone integrity [26].
In the present study, sockets treated with PRF + Collaplug demonstrated ridge preservation effects comparable to those reported by Iasella et al. [4], suggesting that the combination of PRF and collagen plug supports both hard tissue maintenance and increased bone density at the extraction site.
Postoperative Pain:
As summarized in Table 3, postoperative pain scores were evaluated at 24 hours, 3 days, and 1 week following tooth extraction across the three study groups (control, PRF, and PRF + collagen). Across all groups, mean pain scores decreased progressively over time, indicating a natural resolution of postoperative discomfort. At 24 hours, the control group reported the highest pain levels compared to the PRF and PRF + collagen groups. By 3 days and 1-week post-treatment, both PRF-treated groups consistently reported lower pain scores than the control group. These findings indicate that PRF, with or without collagen, is effective in reducing short-term postoperative pain. Consequently, the current study partially rejects the null hypothesis, demonstrating a significant difference in postoperative pain reduction between PRF-treated sites and untreated control sites.
The p-values reported in Table 3 represent the statistical significance of differences in postoperative pain scores among the three groups at each time interval, as determined by one-way ANOVA. Pain scores at 24 hours and 3 days post-treatment were statistically significant (p < 0>
Patient-reported pain is a critical outcome measure in post-extraction recovery [27]. Several studies have employed the visual analog scale (VAS) to quantify pain and patient-reported outcomes [23,25]. Temmerman et al. [23] reported that PRF significantly alleviated pain within 3 to 5 days post-extraction, while Marenzi et al. [25] observed reduced pain in PRF-treated sites for up to 21 days, although these studies did not clearly indicate whether patient blinding was applied. Numerous investigations have also examined the effect of PRF on postoperative pain following mandibular third molar extractions [28].
Consistently, patients in PRF-treated groups reported lower pain scores at all evaluated time points. Comparisons between PRF and control groups on days 7 and 14 showed lower VAS scores in the PRF group. Girish Kumar et al. [29] similarly demonstrated that postoperative analgesic consumption was significantly lower in PRF-treated patients compared to controls during the first and third days.
Moreover, the PRF group exhibited a lower peak pain level on the day of surgery and maintained reduced pain levels up to the 10th postoperative day compared to controls. VAS scores decreased progressively from baseline to day 10 in both groups, but the PRF group consistently reported lower values and returned to baseline pain levels sooner than the control group [29]. These findings support the analgesic and healing-promoting properties of PRF in post-extraction care.
The p-values provided in Table 3 represent the statistical significance of the observed differences in pain scores among the three groups at each time interval, as determined by one-way ANOVA. The p-values for the pain scores at 24 h and 3 days post-treatment were statistically significant (p < 0>
Patients report pain as an important measure [27]. Two studies utilized the visual analog scale to gauge patient-reported outcomes [23,25]. Temmerman et al. [23] concluded that PRF notably alleviated pain sensations within 3 to 5 days, while Marenzi et al. [25] observed reduced pain in the PRF group for up to 21 days. However, neither study specified whether patients received adequate blinding. There are a plethora of studies investigating the effect of PRF on mandibular third molar extraction pain [28].
At all times, the patients in the PRF group reported much lower pain ratings. When comparing the control group to the PRF group on days 7 and 14, the VAS score values were lower in the former. According to Girish Kumar et al. [29], the PRF group’s postoperative analgesic consumption was considerably lower than that of the control group on the first and third days.
In addition to a significantly lower peak pain level on the operation day in the PRF group compared to control group, lower pain levels on the 10th day were noted clearly in the PRF group in comparison to control group. Both groups’ VAS ratings decreased from baseline to the tenth day. The VAS values of the PRF group were consistently lower than those of the control group across all periods. The PRF group’s pain ratings returned to normal levels sooner than those of the control group [29].
The mean pain score for the PRF group was significantly lower at 2.90 (SD 0.96) after 24 h. It dropped to 0.550 (SD 0.60) after three days and stayed at this level for one week.
Similar to the control group, postoperative pain decreased significantly over time, with p-values of 0.000 at both the 3-day and 1-week intervals, indicating a substantial reduction in pain from baseline. In a study by Carmagnola et al. [26], the control group also exhibited notable alveolar bone loss, with a reduction in bone height of 2.12 ± 0.69 mm and a loss in bone width of approximately 1.71 ± 0.49 mm.
Current literature suggests that PRF offers clinical advantages in alveolar ridge preservation due to its ease of use and straightforward handling. Histological analyses have confirmed that PRF enhances both the quality and rate of new bone formation, although its effect on reducing alveolar bone resorption in extraction sockets alone may not always reach statistical significance [30].
Previous studies comparing bone density, width, height, and soft tissue healing among three groups—control, PRF, and PRF + Collaplug—demonstrated improved early soft tissue healing in the PRF-treated groups by postoperative day 7. PRF contributes to soft tissue repair through the sustained release of growth factors and inflammatory cytokines. Preservation of bone height at four months postoperatively was similar between the PRF and PRF + Collaplug groups, attributable to PRF’s role in stimulating neovascularization, enhancing new bone formation, and maintaining vertical ridge dimensions. Horizontal ridge preservation was superior in the PRF + Collaplug group at four months. The Collaplug, when used in combination with PRF, stabilizes the initial clot, prevents the ingrowth of surrounding soft tissue into the socket during healing, and supports the maintenance of ridge width after surgery [17].
Strengths and Limitations
This study provides valuable insights into the immediate outcomes of PRF and PRF + Collaplug interventions in alveolar ridge preservation. One of the strengths of the study is the use of CBCT imaging to quantify ridge width and height changes, along with systematic assessment of postoperative pain, allowing a comprehensive evaluation of both hard and soft tissue outcomes.
However, the study has several limitations. Longitudinal follow-up studies are needed to assess the long-term effects of PRF and PRF + Collaplug on ridge morphology, implant success rates, and patient-centered outcomes such as satisfaction and quality of life. Additionally, variations in treatment protocols—including differences in PRF concentration, clot number, or combinations with other biomaterials—may influence outcomes and should be explored in future research.
Although numerous studies support the positive impact of PRF on alveolar ridge preservation, some investigations report no significant effect on ridge dimensions. Therefore, further well-designed studies are warranted to clarify the clinical efficacy of PRF in extraction socket preservation and its potential role in reducing post-surgical morbidity. Overall, this research contributes to the growing body of evidence on dental biomaterials and highlights the importance of comprehensive evaluation strategies to assess multifaceted clinical outcomes.
In conclusion, the findings of this study indicate that platelet-rich fibrin (PRF) and PRF combined with collagen do not significantly affect alveolar ridge width or height compared to standard post-extraction treatment. Nevertheless, both PRF and PRF + Collaplug demonstrated a clear benefit in reducing short-term postoperative pain, suggesting a potential advantage over conventional treatment protocols. These results support the use of PRF as an adjunct for improving patient comfort in the early post-extraction period, even if its effects on ridge dimensional preservation are limited.
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"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.
Dear Grace Pierce, Editorial Coordinator of the journal IJCCR, I had a very positive experience with Auctores - Journal throughout the publication process. The Editorial Team was highly responsive, professional, and supportive at every stage. I would like to extend my sincere thanks to the Editor: Grace Pierce, for her guidance and assistance. The peer-review process was smooth and constructive, helping improve the quality of my work. I would gladly recommend Auctores Journal to fellow researchers and authors. Dr. SABITA SINHA, Medical Oncologist, MD (Electro Homeopathy).
Dear Maria Emerson, Editorial Coordinator of - Journal of Clinical Research and Reports. ''I am pleased to provide this testimonial following the publication of our recent case report in this journal. The peer review process was rigorous, constructive, thorough, and conducted in a timely manner. The reviewers’ comments were thoughtful, detailed, and highly constructive, contributing substantially to the refinement, clarity, and scientific robustness of our manuscript. The process was conducted with professionalism and academic integrity throughout. The support provided by the editorial office was exemplary. Communication was consistently prompt, clear, and courteous at all stages of the submission and publication process. The editorial team demonstrated a high level of organization and responsiveness, ensuring that all queries were addressed efficiently and that the process remained transparent and well-coordinated. The overall quality of the journal is reflected in its strong editorial standards, commitment to scientific excellence, and dedication to publishing clinically meaningful research. It has been a privilege to publish our work in this journal, and we would welcome the opportunity to contribute further in the future.'' Best wishes from, Dr. Efstratios Trogkanis, Cardiologist.
Dear Reader: We have published several articles in the Auctores Publishing, LLC, journal, Clinical Medical Reviews and Reports in recent years (CMRR). This is an ‘open access’ journal and the following are our observations. From the initial invitation to submit an article, to the final edits of galley proofs, we have found CMRR personnel to be professional, responsive, rapid and thorough. This entire process begins with Catherine Mitchell, Editorial Coordinator. She is simply outstanding, and, I believe, unparalleled in her capacity. I cannot imagine a more responsive and dedicated Editorial Coordinator. As I read the dates and timing of her correspondence with us, it seems that she never sleeps. I hope Auctores Publishing, LLC, appreciates her efforts as much as these authors do. Thank you to Auctores Publishing, LLC, to the Editorial Staff/Board, and to Catherine Mitchell from a grateful author(s).
Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.
Dear Mercy Grace, Editorial Coordinator of Obstetrics Gynecology and Reproductive Sciences, We would like to express our gratitude for your help at all stages of publishing and editing the article. The editors of the magazine answer all the necessary questions and help at every stage. We will definitely continue to cooperate and publish other works in the Obstetrics Gynecology and Reproductive Sciences! Best wishes from, Alla Konstantinovna Politova,
