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Mini Review Article | DOI: https://doi.org/10.31579/2768-2757/136
1General Surgeon, Department of Surgery, Medical Faculty, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.
2Associated professor of nephrology, Department of Internal medicine, Nephrologist, Ali Ibne Abitaleb Hospital, Zahedan University of medical Sciences, Zahedan, I.R. Iran.
3Dentist, Dental faculty, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.
*Corresponding Author: Ahmad Reza Shahraki., General Surgeon, Department of Surgery, Medical Faculty, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.
Citation: Ahmad R. Shahraki, Elham Shahraki, Elahe Shahraki, (2024), Chandipura Virus (Chpv) -The Deadly Paediatric Disease of Monsoon in Bharat, Journal of Clinical Surgery and Research, 5(6); DOI:10.31579/2768-2757/136
Copyright: © 2024, Ahmad Reza Shahraki. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 15 July 2024 | Accepted: 19 August 2024 | Published: 02 September 2024
Keywords: epidemiology; diagnosis; vaccinology and biology
The virus has been detected in CSF as well as sera collected from the patients in the acute phase of illness using CHPV specific one-step RT-PCR assay that detects 10-100 pfu / ml of the virus in human clinical specimens. Real-time one-step RT-PCR indicates linear relationship for a wide range of viral RNA 102-1010.
Chandipura Virus (CHPV) is a virus belongs to the Rhabdoviridae family, which includes rabies, the deadliest zoonotic disease. It is transmitted by sandflies and mosquitoes, including Aedes aegypti, which is also a vector for dengue too. The virus resides in the salivary glands of these insects and can be transmitted to humans or domestic animals through bites of these infected insects. The infection may lead to encephalitis and inflammation of the brain’s most active tissues. The Chandipura virus, belonging the Vesiculovirus genus, was discovered in 1965 in the blood of two individuals suffering from febrile sickness in a hamlet near Nagpur, Maharashtra.
The virus usually spread by the female phlebotomine sandfly, which is abundant during the y monsoon season. Sergentomyia sandflies play a role in the virus’s spread, with Aedes aegypti being highly susceptible and effective in laboratory conditions. Chandipura infection produces encephalitis, which is the inflammation or swelling of brain tissue. However, no viral isolations from mosquitoes have been documented till date.
Chandipura virus (CHPV): Symptoms, impact, treatment and prevention
Typical symptoms include a rapid onset of fever, vomiting, altered mental state, convulsions, diarrhoea, neurological deficits, and signs of meningeal irritation. The virus predominantly affects children under the age of 15, mostly in rural areas. Most affected children experience rapid deterioration, with deaths occurring within 48 hours of hospital admission. Enlisted below are some of the symptoms:
Currently, there is no specific antiviral treatment or vaccine available for the Chandipura virus. Early diagnosis and supportive care, such as managing airways, fluid balance, and the prevention of secondary bacterial infections, are essential for patient management.
Chandipura virus (CHPV) was first discovered during an acute febrile outbreak in Nagpur, Maharashtra state, India from two febrile cases [1965] [1, 2]. It belongs to the genus Vesiculovirus, family Rhabdoviridae. This virus has single-stranded RNA genome with negative polarity and size about 11 kilobases. It has five structural proteins which are coded by genome: the nucleocapsid protein (N), the phosphoprotein (P), the matrix protein (M), the glycoprotein (G) and large structural protein (L). These are produced in the form of five monocistronic mRNAs [3]. The available information suggests that sandflies are the vectors for this virus while antibodies against this have been detected in a wide range of vertebrate animals [4].
General clinical features include high-grade fever of short duration, vomiting, altered sensorium, generalized convulsions and decerabrate posture leading to grade 4 coma, acute encephalitis-encephalopathy and death within a few to 48 hours of hospitalization [5]. The available epidemiological data suggest that this disease mostly occurs in sporadic forms; however, has potential to cause outbreaks. This disease is not in a routine laboratory screening for acute encephalitis syndrome [AES]. Therefore, during any AES syndrome, the role of this virus is not understood. Besides this, there have been many queries about CHPV: is sandflies the only vector? What is the natural cycle? Do small mammal, domestic animals have any role and since the transovarial transmission of virus in sandflies may not be enough for its maintenance in nature. Understanding the natural cycle can help in interventions and prediction off or breaks. This article reviews research activities and further developments occurred during the last 10 years, which are necessary to understand CHPV as a growing concern in India, its epidemiology, diagnosis, vaccinology and biology of the virus.
It is recorded from Indian subcontinent [India, Bhutan and Nepal], Sri Lanka, and Africa (Nigeria, Senegal) [6,7]. Hence, it is speculated that CHPV may be present in other parts of the country. Although, this was first time identified in India during 1965 but the retrospective serological studies indicate exposure of the human population as early as during 1957–58 [1]. Earlier reports suggest that the association of CHPV with a few undiagnosed outbreaks occurred in 1954 in Bihar [8]. However, CHPV was isolated from sera collected from clinically confirmed encephalitis cases in 1983 from Raipur [9] and the Warangal district of Andhra Pradesh (1997 and 2002) [10] suggesting its wide circulation in the country. However, CHPV re-emerged during 2003 in the form of an encephalitis outbreak affecting 11 districts of Andhra Pradesh with a high fatality ratio of about 56% [11]. CHP encephalitis (CHPE) outbreak was simultaneously documented in 15 districts of Maharashtra during the same time [12, 13]. During the subsequent year (2005), CHPV outbreak with 70
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