AUCTORES
Globalize your Research
Research Article | DOI: https://doi.org/: 10.31579/2693-7247/147
1 Yozgat Bozok University School of Health Services, Department of Pharmacy Services
2 Yozgat Bozok University, Faculty of Health Sciences, Department of Nursing
3 Yozgat Bozok University Faculty of Health Sciences, Department of Nutrition and Dietetics
*Corresponding Author: Gökhan Doğukan Akarsu, Yozgat Bozok University School of Health Services, Department of Pharmacy Services
Citation: Gökhan Doğukan Akarsu, Rukiye Höbek Akarsu, Meral EKIM, (2023), Cannabidiol in Rheumatological Diseases: Collection of Clinical and Experimental Data: A Systematic Review. J. Pharmaceutics and Pharmacology Research, 6(6); DOI: 10.31579/2693-7247/147
Copyright: © 2023, Gökhan Doğukan Akarsu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 18 September 2023 | Accepted: 04 October 2023 | Published: 20 October 2023
Keywords: cbd; cannabis; hemp; rheumatologic disease; treatment
The aim of this systematic review is to evaluate the results of cannabidiol (CBD) in rheumatological studies. This study is a systematic review prepared according to the PRISMA checklist and Cochrane guideline. Science Direct, Web of Science, SCOPUS, Springer Link, Networked Digital Library of Theses & Dissertations, Ovid, CINAHL, Pubmed, Cochrane Library, Proquest databases were made by scanning English articles published between 2000-2023. “CBD, Cannabidiol, Hemp, Rheumatic Diseases, Rheumatoid Arthritis, gout, systemic lupus, fibromyalgia, Osteoarthritis, acute rheumatological fever, rheumatologic” etc. words and combinations are used. According to the results of the study, there was not enough research in the literature to evaluate the effectiveness of CBD in rheumatological diseases. Studies have shown that CBD is effective in reducing pain. In a study, it was stated that CBD caused a decrease in the levels of inflammatory markers IL6 and TNFα, and there was no change in liver function tests and kidneys. It is necessary to determine the effectiveness of CBD in rheumatological diseases. Conducting controlled clinical trials after being evaluated with experimental animal models will contribute to the literature and guide future research.
Cannabidiol (CBD) is a type of cannabinoid derived from the cannabis plant. Cannabidiol can also be synthesized in the living body through the endocannaboid system [1]. When it comes to cannabis, the first thing that comes to mind is that it is a prohibited substance and has a drug nature. For this reason, it has always been kept out of sight. As a result of developing researches, it has been determined that tetrahydrocannabinol (THC) constitutes the psychoactive part of cannabis. CBD has no psychoactive properties. On 22/01/2021, the US Food and Drug Administration (FDA) reported that it approved the use of CBD in its pure form for the use of epileptic seizures [2].
Similarly, although the licensing procedures vary from country to country in the European continent, there is no general ban on the use of CBD depending on the THC content.
With the relaxation of restrictions, research is increasing and the effectiveness of CBD in some signaling pathways, disease indications and during the inflammatory response can be evaluated. In some studies, it has been reported that CBD has some positive effects against some diseases, including rheumatic diseases.
Autoimmune diseases can be organ specific or affect more than one organ. Rheumatic diseases, which are among these diseases, are a type of disease that reduces the quality of life of patients with the disease, reduces their comfort, and causes them to encounter situations that remind themselves frequently for the rest of their lives [3].
Some of the rheumatic diseases are rheumatoid arthritis, osteoarthritis, acute rheumatic fever, fibromyalgia and gout. These diseases are heterogeneous diseases with high morbidity and mortality rates [4].
The treatment of rheumatic diseases varies according to the type of the disease, and since it is not possible to cure the disease, slowing and stopping its progression is the best technique available at the moment. Although many different studies continue to be carried out to cure the disease, a fully effective remedy has not yet been found.
There are studies in the literature examining the effect of CBD on rheumatological diseases. It was aimed to compile the methods used in proportion to the dose and duration of these studies in human and animal subjects and to determine the effect of CBD by comparing the experimental results.
Type of Research
This study is a systematic review prepared according to the PRISMA checklist and Cochrane guideline [5-6].
Research Strategy
CBD is a group of molecules obtained from the cannabis plant and can also be produced in the living body through the endocannaboid system. Studies have evaluated the effect of CBD against rheumatological diseases. In this systematic review, the results of the stated effect in human and animal experimental groups will be evaluated depending on the method, daily dose, dosage form and treatment duration.
Science Direct, Web of Science, SCOPUS, Springer Link, Networked Digital Library of Theses & Dissertations, Ovid, CINAHL, Pubmed, Cochrane Library, Proquest databases were made by scanning English articles published between 2000-2023. “CBD, Cannabidiol, Hemp, Rheumatic Diseases, Rheumatoid Arthritis, gout, systemic lupus, fibromyalgia, Osteoarthritis, acute rheumatological fever, rheumatologic” etc. words and combinations are used.
The summaries of 184 studies that formed the universe published between 2000-2023 were systematically examined, and then 8 studies that were suitable for the purpose of the study and examined the effects of CBD on Rheumatological Disease formed the sample of the study (Figure 1).
Although all searches were done by a single reviewer, full-text review and data abstraction were done in duplicate. Experimental and clinical studies examining the effects of CBD on Rheumatological Diseases were included when scanning articles. Studies examining the combined efficacy of other molecules were not included.
Inclusion criteria;
• Full text accessible,
• In the field of CBD and Rheumatological Diseases,
• About Rheumatological Diseases,
• Studies published in the Science Direct, Web of Science, SCOPUS, Springer Link, Networked Digital Library of Theses & Dissertations, Ovid, CINAHL, Index Copernicus, Pubmed, Cochrane Library, Proquest database center between 2000-2023 were included.
In this study, PICOS;
Figure 1: Prisma Flow Chart
Limitation of the study
Reviews that are not included in the Science Direct, Web of Science, SCOPUS, Springer Link, Networked Digital Library of Theses & Dissertations, Ovid, CINAHL, Index Copernicus, Pubmed, Cochrane Library and Proquest databases and that are not recorded in the system are not included.
The limitations of the study are research on the effect of CBD on Rheumatological Diseases, accessing the same compilations with different keywords, and the low number of accessed articles. Other molecules studies are not included. If amount of THC more than 2% total medicine, it does not inclusion on data.
Ethical aspect of research
Ethical permission was not obtained because open access article were open to access were used in this systematic review. Reviews were selected by the researchers considering the PRISMA checklist.
Analysis of data
The data were evaluated using the data summary form prepared by the researchers. The data summary form includes the author, supervisor, year of the study, the purpose of the study and results of the studies. Data summary forms were evaluated independently by the researcher.
The data obtained from the literature with the research are given in the table below. The table includes the name of the article, the year, the subject, the amount of CBD given and the brief results of the article (Table 1).
Table 1: Studies investigating the effect of CBD in rheumatic diseases.
1Holly et al. (2017), in their study, experimental osteoarthritis was induced by injection of 3 mg/50uL monoiodoacetate into the joints of rats, and 100-300 μl of CBD treatment was applied after the 1st and 3rd days. After the treatment, the joints were examined and the petal functions were evaluated using von Frey hair. The tissues were then evaluated under the electron microscope. As a result of the evaluation, it was stated that 300 μl of CBD in the treatment of experimental osteoarthritis induced with monoiodo acetate in rats reduced pain due to osteoarthritis [7].
2Giuggioli et al. (2021), prepared a 10
CBD is a molecule that can be obtained from the cannabis plant, as well as produced synthetically and in the living system through the endocannabinoid system, and shows its effect by binding to the CB1 and CB2 receptors. There is a lot of research done on CBD against different diseases. Some of these have been shown to be effective in psychiatric diseases, obesity, Alzheimer's, cardiovascular diseases, Parkinson's, other neurodegenerative diseases, sleep disorders and various cancers. [15-23].
In addition to all these effects, it has been evaluated that it can affect some immune system disorders together with the CB1 and CB2 receptors it activates, contributing to the literature. Rheumatological diseases are an autoimmune disease associated with chronic inflammation. In the group of rheumatological diseases, there are rheumatoid arthritis, osteoarthritis, systemic lupus erythematous, acute rheumatic fever, fibromyalgia, myofascial pain, gout diseases. Today, intensive research continues to treat these diseases. However, although it is not possible to revert the disease in current methods, it is tried to slow down the rate of disease progression and to keep the comfort of life at the best possible level by reducing the pain.
In the studies mentioned in the results section, it was a priority to conduct the research in a controlled manner, and it was aimed to objectively examine the dose and effect given in this way. Of these studies, only studies with human and animal subjects and investigating the effects on rheumatic diseases were examined. Those who were not under the control of the researcher or the amount of the dose given could not be clearly revealed were not included. Studies have also found sources indicating that CBD is given in different doses, and even in very high amounts, it does not cause a toxic effect [24].
This provides researchers with a wide range of motion to determine the amount of dose to be used. Because of the small amount of one-time effect and the possibility of interaction with food by researchers when administering CBD to the living, some studies have shown that it is administered as a PO, BID, or TID with or immediately after meals.
Gülhan (2013), Verbeeck (2009), Franz et al. (2013) and Yarur et al. (2014), it is aimed to have a high bioavailability of a molecule in the living body. It has been reported that liver, kidney and, if used orally, intestinal adequacy should be examined in order to achieve this [25-28].
Disturbances in these stages may reduce bioavailability and cause unwanted molecular accumulations.
Another method of administration of CBD can be said to be applied topically to the area. Some of the drawbacks of this application are that it can cause excessive sensitivity in the area and cause an allergic reaction. This may be due not only to the CBD, but also to the liquid/solid ingredients that render it liquid for administration, depending on the form in which the CBD is supplied. Or it can be caused by the interaction of these ingredients with CBD. Each of these is effective in the experimental phase and needs to be pre-tested or searched from the literature.
Topical application exists in many research methods. Especially in the dermis, epidermis and hypodermis layers that make up the skin tissue, the permeability of CBD should be created. If the area to be treated is in the epidermis and dermis layers, CBD should be able to act on this area. Especially due to the texture of the skin, the absorption and storage of lipid-based products from the skin can be easier. Molecules that pass from the skin to the vascular system are metabolized in the liver and activated for biological activities. Irregularities in these stages can create toxicity. The other event is that the metabolized CBD is filtered out of the nephrons with its passage from the blood to the kidneys. This stage is just as important as the first stage. Lodzki et al. (2003) reported that after transdermal application of the etosomal system to the abdomen of ICR mice for 72 hours, steady state levels were reached in about 24 hours. Transdermal administration of etosomal CBD has been reported to prevent inflammation and edema caused by basal-plantar injection of carrageenan in the same animal model [29].
In addition, changes in kidney function tests were investigated with oral administration of CBD, but it was known that no significant change was observed [30].
The absorption of a molecule into the body and its removal from the body by being metabolized actually informs the half-life of the molecule. The length of the half-life also means that it remains in circulation too much. Long half-life causes side effects to gradually increase.
For this reason, it reveals that the dose adjustment protocol should be done by considering all these variables. In the literature review, detailed kidney and liver function tests results of CBD have not been found depending on the oral treatment method, and this is a major deficiency for the literature. Although it was reported that there was no change in liver function tests as a result of topical application, the effects of this effect on long-term and overdose levels should be clearly demonstrated. Animal models may be good for this.
Another important issue is that due to the presence of drug interactions, the purification process should be applied and it should not be used together with other drugs. Wilson-Morkeh (2020) mentioned this issue in his study and mentioned that drug interactions can affect the results by creating false positivity or negativity [31].
As a result, no large literature has been found in the literature on the effect of CBD on rheumatological diseases, the effects it gives to the body and its pain relief effect, as well as stopping or reducing the direct inflammatory response. For this reason, topical or oral administration should be applied separately for each of the rheumatological diseases in animal models and general patient groups in which CBD is applied.
Ethics approval and consent to participate Not required. Consent for publication Not required. Availability of data and materials All data is given in the article. For detailed information, please contact GDA.
We declare that we have no conflict of interest. Funding There is no funding source. Authors' contributions
All authors contributed equally to the article.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
