AUCTORES
Globalize your Research
Research Article | DOI: https://doi.org/10.31579/2768-0487/045
1Clinical Pathologist, National Institute of Cardiovascular Diseases, Dhaka.
2Associate Professor, Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University.
3Resident Medical Officer, National Institute of Diseases of the Chest and Hospital, Dhaka.
4Assistant Professor, Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University.
5Medical Officer, Directorate General of Health Services, Dhaka.
6MD(Laboratory Medicine), Bangabandhu Sheikh Mujib Medical University.
7Professor, Ortho-surgery, National Institute of Traumatology and Orthopedic Rehabilitation
8MS in Microbiology, Bangladesh University of Health Sciences.
9Professor and Chairman, Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University.
10Professor and Ex-Chairman, Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University.
*Corresponding Author: Mesbah Uddin Ahmed, MS in Microbiology, Bangladesh University of Health Sciences.
Citation: S Z F Udita, S Ferdousi, Tanveer A Chowdhury, Mst S Yasmin, Mesbah U Ahmed. et al.(2021) Association of Serum Osteocalcin and Neutrophil-Lymphocyte Ratio with Bone Mineral Density for the Diagnosis of Osteoporosis. Journal of Clinical and Laboratory Research. 3(4); DOI:10.31579/2768-0487/045
Copyright: © 2021 Mesbah Uddin Ahmed. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 26 August 2021 | Accepted: 11 September 2021 | Published: 18 September 2021
Keywords: bone mineral density; osteoporosis; osteopenia; t-score; osteocalcin; neutrophil-lymphocyte ratio
Introduction: Osteoporosis is often under diagnosed, under treated and imposed a considerable economic burden on the health system. About two fifth of the post-menopausal women of Bangladesh are affected. Early diagnosis is necessary to halt the disease process. Serum osteocalcin, neutrophil-lymphocyte ratio (NLR) increases and bone mineral density (BMD) decreases in osteoporosis. There is no specific diagnostic test for osteoporosis except BMD. It is costly, has radiation hazard and not available in all laboratories in our country. On the other hand, serum osteocalcin and NLR are easily available and a promising marker which can be done as routine blood test for the diagnosis of osteoporosis.
Objective: The objective of the study was to evaluate the association of serum osteocalcin and NLR with BMD for the diagnosis of osteoporosis.
Materials and methods: This cross-sectional study was conducted in the Department of Laboratory Medicine and the Department of Orthopedic Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU) and Dhaka Medical College Hospital (DMCH) from March, 2020 to February, 2021. A total 50 diagnosed patient of osteoporosis, who fulfil the inclusion and exclusion criteria were selected as study population. They were grouped as normal, osteopenia and osteoporosis according to T-score of BMD report. Serum osteocalcin and NLR evaluated from routine blood test. Statistical analysis was done by statistical package for social science (SPSS) software windows version 22.
Results: Negative Pearson’s correlation was found between serum osteocalcin with T-score of BMD (r=-0.812, p=0.002) and between NLR with T-score of BMD (r=-0.826, p=0.001). In receiver operating characteristic (ROC) curve analysis, cut off value of serum osteocalcin was 18.65 ng/mL having sensitivity 67.0% and specificity 70.0% with a cut off value of NLR was 4.54 with sensitivity 72.0% and specificity 75.0%.
Conclusion: Serum osteocalcin and NLR has significant negative correlation with T-score of BMD. Because of high sensitivity and specificity, serum osteocalcin and NLR may be used to diagnosis of osteoporosis
Osteoporosis is a serious public health concern due to its important worldwide prevalence. Osteoporosis is underdiagnosed, undertreated and imposed a considerable economic burden on the health system [4]. During lifetime 30-50% of women and 15-30% of men are at risk to osteoporosis all over the world [12, 7]. Currently it is estimated that, about 1.6 million hip fractures occur each year worldwide [8]. The incidence is increase to 6.3 million by 2050. Among them more than 50% will occur in Asia [8]. In Bangladesh, 43.6% of 16-45 years old women and 40.70% of 46-65 years old women had osteopenia and 5.5% of 16-45 old women and 41.80% of 46-65 years old women had osteoporosis [1]. Its prevalence is increasing with menopause, vitamin D deficiency, low body weight, low intake of calcium, some diseases and use of some medications [8]. Therefore, it is necessary to find out an easy, reliable, cost effective marker for the diagnosis of osteoporosis. Serum osteocalcin is a single blood-based laboratory test for the diagnosis of osteoporosis with good sensitivity and specificity. It is an accessible, easily performed and has a better role for the diagnosis of osteoporosis. On the other hand, NLR is also a simple, cost effective, repeatable and less hazardous tool for the diagnosis of osteoporosis. It can be done in small setup with minimum laboratory facilities. Though BMD is the gold standard test for the diagnosis of osteoporosis, it has some limitations, like risk of radiation exposure, presence of metal may interfere the result of test, needs expertise, not available in routine hospital setup. In this study, we try to explore the role of serum osteocalcin and NLR in comparison with BMD for the diagnosis of osteoporosis.
Study design: Cross-sectional study
Study duration: March 2020 to February 2021
Place of study: The study was conducted in the Department of Laboratory Medicine and the Department of Orthopedic Surgery, BSMMU and DMCH, Dhaka.
Study population: All clinically suspected patients of osteoporosis from outpatient department (OPD) of Department of Orthopedic Surgery, BSMMU and DMCH was enrolled in to the study. Diagnosis of osteoporosis patient was conducted by history taking and measurement of BMD by DEXA scan.
Inclusion criteria: Female over 45 years of age and Male over 50 years of age.
Exclusion criteria: Acute infection, Chronic infection, Malignancies, Diabetes mellitus, Acromegaly, Cushing’s syndrome, Hyperparathyroidism, Liver disease, Renal disease, Intestinal malabsorption, Hormonal therapy, Use of some medications like antacids containing aluminum, anticonvulsant drugs, steroids, heparin, methotrexate, etc.
Sample size: As per inclusion criteria available diagnosed case of osteoporotic patients were enrolled in this study. Sample size was 89. Sample was collected 50 due to COVID-19 pandemic situation. Among them 8 were normal, 32 were osteopenic patients and 10 were osteoporotic patients.
Sampling technique: Purposive sampling was followed. As per selection criteria the patients are enrolled in this study. The whole procedure was explained to the participants and informed consent of both verbal and written was taken.
Study procedure
After ethical clearance from Institutional Review Board (IRB), diagnosed case of osteoporosis according to BMD report, who were attended in OPD of Department of Orthopedic Surgery, BSMMU and DMCH, was selected.
After considering the inclusion and exclusion criteria the patient was included in this study and full explanation regarding the aims, objectives of the study and necessity of the investigation was informed.
At first age and sex matched osteoporosis patients diagnosed by BMD reports was taken.
Then blood sample of the patient was drawn for serum osteocalcin and NLR. It was done at the Department of Laboratory Medicine, BSMMU.
Blood sample collection
Blood sample was collected from antecubital vein after aseptic precaution with 0.5% chlorhexidine gluconate. About 4.0 mL venous blood was taken into red tube (2.0 mL) and violet tube (2.0 mL). Tube was labeled with the patient’s identification number and kept it for 30 minutes. Then blood was centrifuged 3000 rpm for 5 minutes.
For serum osteocalcin
Blood sample: 2 mL.
Tube: Red screw capped plain tube without anticoagulant.
Specimen: Serum.
For NLR
Blood sample: 2 mL.
Tube: Violet screw capped tube containing EDTA anticoagulant.
Specimen: Whole blood.
Test procedure
For estimation of serum osteocalcin
The serum osteocalcin level was assessed by Electrochemiluminescence Immunoassay (ECLIA) by COBAS immunoassay auto analyzer in the Department of Laboratory Medicine, BSMMU. Result of serum osteocalcin level was based on reference range. Test result was given within 15-20 minutes.
Reference range of serum osteocalcin: In case of adult male, it is 5.8-14.0 ng/mL and in case of adult female it is 3.10-14.4 ng/mL (11).
Grading of serum osteocalcin: In osteopenia it is 19.25±5.09 ng/mL, in mild osteoporosis it is 21.34±3.9 ng/mL and in severe osteoporosis it is 22.9±4.9 ng/mL (Singh, Kumar & Lal, 2015).
For calculation of NLR
Neutrophil-lymphocyte differential count obtained from CBC report which was estimated by Hematology Autoanalyzer (Sysmex XN-2000) which again confirmed manually by peripheral blood smear.
NLR was calculated from dividing the absolute neutrophil count by the absolute lymphocyte count.
Range of NLR: Between 0.78 and 3.53 (Forget et al., 2017).
NLR in osteopenia is 2.37±1.00 and in osteoporosis is 2.54±1.45 (10).
For measurement of BMD
BMD measured by DEXA scan.
BMD grading according to WHO on the basis of T-score (8).
Normal BMD – T-score ≥ -1
Osteopenia – T-score < -1 and > -2.5
Osteoporosis – T-score ≤ -2.5
Distribution of the study subjects according to T-score of femoral neck observed that almost two third (64.0 Percentage) subjects had osteopenia followed by 10 (20.0%) osteoporosis and 8 (16.0%) normal.The mean (±SD) T-score of femoral neck was 0.43±0.92 in normal, -1.79±0.41 in osteopenia and -3.01±0.66 in osteoporosis. The difference was statistically significant (p=0.001) among the subjects.
In this current study, it was observed that most of the patient of osteopenia and osteoporosis were in 51-60 years age group. The mean(±SD) age was 55.25±12.44 years in normal, 63.06±6.46 years in osteopenia and 63.5±8.18 years in osteoporosis. Differences of mean(±SD) age among the subjects were statistically significant (p=0.044).
Serum osteocalcin: In case of adult male, it is 5.8-14.0 ng/mL and in case of adult female it is 3.10-14.4 ng/mL (11). p value reached from ANOVA test
The mean (±SD) serum osteocalcin was 13.88±1.11 ng/mL in normal, 20.84±5.21 ng/mL in osteopenia and 24.32±5.24 ng/mL in osteoporosis. The difference was statistically significant (p=0.001) among the subjects.
Reference range of NLR: 0.78-3.53 (Forget et al. 2017), p value reached from ANOVA test
The mean (±SD) NLR was 3.11±2.8 in normal, 4.49±2.04 in osteopenia and 6.35±2.2 in osteoporosis. The difference was statistically significant (p=0.010) among the subjects.
Figure 1 shows that there is a negative correlation between serum osteocalcin with T-score (r=-0.812). It was observed that the Pearson’s correlation statistically significant (p=0.002).
Figure 2 shows that there is a negative correlation between NLR with T-score (r=-0.826). It was observed that the Pearson’s correlation statistically significant (p=0.001).
The area under the ROC curve of serum osteocalcin and NLR for prediction of osteoporosis is depicted in the above table. ROC curve was constructed using serum osteocalcin with a cut off value of 18.65 ng/mL having 67.0% sensitivity and 70.0% specificity for prediction of osteoporosis. Similarly, NLR had a best combination of sensitivity and specificity with a cut off value of 4.54 having 72.0% sensitivity and 75.0% specificity for prediction of osteoporosis. ROC curve shows, NLR having batter sensitivity 72.0% and specificity 75.0% than serum osteocalcin.
Osteoporosis, a multifactorial process, is a bone metabolic disease. It is often under diagnosed, under treated and imposed a considerable economic burden on the health system. It is one of the important causes of morbidity in elderly population worldwide, including Bangladesh. So, early diagnosis is necessary to halt the disease process. There may be an association between serum osteocalcin, NLR and BMD for the diagnosis of osteoporosis. This cross-sectional study was carried out in the Department of Laboratory Medicine, BSMMU, Shahbag, Dhaka from the period of March 2020 to February 2021. A total of 50 patients with diagnosed case of osteoporosis from the Department of Orthopedic Surgery, BSMMU and DMCH were enrolled in to the study. According to T-score of femoral neck patients were classified as normal (T-score ≥-1), osteopenia (T-score <-1 and >-2.5) and osteoporosis (T-score ≤-2.5). The aim of this study was to evaluate the association between serum osteocalcin, NLR with BMD for the diagnosis of osteoporosis. In this present study, according to T-score of femoral neck it was observed that 16.0% subjects were normal, 64.0% were osteopenia and 20.0% were osteoporosis. We observed that the mean (±SD) T-score of femoral neck was 0.43±0.92 in normal group, -1.79±0.41 in osteopenia and -3.01±0.66 in osteoporosis. Chaudhary et al. (2019) found in their study that normal was 24.2%, osteopenia was 38.5% and osteoporosis was 37.3%. Singh, Kumar and Lal (2015) study observed that there were 39.0
Serum osteocalcin and NLR has significant negative correlation with T-score of BMD. Because of high sensitivity and specificity, serum osteocalcin and NLR may be used to diagnosis of osteoporosis
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
