AUCTORES
Globalize your Research
Research Article | DOI: https://doi.org/10.31579/2639-4162/122
Department of Pharmaceutics, RBVRR Women’s college of Pharmacy, Affiliated to Osmania University, Hyderabad.
*Corresponding Author: Abbaraju Krishna Sailaja, Department of Pharmaceutics, RBVRR Women’s college of Pharmacy, Affiliated to Osmania University, Hyderabad
Citation: Vemula Pooja and Abbaraju K. Sailaja, (2024), An Article on Curcumin Loaded Transferosomes as A Novel Drug Delivery System, J. General Medicine and Clinical Practice, 7(1); DOI:10.31579/2639-4162/122
Copyright: © 2024, Abbaraju Krishna Sailaja. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 04 November 2023 | Accepted: 12 December 2023 | Published: 03 January 2024
Keywords: rollator; walking aid; risks of an walking aid; support and balance control
Curcumin is a natural compound found in turmeric and has shown potential in treating a variety of diseases due to its anti-inflammatory and antioxidant properties. However, curcumin has low bioavailability and poor solubility in water, which limits its therapeutic efficacy. Transferosomes are specialized lipid vesicles that can encapsulate drugs and other bioactive molecules, allowing them to be delivered to specific target tissues. Curcumin, a natural compound found in turmeric, has been the subject of intense study due to its potential health benefits, including anti-inflammatory and antioxidant properties. Transferosomes are lipid-based nanoparticles that can encapsulate hydrophobic compounds like curcumin and improve their delivery to target tissues. They can also enhance the absorption of drugs through the skin or mucous membranes. Several studies have investigated the potential of curcumin loaded transferosomes in various applications, such as wound healing, cancer treatment, and anti-inflammatory therapy. These studies have shown promising results, indicating that transferosomes could be an effective drug delivery system for curcumin. However, more research is needed to optimize the formulation and improve the stability and shelf-life curcumin-loaded transferosomes. Additionally, the safety and toxicity of these nanoparticles need to be thoroughly evaluated before they can be used in clinical application. In our study we have observed drug content 4.47mg/ml and EE% was found to be 94.8%, the percentage of drug release of curcumin transferosomes was observed as 30.8%at time period of 4hr. [1]
Curcumin is a natural polyphenol compound found in turmeric, which has been reported to have various pharmacological properties, including anti-inflammatory, antioxidant, and anticancer activities. However, its poor water solubility and low bioavailability limit its therapeutic potential. To overcome these limitations, curcumin can be loaded into transferosomes, which are lipid-based nanoparticles composed of phospholipids and surfactants that can encapsulate hydrophobic drugs and improve their solubility and bioavailability.[2] Transferosomes can also enhance drug delivery by penetrating through the skin and other biological barriers. Curcumin-loaded transferosomes have shown promising results in preclinical studies as a potential treatment for various diseases, including cancer, inflammatory disorders, and skin diseases. They have been shown to have improved
bioavailability and sustained release of curcumin, leading to enhanced therapeutic effects and reduced toxicity.[3]
Overall, curcumin-loaded transferosomes are a promising drug delivery system that can improve the therapeutic potential of curcumin and other hydrophobic drugs. However, more research is needed to optimize their formulation and evaluate their safety and efficacy in clinical trials.[4]
Composition of Transferosomes
Transferosomes are lipid vesicles or liposomes that are specially designed to improve the delivery of drugs and other substances through the skin or other biological membranes. The composition of transferosomes can vary depending on the specific application, but generally, they are made up of the following components:
1.Phospholipids: These are the main components of the transferosomes and form the lipid bilayer that encapsulates the drug or other substances. The most commonly used phospholipids are soya lecithin, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylglycerol.
2.Surfactants: These are amphiphilic molecules that are added to the lipid bilayer to improve its flexibility and deformability. Examples of surfactants used in transferosomes include SPAN 60,80, Tween 80, sodium cholate, and sodium deoxycholate.
3.Cholesterol: This is added to the transferosomes to increase their stability and rigidity.
4.Drug or other substances: Transferosomes can encapsulate a variety of drugs or other substances, such as peptides, proteins, and vaccines.
5.Other additives: Depending on the specific application, other additives may be added to the transferosomes to improve their performance. For example, propylene glycol can be added to improve the solubility of hydrophilic drugs.
The composition of transferosomes can be optimized for specific applications by adjusting the ratios of the different components and by using different types of phospholipids, surfactants, and other additives.[5]
Table 1: composition of transferosomes
The high deformability of transferosomes allows them to easily adapt to the skin's contours and penetrate through the pores and hair follicles. This makes them an effective carrier for delivering drugs across the skin barrier and into the deeper layers of the skin
Advantages of curcumin-loaded transferosomes
Disadvantages of curcumin loaded transferosomes:
Low loading capacity: Transferosomes have limited capacity to encapsulate curcumin, which can result in low drug loading efficiency and require larger doses to achieve therapeutic effects.
The transferosomes were prepared by modified hand shaking, lipid film hydration technique. Preparing curcumin transferosomes by thin film hydration method involves the following steps:
Selection of lipid and surfactant: The first step is to select an appropriate lipid and surfactant combination that can form stable transferosomes. Phosphatidylcholine and cholesterol are commonly used lipids, and surfactants like Tween 80 or Span 80 can be used to stabilize the transferosomes.
2.Preparation of lipid film: The selected lipid and surfactant are dissolved in a suitable organic solvent like chloroform or methanol. The solvent is then evaporated using a rotary evaporator or a vacuum oven to form a thin lipid film on the walls of the glass vial.
3.Hydration of lipid film: The lipid film is hydrated with an aqueous solution containing curcumin. The hydration can be done by adding the aqueous solution dropwise to the lipid film and shaking the vial gently.
4.Sonication: The vial is then subjected to sonication using a probe so nicator or a bath so nicator to form transferosomes. Sonication helps in breaking down the lipid film into small vesicles and also disperses curcumin in the aqueous phase.
5.Purification and characterization: The transferosomes are purified by centrifugation and characterized for size, shape, and stability. The size of the transferosomes can be determined by dynamic light scattering, and their morphology can be observed using transmission electron microscopy.
Overall, the thin film hydration method is a simple and effective method for preparing curcumin transferosomes that can improve the bioavailability and therapeutic efficacy of curcumin.[8]
Characterization of curcumin loaded transferosomes:
Evaluation:
Optimization of transferosomes preparation:
Transferosomes are lipid-based vesicles that have the ability to carry drugs across biological barriers. They are widely used in pharmaceuticals for the delivery of drugs that have poor water solubility, poor bioavailability or high toxicity. The optimization of transferosomes formulation is important to ensure that the vesicles are stable, biocompatible, and effective in drug delivery. Here are some strategies for optimizing transferosomes formulation.
1.Selection of lipid components: The lipid components used in transferosomes formulation play a crucial role in determining the stability, fluidity and permeability of the vesicles. It is important to select the appropriate lipids that can form a stable bilayer structure and allow for drug encapsulation. Different lipid combinations can be tested to optimize the formulation.
2.Optimization of drug loading: The loading of drugs into transferosomes can affect the stability, size, and encapsulation efficiency of the vesicles. Various methods can be used to optimize drug loading, such as adjusting the drug concentration, pH, temperature and sonication parameters.
3.Addition of stabilizing agents: Stabilizing agents such as surfactants, polymers, and antioxidants can be added to transferosomes formulation to increase the stability and shelf life of the vesicles. The type and concentration of stabilizing agents can be optimized to improve the formulation.
4.Optimization of size and shape: The size and shape of transferosomes can influence their ability to penetrate biological barriers and deliver drugs. Different sonication parameters, including time, power and frequency, can be optimized to control the size and shape of the vesicles.
5.Evaluation of in vitro and in vivo efficacy: The efficacy of transferosomes formulation can be evaluated in vitro and in vivo using different assays. In vitro assays such as drug release studies, stability studies, and cytotoxicity studies can be performed to evaluate the formulation. In vivo studies can be conducted to evaluate the pharmacokinetics, biodistribution, and efficacy of the formulation. In summary, the optimization of transferosomes formulation is a crucial step in developing an effective drug delivery system. Lipid selection, drug loading, stabilizing agents, size and shape optimization, and in vitro and in vivo evaluation are important strategies for optimizing the formulation.[11]
Stability of transferosomes: -
Transferosomes are highly flexible, self-optimizing, and elastic lipid vesicles that are able to encapsulate and transport a wide range of drugs across biological membranes. The stability of transferosomes depends on various factors such as the composition of the lipid bilayer, charge and size of the vesicles, and storage conditions. In general, transferosomes can be stored at refrigerated temperature (2-8°C) for a relatively long period of time, typically several months. However, the stability of transferosomes can be affected by several factors such as temperature, pH, ionic strength, and the presence of enzymes. For instance, high temperatures may cause the lipid bilayer to become unstable, leading to leakage of the encapsulated drug and eventual loss of activity. Similarly, changes in pH or ionic strength can cause the vesicles to undergo destabilization, leading to aggregation or fusion, which can alter their drug release characteristics. In addition, the presence of enzymes such as phospholipases or proteases can cause the lipid bilayer to be degraded, leading to destabilization and loss of the vesicles. To enhance the stability of transferosomes, different techniques have been used such as lyophilization, addition of stabilizing agents such as surfactants or polymers, and optimization of the lipid composition. Overall, the stability of transferosomes is an important consideration in their development and use as drug delivery systems, and their stability can be improved by optimizing their composition, storage conditions, and formulation technique.[12]
Safety measures of transferosomes
They are composed of phospholipids and surfactants, and are capable of encapsulating both hydrophilic and lipophilic drugs. Transferosomes have several advantages over other drug delivery systems, including their ability to improve drug absorption and bioavailability, and their ability to target specific tissues.[13]
However, like any other drug delivery system, transferosomes have safety considerations that need to be taken into account. Here are some important safety considerations related to transferosomes:
1.Toxicity: Some of the ingredients used in transferosomes, such as surfactants, can be toxic in high concentrations. Careful selection of the ingredients used in transferosomes is necessary to minimize toxicity.
2.Stability: Transferosomes are susceptible to degradation, particularly in the presence of enzymes and other biological substances. This can lead to the release of drugs at unintended sites and potentially cause adverse effects.[14]
3.Immunogenicity: The use of foreign substances, such as lipids and surfactants, in transferosomes can trigger an immune response in some individuals. This can lead to allergic reactions or other adverse effects.
4.Pharmacokinetics: The pharmacokinetics of transferosomes can differ from the pharmacokinetics of the drug alone. This can affect drug efficacy and safety, and careful characterization of transferosomes is necessary to ensure appropriate dosing.
5.Storage and handling: Transferosomes are sensitive to temperature and can be easily damaged during storage and handling. Proper storage and handling conditions should be established and followed to ensure the stability and efficacy of the drug. Overall, while transferosomes have many potential advantages as drug delivery systems, it is important to carefully consider their safety considerations and ensure that they are used appropriately to minimize the risk of adverse effects.[15]
Optical Microscopy: The transferosomes are observed under a projection microscope. The vesicles are obtained like Uni-lamellar and multi-lamellar structure as shown in figure 1
Figure1: Vesicles of Curcumin Transferosomes
Drug content was foundto be 4.47 mg/ml and the entrapment efficiency was found to be 94.87%. The diffusion studies were done by Franz diffusion cell by taking 7.4 phosphate buffer. The amount of drug release was done in a period of 5 hours and the percentage of drug release was 30.87% at 4th hour as shown in figure 2.
Figure 2: Invitro drug release of the formulation
Curcumin has been shown to possess various biological activities, including anti-inflammatory, antioxidant, and anticancer properties. However, its poor solubility and bioavailability limit its therapeutic effectiveness. Transferosomes are lipid-based vesicles that can enhance the bioavailability and permeation of drugs across biological barriers. Several studies have investigated the use of transferosomes as a delivery system for curcumin. The results indicate that curcumin-loaded transferosomes have improved stability and bioavailability compared to free curcumin. Moreover, curcumin-loaded transferosomes have demonstrated potential therapeutic effects in various preclinical models, including cancer, Alzheimer's disease, and inflammatory disorders. However, more research is needed to validate their safety and efficacy in humans. With our study we conclude that curcumin-loaded transferosomes have shown promising results as a potential drug delivery system for curcumin
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
