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Short Communication | DOI: https://doi.org/10.31579/2641-0419/467
Sr. Professor & Head of Daswani Dental College affiliated to Rajasthan University of Health Sciences, Jaipur, Rajasthan, India.
*Corresponding Author: Ashish Pandey, Professor & Head of Daswani Dental College affiliated to Rajasthan University of Health Sciences, Jaipur, Rajasthan, India.
Citation: Ashish Pandey, (2025), The Interplay Between Periodontal Disease and Cardiovascular Health: Implications for Dental and Cardiac Clinical Practice, J Clinical Cardiology and Cardiovascular Interventions, 8(6); DOI: 10.31579/2641-0419/467
Copyright: © 2025, Ashish Pandey. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 08 April 2025 | Accepted: 15 April 2025 | Published: 24 April 2025
Keywords: periodontal disease; cardiovascular disease; atherosclerosis; inflammation; endothelial dysfunction; antibiotic prophylaxis; anticoagulation; interdisciplinary care
Periodontal disease (PD) and cardiovascular disease (CVD) are two prevalent chronic conditions with a well-documented bidirectional relationship. Emerging evidence suggests that chronic periodontal inflammation contributes to systemic endothelial dysfunction, atherosclerosis, and adverse cardiovascular events. Conversely, cardiovascular interventions, such as anticoagulation therapy, may influence dental management strategies. This article reviews the pathophysiological mechanisms linking PD and CVD, explores clinical implications for dental and cardiology practitioners, and discusses interdisciplinary approaches to patient care. Understanding this relationship is crucial for optimizing treatment outcomes and reducing systemic complications.
Periodontal disease (PD) is a chronic inflammatory condition affecting the supporting structures of the teeth, with a global prevalence of 20-50% in adults (1). Cardiovascular disease (CVD), including coronary artery disease (CAD) and stroke, remains the leading cause of mortality worldwide (2). Over the past two decades, numerous epidemiological and mechanistic studies have established a significant association between PD and CVD, suggesting that oral inflammation may exacerbate systemic vascular pathology (3).
This article examines the biological pathways connecting PD and CVD, evaluates the impact of dental interventions on cardiovascular health, and discusses clinical considerations for patients undergoing cardiovascular interventions.
Pathophysiological Mechanisms Linking PD and CVD
* Systemic Inflammation and Endothelial Dysfunction
Chronic periodontal inflammation leads to the release of pro-inflammatory cytokines, such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP) (4). These mediators enter systemic circulation, promoting endothelial dysfunction, a key initiator of atherosclerosis (5). Studies have demonstrated that periodontal pathogens, including Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, can invade vascular tissues, contributing to plaque instability (6).
* Bacterial Translocation and Atherogenesis
Periodontal pathogens may disseminate hematogenously, colonizing arterial walls and accelerating atheroma formation (7). P. gingivalis expresses virulence factors, such as gingipains, which degrade endothelial tight junctions and promote foam cell formation (8). Animal models have shown that oral infection with P. gingivalis accelerates aortic plaque development (9).
* Shared Risk Factors
Both PD and CVD share common risk factors, including smoking, diabetes mellitus, and obesity (10). These comorbidities exacerbate systemic inflammation, further amplifying the PD-CVD relationship (11).
Clinical Implications for Dental and Cardiac Practitioners
* Antibiotic Prophylaxis in Cardiac Patients
The American Heart Association (AHA) guidelines recommend antibiotic prophylaxis for high-risk cardiac patients (e.g., prosthetic valves, previous infective endocarditis) undergoing invasive dental procedures (12). However, recent evidence suggests that routine prophylaxis may not be necessary for all at-risk patients, emphasizing individualized risk assessment (13).
* Anticoagulation and Dental Surgery
Patients on anticoagulants (e.g., warfarin, direct oral anticoagulants) require careful management to balance bleeding risks and thromboembolic events (14). Current guidelines advise against routine discontinuation of anticoagulation for minor dental procedures, favoring local hemostatic measures (15).
* Periodontal Therapy and Cardiovascular Outcomes
Randomized controlled trials indicate that periodontal treatment (scaling and root planing) reduces systemic inflammatory markers and may improve endothelial function (16). A meta-analysis by Sanz et al. (17) reported a modest but significant reduction in cardiovascular events following periodontal therapy.
Interdisciplinary Care Strategies
Collaboration between dentists and cardiologists is essential for managing patients with coexisting PD and CVD. Key strategies include:
Screening: Routine periodontal assessment in cardiac patients and vice versa (18).
Risk Modification: Smoking cessation, glycemic control, and dietary counseling (19).
Personalized Treatment Plans: Tailoring dental procedures based on cardiac risk profiles (20).
The interplay between periodontal disease and cardiovascular health underscores the importance of an integrated approach to patient care. Dentists and cardiologists must remain vigilant in identifying at-risk patients and implementing evidence-based interventions to mitigate systemic complications. Future research should focus on longitudinal studies to clarify the causal relationship and optimize treatment protocols.
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