General complication of laparoscopic surgery, necesary review

Review Article | DOI: https://doi.org/10.31579/2690-8794/212

General complication of laparoscopic surgery, necesary review

  • Anthony Alvarez Morales 1
  • Yosniel Lugo Echevarría 2
  • Anaisa León Mursulí 3
  • Pedro Rolando López Rodríguez 4*

1 First-degree specialist in general surgery and assistant professor.

2First-degree specialist in general surgery and assistant professor.

3 Comprehensive general stomatology specialist.

4First and second degree specialist in general surgery, assistant professor, assistant researcher and consulting professor.

*Corresponding Author: Pedro Rolando López Rodríguez, First and second degree specialist in general surgery, assistant professor, assistant researcher and consulting professor.

Citation: Pedro Rolando López Rodríguez, Anthony Alvarez Morales, Yosniel Lugo Echevarría,Anaisa León Mursulí (2024), General complication of laparoscopic surgery, necesary review, Clinical Medical Reviews and Reports; 6(5): DOI: 10.31579/2690-8794/212

Copyright: © 2024, Pedro Rolando López Rodríguez. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: 28 April 2024 | Accepted: 10 April 2024 | Published: 27 May 2024

Keywords: laparascopic surgery; complications; laparascopic techniques

Abstract

Introduction: “Minimal Access Surgery” began in animal laboratories and was later studied in selected academic centers where it was imported to community hospitals only when its benefits and safety were established. 

Objectives: To conduct a detailed review of Complications of laparoscopic surgery with emphasis on those related to entry into the abdominal cavity and bile duct surgery given their high frequency and lethality. 

Subject and methods: A detailed search of literature published in Spanish and English was carried out through PubMed/MEDLINE, Cochrane's registry of systematic reviews and randomized controlled studies, using key words such as “laparoscopic entry”, “trocars injury”, “laparoscopy”. complications”, “laparoscopic injury” and “optical trocars”. Meta-analyses, randomized clinical studies, clinical guidelines, review articles and case series were mainly selected.

Conclusions: Laparoscopy is a relatively safe procedure, however, great care must be taken during access to the abdominal cavity because the majority of complications occur during entry.

Introduction

“Minimal Access Surgery” began in animal laboratories and was later studied in selected academic centers where it was imported to community hospitals only when its benefits and safety were established. Low complication rates were reported by centers specialized in laparoscopic surgery, mostly academic centers. These centers were able to reduce complication rates to a minimum by developing the skills necessary for these surgeries. Unfortunately, many inexperienced surgeons developed these techniques without sufficient training and are responsible for the majority of complications obtained during laparoscopic surgery.[1]

The development of Laparoscopic Cholecystectomy (LC) was not designed to improve the safety of the procedure, but rather to reduce the discomfort associated with the surgical incision.

Doctors who have performed fewer than 100 such procedures have reported a complication rate of 14.7 per 1,000 patients. In contrast, expert surgeons reported having a complication rate of only 3.8 complications per 1000 procedures. The Southern Surgeons' Club reported that the survey or incidence of bile duct injuries was 2.2% when the surgeon had performed fewer than 13 procedures. As surgeons gained experience, the incidence of bile duct injuries eventually decreased to 0.1%[2-3].

Objective

Carry out a detailed review of the Complications of laparoscopic surgery with emphasis on those related to entry into the abdominal cavity and bile duct surgery given their high frequency and lethality.

Methods

A detailed search of literature published in Spanish and English was carried out through PubMed/MEDLINE, Cochrane's registry of systematic reviews and randomized controlled studies, using key words such as “laparoscopic entry”, “trocars injury”, “laparoscopy complications”, “ laparoscopic injury” and “optical trocars”. Meta-analyses, randomized clinical studies, clinical guidelines, review articles and case series were mainly selected.

Development

The use of laparoscopy to perform surgical procedures is increasing as it provides greater benefits, when compared to laparotomy, in terms of faster recovery, less postoperative pain, and shorter hospital stay. However, since it is an invasive procedure, there is a risk of complications. These are divided into Intraoperative and Postoperative, but we are going to refer to Intraoperative, which in turn can be divided into 2 large groups:4

A – General Complications of Laparoscopic Procedures:

1- Related to the Introduction of Needles, Trocars and Insufflation

2- Typical of Pneumoperitoneum

3- Related to the introduction of laparoscopic surgical materials and manipulation of instruments.

B – Specific complications of each technique: (Biliary Surgery)

General Complications of Laparoscopic Procedures:

1 - Related to the Introduction of Needles, Trocars and Insufflation

It is with the introduction of the Veress needle to create the pneumoperitoneum that any laparoscopic procedure begins. The impossibility of creating this adequately makes it impossible to place trocars correctly and will cause the surgery to fail.

Veress Needle and Trocars

Despite the advantages offered by the protection system of this needle during its introduction, different injuries can occur, such as:

- Injury to the Abdominal Wall Vessels:

This complication is relatively frequent, it occurs mainly with the introduction of trocars and especially with those that have sharp edges (they have the advantage of requiring less pressure for their introduction into the abdominal cavity) than with those with a conical tip, less causing this complication. The solution to this is usually the compression of the wall, either directly with the sheath, or with the introduction of the sheath fixing sleeve that has a larger diameter and if it is not controlled, small enlargements of the wound corresponding to the point of bleeding until they are located and hemostasis is achieved.

To avoid this, it is advisable to transilluminate the wall to visualize the larger caliber vessels in order to avoid injury.

- Large Vessel Injury:

This is usually due to injuries to the abdominal aortic bifurcation or the inferior vena cava, producing a large retroperitoneal hematoma that requires urgent laparotomy. The incidence of this complication is fortunately low, amounting to 0.05% in large multicenter series, but frequently fatal, which is why the introduction of the needle and the first trocar must be done with great care and with gentle maneuvers. If an injury occurred, depending on its magnitude, a laparotomy must be performed, checking for the existence of a vascular wound on the posterior face of the vessel at the level of the previous wound, and suturing it if necessary [5-6].

- Hollow Viscera Injury:

This can be in: Stomach, Small Intestine or Colon. It can occur more frequently when there is a previous abdominal surgery, which implies the possible existence of adhesions of the digestive tract to the anterior wall, which recommends puncture with the Veress needle away from the laparotomy scar, in an upper quadrant, normally the left another method of avoiding this is by placing a Hasson trocar under direct vision (open Pneumoperitoneum). This injury can go unnoticed, which increases its severity as it is diagnosed late.

- Solid Viscera Injury:

It is infrequent, it is discovered once the optic is inserted and it is not usually serious; it is usually superficial punctures of the liver, which spontaneously stop bleeding.

- Hernias in the trocar orifices:

Infrequent complication in holes of 5 and 10 mm in a lateral situation, but very common in holes > 10 mm, especially in the midline and in the region of the lower abdomen, although it can appear in the upper abdomen if the incision for extraction is extended. of the surgical specimen, so suturing the aponeurosis of the midline trocars is always recommended. It is also important to take into account when removing the 10 mm trocar, especially the one in the umbilical region, since it cannot be removed suddenly because the CO2 must first be emptied from the cavity otherwise evisceration occurs due to the pressure. positive intra-abdominal that forces the greater omentum, small intestine, out of the abdominal cavity and may go unnoticed at the end of the surgery [7-9].

An example of all of the above is that, in 2001, Bhoyrul and collaborators analyzed 629 injuries caused by trocars, reported to the Food and Drug Administration (FDA) between 1993 and 1996. 32 deaths were reported, of which 26 resulted from injury. vascular and 6 intestinal injuries, disposable trocars were used in 28 deaths, 3 by optical vision and 1 by reusable trocars, 408 injuries were vascular injuries and 182 were visceral injuries, 30 wall hematomas occurred and the other patients were not analyzed. These authors conclude that disposable trocars and direct entry do not reduce visceral complications, and an unrecognized intestinal injury can be fatal [10-12]

Insufflation

- Gas insufflation into the abdominal wall, mesentery, omentum or retroperitoneum:

Insufflation of CO2 into the omentum, mesentery or retroperitoneum produces emphysema that does not have great repercussions and disappears quickly, but the possibility of a vascular or visceral injury below this must be ruled out. These emphysemas often make the operating field difficult since they reduce the visual field and modify anatomical structures.[13]

If this insufflation occurs in the abdominal wall, it causes subcutaneous emphysema, which, although it has no clinical significance, can make it difficult to achieve pneumoperitoneum. It is evidenced by an asymmetrical abdominal distention of the abdominal wall, the presence of subcutaneous emphysema due to crepitus in the abdomen and high pressures marked by the insufflator and which warn us of incorrect placement of the needle.[14-15] In obese patients Gas insufflation may occur in the preperitoneal space that simulates a pneumoperitoneum since it can hold 3 to 4 liters in the preperitoneal space that occurs even with symmetrical abdominal distention, but it is quickly recognized by high pressures maintained in the laparoinsufflator, as well as the absence of negative pressure. Therefore, it is important to always perform negative pressure tests of the abdominal cavity, injection of air or liquid into the abdominal cavity with subsequent aspiration, and laparoinsufflator values below 8 mmHg. This is often detected when introducing the optic and observing that it is not in the abdominal cavity, making it necessary to communicate this space with the intra-abdominal space. [16-18]

2 - Typical of Pneumoperitoneum:

- Gas Embolism:

Produced by the sustained insufflation of CO2 pressures directly into a large-caliber venous vessel, it is a serious complication that requires rapid decompression of the abdominal cavity followed by cardiorespiratory recovery maneuvers, which is why it is recommended not to use flows at the establishment of pneumoperitoneum greater than 1 or 1.5 liters per minute. [19-20]

It is recognized by the appearance of profuse sweating, sustained arterial hypotension, jugular engorgement, tachycardia, cardiac arrhythmias and distal cyanosis, as well as the recording of arterial O2 desaturation and hypercapnia raise the suspicion of this complication.

- Pain in the shoulders:

It seems to be related to the irritation of the diaphragms by CO2 and the rupture of its myofibrils. So an inflation pressure of 1 – 1.5 liters/min. prevents sudden distension of the diaphragm. This pain is easily combatable with analgesics and disappears in the first 48 hours after surgery.

- Iatrogenic Pneumothorax:

Its mechanism of appearance is not clear but barotrauma is invoked due to the sudden insufflation of the pneumoperitoneum, as well as possible congenital diaphragmatic defects that establish a pleuropulmonary communication that makes its establishment possible by increasing intra-abdominal gas pressures. Generally this is resolved in the same surgical procedure, being very complicated if a hypertensive pneumothorax occurs where there is an increase in intrapulmonary pressures and O2 desaturation that is resolved with a Pleurostomy.

- Pneumomediastinum:

This generally occurs in esophageal hiatus surgeries when the abdominal cavity comes into contact with the lower mediastinum, so it is recommended to work with pressures < 12>

-Respiratory problems:

The hypercapnia that occurs during laparoscopic surgery is due to the sum of two factors: the increase in dead space (well-ventilated but poorly perfused alveoli) and the absorption of CO2 by pneumoperitoneum. The measurement of expired CO2 (ETCO2) will be a good non-invasive control method; on the other hand, O2 saturation does not seem to be altered by pneumoperitoneum, but peak pressure (maximum pressure produced in the airway at each time) is elevated. ventilatory cycle, also producing a discrete metabolic acidosis, which becomes more evident the greater the hemodynamic impact. [21-23]

- Hemodynamic Repercussions:

At the beginning of insufflation, there is an increase in Central Venous Pressure (CVP), mean arterial pressure and cardiac output, but once the mean working pressure (12-14 mmHg) is established, it is higher than that of the vena cava, which decreases CVP as well as cardiac output. Hypoxia, hypercapnia and decreased cardiac output may be the most important factors in the development of cardiac rhythm disorders.

3- Related to the introduction of laparoscopic surgical materials and manipulation of instruments:

The use of instruments inside the abdominal cavity must always be carried out under optical vision, to avoid injuries to the different abdominal organs, so we will follow their entire journey from their entry into the cavity. The design of this type of instruments such as scissors, aspiration cannulas and forceps are long, so perforation can occur at any level if these instruments are not entered under endoscopic vision. Injuries caused by incorrect use or uncontrolled mobilization of surgical instruments can go unnoticed, increasing their severity. [24-26]

Electrocoagulation deserves a separate comment, which is used with the dissector, scissors or hemostasis forceps. Its improper use can cause thermal injuries in unwanted places (diaphragm, digestive tract, bile duct, etc. [26]

The high intensity of the light produced by the xenon source is capable of providing burns if the contact between the tip of the endoscope and the tissue or organ is prolonged. Inadvertent burns at the gastrointestinal level can cause perforation peritonitis, which generally appears on the 4th day. postoperative period, which is why the laparoscope must always be removed inside the trocar in the event of loss of pneumoperitoneum. [27]

Specific complications of each technique: (Biliary Surgery)

The risk of bile duct injury during laparoscopic cholecystectomy has increased due to the position and exposure of the anatomical structures of the extrahepatic bile ducts.

"Post-surgical or Iatrogenic Bile Duct Injury" is defined as any change secondary to surgery that causes bile leak from the biliary tree before the duodenal papilla, difficulty or impossibility of the passage of bile to the duodenum, or combinations of these. Vascular lesions of the biliary tree are also included, and can be of the hepatic, common, right or left arteries, as well as the portal vein.[28]

The annual incidence of bile duct injuries increased from about 0.2% in the open cholecystectomy era to approximately 0.5

Conclusion

Laparoscopy is a relatively safe procedure, however, great care must be taken during access to the abdominal cavity because most complications occur during entry.

Cholangiography continues to be, above cholangioresonance, the ideal imaging method to visualize and stage bile duct lesions since it allows percutaneous derivation to control, leak or obstruction of the biliary tree [5].

Biliary Tract Injuries have increased considerably in the last two decades, due to the predominance of laparoscopic cholecystectomy over open surgery, which has been correlated with an increase in the incidence of bile duct injuries. Overall, the frequency of bile duct injuries ranges from 0.1 to 0.6%. These injuries are three to four times more frequent during laparoscopic cholecystectomy (0.3-0.6%) than open cholecystectomy (0.1-0.3%). Strasberg's review is very significant, since in 124,433 patients studied in 22 case series, a percentage of 0.52 is reported with a range of 0 - 2.35% [7].

Bile duct injuries produced during cholecystectomy can be avoided, almost without exception, if several aspects are taken into account, although it seems that the surgeon's good judgment, experience and expertise usually have the greatest weight.

The main Iatrogenic Biliary Tract Injury (LIVB) is undoubtedly the most disastrous accident that a patient could suffer during a laparoscopic cholecystectomy. This is an operation from which “everyone comes out well” and yet Suddenly the panorama has changed radically, the “easy” surgery has become a nightmare. By injuring a patient's bile duct we will have completely changed his life and his future, since the serious consequences of this fact can range from prolonged open surgery with the permanent possibility of repeated cholangitis, restenosis and therefore reoperations to cirrhosis. gallbladder and death.

Conflicts of Interest: The authors declare that they have no conflicts of interest.

References

Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.

img

Virginia E. Koenig

Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.

img

Delcio G Silva Junior

Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.

img

Ziemlé Clément Méda

Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.

img

Mina Sherif Soliman Georgy

We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.

img

Layla Shojaie

The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.

img

Sing-yung Wu

Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.

img

Orlando Villarreal

Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.

img

Katarzyna Byczkowska

Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.

img

Anthony Kodzo-Grey Venyo

Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.

img

Pedro Marques Gomes

Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.

img

Bernard Terkimbi Utoo

This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.

img

Prof Sherif W Mansour

Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.

img

Hao Jiang

As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.

img

Dr Shiming Tang

Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.

img

Raed Mualem

International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.

img

Andreas Filippaios

Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.

img

Dr Suramya Dhamija

Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.

img

Bruno Chauffert

I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!

img

Baheci Selen

"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".

img

Jesus Simal-Gandara

I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.

img

Douglas Miyazaki

We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.

img

Dr Griffith

I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.

img

Dr Tong Ming Liu

I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.

img

Husain Taha Radhi

I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.

img

S Munshi

Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.

img

Tania Munoz

“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.

img

George Varvatsoulias

Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.

img

Rui Tao

Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.

img

Khurram Arshad

Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.

img

Gomez Barriga Maria Dolores

The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.

img

Lin Shaw Chin

Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.

img

Maria Dolores Gomez Barriga