AUCTORES
Globalize your Research
Review Article | DOI: https://doi.org/10.31579/2690-8816/165
Daswani Dental College Affliated to Rajasthan University of Health Sciences, India.
*Corresponding Author: Ashish Pandey. Daswani Dental College affliated to Rajasthan University of Health Sciences, India.
Citation: Ashish Pandey, Gunjan Tomar, (2025), Emergence of Bacteriocin-Producing Vancomycin-Resistant Enterococcus faecium in Nosocomial Settings, J Clinical Research Notes, 6(3); DOI:10.31579/2690-8816/165
Copyright: © 2025, Ashish Pandey. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 22 March 2025 | Accepted: 31 March 2025 | Published: 05 April 2025
Keywords: vancomycin-resistant enterococcus faecium; bacteriocins, nosocomial infections; antimicrobial resistance; genomic adaptations
The rise of vancomycin-resistant Enterococcus faecium (VREfm) presents significant challenges in healthcare environments due to limited treatment options and increased mortality rates. Recent studies have identified VREfm strains capable of producing bacteriocins, antimicrobial peptides that inhibit closely related bacterial species. This review explores the genetic adaptations facilitating bacteriocin production in VREfm, their impact on strain dominance within hospital environments, and potential implications for therapeutic interventions.
Enterococcus faecium is a Gram-positive bacterium that exists as a commensal organism in the human gastrointestinal tract but has evolved into a major nosocomial pathogen, particularly in immunocompromised patients [1]. The emergence of vancomycin-resistant Enterococcus faecium (VREfm) has significantly reduced treatment options and increased infection-related mortality [2]. The persistence and dominance of specific VREfm strains in healthcare environments require a deeper understanding of their adaptive mechanisms. One such mechanism is the acquisition of bacteriocin production, which may enhance strain survival and pathogenic potential [3].
Bacteriocin Production in VREfm
Bacteriocins are ribosomally synthesized antimicrobial peptides that enable bacterial species to inhibit competitors and establish dominance in a given niche [4]. In the case of VREfm, bacteriocin production is believed to provide a selective advantage by suppressing susceptible bacterial populations, facilitating colonization in hospitalized patients [5]. Recent genomic studies have identified bacteriocin-producing VREfm strains with distinct competitive properties that contribute to their persistence in nosocomial settings [6].
Genomic Insights
Whole-genome sequencing has revealed the presence of bacteriocin gene clusters in VREfm, suggesting horizontal gene transfer as a potential acquisition mechanism [7]. These gene clusters encode bacteriocins and their associated immunity proteins, which protect the producing strain from its own antimicrobial compounds [8]. Comparative genomic analyses indicate that these genetic elements are frequently linked to mobile genetic elements, further supporting their role in adaptation and spread within hospital environments [9].
Competitive Advantage in Nosocomial Environments
The ability to produce bacteriocins provides VREfm with a selective advantage in the competitive microbial environment of healthcare settings. Bacteriocin-mediated inhibition of other Enterococcus strains allows VREfm to dominate colonization sites, particularly in patients undergoing antibiotic therapy [10]. The widespread use of broad-spectrum antibiotics disrupts normal flora, creating an ecological vacuum that facilitates the expansion of resistant strains, including bacteriocin-producing VREfm [11].
Clinical Implications
The emergence of bacteriocin-producing VREfm has serious clinical implications. These strains demonstrate increased colonization rates and a higher likelihood of causing invasive infections, making infection control efforts more challenging [12]. Traditional decolonization strategies, such as probiotic administration or selective digestive decontamination, may be less effective against bacteriocin-producing strains due to their enhanced competitive capabilities [13].
Therapeutic Potential of Bacteriocins
Despite their role in VREfm pathogenicity, bacteriocins are being explored as potential antimicrobial agents against multidrug-resistant pathogens [14]. Their specificity and potency make them promising candidates for novel therapies, particularly in targeting resistant enterococcal strains. However, careful consideration is required to mitigate the risk of resistance development and unintended ecological shifts in microbiota composition [15].
The acquisition of bacteriocin production by VREfm represents a significant evolutionary adaptation, contributing to its persistence and spread in hospital environments. Comprehensive genomic surveillance and innovative therapeutic strategies are essential to address the challenges posed by these adaptable pathogens. Future research should focus on understanding bacteriocin regulation, resistance mechanisms, and potential applications in antimicrobial therapy.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
