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Research Article | DOI: https://doi.org/10.31579/2690-8794/306
Cell Biology and Neuroscience, Nelson Biological Laboratories, 604 Allison Road, Piscataway, NJ 08855.
*Corresponding Author: Merrill, G.F, Department of Cell Biology and Neuroscience, Division of Life Sciences, School of Arts and Sciences, Rutgers University, New Brunswick/Piscataway, New Jersey 08855.
Citation: Goncalves J, Patel S., Merrill G.F, (2026) Acetaminophen's Impact on Skeletal Muscles in Young Adults, Clinical Medical Reviews and Reports, 8(3); DOI:10.31579/2690-8794/306
Copyright: © 2026, Merrill, G.F. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 06 February 2026 | Accepted: 23 February 2026 | Published: 12 March 2026
Keywords: muscle strength; muscle fatigue; myoprotective
Globally, acetaminophen has been widely used as an analgesic and antipyretic. However, its role has been expanding in recent years through the use of new surgical approaches such as the Enhanced Recovery after Surgery protocol. In the current experiment we sought to identify differences in muscle strength when university students were treated with acetaminophen as opposed to placebo. The experiment was double blinded. Notably, males were found to have a statistically significant increase (P<0.05) in strength of grip when they were asked to sustain a maximal grip in the presence of acetaminophen. A similar trend was seen in females but results did not achieve statistical significance (P>0.05). We conclude that acetaminophen has previously unreported effects on human skeletal muscle performance that might have important sex-based variability. In addition, with the cost-effective nature of acetaminophen, and with its increasing use in the clinical arena, further work must be done. A few aims of such work should be to discover the medication’s differential actions on various muscle groups under differing conditions and in both sexes.
Acetaminophen is a widely used and inexpensive analgesic and antipyretic, but its potential for other uses is becoming more broadly understood. For example, in patients undergoing cardiac surgery, acetaminophen minimizes acute kidney injury (AKI) (1). Additionally, research in the Merrill Laboratory at Rutgers University has found cardioprotective (2-14), cerebroprotective (15), mitoprotective (15), and myoprotective (16) effects in animals. However, not all these effects have been corroborated in humans.
Even though acetaminophen’s mechanisms of cytoprotection are not fully understood, other research (3, 4) in combination with investigations in cell biology suggest a few possibilities. These include antioxidant scavenging. Acetaminophen is a monophenol and most phenols have antioxidant properties (13). By attenuating the effects of peroxynitrite (5, 8), hydroxyl radical (2), superoxide anion and hydrogen peroxide (10), acetaminophen reduces apoptosis and tissue necrosis (12). Cytotoxic actions of oxidants, left unblocked, can lead to activation of intracellular matrix metalloproteinases (e.g., MMP-2) causing downstream cleavage of troponin-I and impairment of myocardial diastolic function (11, 13, 15).
Furthermore, by reducing plasma concentrations of peroxynitrite, acetaminophen attenuates the ischemia/hypoxia-induced opening of mitochondrial permeability transition pores (MPTP) (10). This helps protect the physiological homeostasis of mitochondrial acid/base balance. Treatment of the tissues with acetaminophen also stabilizes ATPase activity of the sodium-potassium pump, leading to protection/preservation of the transmembrane distribution of anions and cations (7, 11-13).
It is reasonable to infer that the above mechanisms might also be beneficial to skeletal muscle, which is the premise of this experiment. Therefore, we sought to explore if acetaminophen has any impact on forearm skeletal muscle exhaustion. We also hypothesized that acetaminophen-treated participants would be able to sustain grip strength longer than placebo-treated participants.
The aim of this study was to investigate the effects of acetaminophen young adult skeletal muscle, specifically assessing intermittent and sustained conditions. In this experiment, the null hypothesis (H0) stated there will be no statistically significant difference in skeletal muscle function between placebo and acetaminophen treatments. The alternative hypothesis (HA) proposed a statistically significant difference.
Rutgers University students (n = 10) visited the Merrill Laboratory on two separate occasions. Participants were asked to maintain their usual daily routines by not altering their diets, exercise, sleep, or other lifestyle behaviors. All participants agreed to the requirements and remained compliant throughout the study.
Experimental Protocol
Hand grip was used as the measure of skeletal muscle performance. The forearm and hand muscles were involved when performing hand grip exercises during this experiment (Figure 1).
Figure 1: Forearm flexor muscles and other tissues involved in experiment with acetaminophen and young adults. Illustrated by F. Netter (see: Atlas of Human Anatomy 6th Edition 25th Anniversary Edition, F. Netter, M.D. Elsevier, 2014).
These muscles consist mostly of type II fast-twitch fibers, which fatigue more easily than type I slow-twitch fibers that are designed for sustained endurance (18). Three exercises were conducted each time the participants came to the lab. Throughout each experiment, participants assumed a boxer’s stance and faced away from the computer. Participants used their dominant hand to grip instruments.
A baseline grip exercise was conducted using a manual grip force transducer, and these baseline values helped with calibration of a digital dynamometer. In a boxer’s stance, and upon a research assistant’s audible cadence 3, 2, 1, GO, participants were instructed to grip the transducer with their maximum strength. This was exercise number 1.
Following this activity, participants conducted an intermittent grip exercise performed using an electronic model MLT004ST grip force transducer. Data were collected using the electronic grip transducer, which was attached to a data acquisition system paired to a desktop PC computer running LabChart software (v. 8.1.30, 2024). Participants were instructed to grip the transducer for six cycles while following verbal cues (18). This was exercise number 2.
After the intermittent exercise, participants were given a five-minute break, during which time they were permitted to sit down. After the break, participants assumed the boxer's stance for the final exercise. As per the instructor’s command, participants used the same digital dynamometer and data acquisition system to perform a fatigue exercise. Participants were instructed to perform a maximal grip of the electronic force transducer, and
to maintain it for as long as possible. When participants felt fatigue increasing and the need to stop, they notified the instructor approximately ten seconds before releasing their grip. Maximum forces were monitored at the onset and termination of the activity using the data acquisition system (18). This was exercise number 3.
Acetaminophen vs Placebo
Students participated in the above protocol on two separate occasions, occurring no less than 24 hours apart. Four hours prior to arrival, the participant consumed either an oral dose of placebo or acetaminophen (1000 mg). Doses were determined based on pilot data from the Merrill lab collected from a similar population of students (19). Such doses are also used in some hospitals for relief of pain following cardiac surgical procedures (20).
Statistics
All data were separated by gender as previous reports suggest men experience an accelerated metabolism of the medication (21). All data are expressed as means plus or minus one standard error of the mean (X̅ ± S.E.M). Analysis of Variance (ANOVA) was used to identify differences in variability, and statistical significance was defined as P < 0>
Figures 1 and 2 are images of forearm anatomy and equipment used during the experiment, respectively.
Figure 2: Equipment used in current experiment. Both manual and electronic (calibrated) hand-held dynamometers were used. Also shown are the data acquisition system (ADInstruments, Colorado Springs, CO) and a desktop computer running LabChart software (v. 8.30.24).
Figure 3: Sample of both periodic and sustained handgrip exercise in a conditioned, competitive young female gymnast. Note the improvement in muscle function in the presence of acetaminophen.
A sample tracing of the experiment is shown in Figure 3, where the left side illustrates a placebo sample tracing for both intermittent and sustained exercises. The right side indicates the same exercises under acetaminophen conditions. One can observe an increase in both intermittent and sustained grips when the participant is taking 1000 mg of acetaminophen in the sample tracing. For the sustained grip exercise, males (n = 5) had a significantly greater (P<0>
Figure 4: Histogram showing maximum strength of grip in male subjects in the absence and presence of acetaminophen (1000 mg, oral).
Females did not display a similar trend.
Trends in both males and females suggested a higher average maximum force during intermittent exercise under the placebo conditions. For example, males had a maximum force of 44 ± 2.5 (placebo) and 39.8 ± 2.9 (acetaminophen). Similar trends are seen in the female sample. Both males and females had higher minimum grip strengths under acetaminophen conditions during the intermittent exercise. When the female sample tested intermittent grip under placebo conditions, maximum force was 14.2 ± 0.8, while the same group of females under acetaminophen had a maximum force of 15.4 ± 1.6. This trend is replicated within the male sample. In spite of the general variability, there was no statistically significant difference between acetaminophen and placebo during the intermittent grip exercise for both male and female groups.
Previous studies have demonstrated that over-the-counter doses of acetaminophen, when consumed in combination with resistance training, appear to enhance muscle hypertrophy and gains in strength in older adults (22).
Acetaminophen has many potential mechanisms for myoprotection (17) that could ultimately lead to increased time to fatigue and increase in magnitude of force both before and after fatigue. Acetaminophen’s ability to act as an antioxidant/oxygen scavenger is particularly notable during ischemia and reperfusion, such as during sustained, strenuous, strength-training exercises (e.g., heavy lifting) when muscle contraction can actually reduce blood flow (23). Contraction-induced, extravascular compression, can partially occlude blood flow leading to transient tissue ischemia. Such temporary occlusion of blood flow to a working muscle substantially decreases time to fatigue and reduces development of maximal force (24).
Exercise-induced muscle damage increases free radical production, leading to oxidative damage to biomolecules (25). During ischemia and reperfusion, including that caused by exhaustive, heavy exercise, reactive oxygen species such as superoxide anion (O2), hydrogen peroxide (H2O2), hydroxyl radical (OH-), and peroxynitrite (ONOO-) are synthesized and released at greater rates. This can trigger cell death (apoptosis), tissue injury, and necrosis when these induce cellular calcium overload by impairing uptake, accelerating release, and/or a combination of alterations in calcium homeostasis (13). It is hypothesized that acetaminophen can act as an oxidant scavenger due to the structure of the acetaminophen phenolic ring, and thereby blocking cellular cascades that lead to apoptosis and necrosis (12, 26).
Acetaminophen can also attenuate the activation of intracellular MMP-2 and subsequent cleavage of troponin I by reducing the circulating levels of peroxynitrite. Although peroxynitrite itself is damaging to myocardial and endothelial tissue, it has also been shown to activate mediators of cellular damage (e.g., the matrix metalloproteinases). Studies have shown that the intracellular actions of matrix metalloproteinase-2 (MMP-2) is responsible, at least in part, for the injury observed from acute release of peroxynitrite following myocardial ischemia and reperfusion (27). Activation of myocardial MMP-2 causes increased proteolysis of troponin-I (TnI), and results in a decrease in overall cardiac mechanical function (10).
Ischemia and reperfusion cause a significant increase in opening of the mitochondrial permeability transition pore (MPTP), with subsequent mitochondrial swelling, and release of mitochondrial cytochrome c. Experiments on Langendorff-perfused guinea pig hearts revealed that treatment with acetaminophen preserved contractile function (particularly diastolic function) after peroxynitrite administration. Western blotting of heart homogenates showed increased degradative products of TnI in vehicle-treated versus acetaminophen-treated hearts. This physiology and observed inhibition of cytochrome c release in acetaminophen-treated subjects, which is likely a response to the complete upstream inhibition of MPTP opening in the presence of acetaminophen, reveals that acetaminophen is cardioprotective, at least in part, by attenuating peroxynitrite-activated, MMP-2-mediated cleavage of TnI. (10, 12).
The above mechanisms potentially play a part in the results found in this experiment, although they probably do not account for males having the only significantly higher strength of grip. However, the gender-based differences in drug absorption are well documented in the literature (21). And, if this is the case, then there could also be gender-based differences in acetaminophen’s distribution, metabolism, and elimination from the tissues. Additionally, pharmacokinetics in women is affected by lower body weight, slower gastrointestinal motility, and reduced intestinal enzymatic activity, (21). Further study of such prospective differences in acetaminophen’s efficacy and potency in men vs women is warranted.
The need for myoprotective drugs is vast. Everything from Lou Gehrig's disease, to sports injuries, sepsis, and organ protection during surgery could yield potential benefits from broader and more intense research on acetaminophen. As mentioned above, a recent study demonstrated an association between acetaminophen and reduced postoperative acute renal injury in adults undergoing cardiac surgery. Investigators theorized this to be due to a reduction in hemoglobin-induced oxidation of arachidonic acid and subsequent attenuation of intraoperative plasma isofuran concentrations (28). This has significant implications for patients undergoing cardiac surgery and any major surgery with a potentially long ischemic time of organ or muscle.
The hand-held electronic dynamometer which was used to measure grip strength was reported to have caused mild discomfort for some participants. In turn, the discomfort could have influenced participant effort, thus introducing bias or performance variability across testing sessions. The sample size of the experiment was ten total students, five male and five female. This sample size could have limited the ability to identify trends in females. Additionally, the study focused on forearm and hand muscles in a seated, non-weight-bearing position. The above position allows for the testing of small muscle groups, but limits the ability to apply the findings to postural muscles used in whole-body movements. As a result, the effects of acetaminophen on lower-limb, core, or full-body muscular performance remain unknown and should be the focus of future studies.
Acetaminophen has previously unreported effects on human skeletal muscle performance that might have important sex-based variability. In addition, with the cost-effective nature of acetaminophen, and with its increasing use in the clinical arena, further research must be conducted on this topic. A few aims of such work should be to discover the medication’s differential actions on various muscle groups under differing conditions and in both sexes.
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My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.
Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.
Dear Grace Pierce, Editorial Coordinator of the journal IJCCR, I had a very positive experience with Auctores - Journal throughout the publication process. The Editorial Team was highly responsive, professional, and supportive at every stage. I would like to extend my sincere thanks to the Editor: Grace Pierce, for her guidance and assistance. The peer-review process was smooth and constructive, helping improve the quality of my work. I would gladly recommend Auctores Journal to fellow researchers and authors. Dr. SABITA SINHA, Medical Oncologist, MD (Electro Homeopathy).
Dear Maria Emerson, Editorial Coordinator of - Journal of Clinical Research and Reports. ''I am pleased to provide this testimonial following the publication of our recent case report in this journal. The peer review process was rigorous, constructive, thorough, and conducted in a timely manner. The reviewers’ comments were thoughtful, detailed, and highly constructive, contributing substantially to the refinement, clarity, and scientific robustness of our manuscript. The process was conducted with professionalism and academic integrity throughout. The support provided by the editorial office was exemplary. Communication was consistently prompt, clear, and courteous at all stages of the submission and publication process. The editorial team demonstrated a high level of organization and responsiveness, ensuring that all queries were addressed efficiently and that the process remained transparent and well-coordinated. The overall quality of the journal is reflected in its strong editorial standards, commitment to scientific excellence, and dedication to publishing clinically meaningful research. It has been a privilege to publish our work in this journal, and we would welcome the opportunity to contribute further in the future.'' Best wishes from, Dr. Efstratios Trogkanis, Cardiologist.
